Yang Yu

发表

Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity

Zhenghu Chen, Zhenyu Wang, Jonathan C Pang, 2016, Scientific Reports.

Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia

T. Man, Yang Yu, L. Perlaky, 2015, British journal of haematology.

Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo

Zhenghu Chen, Yang Yu, Jiaxiong Lu, 2016, Oncotarget.

Novel Src/Abl tyrosine kinase inhibitor bosutinib suppresses neuroblastoma growth via inhibiting Src/Abl signaling

Zhenghu Chen, Jonathan C Pang, Yang Yu, 2016, Oncotarget.

The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.

Tianshu Yang, Yang Yu, Shayahati Bieerkehazhi, 2017, Cancer letters.

Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma

Zhenghu Chen, Jonathan C Pang, Yang Yu, 2016, Oncotarget.

Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis

Eugene S. Kim, Hao Wang, Yan Shi, 2016, Scientific Reports.

Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma

Tianshu Yang, Yang Yu, Jiaxiong Lu, 2016, Oncotarget.

Second-generation proteasome inhibitor carfilzomib sensitizes neuroblastoma cells to doxorubicin-induced apoptosis

Zhenghu Chen, Yang Yu, Jiaxiong Lu, 2016, Oncotarget.

Tumor Necrosis Factor-α Induces RelA Degradation via Ubiquitination at Lysine 195 to Prevent Excessive Nuclear Factor-κB Activation*

Songbin Fu, Yang Yu, Yanling Zhao, 2009, The Journal of Biological Chemistry.

USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.

J. Qin, Songbin Fu, Xiongbin Lu, 2010, Cellular signalling.

USP 21 negatively regulates antiviral response by acting as a RIGI deubiquitinase

Pumin Zhang, Zhenghu Chen, Yang Yu, 2014 .

Protein Phosphatase 2A Acts as a Mitogen-activated Protein Kinase Kinase Kinase 3 (MEKK3) Phosphatase to Inhibit Lysophosphatidic Acid-induced IκB Kinase β/Nuclear Factor-κB Activation*

Songbin Fu, Xiongbin Lu, Yang Yu, 2010, The Journal of Biological Chemistry.

Novel proteasome inhibitor ixazomib sensitizes neuroblastoma cells to doxorubicin treatment

Zhenghu Chen, Jonathan C Pang, Yang Yu, 2016, Scientific Reports.

Phosphorylation of Thr-516 and Ser-520 in the Kinase Activation Loop of MEKK3 Is Required for Lysophosphatidic Acid-mediated Optimal IκB Kinase β (IKKβ)/Nuclear Factor-κB (NF-κB) Activation*

Songbin Fu, Yang Yu, Jianhua Yang, 2010, The Journal of Biological Chemistry.

MELK is a novel therapeutic target in high-risk neuroblastoma

S. Agarwal, Zhenghu Chen, Yang Yu, 2017, Oncotarget.

mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling

Eugene S. Kim, Wei Liu, J. Dou, 2014, Apoptosis.

BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy

Yang Yu, Jianhua Yang, A. Muth, 2021, Translational oncology.

Novel proteasome inhibitor delanzomib sensitizes cervical cancer cells to doxorubicin-induced apoptosis via stabilizing tumor suppressor proteins in the p53 pathway

Yang Yu, Jiaxiong Lu, Yanling Zhao, 2017, Oncotarget.

ERK Inhibitor Ulixertinib Inhibits High-Risk Neuroblastoma Growth In Vitro and In Vivo

M. Fabbri, S. Jung, Yang Yu, 2022, Cancers.

Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo

Yan Shi, Roma H. Patel, Zhenghu Chen, 2017, Oncotarget.

Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis

J. Dou, Yan Shi, Tianshu Yang, 2016, Scientific Reports.

Inhibition of Ubiquitin-Specific Protease 14 Suppresses Cell Proliferation and Synergizes with Chemotherapeutic Agents in Neuroblastoma

Zhenghu Chen, Yang Yu, Jiaxiong Lu, 2019, Molecular Cancer Therapeutics.

Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.

S. Agarwal, Zhenghu Chen, Yang Yu, 2019, Cancer letters.

PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.

Songbin Fu, Xiongbin Lu, Xia Lin, 2009, Cellular signalling.

SKLB1206, a Novel Orally Available Multikinase Inhibitor Targeting EGFR Activating and T790M Mutants, ErbB2, ErbB4, and VEGFR2, Displays Potent Antitumor Activity Both In Vitro and In Vivo

Yong Xu, Yang Yu, Xin Chen, 2012, Molecular Cancer Therapeutics.

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis

J. Zhao, Yang Yu, Shayahati Bieerkehazhi, 2017, Oncotarget.

Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling

Yang Yu, Yanling Zhao, Hong Zhang, 2013, Scientific Reports.

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

Pumin Zhang, Zhenghu Chen, Yang Yu, 2014, The Journal of experimental medicine.

TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation.

Yang Yu, Hong Zhang, Jianhua Yang, 2011, Cellular signalling.

Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation*

J. Qin, M. Xie, Songbin Fu, 2009, The Journal of Biological Chemistry.

Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis

J. Dou, W. Cao, Zhenyu Wang, 2016, Scientific Reports.

Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression*

M. Xie, Songbin Fu, Yang Yu, 2008, Journal of Biological Chemistry.

Targeting LRH-1 in hepatoblastoma cell lines causes decreased proliferation

B. Liu, Roma H. Patel, Yang Yu, 2018, Oncology reports.

TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells

W. Cao, Zhenyu Wang, Yang Yu, 2016, Scientific Reports.

EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma

S. Agarwal, K. Rajapakshe, C. Coarfa, 2017, Oncotarget.

MEKK3 is required for lysophosphatidic acid-induced NF-kappaB activation.

Songbin Fu, Yang Yu, Hong Zhang, 2009, Cellular signalling.

Delanzomib, a novel proteasome inhibitor, sensitizes breast cancer cells to doxorubicin‐induced apoptosis

Yang Yu, Jiaxiong Lu, Yanling Zhao, 2019, Thoracic cancer.

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

J. Dou, Yang Yu, Hong Zhang, 2013, Cell Death and Disease.

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

Songbin Fu, Yang Yu, Hong Zhang, 2011, Cell Death and Differentiation.

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

J. Dou, Yang Yu, Yanling Zhao, 2014, Cell Death and Disease.

Second-generation proteasome inhibitor carfilzomib enhances doxorubicin-induced cytotoxicity and apoptosis in breast cancer cells

Zhenyu Wang, Yang Yu, Shayahati Bieerkehazhi, 2016, Oncotarget.

mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling

Wei Liu, J. Dou, Yan Shi, 2014, Apoptosis.

Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma

L. Donehower, J. Yang, Yang Yu, 2010, Oncogene.