Wenchao Yang

发表

Efficient synthesis and antiproliferative activity of novel thioether-substituted flavonoids.

Wei Huang, Qiong Chen, Wenchao Yang, 2013, European journal of medicinal chemistry.

Free-energy perturbation simulation on transition states and redesign of butyrylcholinesterase.

Fang Zheng, Chang-Guo Zhan, C. Zhan, 2009, Biophysical journal.

Comparative Kinetics of Qi Site Inhibitors of Cytochrome bc1 Complex: Picomolar Antimycin and Micromolar Cyazofamid

Wenchao Yang, Hui Li, Xiao-Lei Zhu, 2014, Chemical biology & drug design.

Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.

Guang-Fu Yang, Xiao-Lei Zhu, Qi Sun, 2012, Bioorganic & medicinal chemistry.

The assembly of succinate dehydrogenase: a key enzyme in bioenergetics

E. Berry, Wenchao Yang, Xiao-Lei Zhu, 2019, Cellular and Molecular Life Sciences.

Discovery of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors via Pharmacophore-linked Fragment Virtual Screening Approach.

Wenchao Yang, Sheng-quan Hu, Xiao-Lei Zhu, 2016, Journal of agricultural and food chemistry.

Succinate Dehydrogenase: An Ideal Target for Fungicide Discovery

Li Xiong, Wei Huang, Wenchao Yang, 2015 .

Fragment-based Discovery of Flexible Inhibitor Targeting Wild-type Acetohydroxyacid Synthase and P197L Mutant.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2020, Pest management science.

Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(II) metallacycle-loaded biomimic melanin dots

Yao Sun, Wenchao Yang, Guangfu Yang, 2020, Science China Chemistry.

Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations.

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2013, Journal of molecular graphics & modelling.

Computational simulations of structural role of the active-site W374C mutation of acetyl-coenzyme-A carboxylase: Multi-drug resistance mechanism

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2011, Journal of molecular modeling.

Molecular insights into the mechanism of 4‐hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X‐ray crystallography and computational simulations

C. Zhan, Jia-wei Wu, Wenchao Yang, 2019, The FEBS journal.

Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.

C. Zhan, F. Zheng, Wenchao Yang, 2010, Biochemistry.

[Design of acetylcholinesterase inhibitor for Alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands].

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2012, Yao xue xue bao = Acta pharmaceutica Sinica.

Free energy perturbation simulation on transition states and high-activity mutants of human butyrylcholinesterase for (-)-cocaine hydrolysis.

D. Gao, C. Zhan, F. Zheng, 2010, The journal of physical chemistry. B.

Discovery of Specific Nonpeptide Probe for Chymotrypsin via Molecular Docking-Based Virtual Screening and the Application.

Wenchao Yang, Guangfu Yang, Feng-Xu Wu, 2018, ACS applied bio materials.

Nonpeptide-Based Small-Molecule Probe for Fluorogenic and Chromogenic Detection of Chymotrypsin.

Wenchao Yang, Guangfu Yang, Jun-Gu Guo, 2017, Analytical chemistry.

Coumarin-based novel fluorescent zinc ion probe in aqueous solution

Wenchao Yang, Guangfu Yang, Ge‐Fei Hao, 2013 .

Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations.

C. Zhan, Jia-wei Wu, Wenchao Yang, 2019 .

Rieske Iron–Sulfur Protein of the Cytochrome bc1 Complex: A Potential Target for Fungicide Discovery

Wenchao Yang, Hui Li, Xiao-Lei Zhu, 2012, Chembiochem : a European journal of chemical biology.

Fluorogenic and chromogenic detection of carboxypeptidase Y with a nonpeptide-based small-molecule probe

Wenchao Yang, Guangfu Yang, Feng-Xu Wu, 2018, Sensors and Actuators B: Chemical.

Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2019, Biological chemistry.

Redox probes tagged electrochemical aptasensing device for simultaneous detection of multiple cytokines in real time

Wenchao Yang, Guozhen Liu, Guangfu Yang, 2021 .

Non-peptide-based fluorogenic small-molecule probe for elastase.

Wenchao Yang, Guangfu Yang, Qi Sun, 2013, Analytical chemistry.

Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors.

Wenchao Yang, Guangfu Yang, Tao Chen, 2015, Pest management science.

A Highly Sensitive and Selective Fluorescent Probe for Thiophenol Designed via a Twist-Blockage Strategy.

Wenchao Yang, Guangfu Yang, Qi Sun, 2016, Analytical chemistry.

A coumarin-based fluorescent probe for selective and sensitive detection of thiophenols and its application.

Wenchao Yang, Guangfu Yang, Shu-Hou Yang, 2014, Analytical chemistry.

An Activity-based Fluorogenic Probe Enables Cellular and In Vivo Profiling of Carboxylesterase Isozymes.

Yao Sun, Wenchao Yang, Guangfu Yang, 2020, Analytical chemistry.

Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.

Nan Wang, Wenchao Yang, Yitian Dai, 2022, Analytical chemistry.

Structural Insights of 4-Hydrophenylpyruvate Dioxygenase Inhibition by Structurally Diverse Small Molecules

Wenchao Yang, Jiangqing Dong, Hong-Yan Lin, 2022, SSRN Electronic Journal.

Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors.

Wenchao Yang, Guangfu Yang, Feng-Xu Wu, 2019, European journal of medicinal chemistry.

Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2012, Bioorganic & medicinal chemistry letters.

Novel coumarin-based sensitive and selective fluorescent probes for biothiols in aqueous solution and in living cells

Wenchao Yang, Guangfu Yang, Jun Li, 2013 .

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2016, Journal of agricultural and food chemistry.

Synthesis and herbicidal evaluation of triketone-containing quinazoline-2,4-diones.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2014, Journal of agricultural and food chemistry.

Pyrazole-Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2019, Journal of agricultural and food chemistry.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2015, Journal of agricultural and food chemistry.

Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex.

Ge-Fei Hao, Guang-Fu Yang, Xiao-Lei Zhu, 2012, Journal of the American Chemical Society.

Design, Synthesis, and Bioevaluation of Novel Strobilurin Derivatives

Qiong Chen, Wenchao Yang, Hui Li, 2012 .

Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2021, Journal of agricultural and food chemistry.

Structure-Based Discovery of Potential Fungicides as Succinate Ubiquinone Oxidoreductase Inhibitors.

Wenchao Yang, Guangfu Yang, L. Xiong, 2017, Journal of agricultural and food chemistry.

Formation of supramolecular permethrin/β-cyclodextrin nanorods

D. Gao, C. Zhan, Wenchao Yang, 2006 .

Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria.

Yao Sun, Wenchao Yang, Xiaoqiang Chen, 2021, Angewandte Chemie.

Cyanine-based dithienylethenes: synthesis, characterization, photochromism and biological imaging in living cells

Wenchao Yang, Shenghua Liu, Jun Yin, 2015 .

Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress

Wenchao Yang, Xiao Zeng, Jun Yin, 2022, Advanced Agrochem.

Review on the recent progress in the development of fluorescent probes targeting enzymes

Wenchao Yang, Guangfu Yang, Shi-Yu Liu, 2021, Methods and applications in fluorescence.

Preparation and characterization of inclusion complex of iprodione and beta-cyclodextrin to improve fungicidal activity.

Qiong Chen, Wenchao Yang, Hong‐Bo Wang, 2007, Journal of agricultural and food chemistry.

Molecular pathogenesis of tumorigenesis caused by succinate dehydrogenase defect.

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2019, European journal of cell biology.

Near‐Infrared Fluorescence/Photoacoustic Agent with an Intensifying Optical Performance for Imaging‐Guided Effective Photothermal Therapy

Yao Sun, Wenchao Yang, Guangfu Yang, 2020 .

Bioactive Permethrin/β-Cyclodextrin Inclusion Complex

D. Gao, C. Zhan, Wenchao Yang, 2006 .

Synthesis and Herbicidal Activity of Triketone-Aminopyridines as Potent p-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2021, Journal of agricultural and food chemistry.

Where are the New Herbicides?

Wenchao Yang, Qing X. Li, Guangfu Yang, 2021, Pest management science.

Rational Redesign of Enzyme via the Combination of Quantum Mechanics/Molecular Mechanics, Molecular Dynamics, and Structural Biology Study.

C. Zhan, Wenchao Yang, Guangfu Yang, 2021, Journal of the American Chemical Society.

Rational Design and Application of An Indolium-Derived Heptamethine Cyanine with Record-Long NIR-II Emission

Juyoung Yoon, Wenchao Yang, Guangfu Yang, 2021, CCS Chemistry.

Yeast-based assays for detecting protein-protein/drug interactions and their inhibitors.

Wenchao Yang, Guangfu Yang, Behrooz Moosavi, 2017, European journal of cell biology.

Substrate selectivity of high-activity mutants of human butyrylcholinesterase.

C. Zhan, F. Zheng, Wenchao Yang, 2013, Organic & biomolecular chemistry.

Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging.

Yingfu Li, Wenchao Yang, Guangfu Yang, 2018, ACS sensors.

Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy.

Wenchao Yang, Guangfu Yang, Qi Sun, 2017, Chemical communications.

Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants.

D. Gao, C. Zhan, Wenchao Yang, 2007, Journal of the American Chemical Society.

Graphene Oxide Based Recyclable in Vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice.

Wenchao Yang, E. Goldys, Guozhen Liu, 2018, ACS applied materials & interfaces.

Computational redesign of human butyrylcholinesterase for anticocaine medication.

Guangfu Yang, Chang-Guo Zhan, D. Gao, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors.

Wenchao Yang, Hui Li, Guangfu Yang, 2011, Bioorganic & medicinal chemistry.

Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.

C. Zhan, Wenchao Yang, Xi Chen, 2010, Chemico-biological interactions.

Most efficient cocaine hydrolase designed by virtual screening of transition states.

Fang Zheng, Chang-Guo Zhan, D. Gao, 2008, Journal of the American Chemical Society.

A highly efficient cocaine detoxifying enzyme obtained by computational design

C. Zhan, F. Zheng, Wenchao Yang, 2014, Nature Communications.

New inhibitor of 3-phosphoinositide dependent protein kinase-1 identified from virtual screening.

Chang-Guo Zhan, Adel Hamza, A. Hamza, 2012, Bioorganic & medicinal chemistry letters.

Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine

C. Zhan, H. Tai, F. Zheng, 2011, Molecular Pharmacology.

4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Chemical Biology to Agrochemicals.

Wenchao Yang, Guangfu Yang, Behrooz Moosavi, 2017, Journal of agricultural and food chemistry.

Detection of Intracellular Selenol-Containing Molecules Using a Fluorescent Probe with Near-Zero Background Signal.

Guang-Fu Yang, Qi Sun, Wenchao Yang, 2016, Analytical chemistry.

Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.

Yao Sun, Wenchao Yang, Guangfu Yang, 2020, ACS nano.

Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues

Wen-Chao Yang, Hong-Mei Wang, Yu-Ling Xu, 2018, Sensors.

In vivo fluorescent screening for HPPD-targeted herbicide discovery.

Wenchao Yang, Yitian Dai, W. Guo, 2022, Pest management science.

Design of a Metallacycle‐Based Supramolecular Photosensitizer for In Vivo Image‐Guided Photodynamic Inactivation of Bacteria

Yao Sun, Wenchao Yang, Xiaoqiang Chen, 2021, Angewandte Chemie.

Multienzyme-Targeted Fluorescent Probe as a Biosensing Platform for Broad Detection of Pesticide Residues.

Yao Sun, Wenchao Yang, Guangfu Yang, 2021, Analytical chemistry.

Pharmacophore-Oriented Discovery of Novel 1,2,3-Benzotriazine-4-one Derivatives as Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2022, Journal of agricultural and food chemistry.

Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.

Wenchao Yang, Jiangqing Dong, Hong-Yan Lin, 2023, Journal of agricultural and food chemistry.

The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism

C. Zhan, Wenchao Yang, Junjun Liu, 2021 .

Discovery of Novel Pyrazole-Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Lei Wu, Qiong Chen, Wenchao Yang, 2020, Journal of agricultural and food chemistry.

Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery

Feng-Xu Wu, Guang-Fu Yang, Chang-Guo Zhan, 2019, Research.

Development of Small-Molecule Fluorescent Probes Targeting Enzymes

Wenchao Yang, Yuan Li, Dong-Tai Xie, 2022, Molecules.

Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology.

Wenchao Yang, Guang-Fu Yang, Jiangqing Dong, 2023, Trends in biochemical sciences.

In Vivo Diagnostics of Abiotic Plant Stress Responses Via In Situ Real-Time Fluorescence Imaging.

Wenchao Yang, Hong-Yan Lin, Long-Can Mei, 2022, Plant physiology.

Rational Design of Esterase-Insensitive Fluorogenic Probes for In Vivo Imaging.

Wenchao Yang, Long-Can Mei, Fan Wang, 2023, ACS sensors.

Activity-Based Near-Infrared Fluorogenic Probe for Enabling in Vitro and in Vivo Profiling of Neutrophil Elastase.

Wenchao Yang, Guangfu Yang, Rong-Rong Li, 2019, Analytical chemistry.

Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors.

Wenchao Yang, Guangfu Yang, Hong-Yan Lin, 2014, Bioorganic & medicinal chemistry.

Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2014, Bioorganic & medicinal chemistry.

Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.

C. Zhan, F. Zheng, Wenchao Yang, 2013, Chemico-biological interactions.

Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.

C. Zhan, Wenchao Yang, Junjun Liu, 2011, The journal of physical chemistry. B.

Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation.

Guangfu Yang, Chang-Guo Zhan, D. Gao, 2006, Angewandte Chemie.

Quinazoline-2,4-dione: A promising scaffold for herbicide discovery

Wenchao Yang, Guangfu Yang, Hong-Yan Lin, 2021 .

Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor.

Wenchao Yang, Guangfu Yang, Guo-Zhen Liu, 2021, Analytical chemistry.

Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.

Qiong Chen, Wenchao Yang, Xiao-Lei Zhu, 2012, Bioorganic & Medicinal Chemistry.

Biocatalytic Fluoroalkylation Using Fluorinated S-Adenosyl-l-methionine Cofactors.

Wenchao Yang, Wen Liu, Xingang Zhang, 2023, Organic letters.