K. Fukasawa

发表

Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo

H. Hirai, T. Shimomura, Makiko Kobayashi, 2010, Cell cycle.

Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo

H. Hirai, T. Shimomura, Makiko Kobayashi, 2011, Investigational New Drugs.

Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro.

M. Kitagawa, K. Semba, Y. Taya, 2005, Journal of biochemistry.

Cdk-mediated phosphorylation of pRB regulates HDAC binding in vitro.

H. Hirai, K. Fukasawa, T. Takaki, 2004, Biochemical and biophysical research communications.

Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein*

T Honma, H. Hirai, K. Fukasawa, 2001, The Journal of Biological Chemistry.

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

K. Fukasawa, T. Machida, Y. Iwasawa, 2001, Journal of medicinal chemistry.

Evolution of a multigene family that encodes the Kunitz chymotrypsin inhibitor in winged bean: a possible intermediate in the generation of a new gene with a distinct pattern of expression

K. Fukasawa, Y. Sakata, S. Peyachoknagul, 1997, Molecular and General Genetics MGG.

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

K. Fukasawa, S. Nishimura, T. Yoshinari, 1999, Cancer research.

Nucleotide sequence of the putative regulatory region of mouse lactate dehydrogenase-A gene.

K. Fukasawa, S. Li, 1986, The Biochemical journal.

Excess wild-type p53 blocks initiation and maintenance of simian virus 40 transformation

K. Fukasawa, R. Pollack, G. Sakoulas, 1991, Molecular and cellular biology.

Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.

C. Bailly, P. Colson, C. Houssier, 1999, Cancer research.

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.

T Honma, K. Fukasawa, N. Kawanishi, 2001, Journal of medicinal chemistry.

Molecular evolution of mammalian lactate dehydrogenase-A genes and pseudogenes: association of a mouse processed pseudogene with a B1 repetitive sequence.

Wen-Hsiung Li, C. Luo, W. Li, 1986, Molecular biology and evolution.

Molecular nature of spontaneous mutations in mouse lactate dehydrogenase-A processed pseudogenes.

K. Fukasawa, S. Li, F. Sharief, 1987, Genetics.

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Tsuyoshi Arai, Hiroshi Hirai, Takashi Yoshizumi, 2009, Molecular Cancer Therapeutics.

Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen.

Erica M. Stec, K. Fukasawa, P. Hodder, 2010, Assay and drug development technologies.

Complete nucleotide sequence of the mouse lactate dehydrogenase-A functional gene: comparison of the exon-intron organization of dehydrogenase genes.

K. Fukasawa, S. Li, 1987, Genetics.

Protein structure and gene organization of mouse lactate dehydrogenase-A isozyme.

K. Fukasawa, Y. Nakashima, H. Tiano, 1985, European journal of biochemistry.

A new mechanism of acquisition of drug resistance by partial duplication of topoisomerase I.

K. Fukasawa, S. Nishimura, H. Komatani, 1999, Cancer research.

Sequence‐selective DNA cleavage by a topoisomerase I poison, NB‐506

K. Fukasawa, S. Nishimura, H. Komatani, 1998, International journal of cancer.

Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding.

Takashi Yoshizumi, K. Fukasawa, H. Kotani, 2010, Acta crystallographica. Section D, Biological crystallography.

Ubiquitous nuclear proteins bind to 5′ upstream region of major Kunitz chymotrypsin inhibitor gene in winged bean

K. Fukasawa, Y. Sakata, Y. Habu, 1993, Plant Molecular Biology.

Improvement of Devices for Propagation by Cuttings in the Arid Land

K. Fukasawa, Atsushi Ooishi, 1995 .

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

H. Aburatani, A. Yasui, T. Kodama, 1997, Cancer research.