Yingsi Chen

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

Qing Xiang, D. Heimbrook, C. Tovar, 2006, Molecular Cancer Therapeutics.

Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.

L. Vassilev, Qing Xiang, C. Tovar, 2007, Bioorganic & medicinal chemistry letters.

3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors.

U. Kammlott, C. Lukacs, Yi Chen, 2003, Bioorganic & medicinal chemistry letters.

Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.

C. Rondinone, Yingsi Chen, Y. Qian, 2011, Journal of medicinal chemistry.

Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.

Yi Chen, K. Luk, A. Railkar, 2006, Bioorganic & medicinal chemistry letters.

Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.

Yingsi Chen, Y. Qian, R. Taub, 2011, Bioorganic & medicinal chemistry letters.

Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS/MAPK/NF-κB signaling pathway in vivo and in vitro.

Yingsi Chen, Jia Song, Zhini He, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation.

K. Luk, A. Railkar, B. Higgins, 2005, Bioorganic & Medicinal Chemistry.

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.

Nader Fotouhi, Sung-Sau So, S. So, 2006, Journal of medicinal chemistry.

Identification of novel, potent and selective inhibitors of Polo-like kinase 1.

Yi Chen, Zhi Chen, K. Luk, 2012, Bioorganic & Medicinal Chemistry Letters.

Metal impurities cause false positives in high-throughput screening campaigns.

Stephen Gabriel, Binh Vu, Johannes C. Hermann, 2013, ACS medicinal chemistry letters.

Expression and characterization of glycosylated and catalytically active recombinant human alpha-galactosidase A produced in Pichia pastoris.

Yingsi Chen, D. Calhoun, J. André, 2000, Protein expression and purification.