N. Nemoto

发表

Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes.

H. Tamaki, T. Sakuma, Yo-ichi Uchida, 2005, Toxicology.

Genetic Polymorphism of CYP 2 A 6 Gene and Tobacco-induced Lung Cancer Risk in Male Smokers 1

J. Yokota, H. Dosaka-akita, T. Kamataki, 2002 .

Inter-individual variations of arylhydrocarbon-hydroxylase activity in cultured human epidermal and dermal cells.

T. Kuroki, N. Nemoto, J. Hosoi, 1987, Japanese journal of cancer research : Gann.

Synergistic increases of metabolism and oxidation-reduction genes on their expression after combined treatment with a CYP1A inducer and andrographolide.

N. Nemoto, W. Chatuphonprasert, K. Jarukamjorn, 2009, Chemico-biological interactions.

Modified expression of aryl hydrocarbon receptor-related genes by deoxymiroestrol, a phytoestrogen, in mouse hepatocytes in primary culture.

T. Sakuma, N. Nemoto, W. Putalun, 2011, Journal of ethnopharmacology.

Suppression of beta-naphthoflavone induced CYP1A expression and lipid-peroxidation by berberine.

N. Nemoto, W. Chatuphonprasert, K. Jarukamjorn, 2011, Fitoterapia.

Glucuronidation of benzo[a]pyrene in hamster embryo cells.

N. Nemoto, S. Takayama, T. Hirakawa, 1978, Chemico-biological interactions.

Different regulation of the expression of mouse hepatic cytochrome P450 2B enzymes by glucocorticoid and phenobarbital.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 1999, Archives of biochemistry and biophysics.

Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy.

Y. Ouchi, S. Inoue, N. Nemoto, 2002, Journal of molecular endocrinology.

Sex Differences of Drug-metabolizing Enzyme: Female Predominant Expression of Human and Mouse Cytochrome P450 3A Isoforms

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2009 .

Extensive sequence homology of the goldfish ras gene to mammalian ras genes.

T. Ishikawa, N. Nemoto, K. Kodama, 1986, Differentiation; research in biological diversity.

Effects of unsaturated fatty acids on metabolism of benzo[a]pyrene in an NADPH-fortified rat liver microsomal system.

N. Nemoto, S. Takayama, 1983, Carcinogenesis.

Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes.

N. Nemoto, T. Remsungnen, W. Chatuphonprasert, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Regulatory Xenobiotic Responsive Elements in the Distal 5′-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin

T. Sakuma, N. Nemoto, Yuki Kawasaki, 2010, Drug Metabolism and Disposition.

Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver.

T. Sakuma, N. Nemoto, W. Chatuphonprasert, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes.

T. Sakuma, Atika Jaruchotikamol, N. Nemoto, 2007, Toxicology and applied pharmacology.

Enhancer elements in the mouse Cyp1a2 gene for constitutive expression.

T. Sakuma, Yo-ichi Uchida, N. Nemoto, 2002, Biochemical and biophysical research communications.

K region benzo(α)pyrene-4,5-oxide is conjugated by homogeneous gluthathione S-transferases

N. Nemoto, W. Jakoby, H. Gelboin, 1975, Nature.

Different expression of hepatic and renal cytochrome P450s between the streptozotocininduced diabetic mouse and rat

H. Tamaki, T. Sakuma, N. Nemoto, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Induction of drug-metabolizing enzymes in the rat liver by 3'-methyl-4-(dimethylamino)azobenzene.

N. Nemoto, O. Hino, M. Nagao, 1982, Cancer letters.

Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2004, Biochemical and biophysical research communications.

Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine

N. Nemoto, W. Chatuphonprasert, K. Jarukamjorn, 2012, Pharmaceutical biology.

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

N. Nemoto, K. Jarukamjorn, 2008 .

Sulfate conjugation of benzo[a]pyrene metabolites and derivatives

N. Nemoto, S. Takayama, H. Gelboin, 1978 .

Immunohistochemical detection of anti-(±)-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene-bound adduct in nuclei of cultured HeLa cells and mouse lung tissue

T. Ishikawa, Y. Nakatsuru, N. Nemoto, 2004, Journal of Cancer Research and Clinical Oncology.

Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Benzo[a]pyrene Metabolism: Enzymatic and Liquid Chromatographic Analysis and Application to Human Liver, Lymphocytes, and Monocytes

R. Bast, J. Selkirk, J. Whitlock, 1977 .

Stimulative Effect of Cadmium on Prostaglandin E2Production in Primary Mouse Osteoblastic Cells

N. Nemoto, A. Okajima, T. Miyahara, 2001, Calcified Tissue International.

Differences in regulation of gene expression between Cyp1a-1 and Cyp1a-2 in adult mouse hepatocytes in primary culture.

N. Nemoto, J. Sakurai, 1992, Carcinogenesis.

Activation of Cyp1a1 and Cyp1a2 Genes in Adult Mouse Hepatocytes in Primary Culture

N. Nemoto, J. Sakurai, 1993, Japanese journal of cancer research : Gann.

Proline Is Required for Transcriptional Control of the Aromatic Hydrocarbon‐inducible P1450 Gene in C57BL/6 Mouse Monolayer‐cultured Hepatocytes

N. Nemoto, J. Sakurai, 1991, Japanese journal of cancer research : Gann.

Acquisition of aryl hydrocarbon hydroxylase inducibility by aromatic hydrocarbons in monolayer-cultured hepatocytes from nonresponsive mouse strains.

T. Ishikawa, N. Nemoto, J. Sakurai, 1990, Cancer research.

Proline-dependent expression of aryl hydrocarbon hydroxylase in C57BL/6 mouse hepatocytes in primary culture.

T. Ishikawa, N. Nemoto, J. Sakurai, 1989, Cancer research.

Comparison of aryl hydrocarbon hydroxylase activity and inducibility of sister-chromatid exchanges by polycyclic aromatic hydrocarbons in mammalian cell lines.

N. Nemoto, S. Abe, M. Sasaki, 1983, Mutation research.

Sister-chromatid exchange induction by indirect mutagens/carcinogens, aryl hydrocarbon hydroxylase activity and benzo[a]pyrene metabolism in cultured human hepatoma cells ☆

N. Nemoto, S. Abe, M. Sasaki, 1983 .

Cell‐density‐dependent Expression of Cyp1a2 Gene in Monolayer‐cultured Adult Mouse Hepatocytes

N. Nemoto, J. Sakurai, 1993, Japanese journal of cancer research : Gann.

Appearance of tumorous phenotypes in goldfish erythrophores transfected with ras, src, and myc oncogenes and spontaneous differentiation of the transformants in vitro.

T. Ishikawa, N. Nemoto, J. Matsumoto, 1993, The Journal of investigative dermatology.

Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes.

N. Nemoto, J. Sakurai, 1995, Archives of biochemistry and biophysics.

Synergism of Glucocorticoid Hormone with Growth Hormone for Female-Specific Mouse Cyp3a44 Gene Expression

T. Sakuma, N. Nemoto, T. Hashita, 2008, Drug Metabolism and Disposition.

female-specific mouse Cyp3a44 gene expression

T. Sakuma, N. Nemoto, T. Hashita, 2008 .

Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones.

T. Sakuma, N. Nemoto, T. Hashita, 2004, Biochemical and biophysical research communications.

Preferential excision repair and non-preferential photoreactivation of pyrimidine dimers in the c-ras sequence of cultured goldfish cells.

T. Ishikawa, H. Mitani, N. Nemoto, 1991, Mutation research.

New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine.

T. Kamataki, N. Nemoto, T. Yokoi, 2002, Pharmacogenetics.

Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation.

S. Hayakawa, T. Shimizu, N. Nemoto, 2000, Journal of reproductive immunology.

Altered regulation of Cyp1a-1 gene expression during cultivation of mouse hepatocytes in primary culture.

N. Nemoto, J. Sakurai, 1992, Biochemical pharmacology.

The effect of kampo formulae on bone resorption in vitro and in vivo. II. Detailed study of berberine.

T. Suzuki, N. Nemoto, S. Kadota, 1999, Biological & pharmaceutical bulletin.

Metabolism of benzo[a]pyrene and other carcinogens in mouse epidermal keratinocytes in culture.

T. Kuroki, N. Nemoto, J. Hosomi, 1982, Gan.

Metabolism of benzo[a]pyrene in human epidermal keratinocytes in culture.

Y. Kitano, T. Kuroki, N. Nemoto, 1980, Carcinogenesis.

Metabolism of benzo(a)pyrene in epidermal keratinocytes and dermal fibroblasts of humans and mice with reference to variation among species, individuals, and cell types.

T. Kuroki, N. Nemoto, M. Terauchi, 1982, Cancer research.

Alteration of Acetaminophen-induced Cytotoxicity in Mouse Hepatocytes during Primary Culture

T. Sakuma, Atika Jaruchotikamol, N. Nemoto, 2009 .

Establishment of a Hepatocyte Cell Line Producing Growth‐promoting Factors for Liver‐colonizing Tumor Cells

T. Tsuruo, N. Nemoto, A. Komi, 1996, Japanese journal of cancer research : Gann.

Forkhead Box A2–Mediated Regulation of Female-Predominant Expression of the Mouse Cyp2b9 Gene

T. Sakuma, N. Nemoto, T. Hashita, 2008, Drug Metabolism and Disposition.

Forkhead Box A 2 – Mediated Regulation of Female-Predominant Expression of the Mouse Cyp 2 b 9 Gene

T. Sakuma, N. Nemoto, T. Hashita, 2008 .

Inhibitory effects of scopadulcic acid B and its derivatives on bone resorption and osteoclast formation in vitro

N. Nemoto, Toshimitsu Hayashi, U. Sankawa, 1996 .

5 – Glutathione, Glucuronide, and Sulfate Transferase in Polycyclic Aromatic Hydrocarbon Metabolism

N. Nemoto, 1981 .

Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.

Jun Yokota, J. Yokota, H. Dosaka-akita, 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes.

T. Sakuma, Atika Jaruchotikamol, N. Nemoto, 2011, Toxicology.

The effect of low molecular weight chitosan on bone resorption in vitro and in vivo.

N. Nemoto, S. Kadota, Y. Tezuka, 1999, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Binding of 14 C-labeled 4-nitroquinoline 1-oxide to DNA in vivo.

T. Sugimura, N. Nemoto, S. Sato, 1970, Chemico-biological interactions.

Induction of hepatocellular carcinoma in rat liver by initial treatment with benzo(a)pyrene after partial hepatectomy and promotion by phenobarbital.

T. Ishikawa, N. Nemoto, S. Takayama, 1980, Toxicology letters.

Induction of enzyme-altered islands in rat liver by a single treatment with benzo[a]pyrene after partial hepatectomy.

T. Ishikawa, N. Nemoto, S. Takayama, 1979, Gan.

Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.

N. Nemoto, T. Katoh, S. Uchida, 2004, Toxicology.

Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver.

T. Sakuma, Atika Jaruchotikamol, N. Nemoto, 2006, Toxicology.

Regulation of mouse hepatic CYP2D9 mRNA expression by growth and adrenal hormones.

T. Sakuma, Atika Jaruchotikamol, N. Nemoto, 2006, Drug metabolism and pharmacokinetics.

The effect of Kampo formulae on bone resorption in vitro and in vivo. I. Active constituents of Tsu-kan-gan.

N. Nemoto, S. Kadota, Y. Tezuka, 1998, Biological & pharmaceutical bulletin.

Methylation of nuclear and cytoplasmic RNA of mouse liver with dimethylnitrosamine- 3 H.

M. Muramatsu, N. Nemoto, S. Takayama, 1972, Cancer research.

Arachidonic acid-dependent activation of benzo[a]pyrene to bind to proteins with cytosolic and microsomal fractions from rat liver and lung.

N. Nemoto, S. Takayama, 1984, Carcinogenesis.

Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid.

N. Nemoto, H. Gelboin, 1976, Biochemical pharmacology.

Metabolic activation of benzo[a]pyrene, aflatoxin B1, and dimethylnitrosamine by a human hepatoma cell line.

N. Nemoto, T. Utakoji, N. Huh, 1982, Mutation research.

Use of Human Epidermal Keratinocytes in Studies on Chemical Carcinogenesis

Y. Kitano, T. Kuroki, N. Nemoto, 1980 .

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads*

K. Miyazono, M. Kawabata, H. Inoue, 1999, The Journal of Biological Chemistry.

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.

T. Ishikawa, M. Sekiguchi, Y. Nakatsuru, 1993, Proceedings of the National Academy of Sciences of the United States of America.

CYP2A6 gene deletion reduces susceptibility to lung cancer.

J. Yokota, H. Dosaka-akita, T. Kamataki, 1999, Biochemical and biophysical research communications.

A novel female-specific member of the CYP3A gene subfamily in the mouse liver.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2000, Archives of biochemistry and biophysics.

Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone

T. Sakuma, N. Nemoto, M. Fuwa, 2007, Drug Metabolism and Disposition.

Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2002, Archives of biochemistry and biophysics.

Sex-associated expression of mouse hepatic and renal CYP2B enzymes by glucocorticoid hormones.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2001, Biochemical pharmacology.

Targets of Transcriptional Regulation by Transforming Growth Factor‐β: Expression Profile Analysis Using Oligonucleotide Arrays

H. Aburatani, K. Miyazono, M. Kawabata, 2001, Japanese journal of cancer research : Gann.

Nucleotide sequence comparison of the predicted first exonic region of goldfish ras gene between normal and neoplastic tissues

T. Ishikawa, N. Nemoto, J. Matsumoto, 2004, Journal of Cancer Research and Clinical Oncology.

Spontaneous neurinoma in an African lungfish, Protopterus annectens, and DNA repair studies on normal and neoplastic tissues.

T. Ishikawa, N. Nemoto, A. Shima, 1986, Journal of the National Cancer Institute.

O6-methylguanine DNA methyltransferase activity in liver from various fish species.

T. Ishikawa, Y. Nakatsuru, N. Nemoto, 1987, Carcinogenesis.

Enzymatic conversion of benzo(a)pyrene phenols, dihydrodiols and quinones to sulfate conjugates.

N. Nemoto, S. Takayama, H. Gelboin, 1977, Biochemical pharmacology.

Modificationof Benzo(a)pyreneMetabolismwith Microsomesby Additionof Uridine 5'-DiphosphoglucuronicAcid1

N. Nemoto, S. Takayama, 1977 .

Regulation of mouse P(1)450 gene expression in monolayer-cultured hepatocytes from responsive and non-responsive strains.

T. Ishikawa, N. Nemoto, J. Sakurai, 1991, Carcinogenesis.

Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2002, Biochemical pharmacology.

Mechanism of Growth Promoting Activity of Epiregulin in Primary Cultures of Rat Hepatocytes

N. Nemoto, D. Uchida, T. Komurasaki, 2002, Growth factors.

K region benzo (alpha) pyrene-4,5-oxide is conjugated by homogeneous gluthathione S-transferases.

N. Nemoto, W. Jakoby, H. Gelboin, 1975, Nature.

Rapid loss of 7-methylguanine from liver nucleic acids in mice during the initial stage of liver carcinogenesis induced by dimethylnitrosamine.

N. Nemoto, S. Takayama, 1974, Biochemical and biophysical research communications.

Potent modification of inducible CYP1A1 expression by flavonoids.

T. Sakuma, N. Nemoto, W. Chatuphonprasert, 2010, Biological & pharmaceutical bulletin.

A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype.

T. Kamataki, N. Nemoto, T. Yokoi, 1999, Pharmacogenetics.

Change in transcription of repetitive DNA sequences in N-methyl-N'-nitro-N-nitrosoguanidine-transformed hamster cells.

M. Muramatsu, N. Nemoto, S. Takayama, 1973, Cancer research.

A Highly Potent 26,27-Hexafluoro-1a,25-dihydroxyvitamin D3 on Calcification in SV40-Transformed Human Fetal Osteoblastic Cells

T. Sakuma, N. Nemoto, N. Sawada, 2002, Calcified Tissue International.

Modification of benzo(a)pyrene metabolism with microsomes by addition of uridine 5'-diphosphoglucuronic acid.

N. Nemoto, S. Takayama, 1977, Cancer research.

Assay and properties of glutathione-S-benzo(a)pyrene-4,5-oxide transferase.

N. Nemoto, H. Gelboin, 1975, Archives of biochemistry and biophysics.

Effects of activation of UDP-glucuronyl transferase on metabolism of benzo[a]pyrene with rat liver microsomes.

N. Nemoto, S. Takayama, M. Kawana, 1983, Journal of pharmacobio-dynamics.

Inhibition of benzo[a]pyrene-induced mutagenesis in Chinese hamster V79 cells by hemin and related compounds.

N. Nemoto, S. Takayama, M. Tanaka, 1983, Mutation research.

Molecular cloning and functional analysis of cynomolgus monkey CYP1A2.

T. Kamataki, T. Sakuma, N. Nemoto, 1998, Biochemical pharmacology.

Modulations of cytochrome P450 expression in diabetic mice by berberine.

T. Sakuma, N. Nemoto, W. Chatuphonprasert, 2012, Chemico-biological interactions.

Activation of 2-amino-6-methyldipyrido[1,2-a:3' ,2' -d]imidazole, a mutagenic pyrolysis product of glutamic acid, to bind to microsomal protein by NADPH-dependent and -independent enzyme systems.

N. Nemoto, S. Takayama, 1984, Carcinogenesis.

Direct determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine, the main metabolite of MDMA, in human urine.

T. Sakuma, N. Nemoto, H. Tsuchihashi, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands.

T. Sakuma, N. Nemoto, Yuki Kawasaki, 2022, Drug metabolism and pharmacokinetics.

Marmoset CYP1A2: primary structure and constitutive expression in livers.

T. Kamataki, T. Sakuma, N. Nemoto, 1997, Carcinogenesis.

O6-methylguanine-DNA methyltransferase activity in the human lung persists with advancing age.

T. Ishikawa, Y. Nakatsuru, N. Nemoto, 1994, Gerontology.

Comparison of 26,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3 on the resorption of bone explants ex vivo.

N. Nemoto, S. Higuchi, K. Yoda, 1999, Journal of nutritional science and vitaminology.

Modulation of microsome-mediated benzo[a]pyrene-metabolism by serum.

N. Nemoto, S. Takayama, 1982, Carcinogenesis.

Maintenance and activation of Cyp2e-1 gene expression in mouse hepatocytes in primary culture.

Y. Funae, N. Nemoto, J. Sakurai, 1996, Biochimica et biophysica acta.

Discriminating activation of CYP2B9 expression in male C57BL/6 mouse liver by beta-estradiol.

T. Sakuma, N. Nemoto, K. Jarukamjorn, 2000, Biochemical and biophysical research communications.

Elevation of polycyclic aromatic hydrocarbon-inducible aryl hydrocarbon hydroxylase activity in rat hepatocytes in primary culture by inhibitors of poly(ADP-ribose) polymerase.

T. Ishikawa, N. Nemoto, 1988, Carcinogenesis.

Localization of estradiol‐responsive region in the phenobarbital‐responsive enhancer module of mouse Cyp2b‐10 gene

T. Sakuma, N. Nemoto, M. Yamamoto, 2001, Journal of biochemical and molecular toxicology.

Metabolism of 26,27-hexafluoro-1α,25-dihydroxyvitamin D3 and 26,27-hexafluoro1α,23(S)25-trihydroxyvitamin D3 in ROS17/2.8 cells transfected with a plasmid expressing CYP24

T. Sakuma, N. Nemoto, S. Higuchi, 2000 .

Urinary excretion of the main metabolites of 3,4-methylenedioxymethamphetamine (MDMA), including the sulfate and glucuronide of 4-hydroxy-3-methoxymethamphetamine (HMMA), in humans and rats.

T. Sakuma, N. Nemoto, M. Nishikawa, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Elevated expression of the Cyp1a2 gene in the presence of nicotinamide by adult mouse hepatocytes in primary culture.

N. Nemoto, J. Sakurai, 1994, Archives of biochemistry and biophysics.

Formation of N7-methylguanine in nuclear DNA and cytoplasmic RNA in mice on continuous oral administration of dimethylnitrosamine-3H solution

N. Nemoto, S. Takayama, 1973, Zeitschrift für Krebsforschung und Klinische Onkologie.

Metabolic activation of 3-amino-5H-pyrido[4,3-b]indole, a highly mutagenic principle in tryptophan pyrolysate, by rat liver enzymes.

T. Sugimura, N. Nemoto, S. Takayama, 1979, Chemico-biological interactions.