F. Blasco

发表

Expression Profiles of a Human Pancreatic Cancer Cell Line upon Induction of Apoptosis Search for Modulators in Cancer Therapy

M. Masa, J. Hernández, M. Cascalló, 2004, Oncology.

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580.

P. Shi, F. Blasco, M. Hervé, 2014, Antiviral research.

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells.

Yen-Liang Chen, P. Shi, F. Blasco, 2014, Journal of virological methods.

CYP175A1 from Thermus thermophilus HB27, the first β-carotene hydroxylase of the P450 superfamily

F. Blasco, R. Schmid, I. Kauffmann, 2004, Applied Microbiology and Biotechnology.

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

F. Blasco, F. Knoflach, G. Trube, 2009, Bioorganic & medicinal chemistry letters.

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.

Paul W Smith, P. Shi, A. Chao, 2015, ACS medicinal chemistry letters.

A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C-Methylguanosine for the Treatment of Dengue Virus Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, Antimicrobial Agents and Chemotherapy.

A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, bioRxiv.

Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

M. Gurumurthy, F. Blasco, Ramandeep Singh, 2014, PloS one.

Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805

D. Erdmann, J. Brueggen, P. Furet, 2010, Molecular Cancer Therapeutics.

Discovery of Dengue Virus NS4B Inhibitors

Paul W Smith, P. Shi, J. Lescar, 2015, Journal of Virology.

Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.

C. Schnell, P. Furet, F. Blasco, 2022, Journal of medicinal chemistry.

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

G. Bonamy, F. Blasco, B. Striepen, 2017, Nature.

Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.

C. Schnell, F. Blasco, G. Caravatti, 2016, Bioorganic & medicinal chemistry letters.

Trifluoromethyl vs. methyl ability to direct enantioselection in microbial reduction of carbonyl substrates.

F. Blasco, G. Resnati, A. Arnone, 1998 .

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.

Doriano Fabbro, Pascal Furet, Giorgio Caravatti, 2013, Bioorganic & medicinal chemistry letters.

Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.

C. Schnell, P. Furet, F. Blasco, 2015, Bioorganic & medicinal chemistry letters.

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.

J. Peters, F. Blasco, S. Kolczewski, 2008, Bioorganic & medicinal chemistry letters.

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.

Eric Vangrevelinghe, Clive McCarthy, Pascal Furet, 2010, Bioorganic & medicinal chemistry letters.

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

Tove Tuntland, K. Hoffmaster, F. Blasco, 2014, Front. Pharmacol..

Complete diastereocontrol in [3+2] cycloaddition reactions: Synthesis of enantiomerically pure fluoromethyl substituted β-amino acids

F. Blasco, G. Resnati, A. Arnone, 1997 .

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

G. Bonamy, V. Sasseville, Yen-Liang Chen, 2021, Science Translational Medicine.

Cloning, expression, purification and characterization of a novel cytochrome P450 isolated from Thermus thermophilus HB27

F. Blasco, 2002 .

Therapeutic Targeting of Tumor Growth and Angiogenesis with a Novel Anti-S100A4 Monoclonal Antibody

S. Dakhel, L. Padilla, J. Adán, 2013, PloS one.

Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir

G. Wang, Yen-Liang Chen, Daniela Cerny, 2013, Journal of Virology.

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

Paul W Smith, K. Kuhen, P. Bifani, 2013, Science Translational Medicine.

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

F. Blasco, V. Dartois, A. Goh, 2014, Antimicrobial Agents and Chemotherapy.

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.

J. Peters, F. Blasco, S. Kolczewski, 2008, Bioorganic & medicinal chemistry letters.

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.

J. Mestan, P. Manley, F. Blasco, 2013, Bioorganic & medicinal chemistry.

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

Paul W Smith, K. Kuhen, P. Tonge, 2015, Science Translational Medicine.

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors.

Eric Vangrevelinghe, Marc Lang, Pascal Furet, 2010, Bioorganic & medicinal chemistry letters.

Preliminary Characterization and Crystal Structure of a Thermostable Cytochrome P450 from Thermus thermophilus *

T. Poulos, A. Henne, J. Yano, 2003, The Journal of Biological Chemistry.

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

Martin Stahl, Jörg Benz, Daniel Schlatter, 2009, European journal of medicinal chemistry.

Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]

D. Fabbro, J. Hamon, P. Furet, 2013 .

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

F. Blasco, F. Knoflach, G. Trube, 2009, Bioorganic & Medicinal Chemistry Letters.

Optimised method to estimate octanol water distribution coefficient (logD) in a high throughput format.

F. Blasco, Ying Wei Ivan Low, Francesca Blasco, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.