Rachel J Parsons

发表

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.

M. Noble, J. Endicott, N. Curtin, 2003, Bioorganic & medicinal chemistry letters.

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

M. Drysdale, N. Foloppe, J. Murray, 2009, Journal of medicinal chemistry.

Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.

X. Barril, B. Davis, M. Drysdale, 2009, Journal of Medicinal Chemistry.

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

L. Johnson, M. Noble, J. Endicott, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.

N. Curtin, I. Hardcastle, R. Griffin, 2010, Organic & biomolecular chemistry.

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Melanie H. Wong, S. Lightowler, G. Kennett, 2009, Bioorganic & medicinal chemistry letters.

Pro-apoptotic Mechanisms of Action of a Novel Vitamin E Analog (α-TEA) and a Naturally Occurring Form of Vitamin E (δ-Tocotrienol) in MDA-MB-435 Human Breast Cancer Cells

Rachel J Parsons, B. G. Sanders, K. Kline, 2004 .

Ligand specificity in the CRAL-TRIO protein family.

Rachel J Parsons, C. Panagabko, S. Morley, 2003, Biochemistry.

Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.

Melanie H. Wong, S. Lightowler, G. Kennett, 2012, Bioorganic & medicinal chemistry letters.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Mike Wood, Terry Shaw, M. Drysdale, 2011, Journal of medicinal chemistry.

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2.

M. Noble, J. Endicott, N. Curtin, 2007, Organic & biomolecular chemistry.

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

M. Drysdale, J. Murray, Rachel J Parsons, 2010, Cancer Chemotherapy and Pharmacology.

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Mike Wood, Ben Davis, Terry Shaw, 2017, Journal of medicinal chemistry.

Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells.

Rachel J Parsons, B. G. Sanders, K. Kline, 2004, Nutrition and cancer.

Fragment docking supported by NMR shift perturbations

B. Davis, M. Drysdale, M. Jensen, 2014 .

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

M. Drysdale, J. Murray, Rachel J Parsons, 2011, Journal of medicinal chemistry.