Y. Yamaguchi

Y. Ito, K. Shigesada, Y. Yamaguchi, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Differential Regulation of NF- (cid:2) B by Elongation Factors Is Determined by Core Promoter Type (cid:1)

H. Handa, Y. Yamaguchi, E. Ainbinder, 2007 .

Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation

Tomomi Sato, H. Handa, I. Aoki, 2019, iScience.

A Novel Hydrogen Peroxide-induced Phosphorylation and Ubiquitination Pathway Leading to RNA Polymerase II Proteolysis*

H. Handa, Y. Yamaguchi, J. Kato, 2004, Journal of Biological Chemistry.

Evidence that SV40 VP1–DNA interactions contribute to the assembly of 40‐nm spherical viral particles

K. Kataoka, H. Handa, Y. Yamaguchi, 2007, Genes to cells : devoted to molecular & cellular mechanisms.

Searching for genetic factors involved in hybrid lethality in Nicotiana; Possible use of a cultured cell line of a hybrid

Yoshikazu Tanaka, Y. Yamaguchi, M. Inoue, 2006 .

Plant Biotechnology 23, 487–492 (2006)

Yoshikazu Tanaka, Y. Yamaguchi, M. Inoue, 2006 .

Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity

Sachiko Okamoto, H. Handa, Y. Yamaguchi, 2007, Genes to cells : devoted to molecular & cellular mechanisms.

Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.

C. Moskaluk, H. Handa, Rong Li, 2004, Genes & development.

A wealth of evidence strongly supports the paramount importance of the ER – estrogen signaling pathway to breast cancer development

C. Moskaluk, H. Handa, Rong Li, 2004 .

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

H. Handa, M. Ohmura, M. Suematsu, 2016, Nature Communications.

Title Haem-dependent dimerization of PGRMC 1 / Sigma-2 receptorfacilitates cancer proliferation and chemoresistance

H. Handa, M. Ohmura, M. Suematsu, 2016 .

NTP-driven Translocation by Human RNA Polymerase II*

Hiroshi Handa, Yuki Yamaguchi, Honggao Yan, 2003, The Journal of Biological Chemistry.

Assay of transient state kinetics of RNA polymerase II elongation.

H. Handa, Y. Yamaguchi, Y. Nedialkov, 2003, Methods in enzymology.

Three human RNA polymerases interact with TFIIH via a common RPB6 subunit

Y. Yamaguchi, Y. Nishimura, M. Okuda, 2021, Nucleic acids research.

Hepatitis Delta Antigen and RNA Polymerase II

Y. Yamaguchi, H. Handa, 2006 .

Promoter-proximal pausing and its release: molecular mechanisms and physiological functions.

Hiroshi Handa, Yuki Yamaguchi, H. Handa, 2010, Experimental cell research.

NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.

H. Handa, D. Gilmour, Y. Yamaguchi, 2003, Genes & development.

A Highly Purified RNA Polymerase II Elongation Control System*

H. Handa, D. Price, T. Wada, 2001, The Journal of Biological Chemistry.

NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation

Hiroshi Handa, Toshiyuki Takagi, Yuki Yamaguchi, 1999, Cell.

PAX6 expression in the developing human eye

H. Handa, Y. Yamaguchi, S. Kohsaka, 1999, The British journal of ophthalmology.

Affinity Chromatographic Materials

H. Handa, Y. Yamaguchi, S. Sakamoto, 2014 .

A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads

H. Handa, M. Kizaki, Y. Yamaguchi, 2006, Molecular Pharmacology.

Cloning of the hamster androgen receptor gene.

Y. Yamaguchi, H. Handa, K. Shiba, 2001, Journal of dermatological science.

Structural basis of thalidomide enantiomer binding to cereblon

H. Handa, T. Hakoshima, Y. Yamaguchi, 2018, Scientific Reports.

Differential Regulation of NF-κB by Elongation Factors Is Determined by Core Promoter Type

Hiroshi Handa, Yuki Yamaguchi, H. Handa, 2007, Molecular and Cellular Biology.

Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor.

Toshihiko Ogura, Hiroshi Handa, Yuki Yamaguchi, 2005, Human molecular genetics.

The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure.

H. Handa, M. Nakafuku, T. Ogura, 2005, Human molecular genetics.

Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies.

M. Yamada, Y. Yamaguchi, A. Kanai, 1999, American journal of human genetics.

Elongation Inhibition by DRB Sensitivity-Inducing Factor Is Regulated by the A20 Promoter via a Novel Negative Element and NF-κB

Hiroshi Handa, Yuki Yamaguchi, H. Handa, 2004, Molecular and Cellular Biology.

Autoregulation of Pax6 transcriptional activation by two distinct DNA‐binding subdomains of the paired domain

H. Handa, M. Yamada, Y. Yamaguchi, 1997, Genes to cells : devoted to molecular & cellular mechanisms.

Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

H. Urlaub, M. Oren, A. Brik, 2013, Cell reports.

Activation‐induced cytidine deaminase auto‐activates and triggers aberrant gene expression

Y. Yamaguchi, Prabha Tiwari, K. Yoshizaki, 2013, FEBS letters.

The role of Mediator and Little Elongation Complex in transcription termination

Yutaka Suzuki, M. Washburn, Ichigaku Takigawa, 2020, Nature Communications.

Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation

Hiroshi Handa, Yuki Yamaguchi, Tadashi Wada, 2010, Genes to cells : devoted to molecular & cellular mechanisms.

Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations.

H. Handa, K. Tadokoro, M. Yamada, 2003, American journal of human genetics.

Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide

H. Handa, Y. Yamaguchi, S. Sakamoto, 2020, Scientific Reports.

Transcriptional Pausing Caused by NELF Plays a Dual Role in Regulating Immediate-Early Expression of the junB Gene

H. Handa, T. Wada, Y. Yamaguchi, 2006, Molecular and Cellular Biology.

Evidence that P‐TEFb alleviates the negative effect of DSIF on RNA polymerase II‐dependent transcription in vitro

H. Handa, T. Wada, Y. Yamaguchi, 1998, The EMBO journal.

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.

K. Yano, F. Winston, H. Handa, 1998, Genes & development.

Casein kinase II interacts with the bZIP domains of several transcription factors.

T. Wada, Y. Yamaguchi, J. Hasegawa, 1998, Nucleic acids research.

ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells

H. Handa, M. Kizaki, Y. Yamaguchi, 2020, Nature Chemical Biology.

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.

H. Handa, A. Berk, Y. Yamaguchi, 2005, Molecular cell.

Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology.

H. Handa, Y. Yamaguchi, Takumi Ito, 2021, Cell chemical biology.

TFII‐I down‐regulates a subset of estrogen‐responsive genes through its interaction with an initiator element and estrogen receptor α

H. Handa, T. Wada, Y. Yamaguchi, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library

M. Horikoshi, H. Handa, Y. Yamaguchi, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.

H. Handa, H. Tanabe, Y. Yamaguchi, 2007, Molecular cell.

P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.

Hiroshi Handa, Yuki Yamaguchi, Sachiko Okamoto, 2006, Molecular cell.

The regulation of elongation by eukaryotic RNA polymerase II: a recent view.

T. Wada, Y. Yamaguchi, H. Handa, 2001, Molecules and cells.

Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins

P. Sharp, H. Handa, T. Wada, 1999, Molecular and Cellular Biology.

Tat-SF 1 Protein Associates with RAP 30 and Human SPT 5 Proteins

P. Sharp, H. Handa, T. Wada, 1999 .

Spt 5 ? homologs polymerase II processivity , is composed of human Spt 4 and DSIF , a novel transcription elongation factor that regulates RNA

K. Yano, H. Handa, S. Buratowski, 1998 .

Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence

Iwao Kanno, Jeff Kershaw, Takayuki Obata, 2013, NeuroImage.

TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis

Hidefumi Suzuki, Ryo Maeda, Y. Yamaguchi, 2019, Scientific Reports.

Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation

H. Handa, T. Wada, Y. Yamaguchi, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

Repression of RNA Polymerase II Elongation In Vivo Is Critically Dependent on the C-Terminus of Spt5

H. Handa, X. Contreras, B. Peterlin, 2009, PloS one.

Molecular characterization of Drosophila NELF

H. Handa, D. Gilmour, Y. Yamaguchi, 2005, Nucleic acids research.

Locus-Specific Requirements for Spt5 in Transcriptional Activation and Repression in Drosophila

H. Handa, R. Phillips, D. Ish-Horowicz, 2004, Current Biology.

Stimulation of RNA Polymerase II Elongation by Hepatitis Delta Antigen

K. Yano, H. Handa, T. Wada, 2001, Science.

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

G. Orphanides, D. Reinberg, H. Handa, 2000, Molecular cell.

The role of Mediator and Little Elongation Complex in transcription termination

Yutaka Suzuki, M. Washburn, Ichigaku Takigawa, 2020, Nature Communications.

Effects of Endogenous DNA Base Lesions on Transcription Elongation by Mammalian RNA Polymerase II

H. Handa, T. Wada, Y. Yamaguchi, 2003, The Journal of Biological Chemistry.

NF-Y Is Essential for the Recruitment of RNA Polymerase II and Inducible Transcription of Several CCAAT Box-Containing Genes

Hiroshi Handa, Yuki Yamaguchi, Tadashi Wada, 2005, Molecular and Cellular Biology.

Correction for Cao et al., Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex

H. Handa, Y. Yamaguchi, Junichi Yamamoto, 2015, Molecular and Cellular Biology.

In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer.

H. Handa, A. Berk, I. Kukimoto, 2011, Virology.

Development of a chemical screening system using aqueorin-fused protein.

H. Handa, Y. Yamaguchi, S. Inouye, 2008, Biochemical and biophysical research communications.

Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis

H. Handa, Y. Yamaguchi, S. Sakamoto, 2013, Molecular Pharmacology.

Vitamin K 2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis s

H. Handa, Y. Yamaguchi, S. Sakamoto, 2013 .

Development and application of high-performance affinity beads: toward chemical biology and drug discovery.

H. Handa, Y. Yamaguchi, S. Sakamoto, 2009, Chemical record.

Salicylic Acid Induces Mitochondrial Injury by Inhibiting Ferrochelatase Heme Biosynthesis Activity

O. Nureki, H. Handa, Masato Yugami, 2013, Molecular Pharmacology.

Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle.

Hiroshi Handa, Yuko Kitagawa, Satoshi Sakamoto, 2014, Clinical chemistry.

Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis.

K. Kataoka, H. Handa, M. Suematsu, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm.

H. Handa, M. Tatsuno, Y. Yamaguchi, 2008, Biochemical and biophysical research communications.

Adeno-Associated Virus Site-Speciﬁc Integration Is Regulated by TRP-185 (cid:1)

H. Handa, T. Wada, Y. Yamaguchi, 2007 .

Adeno-Associated Virus Site-Specific Integration Is Regulated by TRP-185

H. Handa, T. Wada, Y. Yamaguchi, 2006, Journal of Virology.

Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1.

H. Handa, I. Aoki, Y. Yamaguchi, 2013, Journal of biotechnology.

Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis

H. Handa, Y. Yamaguchi, N. Inukai, 2009, Genes to cells : devoted to molecular & cellular mechanisms.

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

H. Handa, Y. Yamaguchi, Minoru Yoshida, 2014, The Journal of Antibiotics.

SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes

H. Handa, Y. Yamaguchi, Takamasa Inoue, 2014, Biotechnology reports.

Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide

H. Handa, Y. Yamaguchi, S. Sakamoto, 2020, Scientific Reports.

Hepatitis Delta Virus

H. Handa, P. Roingeard, Y. Yamaguchi, 2006 .

TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis

Hidefumi Suzuki, Ryo Maeda, Y. Yamaguchi, 2019, Scientific Reports.

Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

H. Urlaub, M. Oren, A. Brik, 2013, Cell Reports.

Promoter-proximal pausing and its release: molecular mechanisms and physiological functions.

H. Handa, Y. Yamaguchi, Junichi Yamamoto, 2010, Experimental cell research.

Structural basis of thalidomide enantiomer binding to cereblon

H. Handa, T. Hakoshima, Y. Yamaguchi, 2018, Scientific Reports.

Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases.

Y. Yamaguchi, Hiroshi Handa, Hiroyuki Kamiya, 2009, Free radical biology & medicine.

Vesnarinone Suppresses TNFα mRNA Expression by Inhibiting Valosin-Containing Protein

H. Handa, S. Aizawa, M. Tokunaga, 2013, Molecular Pharmacology.