J. Litz

发表

Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.

S. Grant, J. Litz, P. Carlson, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Lek Associates with and Is Activated by Kit in a Small Cell Lung Cancer Cell Line : Inhibition of SCF-mediated Growth by the Src Family Kinase Inhibitor PPI 1

Geoffrey, J. Litz, W. Krystal, 2006 .

The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling.

F. Hofmann, E. Buchdunger, C. García-echeverría, 2004, Molecular cancer therapeutics.

Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737

J. Litz, G. Krystal, B. Chao, 2009, Molecular Cancer Therapeutics.

Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt.

D. Ludwig, J. Litz, G. Krystal, 2007, Lung cancer.

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts

S. Kanner, T. Sturgill, J. Litz, 1990, The Journal of cell biology.

Electroconvulsive Treatment Induces a Rapid and Transient Increase in Tyrosine Phosphorylatin of a 40‐Kilodalton Protein Associated with Microtubule‐Associated Protein 2 Kinase Activity

R. Huganir, P. Worley, J. Baraban, 1991, Journal of neurochemistry.

Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures.

J. Litz, R. Stravitz, P. Hylemon, 1992, The Journal of biological chemistry.

Modulation of pp60c‐src tyrosine kinase activity during secretion in stimulated bovine adrenal chromaffin cells

J. Litz, C. Creutz, D. Payne, 1989, Journal of neuroscience research.

Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1α activity and vascular endothelial growth factor expression in small cell lung cancer cells

J. Litz, G. Krystal, 2006, Molecular Cancer Therapeutics.

Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy.

J. Litz, G. Krystal, Geoffrey Sulanke, 2002, Molecular cancer therapeutics.

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

S. Honsawek, E. Buchdunger, J. Litz, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

J. Massagué, A. Chiang, P. Wipf, 2007, Nature chemical biology.

The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes Small Cell Lung Cancer Cell Lines to the Effects of Chemotherapy

F. Hofmann, E. Buchdunger, C. García-echeverría, 2005, Clinical Cancer Research.

Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors

J. Litz, G. Krystal, S. Hines, 1999, Breast Cancer Research and Treatment.

Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1.

J. Litz, G. Krystal, G W Krystal, 1998, Cancer research.

Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins.

J. Litz, P. Carlson, G. Krystal, 1997, Cancer research.

Src family kinase activity is required for Kit-mediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells.

P. Dent, G. Krystal, J. Litz, 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Didox‐A Multipotent Drug for Treating Demyelinating disease

J. Litz, J. Paletta, J. Dupree, 2012 .

The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression.

J. Litz, G. Krystal, K. Lipson, 2004, Lung cancer.