W. W. ten Bokkel Huinink

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Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer.

J. Wanders, E. Raymond, J. Schellens, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Treatment of skin metastases of breast cancer

W. W. ten Bokkel Huinink, 1999, Cancer chemotherapy and pharmacology.

Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane® and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC)

H. Rosing, W. W. ten Bokkel Huinink, A. Bult, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Treatment of two patients with B cell lymphoma with monoclonal anti-idiotype antibodies.

W. W. ten Bokkel Huinink, A. Hekman, E. Rankin, 1985, Blood.

Clinical pharmacology of carboplatin administered in combination with paclitaxel.

G. Giaccone, P. Postmus, J. Beijnen, 1997, Seminars in oncology.

Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre.

G. Giaccone, O. Dalesio, P. Postmus, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.

A. C. Dubbelman, J. Beijnen, W. W. ten Bokkel Huinink, 1997, British Journal of Cancer.

Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel

J. Schellens, J. Beijnen, W. W. ten Bokkel Huinink, 2001, European Journal of Clinical Pharmacology.

High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma.

H. Rosing, J. Beijnen, W. W. ten Bokkel Huinink, 1993, Journal of chromatography.

Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors.

J. Schellens, J. Beijnen, W. W. ten Bokkel Huinink, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Taxanes: a new class of antitumor agents.

J. Beijnen, W. W. ten Bokkel Huinink, H. Pinedo, 1995, Cancer investigation.

Bioanalysis, pharmacokinetics, and pharmacodynamics of the novel anticancer drug paclitaxel (Taxol).

G. Giaccone, J. Beijnen, W. W. ten Bokkel Huinink, 1994, Seminars in oncology.

Intraperitoneal-administered carboplatin in patients with ovarian cancer; influence of a dwell-time on toxicity and response.

A. C. Dubbelman, J. Beijnen, J. Mcvie, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

H. Rosing, J. Beijnen, J. Lieverst, 2002, British Journal of Cancer.

A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer

D. Richel, J. Beijnen, W. W. ten Bokkel Huinink, 2004, British Journal of Cancer.

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

D. Richel, J. Schellens, H. Rosing, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks

H. Rosing, J. Beijnen, G. Groenewegen, 2004, British Journal of Cancer.

Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.

J. Schellens, H. Rosing, J. Beijnen, 1999, Pharmacological research.

Phase II trial of topically applied miltefosine solution in patients with skin-metastasized breast cancer

H. Sindermann, J. Beijnen, W. W. ten Bokkel Huinink, 1999, British Journal of Cancer.

High-dose paclitaxel with granulocyte colony-stimulating factor in patients with advanced breast cancer refractory to anthracycline therapy: a European Cancer Center trial.

J. Heimans, J. Beijnen, T. Postma, 1995, Seminars in oncology.

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.

D. Richel, J. Schellens, H. Rosing, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Long-term survival in ovarian cancer. Mature data from The Netherlands Joint Study Group for Ovarian Cancer.

J. Neijt, P. Willemse, W. W. ten Bokkel Huinink, 1991, European journal of cancer.

Do topotecan concentrations in saliva reflect plasma concentrations?

H. Rosing, W. W. ten Bokkel Huinink, L. V. van Warmerdam, 1995 .

Biodetermination of N-(deacetyl-O-4-vinblastoyl-23)-L-tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection.

J. Beijnen, W. W. ten Bokkel Huinink, O. van Tellingen, 1992, Journal of chromatography.

High-performance liquid chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolite 4-O-deacetylvinblastine-3-oic acid in biological fluids.

J. Beijnen, W. W. ten Bokkel Huinink, O. van Tellingen, 1991, Journal of chromatography.

Bio-analysis of N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate, methane sulphonate (VileE) by high-performance liquid chromatography with fluorescence detection.

J. Beijnen, W. W. ten Bokkel Huinink, O. van Tellingen, 1990, Journal of pharmaceutical and biomedical analysis.

Phase I study of vintriptol, a tryptophan ester of vinblastine.

A. C. Dubbelman, J. Wanders, J. Beijnen, 1991, European journal of cancer.

High-performance liquid chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol.

J. Beijnen, W. W. ten Bokkel Huinink, O. van Tellingen, 1990, Journal of chromatography.

Highly elevated serum CA 125 levels in a patient with cardiac failure.

W. W. ten Bokkel Huinink, J. Bonfrer, T. Helmerhorst, 1993, European journal of obstetrics, gynecology, and reproductive biology.

Dose-finding and sequencing study of paclitaxel and carboplatin in non-small cell lung cancer.

G. Giaccone, O. Dalesio, P. Postmus, 1995, Seminars in oncology.

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.

H. Rosing, J. Beijnen, W. W. ten Bokkel Huinink, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Advanced epithelial ovarian cancer: 1998 consensus statements.

J. Neijt, G. Rustin, J. Berek, 1993 .

Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer.

S. Rodenhuis, D. Richel, J. Schornagel, 1995, Cancer investigation.

Phase II study of the combination carboplatin and paclitaxel in patients with ovarian cancer.

S. Rodenhuis, J. Beijnen, W. W. ten Bokkel Huinink, 1997, Annals of oncology : official journal of the European Society for Medical Oncology.

Toxicity grading systems. A comparison between the WHO scoring system and the Common Toxicity Criteria when used for nausea and vomiting.

A. C. Dubbelman, O. Dalesio, N. Aaronson, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

The role of surgery in advanced testicular cancer.

W. W. ten Bokkel Huinink, J. Delemarre, Q. V. van Hoesel, 1983, The Netherlands journal of surgery.

Neutropenic enterocolitis in a patient with ovarian cancer after treatment with high-dose carboplatin and granulocyte macrophage-colony stimulating factor (GM-CSF).

S. Rodenhuis, W. W. ten Bokkel Huinink, L. Vlasveld, 1990, The Netherlands journal of medicine.

Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.

J. Schellens, H. Rosing, J. Beijnen, 1998, Anti-cancer drugs.

Docetaxel in 253 previously treated patients with progressive locally advanced or metastatic breast cancer: results of a compassionate use program in The Netherlands

J. Verweij, J. Beijnen, W. W. ten Bokkel Huinink, 2000, Anti-Cancer Drugs.

Hepatic metabolism of paclitaxel and its impact in patients with altered hepatic function.

J. Beijnen, W. W. ten Bokkel Huinink, J. Vermorken, 1997, Seminars in oncology.

Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.

H. Rosing, J. Beijnen, W. W. ten Bokkel Huinink, 1995, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors.

J. Schellens, J. Lieverst, W. W. ten Bokkel Huinink, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

High-performance liquid chromatographic analysis of the investigational anticancer drug 9-aminocamptothecin, as the lactone form and as the total of the lactone and the hydroxycarboxylate forms, in micro-volumes of human plasma.

W. W. ten Bokkel Huinink, M. Hillebrand, A. Bult, 1998, Journal of pharmaceutical and biomedical analysis.

High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma.

S. Rodenhuis, J. Beijnen, W. W. ten Bokkel Huinink, 1990, Journal of pharmaceutical and biomedical analysis.

Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.

J. Beijnen, W. W. ten Bokkel Huinink, F. Zoetmulder, 2000, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Effect of Cisplatin-Containing Chemotherapy on Lithium Serum Concentrations

S. Rodenhuis, J. Wanders, J. Beijnen, 1992, The Annals of pharmacotherapy.

Treatment of seminomas with chemotherapy.

W. W. ten Bokkel Huinink, S. Williams, A. van Oosterom, 1984, Progress in clinical and biological research.

Acute leukemia following therapy for teratoma.

J. Mcvie, W. W. ten Bokkel Huinink, K. Hoekman, 1984, European journal of cancer & clinical oncology.

5-Fluorouracil plus tauromustine in advanced colorectal cancer: unexpected negative results.

J. Mcvie, W. W. ten Bokkel Huinink, B. Taal, 1990, European journal of cancer.

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

J. Schellens, H. Rosing, J. Beijnen, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.

J. Schellens, H. Rosing, J. Beijnen, 2002, European journal of cancer.

Current status of systemic chemotherapy in the treatment of advanced ovarian cancer with emphasis on CHAP-5.

W. W. ten Bokkel Huinink, H. Pinedo, A. van Oosterom, 1984, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.

H. Bartelink, J. Beijnen, A. Begg, 1998, European journal of cancer.

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.

J. Schellens, H. Rosing, J. Beijnen, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.

S. Rodenhuis, H. Rosing, J. Beijnen, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Intracardiac metastases, report of three cases.

W. Mooi, W. W. ten Bokkel Huinink, L. T. Vlasveld, 1991, The Netherlands journal of medicine.

Randomized trial comparing two combination chemotherapy regimens (CHAP-5 v CP) in advanced ovarian carcinoma.

J. Neijt, J. Bouma, W. W. ten Bokkel Huinink, 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Predictability of the survival of patients with advanced ovarian cancer.

J. Neijt, W. W. ten Bokkel Huinink, J. van Houwelingen, 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Mitoxantrone extravasation injury.

J. Beijnen, W. W. ten Bokkel Huinink, F. T. Peters, 1987, Cancer treatment reports.

Successful docetaxel rechallenge with cromoglycate after major sensitivity reactions.

S. Rodenhuis, W. W. ten Bokkel Huinink, A. Westermann, 1996, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer

J. Beijnen, J. Schornagel, W. W. ten Bokkel Huinink, 2006, British Journal of Cancer.

Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion.

S. Rodenhuis, H. Rosing, J. Beijnen, 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography.

W. W. ten Bokkel Huinink, O. van Tellingen, M. Hillebrand, 1995, Journal of chromatography. B, Biomedical applications.

Continuous infusion of low-dose topotecan: pharmacokinetics and pharmacodynamics during a phase II study in patients with small cell lung cancer.

J. Beijnen, W. W. ten Bokkel Huinink, M. Schot, 1998, Anti-cancer drugs.

Combination chemotherapy with tauromustine (TCNU), 5-fluorouracil and leucovorin in advanced colorectal carcinoma: a dose-finding study.

S. Rodenhuis, W. W. ten Bokkel Huinink, B. Taal, 1993, Annals of oncology : official journal of the European Society for Medical Oncology.

EAP in advanced gastric cancer.

S. Rodenhuis, W. W. ten Bokkel Huinink, B. Taal, 1990, Journal of Clinical Oncology.

Intraperitoneal chemotherapy in ovarian carcinoma.

A. V. van Oosterom, W. W. ten Bokkel Huinink, E. D. de Bruijn, 1987, Netherlands Journal of Medicine.

Tauromustine (TCNU) combined with 5-fluorouracil and leucovorin in the treatment of advanced colon cancer.

S. Rodenhuis, W. W. ten Bokkel Huinink, B. Taal, 1993, European journal of cancer.

Phase II clinical trial of doxifluridine in patients with advanced ovarian cancer.

W. W. ten Bokkel Huinink, J. Vermorken, P. Willemse, 1991, European journal of cancer.

Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study.

S. Rodenhuis, H. Rosing, W. W. ten Bokkel Huinink, 1999, Anti-cancer drugs.