C. E. Arris

发表

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Jane A. Endicott, Thomas G. Davies, Nicola J. Curtin, 2002, Nature Structural Biology.

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.

L. Johnson, M. Noble, J. Endicott, 2003, Bioorganic & medicinal chemistry letters.

Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha.

C. E. Arris, C. Sheridan, D. Bevitt, 2003, Biochimica et biophysica acta.

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.

N. Curtin, R. Griffin, B. Golding, 2000, Journal of medicinal chemistry.

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).

N. Curtin, R. Griffin, B. Golding, 1994, Anti-cancer drug design.

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.

Yuzhu Chen, M. Noble, J. Endicott, 2004, Journal of medicinal chemistry.

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.

L. Johnson, M. Noble, J. Endicott, 2002, Journal of medicinal chemistry.

Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.

A H Calvert, E. Sausville, L. Johnson, 2000, Journal of medicinal chemistry.

DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767.

N. Curtin, D. Newell, D. Blakey, 2002, European journal of cancer.

Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients.

C. E. Arris, D. Bevitt, Zheng Li, 2003, Biochimica et biophysica acta.