H. Fretz

发表

Protein kinases as targets for anticancer agents: from inhibitors to useful drugs.

Bhabatosh Chaudhuri, Doriano Fabbro, Pascal Furet, 2002, Pharmacology & therapeutics.

Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.

D. Fabbro, P. Furet, T. O'reilly, 2001, Journal of the National Cancer Institute.

Novel Cdk inhibitors restore TGF-beta sensitivity in cdk4 overexpressing epithelial cells.

H. Fretz, R. Soni, L. Muller, 2000, Biochemical and biophysical research communications.

The synthesis of peptides by a combined solid phase and solution method

H. Fretz, A. Flörsheimer, B. Riniker, 1993 .

Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product.

P. Furet, H. Fretz, R. Soni, 2000, Biochemical and biophysical research communications.

Regioselectivity and deuterium isotope effects in geraniol hydroxylation by the cytochrome P-450 monooxygenase from Catharanthus roseus (L.) G. Don

H. Fretz, W. Woggon, 1986 .

Rapamycin and FK506 binding proteins (immunophilins)

S. Schreiber, William Arbuthnot Sir Lane, H. Fretz, 1991 .

O-(Carboxydifluoromethyl)-L-tyrosine: Design and synthesis of a novel non phosphorous-containing phosphotyrosine isostere

H. Fretz, 1998 .

Synthesis of Modified Tripeptides and Tetrapeptides as potential bisubstrate inhibitors of the epidermal growth factor receptor protein tyrosine kinase

P. Furet, H. Mett, P. Traxler, 1997 .

Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold.

D. Renneberg, H. Fretz, X. Leroy, 2013, Bioorganic & medicinal chemistry letters.

Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype.

H. Fretz, X. Leroy, M. Riederer, 2012, Bioorganic & medicinal chemistry letters.

SYNTHESIS OF NOVEL L-PHENYLALANINE DERIVATIVES SUBSTITUTED WITH A KETO YLIDE AS STABLE PRECURSOR OF A VICINAL TRICARBONYL MOIETY

H. Fretz, 1996 .

Synthetic Models of the Active Site of Cytochrome P-450. 1st Communication. The Synthesis of a Doubly-Bridged Iron(II)-Porphyrin Carrying a Tightly Bound Thiolate Ligand†

H. Fretz, U. Piantini, W. Woggon, 1987 .

The Allylic Oxidation of Geraniol Catalyzed by Cytochrome P‐450Cath., Proceeding with retention of configuration

H. Fretz, W. Woggon, R. Voges, 1989 .

A practical dealkylation procedure for O,O-dimethyl-phosphotyrosyl-containing peptide-resins

H. Fretz, 2004, Letters in Peptide Science.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968).

H. Fretz, J. Segrestaa, T. Pfeifer, 2015, Journal of medicinal chemistry.

Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands.

P. Furet, C. García-echeverría, P. Chène, 1997, Biochemistry.

A General Strategy for the Synthesis of Large Peptides: r1~he Combined Solid-Phase and Solution Approach.

H. Fretz, A. Flörsheimer, P. Sieber, 1993 .

Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.

P. Furet, C. García-echeverría, H. Fretz, 1998, Journal of molecular biology.

DNA binding properties of the marine sponge pigment fascaplysin.

B. Chaudhuri, H. Fretz, A. Hörmann, 2001, Bioorganic & medicinal chemistry.

N α-Fmoc-O, O-(dimethylphospho)-L-tyrosine fluoride: A convenient building block for the solid-phase synthesis of phosphotyrosyl peptides

H. Fretz, 1997, Letters in Peptide Science.

Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.

L. Meijer, P. Furet, B. Chaudhuri, 2002, Journal of medicinal chemistry.

Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode

D. Erdmann, P. Furet, C. García-echeverría, 1996, Nature Structural Biology.

The substrate specificity of tocopherol cyclase.

A. Stocker, H. Fretz, W. Woggon, 1996, Bioorganic & Medicinal Chemistry.

Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist.

H. Fretz, X. Leroy, M. Riederer, 2013, Journal of medicinal chemistry.

Towards a rational approach in the finding of potent peptide ligands for Grb2 SH2

P. Furet, C. García-echeverría, H. Fretz, 2002 .

Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain.

P. Furet, C. García-echeverría, H. Fretz, 1998, Bioorganic & medicinal chemistry letters.

Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain.

P. Furet, C. García-echeverría, H. Fretz, 1998, Journal of medicinal chemistry.

Structure-based design of compounds inhibiting Grb2-SH2 mediated protein-protein interactions in signal transduction pathways.

P. Furet, C. García-echeverría, H. Fretz, 2000, Current pharmaceutical design.

Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching

Thomas Meyer, Pascal Furet, Peer R. E. Mittl, 2001, J. Comput. Aided Mol. Des..

Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1.

P. Furet, C. García-echeverría, H. Fretz, 2000, Bioorganic & medicinal chemistry letters.

Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.

P. Furet, C. García-echeverría, H. Fretz, 1998, Journal of medicinal chemistry.

Discovery of 3-aminobenzyloxycarbonyl as an N-terminal group conferring high affinity to the minimal phosphopeptide sequence recognized by the Grb2-SH2 domain.

P. Furet, C. García-echeverría, H. Fretz, 1997, Journal of medicinal chemistry.

Investigations on the Reactivity of Fascaplysin, Part II, General Stability Considerations and Products Formed with Nucleophiles

M. Lang, H. Fretz, J. Schoepfer, 2001 .

Aspects of the molecular structure and dynamics of neuropeptide Y.

A. Drake, H. Fretz, A. Nordmann, 1999, European journal of biochemistry.

Solid phase synthesis of peptides containing novel L-phenylalanine derivatives substituted with vicinal tricarbonyl moieties

H. Fretz, 1996 .