T. Tamaoki

发表

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation.

I. Takahashi, K. Asano, I. Kawamoto, 1989, The Journal of antibiotics.

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

S. Akinaga, T. Tamaoki, K. Gomi, 1991, Cancer research.

Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole.

M. Shimizu, S. Akinaga, T. Tamaoki, 1999, Anti-cancer drugs.

Chemoprotective effects of KF41399, a derivative of carbazole compounds, on nimustine-induced thrombocytopenia.

S. Akinaga, Y. Shiotsu, H. Mizoguchi, 2000, Blood.

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

T. Tamaoki, M. Morimoto, H. Nomoto, 1986, Biochemical and biophysical research communications.

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

T. Tamaoki, H. Nakano, 1990, Bio/Technology.

Modulation of oligosaccharide structure of a pro-urokinase derivative (pro-UKΔGS1) by changing culture conditions of a lymphoblastoid cell line Namalwa KJM-1 adapted to serum-free medium

M. Satoh, T. Tamaoki, M. Hasegawa, 2004, Cytotechnology.

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.

T. Tamaoki, H. Nakano, M. Morimoto, 1989, The Journal of antibiotics.

Lymphocyte membrane modifications induced by HIV infection.

D. Church, M. Gill, S. Hakomori, 1994, The Tohoku journal of experimental medicine.

Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C.

S. Akinaga, I. Takahashi, T. Tamaoki, 1990, Advances in second messenger and phosphoprotein research.

Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C.

I. Takahashi, T. Tamaoki, H. Nakano, 1990, The Journal of pharmacology and experimental therapeutics.

Inhibition of protein kinase C by calphostin C is light-dependent.

J. Howbert, I. Takahashi, T. Tamaoki, 1991, Biochemical and biophysical research communications.

Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae.

T. Kataoka, Y. Yamawaki-Kataoka, H. Tanaka, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Hair follicle elongation in organ culture of skin from newborn and adult mice.

T. Tamaoki, T. Kamiya, A. Shirai, 1998, Journal of dermatological science.

Binding Signaling Molecules Antitumor Activity via Selective Depletion of Hsp 90 Vivo in KF 25706 , a Novel Oxime Derivative of Radicicol , Exhibits

L. Neckers, S. Soga, S. Akinaga, 1999 .

UCS15A, a non-kinase inhibitor of Src signal transduction

Sreenath V. Sharma, T. Tamaoki, H. Nakano, 2001, Oncogene.

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.

L. Neckers, S. Soga, S. Akinaga, 2000, Blood.

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

L. Neckers, S. Soga, S. Akinaga, 2000 .

Expression of Ley antigen in human immunodeficiency virus-infected human T cell lines and in peripheral lymphocytes of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC)

M. Gill, S. Hakomori, T. Tamaoki, 1988, The Journal of experimental medicine.

Modulation of oligosaccharide structure of a pro-urokinase derivative (pro-UKΔGS1) by culture conditions

T. Tamaoki, M. Hasegawa, K. Yamaguchi, 1994 .

Novel substituted indolocarbazoles as potent and selective inhibitors of protein kinase C

J. Lown,, T. Tamaoki, H. Nagata, 1995 .

Tetrocarcins, new antitumor antibiotics. 3. Antitumor activity of tetrocarcin A.

T. Tamaoki, M. Morimoto, F. Tomita, 1982, Journal of antibiotics (Tokyo. 1968).

KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.

T. Tamaoki, T. Kamiya, A. Shirai, 2001, Journal of dermatological science.

The P53 Tumour Suppressor Gene Regulates a Dna Damage-triggered G1 Checkpoint (hartwell and Kastan, 1994). P53-dependent Growth Arrest Occurs upon Transcriptional Activation of P21, Which in Turn Inhibits Cyclin-dependent Kinase-mediated Phosphorylation Of

S. Akinaga, Y. Yamaoka, W. Benedict, 2022 .

Biosynthesis of tetrocarcin. Incorporation of 14C- and 13C-labeled compounds into tetrocarcin.

T. Tamaoki, F. Tomita, 1983, The Journal of antibiotics.

Inhibition of Lymphocyte Kinase Lck and Phosphatidylinositol 3-kinase by a Novel Immunosuppressant, Lymphostin

I. Takahashi, T. Tamaoki, S. Nakanishi, 2002, Bioscience, biotechnology, and biochemistry.

Stereospecific antitumor activity of radicicol oxime derivatives

M. Shimizu, Sreenath V. Sharma, L. Neckers, 2001, Cancer Chemotherapy and Pharmacology.

Combined effect of navelbine with medroxyprogesterone acetate against human breast carcinoma MCF-7 cells in vitro.

M. Shimizu, S. Akinaga, T. Tamaoki, 1998, British Journal of Cancer.

Novel antitumor antibiotics, tetrocarcins.

T. Tamaoki, M. Morimoto, F. Tomita, 1980, The Journal of antibiotics.

Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration

S. Akinaga, Takeshi Takahashi, T. Tamaoki, 1999, Cancer Chemotherapy and Pharmacology.

Hair follicle elongation in vitro of whole skin pieces from mice

T. Tamaoki, Seiji Sato, T. Kamiya, 1995, In Vitro Cellular & Developmental Biology - Animal.

Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: taxonomy of the producing organism, fermentation, isolation and biological activities.

K. Ochiai, I. Takahashi, T. Tamaoki, 1997, The Journal of antibiotics.

Attempts to enhance RNA synthesis and isolate mRNA from mast cells.

T. Tamaoki, H. Fujimaki, A. Befus, 1987, Advances in experimental medicine and biology.

Constituents of a fern, Davallia mariesii Moore. I. Isolation and structures of davallialactone and a new flavanone glucuronide.

J. H. Park, T. Tamaoki, H. Nakano, 1990, Chemical & pharmaceutical bulletin.

Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins.

T. Kataoka, Y. Yamawaki-Kataoka, T. Tamaoki, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Expression of intact Ki-ras p21 protein in Escherichia coli.

T. Mizukami, M. Perucho, T. Tamaoki, 1985, Biochemical and biophysical research communications.

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.

T. Tamaoki, H. Nakano, M. Morimoto, 1989, Biochemical and biophysical research communications.

Synthesis and antitumor activity of duocarmycin derivatives: modification of segment-A of A-ring pyrrole compounds.

T. Tamaoki, M. Okabe, C. Murakata, 1999, Journal of Medicinal Chemistry.

Tetrocarcins E1, E2, F and F-1, new antibiotics. Fermentation, isolation and characterization.

T. Tamaoki, F. Tomita, M. Kasai, 1982, The Journal of antibiotics.

Quinocarcin, a novel antitumor antibiotic. 3. Mode of action.

T. Tamaoki, F. Tomita, K. Takahashi, 1984, The Journal of antibiotics.

Synthesis and antitumor activity of duocarmycin derivatives: modification at C-8 position of A-ring pyrrole compounds bearing the simplified DNA-binding groups.

T. Tamaoki, K. Gomi, M. Okabe, 2000, Bioorganic & medicinal chemistry.

Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.

T. Tamaoki, M. Morimoto, F. Tomita, 1980, The Journal of antibiotics.

Gilvocarcins, new antitumor antibiotics. 4. Mode of action.

T. Tamaoki, F. Tomita, K. Takahashi, 1982, The Journal of antibiotics.

Constituents of a Fern, Davallia mariesii MOORE. II. Identification and 1H- and 13C-Nuclear Magnetic Resonance Spectra of Procyanidin B-5, Epicatechin-(4β→8)-epicatechin-(4β→6)-epicatechin, and Epicatechin-(4β→6)-epicatechin-(4β→8)-epicatechin-(4β→6)-epicatechin

T. Tamaoki, H. Nakano, Y. Tezuka, 1992 .

Metabolism and ribonucleotide reductase inhibition of (E )-2′-deoxy-2′-(fluoromethylene)cytidine, MDL 101,731, in human cervical carcinoma HeLa S3 cells

S. Akinaga, Takeshi Takahashi, T. Tamaoki, 1998, Cancer Chemotherapy and Pharmacology.

Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity.

I. Takahashi, T. Tamaoki, H. Nakano, 1989, Biochemical and biophysical research communications.

Constituents of a Fern, Davallia mariesii MOORE. V.Isolation and Structures of Davallin, a New Tetrameric Proanthocyanidin, and Two New Phenolic Glycosides

T. Tamaoki, H. Nakano, Y. Tezuka, 1993 .

Constituents of a Fern, Davallia mariesii MOORE. III. Revised Structure and Absolute Configuration of Davallialactone

T. Tamaoki, H. Nakano, Y. Tezuka, 1992 .

Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin.

T. Ashizawa, T. Tamaoki, Y. Kanda, 2003, Bioorganic & medicinal chemistry letters.

Antitumor activity of KF22678, a novel thioester derivative of leinamycin.

T. Ashizawa, T. Tamaoki, K. Gomi, 1999, Anti-cancer drugs.

TETROCARCINS, NOVEL ANTITUMOR ANTIBIOTICS

T. Tamaoki, F. Tomita, 1980 .

Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.

T. Tamaoki, F. Tomita, 1980, The Journal of antibiotics.

FERMENTATION , ISOLATION , PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

T. Tamaoki, H. Nakano, T. Iida, 2006 .

Optimization of cell culture conditions for G-CSF (granulocyte-colony stimulating factor) production by genetically engineered namalwa KJM-1 cells

M. Satoh, T. Tamaoki, M. Hasegawa, 1991, Cytotechnology.

The relationship between the antitumor activity and the ribonucleotide reductase inhibitory activity of (E)-2'-deoxy-2'-(fluoromethylene) cytidine, MDL 101,731.

S. Akinaga, T. Tamaoki, M. Okabe, 1998, Anti-cancer drugs.

In vitro and in vivo effects of KT6352, a derivative of indolocarbazole compounds, on murine megakaryocytopoiesis.

S. Akinaga, Y. Shiotsu, H. Mizoguchi, 1998, Experimental hematology.

Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors.

T. Tamaoki, 1991, Methods in enzymology.

Characterization of the molecules involved in the hematopoietic microenvironment provided by mouse stromal cell line MC3T3-G2/PA6 using a unique reporter system that analyzes the direct cell-to-cell interaction.

M. Satoh, I. Takahashi, T. Tamaoki, 1997, Acta haematologica.

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

L. Neckers, S. Soga, S. Akinaga, 1999, Cancer research.

The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells

M. Kuwano, S. Sato, T. Tamaoki, 1993, The Journal of cell biology.

G1–checkpoint Function Including a Cyclin‐dependent Kinase 2 Regulatory Pathway as Potential Determinant of 7–Hydroxystaurosporine (UCN‐01)‐induced Apoptosis and G1–phase Accumulation

M. Shimizu, S. Akinaga, T. Tamaoki, 1999, Japanese journal of cancer research : Gann.

UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily

T. Kuroki, T. Tamaoki, S. Hirai, 1995, FEBS letters.

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

I. Takahashi, T. Tamaoki, H. Nakano, 1989, The Journal of antibiotics.

Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

H. Iba, Y. Kuzuu, I. Takahashi, 1987, The Journal of antibiotics.

Purification and Characterization of Formaldehyde Dehydrogenase in a Methanol-utilizing Yeast, Kloeckera sp. No. 2201

Y. Tani, T. Tamaoki, K. Ogata, 1972 .

Stabile production of a thrombin resistant pro-urokinase derivative (PRO-UKS1) by Namalwa KJM-1 cells adapted to serum-free medium

M. Satoh, T. Nishi, T. Mizukami, 2004, Cytotechnology.

Dissociation of Escherichia coli ribosomes. Role of initiation factors.

T. Tamaoki, S. H. Miall, 1972, Biochemistry.

Topical application of cyclosporin A induces rapid-remodeling of damaged anagen hair follicles produced in cyclophosphamide administered mice.

T. Tamaoki, T. Kamiya, A. Shirai, 2001, Journal of dermatological science.

Mouse bone marrow stromal cell line MC3T3-G2/PA6 with hematopoietic-supporting activity expresses high levels of stem cell antigen Sca-1.

M. Satoh, Y. Shiotsu, T. Tamaoki, 1997, Experimental hematology.

UCN‐01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogation

M. Shimizu, S. Akinaga, R. Takahashi, 2000, International journal of cancer.

Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).

M. Shimizu, S. Akinaga, T. Tamaoki, 1999, Cancer research.

NOVEL ANTITUMOR ANTIBIOTICS 11 . ISOLATION , CHARACTERIZATION AND ANTITUMOR ACTIVITY

T. Tamaoki, M. Morimoto, F. Tomita, 2006 .

UCN-1028A, a novel and specific inhibitor of protein kinase C, from Cladosporium.

T. Tamaoki, H. Nakano, K. Ando, 1989, The Journal of antibiotics.

Staurosporine‐related compounds, K252a and UCN‐01, inhibit both cPKC and nPKC

T. Tamaoki, T. Saido, S. Ohno, 1993, FEBS letters.

Isolation and in vitro translation of mRNA from rat peritoneal mast cells and rat basophilic leukemia cells.

T. Tamaoki, H. Fujimaki, A. Befus, 1988, Journal of immunological methods.

Constituents of a Fern, Davallia mariesii Moore. IV. Isolation and Structures of a Novel Norcarotane Sesquiterpene Glycoside, a Chromone Glucuronide, and Two Epicatechin Glycosides.

T. Tamaoki, H. Nakano, Y. Tezuka, 1992 .