P. Blumberg

S. Yuspa, M. Kazanietz, P. Blumberg, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

HighlyLipophilicPhorbolEstersas Inhibitorsof Specific [ 3 H ] Phorbol 12 , 13-DibutyrateBinding

P. Blumberg, N. A. Sharkey, 2006 .

Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol.

K. Leach, P. Blumberg, 1985, Cancer research.

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2.

P. Blumberg, R. Boutwell, 1981, Critical reviews in toxicology.

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1.

P. Blumberg, 1980, Critical reviews in toxicology.

Characterization of specific binding of [3H]phorbol 12,13-dibutyrate and [3H]phorbol 12-myristate 13-acetate to mouse brain.

P. Blumberg, W. Dunphy, K. B. Delclos, 1980, Cancer research.

Different biological targets for resiniferatoxin and phorbol 12-myristate 13-acetate.

P. Blumberg, P. E. Driedger, 1980, Cancer research.

Quantitative correlation between in vitro and in vivo activities of phorbol esters.

P. Blumberg, P. E. Driedger, 1979, Cancer research.

Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency

P. Blumberg, N. Lewin, N. Kedei, 2018, Chembiochem : a European journal of chemical biology.

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.

P. Blumberg, M. Krische, N. Lewin, 2016, Journal of the American Chemical Society.

Protein kinase C isoenzymes differentially regulate the differentiation‐dependent expression of adhesion molecules in human epidermal keratinocytes

P. Blumberg, T. Bíró, B. Tóth, 2009, Experimental dermatology.

RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes*

P. Blumberg, J. Stone, P. Lorenzo, 2003, Journal of Biological Chemistry.

Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.

Z. Szallasi, S. Yuspa, P. Blumberg, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

P. Blumberg, A. Jeng, U. Lichti, 1985, Cancer research.

Phosphorylation Specificities of Protein Kinase C Isozymes for Bovine Cardiac Troponin I and Troponin T and Sites within These Proteins and Regulation of Myofilament Properties*

D. Fabbro, Y. Hannun, G. Blobe, 1996, The Journal of Biological Chemistry.

Permanent efforts of neonatally administered resiniferatoxin in the rat

Z. Szallasi, P. Blumberg, A. Szallasi, 1990, Brain Research.

The stimulation of capsaicin‐sensitive neurones in a vanilloid receptor‐mediated fashion by pungent terpenoids possessing an unsaturated 1,4‐dialdehyde moiety

P. Blumberg, T. Bíró, A. Szallasi, 1996, British journal of pharmacology.

RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma

Luowei Li, S. Yuspa, P. Blumberg, 2011, Oncogene.

RasGRP links T-cell receptor signaling to Ras.

P. Blumberg, J. Stone, H. Ostergaard, 2000, Blood.

Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

J. Strominger, P. Blumberg, 1974, Bacteriological reviews.

Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration

T. Hökfelt, G. Bennett, P. Blumberg, 1996, Brain Research.

Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists.

Vladimir A. Pavlyukovets, Sun Choi, Jeewoo Lee, 2009, Bioorganic & medicinal chemistry.

Phosphorylation of Protein Kinase Cδ on Distinct Tyrosine Residues Regulates Specific Cellular Functions*

P. Blumberg, S. Garfield, C. Brodie, 2000, The Journal of Biological Chemistry.

Tyrosine Phosphorylation of Protein Kinase Cδ Is Essential for Its Apoptotic Effect in Response to Etoposide

P. Blumberg, C. Brodie, G. Kazimirsky, 2002, Molecular and Cellular Biology.

Infection of Glioma Cells with Sindbis Virus Induces Selective Activation and Tyrosine Phosphorylation of Protein Kinase C δ

P. Blumberg, S. Lustig, D. Kobiler, 2002, The Journal of Biological Chemistry.

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.

P. Dennis, K. West, A. Clark, 2003, Cancer research.

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

W. Kolch, G. Martiny-Baron, H. Mischak, 1993, The Journal of biological chemistry.

Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.

Z. Szallasi, W. Anderson, S. Yuspa, 1995, Biochemical and biophysical research communications.

Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-Δ with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-δ

James S. Song, Z. Szallasi, P. Blumberg, 1998, Oncogene.

Protein Kinase Cδ Targets Mitochondria, Alters Mitochondrial Membrane Potential, and Induces Apoptosis in Normal and Neoplastic Keratinocytes When Overexpressed by an Adenoviral Vector

Luowei Li, S. Yuspa, P. Blumberg, 1999, Molecular and Cellular Biology.

Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.

F. Umansky, P. Blumberg, C. Brodie, 2001, Cancer research.

Protein Kinase Cα and Protein Kinase Cδ Play Opposite Roles in the Proliferation and Apoptosis of Glioma Cells

F. Umansky, P. Blumberg, C. Brodie, 2001 .

Roles of Tyrosine Phosphorylation and Cleavage of Protein Kinase Cδ in Its Protective Effect Against Tumor Necrosis Factor-related Apoptosis Inducing Ligand-induced Apoptosis*

W. Lu, P. Blumberg, Donghong Ju, 2005, Journal of Biological Chemistry.

Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C.

P. Blumberg, A. Kozikowski, N. Lewin, 2001, Bioorganic & medicinal chemistry letters.

Specific binding of phorbol ester tumor promoters.

P. Blumberg, P. E. Driedger, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

K. Leach, P. Blumberg, N. A. Sharkey, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Function of RasGRP3 in the formation and progression of human breast cancer

Z. Nagy, G. Vereb, P. Blumberg, 2014, Molecular Cancer.

Visualization by [3H]resiniferatoxin autoradiography of capsaicin-sensitive neurons in the rat, pig and man.

T. Hökfelt, P. Blumberg, A. Szallasi, 1994, European journal of pharmacology.

A Phospholipase C-γ1–Independent, RasGRP1-ERK–Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells–Y136F Mutant Mice

L. Samelson, P. Blumberg, R. Kortum, 2013, The Journal of Immunology.

Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC.

P. Blumberg, N. Lewin, N. Kedei, 2016, Tetrahedron letters.

Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.

P. Blumberg, N. Lewin, A. Rudra, 2012, Bioorganic & medicinal chemistry letters.

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.

Z. Szallasi, P. Blumberg, C. Smith, 1994, The Journal of biological chemistry.

STRUCTURE-BASED DESIGN OF A NEW CLASS OF PROTEIN KINASE C MODULATORS

Shaomeng Wang, P. Blumberg, L. Qiao, 1998 .

Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.

R. Glazer, P. Blumberg, A. Kozikowski, 1997, Journal of medicinal chemistry.

New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.

P. Blumberg, A. Kozikowski, P. Petukhov, 2003, Journal of medicinal chemistry.

Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells.

M. Dell'aquila, P. Blumberg, H. Nguyen, 1987, Cancer research.

New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.

J. Sridhar, P. Blumberg, A. Kozikowski, 2003, Journal of medicinal chemistry.

[3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents

P. Blumberg, A. Szallasi, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.

J. Strominger, P. Blumberg, H. Suginaka, 1972, The Journal of biological chemistry.

Covalent affinity chromatography of penicillin-binding components from bacterial membranes.

J. Strominger, P. Blumberg, 1974, Methods in enzymology.

Five penicillin-binding components occur in Bacillus subtilis membranes.

J. Strominger, P. Blumberg, 1972, The Journal of biological chemistry.

Pharmacologic and neurochemical evidence for the activation of capsaicin-sensitive sensory nerves by lipoxin A4 in guinea pig bronchus.

P. Blumberg, A. Szallasi, S. Manzini, 1992, The American review of respiratory disease.

A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.

Z. Szallasi, K. Gustafson, O. Weislow, 1992, Journal of medicinal chemistry.

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

Z. Szallasi, H. Mischak, M. Kazanietz, 1993, The Journal of biological chemistry.

Protein Kinase C as the Site of Action of the Phorbol Ester Tumor Promoters

M. Dell'aquila, P. Blumberg, B. Warren, 1987 .

Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters.

R. Modali, M. Kazanietz, P. Blumberg, 1997, The Journal of biological chemistry.

Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity.

M. Kazanietz, P. Blumberg, N. Lewin, 1995, The Journal of biological chemistry.

PENICILLIN BINDING COMPONENTS OF BACTERIAL CELLS AND THEIR RELATIONSHIP TO THE MECHANISM OF PENICILLIN ACTION

P. Blumberg, 1974, Annals of the New York Academy of Sciences.

Penicillin Binding Components in Bacillius subtilis During Sporulation

J. Strominger, P. Blumberg, R. A. Anwar, 1974, Journal of bacteriology.

Inhibition of the Bacillus subtilis Membrane-Bound d-Alanine Carboxypeptidase by 6-Aminopenicillanic Acid Covalently Coupled to Sepharose

D. Storm, J. Strominger, P. Blumberg, 1974, Journal of bacteriology.

Mechanism of Action and Development of Resistance to a New Amidino Penicillin

J. Strominger, P. Blumberg, P. Linnett, 1974, Journal of bacteriology.

d-Alanine Carboxypeptidase and Cell Wall Cross-Linking in Bacillus subtilis

J. Strominger, P. Blumberg, A. Sharpe, 1974, Journal of bacteriology.

Characterization of functional vanilloid receptors expressed by mast cells.

R. Paus, P. Blumberg, T. Bíró, 1998, Blood.

Isolation by covalent affinity chromatography of the penicillin-binding components from membranes of Bacillus subtilis.

J. Strominger, P. Blumberg, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Inactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis.

J. Strominger, P. Blumberg, 1971, Proceedings of the National Academy of Sciences of the United States of America.

How penicillin kills bacteria: progress and problems

J. Strominger, P. Blumberg, H. Suginaka, 1971, Proceedings of the Royal Society of London. Series B. Biological Sciences.

The effect of phorbol diesters on chicken embryo fibroblasts.

P. Blumberg, P. E. Driedger, 1977, Cancer research.

Overexpression of Protein Kinase C Isoform but not δ in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

Z. Szallasi, P. Blumberg, R. A. Mufson, 1998 .

Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression.

Z. Szallasi, P. Blumberg, R. A. Mufson, 1998, Blood.

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation

Y. Zhang, X. Xie, P. Blumberg, 2016, The AAPS Journal.

Response to Etoposide Is Essential for Its Apoptotic Effect in δ C Tyrosine Phosphorylation of Protein Kinase

P. Blumberg, C. Brodie, G. Kazimirsky, 2001 .

TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation.

Jeewoo Lee, P. Blumberg, L. Pearce, 2011, Current topics in medicinal chemistry.

Effect of proteases on activation of resting chick embryo fibroblasts and on cell surface proteins

P. Robbins, P. Blumberg, 1975, Cell.

Binding of (14C)penicillin G to the membrane-bound and the purified D-alanine carboxypeptidases from Bacillus stearothermophilus and Bacillus subtilis and its release.

J. Strominger, P. Blumberg, R. Yocum, 1974, The Journal of biological chemistry.

Purification and characterization of the thermophilic D-alanine carboxypeptidase from membranes of Bacillus stearothermophilus.

J. Strominger, P. Blumberg, R. Yocum, 1974, The Journal of biological chemistry.

Proton inhibition of [3H]resiniferatoxin binding to vanilloid (capsaicin) receptors in rat spinal cord.

P. Blumberg, A. Szallasi, J. Lundberg, 1995, European journal of pharmacology.

Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences

C. Goso, P. Blumberg, A. Szallasi, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat.

C. Goso, P. Blumberg, A. Szallasi, 1993, European journal of pharmacology.

Chemotherapeutic Resistance Promotes Cellular Survival and δ Lung Cancer Cells : PKC Altered Protein Kinase C ( PKC ) Isoforms in Non-Small Cell

P. Dennis, K. West, A. Clark, 2003 .

Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C.

P. Blumberg, A. Kozikowski, N. Lewin, 2001, Bioorganic & medicinal chemistry letters.

The Catalytic Domain of Protein Kinase Cδ Confers Protection from Down-regulation Induced by Bryostatin 1*

P. Blumberg, P. Ács, G. Pettit, 1997, The Journal of Biological Chemistry.

Conformationally constrained analogues of diacylglycerol. 9.1 the effect of side-chain orientation on the protein kinase C (PK-C) binding affinity of σ-lactones

Jeewoo Lee, P. Blumberg, V. Marquez, 1994 .

Conformationally constrained analogues of dag .8. Changes in PK-C binding affinity produced by isosteric groups of the 3-O-acyl function in 2-deoxy-L-ribonolactones

Jeewoo Lee, P. Blumberg, Rajiv Sharma, 1994 .

Conformationally constrained analogues of diacylglycerol (DAG). 3. Interaction of α-alkyl-γ-lactones with protein kinase C (PK-C)

Jeewoo Lee, M. Kazanietz, P. Blumberg, 1993 .

The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta.

H. Mischak, M. Kazanietz, P. Blumberg, 1992, Gene.

Purification of stable protein kinase C from mouse brain cytosol by specific ligand elution using fast protein liquid chromatography.

P. Blumberg, A. Jeng, N. A. Sharkey, 1986, Cancer research.

A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.

P. Blumberg, J. Stone, A. Lopez-Campistrous, 2009, Experimental hematology.

Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface.

P. Blumberg, R. Jelinek, V. Marquez, 2008, Langmuir : the ACS journal of surfaces and colloids.

Engineering vanilloid-sensitivity into the rat TRPV2 channel

Sonya M. Hanson, P. Blumberg, S. Newstead, 2016, eLife.

Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun.

Z. Szallasi, M. Kazanietz, P. Blumberg, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.

P. Blumberg, J. Stone, M. Beheshti, 2000, Molecular pharmacology.

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

P. Blumberg, S. Garfield, G. Czifra, 2011, Biochemical Pharmacology.

Protein Kinase C as the Receptor for the Phorbol Ester Tumor Promoters: Sixth Rhoads Memorial Award Lecture1

P. Blumberg, 2006 .

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.

J. Cox, P. Blumberg, A. Tauber, 1985, The Journal of clinical investigation.

Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18.

P. Blumberg, F. Gao, N. Lewin, 1996, Journal of natural products.

Phosphorylation of Protein Kinase Cδ on Distinct Tyrosine Residues Induces Sustained Activation of Erk1/2 via Down-regulation of MKP-1

Yehuda Brody, P. Blumberg, C. Brodie, 2008, Journal of Biological Chemistry.

Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kinase C via a competitive mechanism.

P. Blumberg, N. A. Sharkey, 1985, Biochemical and biophysical research communications.

2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.

Sun Choi, Jeewoo Lee, P. Blumberg, 2016, Bioorganic & medicinal chemistry.

PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.

T. Hyman, P. Blumberg, H. Rubinfeld, 2004, Molecular pharmacology.

Highly lipophilic phorbol esters as inhibitors of specific [3H]phorbol 12,13-dibutyrate binding.

P. Blumberg, N. A. Sharkey, 1985, Cancer research.

Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells.

M. Dell'aquila, P. Blumberg, G. Pettit, 1988, Cancer research.

Second stage tumor promoters: differences in biological potency and phorbol ester receptor affinity in C6 cells.

K. Leach, P. Blumberg, M. Frost, 1987, Cancer letters.

Phospholipid and Ca++ dependency of phorbol ester receptors

P. Blumberg, B. König, P. A. Di Nitto, 1985, Journal of cellular biochemistry.

Receptors for the phorbol ester tumour promoters.

K. Leach, P. Blumberg, A. Jeng, 1985, Ciba Foundation symposium.

Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol ester.

P. Blumberg, K. B. Delclos, E. Yeh, 1983, Proceedings of the National Academy of Sciences of the United States of America.

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.

P. Blumberg, N. Lewin, N. Kedei, 2009, Organic letters.

Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.

Dennie S. Welch, P. Blumberg, N. Lewin, 2009, Organic letters.

Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.

P. Blumberg, N. Lewin, N. Kedei, 2008, Journal of the American Chemical Society.

Phorbol esters modulate the Ras exchange factor RasGRP3.

P. Blumberg, J. Stone, D. Bottorff, 2001, Cancer research.

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

H. Mischak, J. Pierce, M. Kazanietz, 1993, The Journal of biological chemistry.

Relationship between biological responsiveness to phorbol esters and receptor levels in GH4C1 rat pituitary cells.

P. Blumberg, A. Tashjian, S. Jaken, 1981, Cancer research.

Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells.

M. Kazanietz, P. Blumberg, K. Ozawa, 1993, The Journal of biological chemistry.

Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes*

A. Kraker, S. Yuspa, P. Blumberg, 2002, The Journal of Biological Chemistry.

Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes.

M. Kazanietz, P. Blumberg, F. Gao, 1994, Molecular pharmacology.

Effect of microinjected catalytic fragment of protein kinase C on morphological change in Swiss 3T3 cells.

M. Willingham, P. Blumberg, H. Nakakuma, 1989, Cancer communications.

Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor

Jeewoo Lee, P. Blumberg, G. Acs, 1995 .

Characterization of the Cysteine-rich Region of the Caenorhabditiselegans Protein Unc-13 as a High Affinity Phorbol Ester Receptor

M. Kazanietz, P. Blumberg, N. Lewin, 1995, The Journal of Biological Chemistry.

Effect of a phorbol ester on a transformation-sensitive surface protein of chick fibroblasts

P. Blumberg, P. Rossow, P. E. Driedger, 1976, Nature.

PHORBOL ESTER RECEPTORS AND THE IN VITRO EFFECTS OF TUMOR PROMOTERS

K. Leach, P. Blumberg, K. B. Delclos, 1983, Annals of the New York Academy of Sciences.

Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level

P. Blumberg, L. Pearce, Jihyae Ann, 2019, Biomolecules & therapeutics.

Effect of phospholipid on substrate phosphorylation by a catalytic fragment of protein kinase C.

P. Blumberg, A. Jeng, T. Nakadate, 1987, The Journal of biological chemistry.

Vanilloid (Capsaicin) receptors and mechanisms.

P. Blumberg, A. Szallasi, P M Blumberg, 1999, Pharmacological reviews.

Effect of alteration of the heterocyclic nucleus of ILV on its isoform selectivity for PKC. Palladium catalyzed route to benzofuran analogues of ILV

P. Blumberg, A. Kozikowski, N. Lewin, 1995 .

6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists.

K. Schiene, Sun Choi, Jeewoo Lee, 2015, Bioorganic & medicinal chemistry letters.

Screening TRPV1 antagonists for the treatment of pain: lessons learned over a decade

P. Blumberg, A. Szallasi, József Lázár, 2009, Expert opinion on drug discovery.

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.

Ji-Young Hwang, Larry V. Pearce, Peter M. Blumberg, 2019, European journal of medicinal chemistry.

Antinociceptive Pharmacology of N-(4-Chlorobenzyl)-N′-(4-hydroxy-3-iodo-5-methoxybenzyl) Thiourea, a High-Affinity Competitive Antagonist of the Transient Receptor Potential Vanilloid 1 Receptor

P. Blumberg, Zili Chen, A. Kozikowski, 2007, Journal of Pharmacology and Experimental Therapeutics.

Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine.

P. Blumberg, R. Pettit, N. Lewin, 2004, The Journal of organic chemistry.

Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.

Jiyoun Lee, S. Y. Kim, Jeewoo Lee, 2004, Bioorganic & medicinal chemistry.

N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region".

Jeewoo Lee, P. Blumberg, L. Pearce, 2004, Bioorganic & medicinal chemistry.

3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.

P. Blumberg, V. Marquez, Q. J. Wang, 1999, Bioorganic & medicinal chemistry letters.

N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.

Ji-Min Kim, Attila Toth, Jiyoun Lee, 2003, Journal of medicinal chemistry.

N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics.

P. Blumberg, V. Marquez, S Y Kim, 2001, Bioorganic & medicinal chemistry.

2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.

Dong Wook Kang, Sun Choi, Mi-Yeon Kim, 2012, Journal of medicinal chemistry.

Discovery of 1-(1H-Indazol-4-yl)-3-((1-Phenyl-1H-Pyrazol-5-yl)methyl) Ureas as Potent and Thermoneutral TRPV1 Antagonists.

G. Bahrenberg, P. Blumberg, Sun-Ok Kwon, 2020, Bioorganic & medicinal chemistry letters.

Discovery of indane propanamides as potent and selective TRPV1 antagonists.

G. Bahrenberg, P. Blumberg, Y. H. Kim, 2019, Bioorganic & medicinal chemistry letters.

Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists.

G. Bahrenberg, P. Blumberg, Changhoon Kim, 2018, Bioorganic & medicinal chemistry letters.

t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

Sun Choi, G. Bahrenberg, P. Blumberg, 2017, Bioorganic & medicinal chemistry.

Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.

Sun Choi, P. Blumberg, Changhoon Kim, 2016, Bioorganic & medicinal chemistry letters.

Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.

M. Cui, Sun Choi, G. Bahrenberg, 2015, Bioorganic & medicinal chemistry.

α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists.

M. Cui, Sun Choi, G. Bahrenberg, 2015, Bioorganic & medicinal chemistry letters.

Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

HyungChul Ryu, Suyoung Yoon, K. Schiene, 2015, European journal of medicinal chemistry.

Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.

Vladimir A. Pavlyukovets, S. Y. Kim, Jeewoo Lee, 2005, Bioorganic & medicinal chemistry letters.

Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.

Vladimir A. Pavlyukovets, Jiyoun Lee, S. Y. Kim, 2005, Bioorganic & medicinal chemistry letters.

N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands.

P. Blumberg, J. Lee, T. Szabó, 2001, Bioorganic & medicinal chemistry.

Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.

P. Blumberg, R. Pettit, N. Lewin, 2004, Journal of medicinal chemistry.

Synthesis of two rigid diacylglycerol analogues having a perhydro furo[3,2-b]furan bis-γ-butyrolactone skeleton. 3.

Jeewoo Lee, M. Kazanietz, P. Blumberg, 1993 .

Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

P. Blumberg, M. Peach, N. Lewin, 2014, Journal of the American Chemical Society.

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

B Bienfait, B. Bienfait, P. Blumberg, 2000, Journal of medicinal chemistry.

Distinct features of recombinant rat vanilloid receptor-1 expressed in various expression systems

P. Blumberg, T. Bíró, L. Kovács, 2003, Cellular and Molecular Life Sciences CMLS.

Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1.

P. Blumberg, S. Garfield, G. Pettit, 1999, Cancer research.

Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase Cδ Provides an Integrated Measure of Its Modulation in Response to Ligands

P. Blumberg, P. Goldsmith, A. Telek, 2014, Journal of medicinal chemistry.

Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.

P. Blumberg, A. Rudra, A. Telek, 2013, Biochemical pharmacology.

Molecular and Cellular Pathobiology Rasgrp3 Contributes to Formation and Maintenance of the Prostate Cancer Phenotype

Luowei Li, S. Yuspa, P. Blumberg, 2022 .

Cancer esearch cular and Cellular Pathobiology GRP 3 Contributes to Formation and Maintenance of the R state Cancer Phenotype

Yang, Luowei Li, S. Yuspa, 2010 .

Vanilloid receptors: new insights enhance potential as a therapeutic target

P. Blumberg, A. Szallasi, 1996, Pain.

Endovanilloid signaling in pain

V. Marzo, P. Blumberg, A. Szallasi, 2002, Current Opinion in Neurobiology.

Munc13 Is a Molecular Target of Bryostatin 1

P. Blumberg, Youngki You, N. Kedei, 2019, Biochemistry.

Biological responsiveness to the phorbol esters and specific binding of [3H]phorbol 12,13-dibutyrate in the nematode Caenorhabditis elegans, a manipulable genetic system.

P. Blumberg, K. Lew, S. Chritton, 1982, Teratogenesis, carcinogenesis, and mutagenesis.

Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells.

P. Blumberg, A. Tashjian, S. Jaken, 1981, Cancer research.

Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition.

Z. Szallasi, P. Blumberg, J. Rivera, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinase C epsilon subcellular localization domains and proteolytic degradation sites. A model for protein kinase C conformational changes.

Z. Szallasi, W. Anderson, P. Blumberg, 1995, The Journal of biological chemistry.

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

P. Blumberg, P M Blumberg, 1988, Cancer research.

2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.

S. Y. Kim, Jeewoo Lee, P. Blumberg, 2006, Bioorganic & medicinal chemistry.

5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.

P. Blumberg, V. Marquez, N. Lewin, 2001, Farmaco.

Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.

Jeewoo Lee, P. Blumberg, Kang-Pil Kim, 2004, Bioorganic & medicinal chemistry letters.

Thapsigargin binds to and inhibits the cloned vanilloid receptor-1.

P. Blumberg, Yun Wang, N. Kedei, 2002, Biochemical and biophysical research communications.

Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.

P. Blumberg, P. Goldsmith, Peter M Blumberg, 2013, Analytical biochemistry.

Mechanism of action of the phorbol ester tumor promoters: specific receptors for lipophilic ligands.

K. Leach, P. Blumberg, A. Jeng, 1984, Biochemical pharmacology.

Tissue and species specificity for phorbol ester receptors.

P. Blumberg, K. B. Delclos, S. Jaken, 1983, Basic life sciences.

Relationship between mezerein-mediated biological responses and phorbol ester receptor occupancy.

P. Blumberg, A. Tashjian, M. Shupnik, 1983, Cancer research.

Relation of human neutrophil phorbol ester receptor occupancy and NADPH- oxidase activity

P. Blumberg, D. Brettler, A. Tauber, 1982 .

Analysis of phorbol ester receptors in phorbol ester unresponsive 3T3 cell variants.

P. Blumberg, H. Herschman, E. Butler‐Gralla, 1981, Biochemical and biophysical research communications.

Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain.

P. Blumberg, W. Dunphy, M. Castagna, 1981, Cancer research.

Specific binding of phorbol ester tumor promoters to mouse tissues and cultured cells.

P. Blumberg, W. Dunphy, K. B. Delclos, 1982, Carcinogenesis; a comprehensive survey.

Specific binding of phorbol ester tumor promoters to mouse skin

P. Blumberg, K.Barry Delclos, D. S. Nagle, 1980, Cell.

Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous activities in vivo.

P. Blumberg, P. E. Driedger, 1980, Cancer research.

Decrease in collagen production in normal and Rous sarcoma virus-transformed chick embryo fibroblasts induced by phorbol myristate acetate.

P. Blumberg, K. B. Delclos, K. Delclos, 1979, Cancer research.

Wealth of opportunity - the C1 domain as a target for drug development.

Megan L. Peach, Dajun Yang, P. Blumberg, 2008, Current drug targets.

Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts.

Z. Szallasi, Luowei Li, S. Yuspa, 2000, Carcinogenesis.

Inhibitors of Protein Kinase C and Related Receptors for the Lipophilic Second-Messenger sn-1,2-Diacylglycerol

P. Blumberg, P. Ács, P. Lorenzo, 2000 .

Requirement for a Negative Charge at Threonine 60 of the FcRγ for Complete Activation of Syk*

Z. Szallasi, P. Blumberg, J. Rivera, 1999, The Journal of Biological Chemistry.

Protein Kinase C δ (PKCδ) Inhibits the Expression of Glutamine Synthetase in Glial Cells via the PKCδ Regulatory Domain and Its Tyrosine Phosphorylation*

P. Blumberg, C. Brodie, P. Ács, 1998, The Journal of Biological Chemistry.

Biochemical Mechanisms of Action of the Phorbol Ester Class of Tumor Promoters

P. Blumberg, A. Jeng, 1989 .

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.

P. Blumberg, A. Szallasi, É. Mezey, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Epidermal Cells Effects of Phorbol Ester Tumor Promoters on Primary Mouse Partial Parallelism and Partial Blockade by Bryostatin 1 of Updated

S. Yuspa, P. Blumberg, G. Pettit, 2006 .

Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations.

P. Blumberg, G. Pettit, B. Warren, 1988, Cancer research.

Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.

S. Yuspa, P. Blumberg, G. Pettit, 1987, Cancer research.

Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons.

Z. Szallasi, P. Blumberg, A. Szallasi, 1990, The Journal of pharmacology and experimental therapeutics.

Structural basis of RasGRP binding to high-affinity PKC ligands.

I. Enyedy, Shaomeng Wang, P. Blumberg, 2002, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity

P. Blumberg, V. Marquez, K. Nacro, 2002 .

Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.

P. Blumberg, V. Marquez, D. Sigano, 2004, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.

Z. Szallasi, G. Milne, P. Blumberg, 1996, Journal of medicinal chemistry.

Dialdehyde sesquiterpenes and other terpenoids as vanilloids.

P. Blumberg, T. Bíró, A. Szallasi, 1998, European journal of pharmacology.

RasGRP3 regulates the migration of glioma cells via interaction with Arp3

L. Poisson, P. Blumberg, C. Brodie, 2015, Oncotarget.

Design and construction of a simple and inexpensive slab gel electrophoresis apparatus.

P. Blumberg, P. E. Driedger, 1978, Analytical biochemistry.

Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants.

M. Kazanietz, P. Blumberg, R. Solaro, 1996, Biochemistry.

Wnts induce migration and invasion of myeloma plasma cells.

J. Shaughnessy, J. Rubin, S. Rudikoff, 2005, Blood.

Anandamide and the vanilloid receptor (TRPV1).

P. Blumberg, A. Tóth, J. Boczán, 2009, Vitamins and hormones.

Dimeric and high molecular weight forms of the large external transformation-sensitive protein on the surface of chick embryo fibroblasts.

P. Blumberg, P. Rossow, M. McConnell, 1978, The Journal of biological chemistry.

A non‐pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors

P. Blumberg, T. Bíró, A. Szallasi, 1999, British journal of pharmacology.

The V5 Domain of Protein Kinase C Plays a Critical Role in Determining the Isoform-Specific Localization, Translocation, and Biological Function of Protein Kinase C-δ and -ε

H. Mischak, P. Blumberg, C. Larsson, 2004, Molecular Cancer Research.

The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon.

H. Mischak, P. Blumberg, C. Larsson, 2004, Molecular cancer research : MCR.

Regulation of cell apoptosis by protein kinase c δ

P. Blumberg, C. Brodie, 2004, Apoptosis.

Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn.

T. Hökfelt, P. Blumberg, A. Szallasi, 1996, European journal of pharmacology.

Tumor Promotion: A Problem of Differential Responses of Normal and Neoplastic Cells to Trophic Stimuli

S. Yuspa, P. Blumberg, H. Hennings, 1987 .

Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes

P. Blumberg, T. Bíró, G. Czifra, 2004, Cellular and Molecular Life Sciences CMLS.

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3.

Z. Szallasi, P. Blumberg, J. Rivera, 1997, Journal of immunology.

Phorbol ester action is independent of viral and cellular src kinase levels.

P. Blumberg, K. B. Delclos, A. R. Goldberg, 1980, Science.

Overexpression of Protein Kinase C Isoform (cid:101) but not (cid:100) in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

Z. Szallasi, P. Blumberg, R. A. Mufson, 1998 .

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product

T. Fleming, S. Aaronson, P. Blumberg, 1987, Molecular and cellular biology.

Heterogeneity of [3H]phorbol 12,13-dibutyrate binding in primary mouse keratinocytes at different stages of maturation.

S. Yuspa, P. Blumberg, A. Jeng, 1985, Cancer research.

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

S. Yuspa, P. Blumberg, A. Tauber, 1988, Cancer research.

Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells.

Z. Szallasi, S. Bates, S. Scala, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Discovery of Non-pungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.

S. Hwang, P. Blumberg, L. Pearce, 2019, Journal of medicinal chemistry.

Protein Kinase C as the Receptor for the Phorbol Ester Tumor Promoters : Sixth Rhoads Memorial Award Lecture 1

P. Blumberg, 2006 .

Phorbol esters as probes of the modulatory site on protein kinase C–an overview

M. Dell'aquila, P. Blumberg, B. Warren, 1987 .

Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor.

P. Blumberg, A. Szallasi, P M Blumberg, 1990, Life sciences.

Antineoplastic agents. 224. Isolation and structure of neristatin 1

F. Gao, P. Blumberg, N. Lewin, 1991 .

A palladium catalyzed route to a benzofuran analogue of idolactam V (ILV): Effects on PKC isotype selectivity

P. Blumberg, A. Kozikowski, N. Lewin, 1994 .

Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators.

C. George, S. Sakamuri, P. Blumberg, 2002, Organic letters.

General and Stereospecific Route to 9-Substituted, 8,9-Disubstituted, and 9,10-Disubstituted Analogues of Benzolactam-V8

P. Blumberg, A. Kozikowski, N. Lewin, 1999 .

Ligand-induced Dynamic Membrane Changes and Cell Deletion Conferred by Vanilloid Receptor 1*

M. Iadarola, R. Fields, P. Blumberg, 2001, The Journal of Biological Chemistry.

Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog

F. Joó, P. Blumberg, A. Szallasi, 1989, Brain Research.

Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta.

P. Blumberg, N. Lewin, Youngki You, 2018, Biochimica et biophysica acta. Biomembranes.

Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules).

P. Blumberg, A. Szallasi, P M Blumberg, 1993, Advances in pharmacology.

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis (*)

G. Milne, Shaomeng Wang, M. Kazanietz, 1995, The Journal of Biological Chemistry.

Interaction between protein kinase Cmu and the vanilloid receptor type 1.

Yun Wang, P. Blumberg, Min Wang, 2004, The Journal of biological chemistry.

Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin

S. Yuspa, P. Blumberg, Jessica S. Kelsey, 2016, Molecular carcinogenesis.

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.

K. Koehler, M. Dell'aquila, P. Blumberg, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Charge Density Influences C1 Domain Ligand Affinity and Membrane Interactions

P. Blumberg, I. Gorshkova, N. Lewin, 2014, Chembiochem : a European journal of chemical biology.

Rational Design of Drugs That Induce Human Immunodeficiency Virus Replication

D. Hamer, T. Chun, P. Blumberg, 2003, Journal of Virology.

Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate.

D. Hamer, P. Blumberg, S. Bocklandt, 2003, Antiviral research.

Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin.

Z. Szallasi, P. Blumberg, L. Krsmanovic, 1993, Cancer research.

Non-promoting 12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate 13-acetate-induced acute and chronic biological responses in CD-1 mouse skin.

Z. Szallasi, P. Blumberg, K. Krausz, 1992, Carcinogenesis.

Prostratin, a nonpromoting phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin.

Z. Szallasi, P. Blumberg, 1991, Cancer research.

A Novel Diacylglycerol-lactone Shows Marked Selectivity in Vitro among C1 Domains of Protein Kinase C (PKC) Isoforms α and δ as Well as Selectivity for RasGRP Compared with PKCα*

P. Blumberg, J. Stone, Y. Pu, 2005, Journal of Biological Chemistry.

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.

Megan L. Peach, J. Deschamps, N. Colburn, 2008, Journal of medicinal chemistry.

Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity

P. Blumberg, Jisheng Han, Qi-hua He, 2008, PAIN®.

Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes.

Z. Szallasi, P. Blumberg, C. Smith, 1994, Journal of Biological Chemistry.

Analysis by Fluorescence Resonance Energy Transfer of the Interaction between Ligands and Protein Kinase Cδ in the Intact Cell*

P. Blumberg, S. Garfield, Derek C. Braun, 2005, Journal of Biological Chemistry.

Both the Catalytic and Regulatory Domains of Protein Kinase C Chimeras Modulate the Proliferative Properties of NIH 3T3 Cells*

Z. Szallasi, P. Blumberg, J. Mushinski, 1997, The Journal of Biological Chemistry.

Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ).

B. Prasad, P. Blumberg, N. Lewin, 2013, The Biochemical journal.

Characterization of the Differential Roles of the Twin C1a and C1b Domains of Protein Kinase Cδ*

P. Blumberg, Y. Pu, S. Garfield, 2009, Journal of Biological Chemistry.

Effects on Ligand Interaction and Membrane Translocation of the Positively Charged Arginine Residues Situated along the C1 Domain Binding Cleft in the Atypical Protein Kinase C Isoforms*

Megan L. Peach, P. Blumberg, Y. Pu, 2006, Journal of Biological Chemistry.

Molecular Determinants of Vanilloid Sensitivity in TRPV1*

Attila Toth, Vellarkad N Viswanadhan, J. Treanor, 2004, Journal of Biological Chemistry.

Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.

P. Blumberg, H. Kalish, N. Kedei, 2017, Biochimica et biophysica acta. Biomembranes.

Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine synthetase.

I. Kuperstein, P. Blumberg, C. Brodie, 1998, Brain research. Molecular brain research.

Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1

P. Blumberg, Z. Papp, Z. Bagi, 2006, Molecular Pharmacology.

Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain.

L. Csiba, P. Blumberg, Z. Papp, 2005, Brain research. Molecular brain research.

Specific binding of [20-3H]12-deoxyphorbol 13-isobutyrate to phorbol ester receptor subclasses in mouse skin particulate preparations.

P. Blumberg, J. A. Dunn, 1983, Cancer research.

Stoichiometric binding of diacylglycerol to the phorbol ester receptor

P. Blumberg, P. DiNitto, Bernhard König, 1985, Journal of cellular biochemistry.

Regulation of actin cytoskeleton in lymphocytes: PKC‐δ disrupts IL‐3–induced membrane ruffles downstream of Rac1

R. Nordan, M. Blagosklonny, P. Nguyen, 1999, Journal of cellular physiology.

Trifluoperazine modulates [3H]resiniferatoxin binding by human and rat vanilloid (capsaicin) receptors and affects 45Ca uptake by adult rat dorsal root ganglion neurones.

M. Palkovits, P. Blumberg, G. Acs, 1995, The Journal of pharmacology and experimental therapeutics.

Prostratili, a Nonpromoting Phorbol Ester, Inhibits Induction by Phorbol 12-Myristate 13-Acetate of Ornithine Decarboxylase, Edema, and Hyperplasia in CD-I Mouse Skin

Z. Szallasi, P. Blumberg, 2006 .

Differential Activation and Desensitization of Sensory Neurons by Resiniferatoxin

P. Blumberg, T. Bíró, G. Acs, 1997, The Journal of Neuroscience.

Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein*

P. Blumberg, V. Marquez, K. Nacro, 1999, The Journal of Biological Chemistry.

Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.

Z. Szallasi, S. Yuspa, P. Blumberg, 1994, Molecular pharmacology.

Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells.

P. Lazarovici, W. Anderson, P. Blumberg, 1999, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress

Yong Shen, B. Langley, P. Blumberg, 2009, ChemMedChem.

M. Kazanietz, P. Blumberg, L. Areces, 1994, The Journal of biological chemistry.

Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

Z. Szallasi, P. Blumberg, T. Bíró, 1996, The Journal of Biological Chemistry.

Pharmacological characterization of vanilloid receptor located in the brain.

M. Palkovits, P. Blumberg, T. Bíró, 2002, Brain research. Molecular brain research.

Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment

T. Hökfelt, P. Blumberg, A. Szallasi, 1995, Brain Research.

Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root anglion membranes

Peter M. Blumberg, P. Blumberg, A. Szallasi, 1990, Brain Research.

Protein kinase Cδ promotes proliferation and induces malignant transformation in skeletal muscle

Z. Nagy, P. Blumberg, T. Bíró, 2014, Journal of cellular and molecular medicine.

Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.

B. Bienfait, P. Blumberg, V. Marquez, 2000, Bioorganic & medicinal chemistry letters.

Protein kinase C in cell signaling: strategies for the development of selective inhibitors.

Z. Szallasi, M. Kazanietz, P. Blumberg, 1995, Agents and actions. Supplements.

Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia.

P. Blumberg, A. Szallasi, P M Blumberg, 1991, Life sciences.

Regional localization by light microscopic autoradiography of receptors in mouse brain for phorbol ester tumor promoters.

P. Blumberg, D. S. Nagle, 1983, Cancer letters.

Variation with embryonic development and regional localization of specific [3H]phorbol 12,13-dibutyrate binding to brain.

P. Blumberg, S. Jaken, M. Castagna, 1981, Cancer research.

rat skeletal muscle arterioles and in CHO-TRPV1 cells by anandamide

P. Blumberg, Z. Papp, Z. Bagi, 2005 .

Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat.

P. Blumberg, Yun Wang, N. Kedei, 2003, Life sciences.

Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity*

Megan L. Peach, P. Blumberg, D. Lundberg, 2016, The Journal of Biological Chemistry.

Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.

P. Blumberg, R. Jelinek, M. Peach, 2014, Bioorganic & medicinal chemistry.

The C1 domain of Vav3, a novel potential therapeutic target.

P. Blumberg, Jessica S. Kelsey, T. Géczy, 2017, Cellular signalling.

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

Megan L. Peach, P. Blumberg, Y. Pu, 2014, Journal of medicinal chemistry.

Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C

S. Aaronson, P. Blumberg, J. Lacal, 1986, Nature.

The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytes.

T. Giese, H. Mischak, P. Blumberg, 1997, The Journal of biological chemistry.

The Catalytic Domain of Protein Kinase C-δ in Reciprocal δ and ε Chimeras Mediates Phorbol Ester-induced Macrophage Differentiation of Mouse Promyelocytes*

T. Giese, H. Mischak, P. Blumberg, 1997, The Journal of Biological Chemistry.

Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift.

Sun Choi, Yoonji Lee, P. Blumberg, 2021, Journal of medicinal chemistry.

Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D.

P. Blumberg, J. Van Lint, V. Marquez, 2003, Molecular pharmacology.

Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies

Dong Wook Kang, Sun Choi, Jin Hee Lee, 2011, J. Comput. Aided Mol. Des..

Analysis of the Native Quaternary Structure of Vanilloid Receptor 1* 210

Peter M. Blumberg, Michael J. Iadarola, M. Iadarola, 2001, The Journal of Biological Chemistry.

High affinity antagonists of the vanilloid receptor.

Jiyoun Lee, P. Blumberg, Y. Suh, 2002, Molecular pharmacology.

Phorbol diester and epidermal growth factor receptors in 12-O-tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells.

N. Colburn, B. Magun, G. Hegamyer, 1982, Cancer research.

Relation of human neutrophil phorbol ester receptor occupancy and NADPH-oxidase activity.

P. Blumberg, D. Brettler, A. Tauber, 1982, Blood.

Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure–Function Relationships

P. Blumberg, G. Pettit, N. Kedei, 2015, Journal of natural products.

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

K. Koehler, P. Blumberg, P. Wender, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological evaluation of [¹¹C]SB366791: a new PET-radioligand for in vivo imaging of the TRPV1 receptor.

Koen Van Laere, Guy Bormans, Alfons Verbruggen, 2013, Nuclear medicine and biology.

The Catalytic Domain of Protein Kinase C Chimeras Modulates the Affinity and Targeting of Phorbol Ester-induced Translocation*

Z. Szallasi, P. Blumberg, T. Bíró, 1997, The Journal of Biological Chemistry.

Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain.

P. Blumberg, G. Pettit, C. L. Herald, 1988, Biochemical pharmacology.

Comparison of the roles of the C1a and C1b domains of protein kinase C alpha in ligand induced translocation in NIH 3T3 cells

Z. Szallasi, P. Blumberg, G. Wagner, 1999, FEBS letters.

Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells

K. Jacobson, P. Blumberg, C. Brodie, 1998, FEBS letters.

Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper

P. Blumberg, A. Szallasi, A. Szallasi, 1989, Neuroscience.

Characterization of vanilloid receptors in the dorsal horn of pig spinal cord

P. Blumberg, A. Szallasi, 1991, Brain Research.

2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions.

Vladimir A. Pavlyukovets, P. Blumberg, Keliang Liu, 2012, Bioorganic & medicinal chemistry.

Non‐phorbol mouse skin tumor promoters do not mimic phorbol myristate acetate in its effects on chick embryo fibroblasts

P. Blumberg, P. E. Driedger, 1978, International journal of cancer.

Vanilloid receptor loss in rat sensory ganglia associated with long term desensitization to resiniferatoxin

Peter M. Blumberg, P. Blumberg, A. Szallasi, 1992, Neuroscience Letters.

Neurogenic component of phorbol ester-induced mouse skin inflammation.

P. Blumberg, A. Szallasi, 1989, Cancer research.

New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation.

G. Bormans, K. Van Laere, P. Blumberg, 2013, ACS chemical neuroscience.

Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.

Vladimir A. Pavlyukovets, P. Blumberg, S. Wincovitch, 2007, Journal of medicinal chemistry.

Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors

Dong Wook Kang, Attila Toth, HyungChul Ryu, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differential irreversible insertion of protein kinase C into phospholipid vesicles by phorbol esters and related activators.

M. Kazanietz, P. Blumberg, K. Krausz, 1992, The Journal of biological chemistry.

Influence of side chains on phorbol ester binding to protein kinase C

P. Blumberg, N. A. Sharkey, E. Yeh, 1987 .

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action.

P. Blumberg, A. Jeng, T. Nakadate, 1988, Biochemical pharmacology.

Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation

X. Xie, P. Blumberg, Yu Zhang, 2016, The AAPS Journal.

The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.

Sun Choi, P. Blumberg, L. Pearce, 2013, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring.

Megan L. Peach, P. Blumberg, M. Peach, 2016, The Journal of organic chemistry.

PALATABLE TO BIRDS BUT NOT PALATABLE TO ANIMALS HAVING CAPSACIN SENSTIVE RECEPTORS

P. Blumberg, Sudol, R. Neil, 2017 .

The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons.

P. Blumberg, A. Szallasi, J. Krause, 1999, Molecular pharmacology.

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

M. James, K. Leach, P. Blumberg, 1983, Proceedings of the National Academy of Sciences of the United States of America.

High-affinity partial agonists of the vanilloid receptor.

P. Blumberg, A. Tóth, Richard Tran, 2003, Molecular pharmacology.

Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations.

M. Palkovits, P. Blumberg, G. Acs, 1996, Life sciences.

Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.

Vladimir A. Pavlyukovets, P. Blumberg, L. Pearce, 2010, Bioorganic & medicinal chemistry.

Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.

S. Y. Kim, Jeewoo Lee, P. Blumberg, 2004, Bioorganic & medicinal chemistry.

Synthesis and Pharmacological Evaluation of 8‐ and 9‐Substituted Benzolactam‐V8 Derivatives as Potent Ligands for Protein Kinase C, a Therapeutic Target for Alzheimer's Disease

P. Blumberg, A. Kozikowski, N. Lewin, 2006, ChemMedChem.

Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics.

Jeewoo Lee, P. Blumberg, Kang-Pil Kim, 2002, Bioorganic & medicinal chemistry.

Receptor activity and conformational analysis of 5'-halogenated resiniferatoxin analogs as TRPV1 ligands.

Sun Choi, Jeewoo Lee, P. Blumberg, 2011, Bioorganic & medicinal chemistry letters.

Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin.

Vladimir A. Pavlyukovets, Jeewoo Lee, P. Blumberg, 2007, Bioorganic & medicinal chemistry letters.

Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.

P. Blumberg, Yun Wang, L. Pearce, 2005, Life sciences.

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation.

P. Blumberg, N. Lewin, Jessica S. Kelsey, 2018, Biochemistry.

Functional Analysis of Capsaicin Receptor (Vanilloid Receptor Subtype 1) Multimerization and Agonist Responsiveness Using a Dominant Negative Mutation

Hong Wang, P. Blumberg, E. Kuzhikandathil, 2001, The Journal of Neuroscience.

Activity of phorbol ester tumor promoters on enucleated Swiss 3T3 cells.

P. Blumberg, D. S. Nagle, 1980, Cancer research.

Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists.

Vladimir A. Pavlyukovets, Sun Choi, S. Y. Kim, 2007, Bioorganic & medicinal chemistry.

Phosphorylation of ras oncogene product by protein kinase C.

S. Srivastava, P. Blumberg, J. Lacal, 1987, Biochemical and biophysical research communications.

Mouse Epidermal Cells-Tetradecanoylphorbol-13-acetate-resistant and-sensitive O Phorbol Diester and Epidermal Growth Factor Receptors in 12-Updated Version

N. Colburn, B. Magun, G. Hegamyer, 2006 .

Epidural resiniferatoxin induced prolonged regional analgesia to pain

M. Iadarola, P. Blumberg, T. Szabó, 1999, Brain Research.

Comparison of subcellular activation of the human neutrophil NADPH-oxidase by arachidonic acid, sodium dodecyl sulfate (SDS), and phorbol myristate acetate (PMA).

J. Cox, P. Blumberg, A. Tauber, 1987, Journal of immunology.

beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.

E. Kremmer, B. Bienfait, H. Mischak, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Molecular Basis for Failure of “Atypical” C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester*

Megan L. Peach, P. Blumberg, M. Peach, 2012, The Journal of Biological Chemistry.

Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.

M. Kazanietz, P. Blumberg, M. Sosa, 2009, Biochemistry.

Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

M. Kazanietz, P. Blumberg, M. Abba, 2019, Scientific Reports.

Synthetic Caged DAG‐lactones for Photochemically Controlled Activation of Protein Kinase C

T. Narumi, P. Blumberg, H. Tamamura, 2011, Chembiochem : a European journal of chemical biology.

Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins.

P. Blumberg, V. Marquez, N. Lewin, 2008, Journal of medicinal chemistry.

Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin.

P. Blumberg, P M Blumberg, D J de Vries, 1989, Life sciences.

Synthetic conversion of bryostatin 2 to bryostatin 1 and related bryopyrans

P. Blumberg, D. Sengupta, G. Pettit, 1991 .

Conformationally constrained analogues of diacylglycerol. 5. 2,5-Dideoxy-3-O-tetradecanoyl-D-galactono-1,4-lactone: A superior homologue of 3-O-tetradecanoyl-2-deoxy-L-ribonolactone with PK-C binding affinity.

G. Milne, P. Blumberg, Rajiv Sharma, 1993 .

Conformationally constrained analogs of diacylglycerol. Interaction of .gamma.-lactones with the phorbol ester receptor of protein kinase C

G. Milne, M. Kazanietz, P. Blumberg, 1992 .

Phosphorylation of the gamma chain of the high affinity receptor for immunoglobulin E by receptor-associated protein kinase C-delta.

M. Kazanietz, P. Blumberg, J. Rivera, 1994, The Journal of biological chemistry.

Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat.

M. Palkovits, P. Blumberg, G. Acs, 1994, Life sciences.

Conformationally Constrained Analogues of Diacylglycerol. Interaction of γ-Lactones with the Phorbol Ester Receptor of Protein Kinase C.

G. Milne, M. Kazanietz, P. Blumberg, 2010 .

Conformationally constrained analogues of diacylglycerol having a perhydrofuro[3,4-c]furan-1,4-dione bis-γ-butyrolactone skeleton

Jeewoo Lee, P. Blumberg, V. Marquez, 1998, Archives of pharmacal research.

Synthesis of bis-gamma-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures.

P. Blumberg, V. Marquez, N. Lewin, 1996, Bioorganic & medicinal chemistry.

Conformationally constrained analogues of DAG.7. Interaction of a medium-size ε-lactone with protein kinase C (PK-C)_

Jeewoo Lee, P. Blumberg, V. Marquez, 1994 .

Conformationally constrained analogues of diacylglycerol. 6. Changes in PK-C binding affinity for 3-O-acyl-2-deoxy-L-ribonolactones bearing different acyl chains.

Jeewoo Lee, Shaomeng Wang, M. Kazanietz, 1994 .

Conformationally constrained analogues of diacylglycerol (DAG)-II. Differential interaction of δ-lactones and γ-lactones with protein kinase C (PK-C)

Jeewoo Lee, M. Kazanietz, P. Blumberg, 1993 .

Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli

P. Blumberg, C. Brodie, E. Appel, 1997, Neuroreport.

Protein Kinase C-α Activity Modulates Transepithelial Permeability and Cell Junctions in the LLC-PK1 Epithelial Cell Line*

Z. Szallasi, D. Rosson, P. Blumberg, 1997, The Journal of Biological Chemistry.

Chiral 2-phenyl-3-hydroxypropyl esters as PKC-alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies.

F. Vasile, D. Potenza, D. Rossi, 2021, Chirality.

Specific vanilloid responses in C6 rat glioma cells.

P. Blumberg, T. Bíró, C. Brodie, 1998, Brain research. Molecular brain research.

Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1.

P. Blumberg, 2007, Molecular interventions.

Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.

P. Blumberg, V. Marquez, S. Wang, 1998, Bioorganic & medicinal chemistry letters.

Resiniferatoxin‐type phorboid vanilloids display capsaicin‐like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1

P. Blumberg, T. Bíró, A. Szallasi, 1999, British journal of pharmacology.

4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands.

Sun Choi, G. Bahrenberg, P. Blumberg, 2018, Bioorganic & medicinal chemistry.

Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

Sun Choi, G. Bahrenberg, P. Blumberg, 2017, Bioorganic & medicinal chemistry letters.

2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.

M. Cui, Sun Choi, P. K. Sharma, 2014, Bioorganic & medicinal chemistry letters.

TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.

Sun Choi, HyungChul Ryu, Peter M. Blumberg, 2013, Bioorganic & medicinal chemistry.

2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region.

Dong Wook Kang, Sun Choi, HyungChul Ryu, 2013, European journal of medicinal chemistry.

2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.

K. Schiene, M. Cui, Sun Choi, 2014, Bioorganic & medicinal chemistry letters.

Modulation by palmitoylcarnitine of protein kinase C activation.

P. Blumberg, T. Nakadate, 1987, Cancer research.

Synthesis of the benzofuran analogue of ILV, a new protein kinase C(PKC) activator

P. Blumberg, A. Kozikowski, N. Lewin, 1994 .

Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.

P. Blumberg, H. Tamamura, V. Marquez, 2004, Journal of medicinal chemistry.

Isolation and structure of pedilstatin from a Republic of maldives Pedilanthus sp.1

M. Boyd, J. Mcmahon, P. Blumberg, 2002 .

Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.

S. Yuspa, P. Blumberg, E. Rivedal, 1988, Cancer research.

Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding.

T. Narumi, P. Blumberg, H. Tamamura, 2011, Bioconjugate chemistry.

Synthesis and protein kinase C binding activity of benzolactam-V7.

P. Blumberg, A. Kozikowski, S. Wang, 1999, Bioorganic & medicinal chemistry letters.

Association of phorbol ester receptor down modulation with a cryptic receptor state.

P. Blumberg, A. Tashjian, H. Feldman, 1983, Cancer research.

Nerve growth factor-induced neuronal differentiation of PC12 pheochromocytoma cells: Lack of inhibition by a tumor promoter

L. Greene, D. Burstein, P. Blumberg, 1982, Brain Research.

Complex Regulation of TRPV1 by Vanilloids

P. Blumberg, A. Szallasi, 2007 .

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).

B. Bienfait, P. Blumberg, V. Marquez, 1998, Bioorganic & medicinal chemistry letters.

Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.

S. Y. Kim, Jeewoo Lee, I. Mook‐Jung, 2006, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.

B. Bienfait, P. Blumberg, H. Tamamura, 2000, Journal of medicinal chemistry.

Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1).

P. Blumberg, L. Pearce, Jihyae Ann, 2017, Journal of medicinal chemistry.

Structural Insight into Tetrameric hTRPV1 from Homology Modeling, Molecular Docking, Molecular Dynamics Simulation, Virtual Screening, and Bioassay Validations

Peng Yang, Xiaole Yang, Xiaomeng Xu, 2015, J. Chem. Inf. Model..

Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1

Vladimir A. Pavlyukovets, P. Blumberg, S. Wincovitch, 2006, Molecular Pharmacology.

Resiniferatoxin‐Amide and Analogues as Ligands for Protein Kinase C and Vanilloid Receptors and Determination of Their Biological Activities as Vanilloids

G. Milne, Jeewoo Lee, Shaomeng Wang, 1995, Journal of neurochemistry.

[3H]resiniferatoxin binding by the human vanilloid (capsaicin) receptor.

M. Palkovits, P. Blumberg, G. Acs, 1994, Brain research. Molecular brain research.

Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin.

P. Blumberg, T. Bíró, G. Acs, 1997, The journal of investigative dermatology. Symposium proceedings.

Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors.

P. Blumberg, T. Bíró, L. Kovács, 2004, Life sciences.

Use of a cDNA microarray to determine molecular mechanisms involved in grey platelet syndrome

W. Gahl, M. Huizing, T. Hyman, 2003, British journal of haematology.

Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.

M. Boyd, J. Mcmahon, P. Blumberg, 2002, Journal of natural products.

Altered calcium handling following the recombinant overexpression of protein kinase C isoforms in HaCaT cells

L. Csernoch, P. Blumberg, T. Bíró, 2008, Experimental dermatology.

Activation of human neutrophil NADPH-oxidase in vitro by the catalytic fragment of protein kinase-C.

J. Cox, P. Blumberg, A. Tauber, 1989, Biochemical and biophysical research communications.

Design of a high-affinity competitive antagonist of the vanilloid receptor selective for the calcium entry-linked receptor population.

P. Blumberg, Zili Chen, A. Kozikowski, 2004, Molecular pharmacology.

The C1 domain of Vav3, a novel potential therapeutic target.

P. Blumberg, Jessica S. Kelsey, T. Géczy, 2017, Cellular Signalling.

Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat.

C. Goso, P. Blumberg, A. Szallasi, 1993, The Journal of pharmacology and experimental therapeutics.

Identification of alpha-1-acid glycoprotein (orosomucoid) as a major vanilloid binding protein in serum.

P. Blumberg, A. Szallasi, N. Lewin, 1992, The Journal of pharmacology and experimental therapeutics.

Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.

P. Blumberg, G. Acs, V. Marquez, 1996, Brain research. Molecular brain research.

Phosphorylation of Protein Kinase Cδ on Distinct Tyrosine Residues Induces Sustained Activation of Erk1/2 via Down-regulation of MKP-1

Yehuda Brody, P. Blumberg, C. Brodie, 2008, Journal of Biological Chemistry.

Altered calcium handling following the recombinant overexpression of protein kinase C isoforms in HaCaT cells

L. Csernoch, P. Blumberg, T. Bíró, 2008, Experimental dermatology.

Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cδ

P. Blumberg, T. Bíró, G. Czifra, 2006 .

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

T. Narumi, P. Blumberg, H. Tamamura, 2009, Journal of peptide science : an official publication of the European Peptide Society.

New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation.

G. Bormans, K. Van Laere, P. Blumberg, 2013, ACS chemical neuroscience.

Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta.

P. Blumberg, T. Bíró, G. Czifra, 2006, Cellular signalling.

Specific labeling of mouse brain membrane phospholipids with [ 20-3 H ] phorbol 12p-azidobenzoate 13-benzoate , a photolabile phorbol ester ( tumor promotion / photoaffinity labeling / receptors / carcinogenesis )

P. Blumberg, E. Yeh, K. Delclos, 2022 .

C. Lau, P. Blumberg, W. G. Dunphy, 1980 .

The SAR analysis of TRPV1 agonists with the α-methylated B-region.

Vladimir A. Pavlyukovets, P. Blumberg, L. Pearce, 2012, Bioorganic & medicinal chemistry letters.

Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat.

C. Goso, P. Blumberg, A. Szallasi, 1993, Life sciences.

RasGRP3 regulates the migration of glioma cells via interaction with Arp3

L. Poisson, P. Blumberg, C. Brodie, 2015, Oncotarget.

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

P. Blumberg, S. Garfield, G. Czifra, 2011, Biochemical pharmacology.

Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.

Megan L. Peach, P. Blumberg, N. Lewin, 2010, Angewandte Chemie.

Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain.

P. Blumberg, M. Castagna, R. Kochenburger, 1981, Cancer research.

Mechanism of Action and Development of Resistance to a New Amidino Penicillin

J. Strominger, P. Blumberg, P. Linnett, 1974, Journal of bacteriology.

Bryostatin 1 in Primary Mouse Epidermal Cells by Phorbol 12 , 13-Dibutyrate Contrasting Duration of Inhibition of Cell-Cell Communication

S. Yuspa, P. Blumberg, G. Pettit, 2006 .

Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.

Megan L. Peach, P. Blumberg, R. Jelinek, 2014, Bioorganic & medicinal chemistry.

Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

Megan L. Peach, P. Blumberg, N. Lewin, 2014, Journal of the American Chemical Society.

Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system.

P. Blumberg, P. Goldsmith, N. Kedei, 2013, Analytical biochemistry.

Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.

P. Blumberg, S. Garfield, N. Lewin, 2013, ACS chemical biology.

Protein kinase C in signal transduction and carcinogenesis.

Z. Szallasi, M. Kazanietz, P. Blumberg, 1994, Progress in clinical and biological research.