J. Delcros

发表

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

L Meijer, L. Meijer, M. Inagaki, 1997, European journal of biochemistry.

Non-canonical NOTCH3 signalling limits tumour angiogenesis

Pierre Saintigny, Benjamin Gibert, I. Treilleux, 2017, Nature Communications.

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells

A. Puisieux, A. Morel, P. Mehlen, 2015, Nucleic acids research.

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells

A. Puisieux, A. Morel, P. Mehlen, 2015, Nucleic acids research.

Polyamine deprivation prevents the development of tumour-induced immune suppression.

J. Bansard, J. Delcros, J. Moulinoux, 1997, British Journal of Cancer.

Polyamine deprivation alters formalin-induced hyperalgesia and decreases morphine efficacy.

J. Delcros, J. Moulinoux, D. Desury, 1999, Life sciences.

F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.

J. Annereau, C. Bailly, J. Barret, 2008, Cancer research.

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers.

Trushar R. Patel, D. Neves, P. Mehlen, 2016, Cancer cell.

Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells.

B. Feuerstein, L. Marton, J. Delcros, 1992, The Biochemical journal.

Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes

M. Rissel, A. Guillouzo, J. Delcros, 1998, Hepatology.

Molecular characterization of Netrin-1 and APP receptor binding: New leads to block the progression of senile plaques in Alzheimer's disease.

J. Ferrer, P. Mehlen, J. Delcros, 2017, Biochemical and biophysical research communications.

Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells

J. Delcros, C. Prigent, R. Giet, 2006, Journal of Cell Science.

A simple assay for the measurement of plasma antioxidant status using spontaneous autoxidation of homovanillic acid.

J. Delcros, J. Moulinoux, F. Gaboriau, 2002, Journal of pharmacological and toxicological methods.

Differential recognition of free and covalently bound polyamines by the monoclonal anti-spermine antibody SPM8-2.

J. Delcros, J. Moulinoux, V. Thomas, 1995, Journal of immunological methods.

Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis

C. Costechareyre, G. Ichim, P. Mehlen, 2020, Cancer Research.

Retro hydrazino-azapeptoids as peptidomimetics of proteasome inhibitors.

J. Delcros, Y. Arlot-Bonnemains, M. Baudy-Floc’h, 2005, Journal of medicinal chemistry.

Hydrazino-aza and N-azapeptoids with therapeutic potential as anticancer agents.

J. Delcros, Y. Arlot-Bonnemains, M. Baudy-Floc’h, 2003, Bioorganic & medicinal chemistry.

Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines.

G. Lescoat, D. Gilot, P. Brissot, 2000, Carcinogenesis.

Edinburgh Research Explorer Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells during

A. Puisieux, A. Morel, P. Mehlen, 2018 .

Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.

J. Bénard, G. Ichim, P. Mehlen, 2010, The Journal of clinical investigation.

Molecular requirements for polyamines binding to the antispermine monoclonal antibody Spm8-2.

J. Delcros, J. Moulinoux, V. Thomas, 1996, Hybridoma.

Atmospheric pressure chemical ionization-mass spectrometry method to improve the determination of dansylated polyamines.

J. Delcros, J. Moulinoux, F. Gaboriau, 2003, Analytical biochemistry.

Human monocyte‐derived macrophages and dendritic cells are comparably effective in vitro in presenting HLA class I‐restricted exogenous peptides

J. Delcros, F. Jotereau, G. Corradin, 1997, Immunology.

Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines.

J. Delcros, P. Uriac, V. Eifler-Lima, 2006, Journal of medicinal chemistry.

Polyamine sulfonamides with NMDA antagonist properties are potent calmodulin antagonists and cytotoxic agents.

J. Delcros, J. Moulinoux, P. Uriac, 1998, The international journal of biochemistry & cell biology.

Designing the polyamine pharmacophore: influence of N-substituents on the transport behavior of polyamine conjugates.

J. Delcros, N. Kaur, Otto Phanstiel Iv, 2008, Journal of medicinal chemistry.

Synthesis and biological evaluation of dihydromotuporamine derivatives in cells containing active polyamine transporters.

J. Delcros, N. Kaur, O. Phanstiel, 2005, Journal of medicinal chemistry.

N1-substituent effects in the selective delivery of polyamine conjugates into cells containing active polyamine transporters.

Min Huang, J. Delcros, M. Sigman, 2004, Journal of medicinal chemistry.

Antioxidative properties of natural polyamines and dimethylsilane analogues

J. Delcros, J. Moulinoux, M. Vaultier, 2005, Redox report : communications in free radical research.

Protein‐bound polyamines in the plasma of mice grafted with the Lewis lung carcinoma

J. Delcros, J. Moulinoux, A. Roch, 1987, FEBS letters.

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

H. Gohlke, J. Delcros, C. Gertzen, 2015, Pharmaceuticals.

Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates.

J. Delcros, P. Uriac, S. Tomasi, 2010, Journal of medicinal chemistry.

Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.

J. Delcros, P. Uriac, B. Carboni, 1998, Bioorganic & medicinal chemistry letters.

Creation of New Boron–Carbon Bonds by Dichlorocarbene Insertion into the Boron–Hydrogen Bond of Amine– and Phosphine–Boranes

J. Delcros, B. Carboni, L. Monnier, 2000 .

Synthesis and biological evaluation of N1-(anthracen-9-ylmethyl)triamines as molecular recognition elements for the polyamine transporter.

J. Delcros, J. Biggerstaff, Chaojie Wang, 2003, Journal of medicinal chemistry.

Synthesis and cytotoxic activities of usnic acid derivatives.

J. Delcros, P. Uriac, J. Boustie, 2008, Bioorganic & medicinal chemistry.

Cytotoxic activity of compounds from the lichen: Cladonia convoluta.

J. Delcros, J. Boustie, S. Tomasi, 2004, Planta medica.

Molecular requirements for targeting the polyamine transport system. Synthesis and biological evaluation of polyamine-anthracene conjugates.

J. Delcros, J. Biggerstaff, Chaojie Wang, 2003, Journal of medicinal chemistry.

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

Trushar R. Patel, H. Clausen‐Schaumann, P. Mehlen, 2016, Nature Communications.

Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.

J. Delcros, I. S. Blagbrough, P. Uriac, 2002, Journal of medicinal chemistry.

The competitive inhibition of tissue transglutaminase by α‐difluoromethylornithine

J. Delcros, A. Roch, G. Quash, 1984 .

Polyamine transport in mammalian cells. An update.

J. Delcros, J. Moulinoux, N. Seiler, 1996, The international journal of biochemistry & cell biology.

A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium.

J. Delcros, N. Kaur, O. Phanstiel, 2008, Journal of medicinal chemistry.

Transglutaminase activity and putrescine‐binding capacity in cloned cell lines with different metastatic potential

M. Poupon, J. Delcros, A. Roch, 1986, FEBS letters.

Phosphorylation of Maskin by Aurora-A Participates in the Control of Sequential Protein Synthesis during Xenopus laevis Oocyte Maturation*

J. Delcros, C. Prigent, J. Cremet, 2005, Journal of Biological Chemistry.

Study by optical spectroscopy and molecular dynamics of the interaction of acridine-spermine conjugate with DNA.

F. Sánchez-Jiménez, J. Delcros, A. Moya-García, 2008, Biophysical chemistry.

Identification of the Leukemia Inhibitory Factor Cell Targets Within the Rat Testis

J. Toppari, I. Dorval-Coiffec, B. Jégou, 2005, Biology of reproduction.

In Vivo Antitumor Activity of Clitocine, an Exocyclic Amino Nucleoside Isolated from Lepista inversa

J. Bansard, J. Delcros, J. Boustie, 2006, ChemMedChem.

Effect of spermine conjugation on the interaction of acridine with alternating purine-pyrimidine oligodeoxyribonucleotides studied by CD, fluorescence and absorption spectroscopies.

F. Sánchez-Jiménez, J. Delcros, A. J. Ruiz-Chica, 2008, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

In vivo Antitumor Activity of Clitocine (I), an Exocyclic Amino Nucleoside Isolated from Lepista inversa.

J. Bansard, J. Delcros, J. Boustie, 2006 .

Toxicity and Antitumor Activity of a Crude Extract from Lepista inversa (Scop.:Fr.) Pat. (Agaricomycetideae): A Preliminary Study

J. Delcros, J. Boustie, C. Bézivin, 2003 .

Intercalation and groove binding of an acridine–spermine conjugate on DNA sequences: an FT–Raman and UV–visible absorption study

Francisca Sánchez-Jiménez, F. Sánchez-Jiménez, J. Delcros, 2005 .

Bis(7-amino-4-azaheptyl)dimethlysilane and bis(7-ethylamino-4-azaheptyl)dimethylsilane: inhibition of tumor cell growth in vitro and in vivo.

J. Delcros, J. Moulinoux, M. Vaultier, 1996, Cancer research.

Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues

J. Delcros, C. Prigent, F. Curcio, 2006, International journal of cancer.

Glypican-1 Is a Vehicle for Polyamine Uptake in Mammalian Cells

K. Mani, J. Delcros, M. Belting, 2003, Journal of Biological Chemistry.

A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.

A. Khaled, J. Delcros, N. Kaur, 2008, Journal of medicinal chemistry.

Structure-activity investigations of polyamine-anthracene conjugates and their uptake via the polyamine transporter

J. Delcros, N. Kaur, O. Phanstiel, 2007, Amino Acids.

Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters.

J. Delcros, J. Biggerstaff, Chaojie Wang, 2003, Journal of medicinal chemistry.

Targeting netrin‐3 in small cell lung cancer and neuroblastoma

D. Neves, P. Saintigny, P. Mehlen, 2021, EMBO molecular medicine.

Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues

Matteo Toller, J. Delcros, Aurélie Guého, 2007, Endocrine-related cancer.

Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines.

J. Delcros, F. Curcio, Y. Arlot-Bonnemains, 2008, Endocrine-related cancer.

Effects of the Aurora kinases inhibitor VX-680 on anaplastic thyroid cancer derived cell lines

J. Delcros, F. Curcio, Y. Arlot-Bonnemains, 2008 .

Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC)

J. Patard, P. Fergelot, J. Delcros, 2013, PloS one.

Aurora-A kinase Ser349 phosphorylation is required during Xenopus laevis oocyte maturation.

J. Delcros, C. Prigent, N. Morin, 2008, Developmental biology.

Molecular analysis of the combining site of a monoclonal antibody against spermine.

J. Delcros, J. Moulinoux, A. Royou, 1999, Molecular immunology.

Polyamine-antibody interactions: a conserved binding site motif.

J. Delcros, J. Johnston, D. Athwal, 1998, Biochemical Society Transactions.

Spermidine uptake by erythrocytes from normal and Lewis lung carcinoma (3LL) grafted mice: I. In vitro study.

J. Delcros, N. Khan, R. Havouis, 1989, Anticancer research.

Chemical features of the protein kinase CK2 polyamine binding site.

E. Chambaz, J. Delcros, D. Leroy, 1997, Biochemistry.

Immunohistochemical analysis of tumor polyamines discriminates high-risk patients undergoing nephrectomy for renal cell carcinoma.

N. Rioux-Leclercq, F. Guillé, J. Patard, 2004, Human pathology.

Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression

J. Scoazec, P. Mehlen, J. Delcros, 2009, Proceedings of the National Academy of Sciences.

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference

Z. Herceg, P. Mehlen, J. Delcros, 2016, EMBO molecular medicine.

AB668, a novel highly selective protein kinase CK2 inhibitor with a distinct anti-tumor mechanism as compared to CX-4945 and SGC-CK2-1

J. Delcros, J. Guichou, I. Krimm, 2022, bioRxiv.

Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas

K. Tarte, G. Salles, J. Blachier, 2016, EMBO molecular medicine.

Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis.

V. Laudet, P. Mehlen, J. Delcros, 2009, Developmental cell.

High levels of spermine in IVF medium as a negative predictor of subsequent success of embryo transfer

J. Delcros, D. Clark, I. Craft, 1996, Journal of Assisted Reproduction and Genetics.

Alteration of intestinal putrescine uptake in tumour-bearing rats.

J. Delcros, J. Moulinoux, G. Desury, 2002, International journal of oncology.

Proteasome inhibitors as therapeutic agents: current and future strategies.

J. Delcros, C. Prigent, Y. Arlot-Bonnemains, 2003, Current medicinal chemistry.

Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer

F. Padilla, P. Mehlen, J. Delcros, 2018, Theranostics.

From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors

D. Sarrut, David Sarrut, P. Mehlen, 2023, EMBO molecular medicine.

Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity

J. Scoazec, P. Mehlen, J. Delcros, 2013, PLoS biology.

A quantitative and qualitative study of the transglutaminase‐mediated insertion of polyamines into plasma proteins from patients with bronchopulmonary cancer

J. Delcros, J. Moulinoux, A. Roch, 1984, International journal of cancer.

Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules

J. Preto, J. Delcros, Céline Freton, 2023, Journal of enzyme inhibition and medicinal chemistry.

Induction of Fos protein expression in spinal cord neurons of tumour-bearing rats

J. Delcros, J. Moulinoux, H. Jouan, 1999, British Journal of Cancer.

A novel covalent enzyme-linked immunoassay (CELIA) for simultaneously measuring free and immune complex bound antibodies of defined specificity. I. Application to naturally occurring antipolyamine antibodies in human sera.

J. Richard, J. Delcros, A. Roch, 1990, Journal of immunological methods.

Differential effects of spermine and its analogues on the structures of polynucleotides complexed with ethidium bromide.

R. Shafer, B. Feuerstein, L. Marton, 1993, The Biochemical journal.

Polyamine modulation of iron uptake in CHO cells.

G. Lescoat, J. Delcros, J. Moulinoux, 2004, Biochemical pharmacology.

A novel peptide derived from vascular endothelial growth factor prevents amyloid beta aggregation and toxicity

J. Delcros, N. Chounlamountri, P. Salin, 2023, Aging cell.

Development of Polyamine Lassos as Polyamine Transport Inhibitors.

J. Delcros, O. Phanstiel, Richard A Gardner, 2022, ACS medicinal chemistry letters.

(Z)-1,4-diamino-2-butene as a vector of boron, fluorine, or iodine for cancer therapy and imaging: synthesis and biological evaluation.

J. Delcros, J. Moulinoux, F. Carreaux, 2002, Bioorganic & medicinal chemistry.

Diagnostic and therapeutic procedures with haptens and glycoproteins (antigens and antibodies) coupled covalently by specific sites to insoluble supports.

J. Delcros, A. Roch, G. Quash, 1989, Targeted diagnosis and therapy.

Edinburgh Research Explorer Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference

Z. Herceg, P. Mehlen, J. Delcros, 2016 .

Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer

F. Padilla, P. Mehlen, J. Delcros, 2015 .