J. Diehl

发表

The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts

James M. Roberts, Paul Olivier, M. Roussel, 1999, The EMBO journal.

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

J. Debnath, J. Diehl, Á. Avivar-Valderas, 2011, Molecular and Cellular Biology.

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

D. Petrov, N. Krogan, J. Demeter, 2021, Nature.

Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.

J. Diehl, W. Rozpędek, D. Pytel, 2019, Current medicinal chemistry.

Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis

K. Knudsen, J. Diehl, 2018 .

Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibility.

Bhaskar Ponugoti, J. Diehl, 2010, Genes & cancer.

DNA damage-dependent cyclin D1 proteolysis: GSK3β holds the smoking gun

J. Diehl, Laura L Pontano, 2009, Cell cycle.

of Cyclin D1 by the SCF FBX4-aB Crystallin Complex

J. Harper, A. Rustgi, S. Fuchs, 2006 .

Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

A. Klein-Szanto, J. Harper, A. Rustgi, 2006 .

A Novel WISp39 Protein Links Hsp90 and p21 Stability to the G 2 /M

S. Benzeno, J. Diehl, 2005 .

Cyclin D1 and Pancreatic Carcinoma: A Proliferative Agonist and Chemotherapeutic Antagonist

S. Benzeno, J. Diehl, 2005, Clinical Cancer Research.

A novel WISp39 protein links Hsp90 and p21 stability to the G2/M checkpoint

S. Benzeno, J. Diehl, 2005, Cancer biology & therapy.

Hsc70 Regulates Accumulation of Cyclin D1 and Cyclin D1-Dependent Protein Kinase

A. Emili, J. Diehl, Wensheng Yang, 2003, Molecular and Cellular Biology.

Hsc 70 Regulates Accumulation of Cyclin D 1 and Cyclin D 1-Dependent Protein Kinase

A. Emili, J. Diehl, Wensheng Yang, 2003 .

p21Cip1 Promotes Cyclin D1 Nuclear Accumulation via Direct Inhibition of Nuclear Export*

J. Diehl, J. Alt, A. Gladden, 2002, The Journal of Biological Chemistry.

PERK mediates cell-cycle exit during the mammalian unfolded protein response.

J. W. Brewer, J. Diehl, J A Diehl, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation.

J L Cleveland, J. Cleveland, J. Diehl, 2000, Genes & development.

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

F. Zindy, I. Stamenkovic, J. Jorcano, 1997, Genes & development.

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

Randal J. Kaufman, Mark Hannink, J. Alan Diehl, 2003, Molecular and Cellular Biology.

Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation.

K. Flaherty, A. Rustgi, W. El-Deiry, 2007, Cancer research.

The PKR-Like Endoplasmic Reticulum Kinase Promotes the Dissemination of Myc-Induced Leukemic Cells

S. Fuchs, C. Koumenis, J. Diehl, 2019, Molecular Cancer Research.

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors

K. Seyb, M. Glicksman, S. Ray, 2014, Journal of biomolecular screening.

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

J. Diehl, W. Rozpędek, D. Pytel, 2019, International journal of molecular sciences.

Tumor necrosis factor-alpha-dependent activation of a RelA homodimer in astrocytes. Increased phosphorylation of RelA and MAD-3 precede activation of RelA.

J. Diehl, M. Hannink, W. Tong, 1995, The Journal of biological chemistry.

I kappa B-alpha-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: phosphorylation of C-terminal serine residues of I kappa B-alpha is specifically required for inhibition of DNA-binding.

J. Diehl, M. Hannink, S. Sachdev, 1995, Oncogene.

NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.

A. Klein-Szanto, M. Herlyn, Y. Yashiro‐Ohtani, 2010, Gastroenterology.

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway.

J. Diehl, S. Cullinan, 2006, The international journal of biochemistry & cell biology.

Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer.

A. Klein-Szanto, P. Gimotty, M. Herlyn, 2010, Cancer research.

UPR-inducible miRNAs contribute to stressful situations.

J. Diehl, D. Pytel, N. Chitnis, 2013, Trends in biochemical sciences.

Translation Mediated by the Internal Ribosome Entry Site of thecat-1 mRNA Is Regulated by Glucose Availability in a PERK Kinase-dependent Manner*

A. Koromilas, M. Hatzoglou, J. Diehl, 2002, The Journal of Biological Chemistry.

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.

F. Zindy, C. Sherr, T. Kamijo, 1999, Cancer research.

Cell cycle progression without cyclin E/CDK2: breaking down the walls of dogma.

J. Diehl, A. Gladden, Andrew B Gladden, 2003, Cancer cell.

PERK-dependent regulation of IAP translation during ER stress

R. Hamanaka, S. Liebhaber, J. Diehl, 2008, Oncogene.

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

L. Chodosh, Nancy L. Maas, J. Kushner, 2012, Molecular cell.

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.

A. Klein-Szanto, J. Harper, A. Rustgi, 2006, Molecular cell.

Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy

A. Klein-Szanto, H. Nakagawa, E. Noguchi, 2021, Biomolecules.

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression.

C. Sherr, J. W. Brewer, L. Hendershot, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation

A. Klein-Szanto, A. Rustgi, L. P. Vaites, 2011, Molecular and Cellular Biology.

to Cyclin D1 Overexpression in Human Cancer

A. Rustgi, D. Lin, H. Nakagawa, 2008 .

Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.

A. Rustgi, D. Lin, H. Nakagawa, 2008, Cancer cell.

IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment.

A. Klein-Szanto, P. Gimotty, S. Natsugoe, 2014, American journal of cancer research.

PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress*

J. Alan Diehl, J. Diehl, S. Cullinan, 2004, Journal of Biological Chemistry.

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

J. Diehl, David R. Wise, M. Simon, 2008, Journal of Biological Chemistry.

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

J. Debnath, N. Bardeesy, J. Diehl, 2013, Oncogene.

Tumor progression and the Different Faces of the PERK kinase

J. Diehl, D. Pytel, I. Majsterek, 2015, Oncogene.

The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

J. Harper, Jianping Jin, J. Diehl, 2004, Molecular and Cellular Biology.

Cyclin D1 and p21 is elevated in the giant cells of giant cell tumors

J. Wunder, R. Kandel, J. Diehl, 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

M. Herlyn, Gao Zhang, S. Fuchs, 2016, PLoS genetics.

Molecular Pathways: The PERKs and Pitfalls of Targeting the Unfolded Protein Response in Cancer

Nancy L. Maas, J. Diehl, Alan Diehl, 2014, Clinical Cancer Research.

Generation and characterization of an analog-sensitive PERK allele

Nancy L. Maas, J. Diehl, Nickpreet Singh, 2014, Cancer biology & therapy.

High-Throughput Assay for Identification of PERK Inhibitors Enzymatic Characterization of ER Stress-Dependent Kinase , PERK , and Development of a-Jul

K. Seyb, M. Glicksman, S. Ray, 2014 .

MINI-REVIEWS AND PERSPECTIVES The Cell Biology of the Unfolded Protein Response

S. Fuchs, C. Koumenis, J. Diehl, 2011 .

The cell biology of the unfolded protein response.

S. Fuchs, C. Koumenis, J. Diehl, 2011, Gastroenterology.

Ribosomal Stress Couples the Unfolded Protein Response to p53-dependent Cell Cycle Arrest*

M. Dai, R. Hamanaka, Hua Lu, 2006, Journal of Biological Chemistry.

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

G. Freeman, P. Hammerman, A. Bass, 2018, Cancer Immunology Research.

Title : BET bromodomain inhibition cooperates with PD-1 blockade to facilitate antitumor 1 response in Kras-mutant non-small cell lung cancer

G. Freeman, P. Hammerman, Kwok-Kin Wong, 2018 .

Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms.

E. Dmitrovsky, D. Sekula, J. Diehl, 2005, Cancer research.

HIF-2α dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma

J. Ochocki, J. Diehl, E. Bobrovnikova-Marjon, 2015 .

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

Y. Peterson, P. Howe, J. Diehl, 2017, Nature Communications.

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6.

A. Yoshida, J. Diehl, Eric K. Lee, 2016, Cancer research.

A central domain of cyclin D1 mediates nuclear receptor corepressor activity

J. Meller, K. Knudsen, J. Diehl, 2005, Oncogene.

Lysine 269 is essential for cyclin D1 ubiquitylation by the SCFFbx4/αB-crystallin ligase and subsequent proteasome-dependent degradation

J. Diehl, Barbash O., Egan E., 2009, Oncogene.

Mutant p53 regulates Survivin to foster lung metastasis

A. Bass, A. Klein-Szanto, Kwok-Kin Wong, 2021, Genes & development.

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

A. Klein-Szanto, M. Herlyn, A. Rustgi, 2010, Proceedings of the National Academy of Sciences.

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

A. Hatzigeorgiou, E. Puré, J. Tobias, 2022, Nature Cell Biology.

AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture

A. Klein-Szanto, A. Rustgi, W. El-Deiry, 2007, Oncogene.

Glycogen synthase kinase-3 b regulates cyclin D1 proteolysis and subcellular localization

M. Roussel, C. Sherr, M. Cheng, 1998 .

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

M. Feldman, S. Fuchs, C. Koumenis, 2015, The Journal of clinical investigation.

Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone‐treated MCF‐7 breast cancer cells

J. Diehl, J. S. Foster, A. Bukovsky, 2002, Molecular carcinogenesis.

FBXO4 loss facilitates carcinogen induced papilloma development in mice

A. Bass, A. Klein-Szanto, Kwok-Kin Wong, 2015, Cancer biology & therapy.

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease.

J. Diehl, W. Rozpędek, D. Pytel, 2015, Current medicinal chemistry.

ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis

C. Bassing, L. P. Vaites, J. Diehl, 2014, Oncogene.

Consequence of the tumor-associated conversion to cyclin D1b

S. Tomlins, F. Feng, W. Koch, 2015, EMBO molecular medicine.

Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2–7 complex

D. Lin, J. Diehl, P. Aggarwal, 2008, Proceedings of the National Academy of Sciences.

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.

X. Hua, J. Diehl, E. Brown, 2006, Cancer research.

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

C. Thompson, G. Hatzivassiliou, J. Diehl, 2008, Proceedings of the National Academy of Sciences.

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.

S. Natsugoe, A. Rustgi, H. Nakagawa, 2015, Cancer discovery.

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

J. Kushner, Qian-chun Yu, J. Diehl, 2012, Molecular and Cellular Biology.

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression.

H. Rui, D. Davar, J. Kirkwood, 2016, Cell reports.

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate

J. Diehl, D. Pytel, I. Majsterek, 2021, Biomedicines.

An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression

A. Hatzigeorgiou, E. Puré, J. Tobias, 2020 .

Cyclin D2 protein stability is regulated in pancreatic beta-cells.

J. Kushner, J. Diehl, S. Long, 2009, Molecular endocrinology.

Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids.

G. Ginsberg, A. Bass, S. Natsugoe, 2020, Current protocols in stem cell biology.

Generation and characterization of patient-derived esophageal cancer organoids

G. Ginsberg, A. Bass, S. Natsugoe, 2020 .

Identification of a C/EBP-Rel complex in avian lymphoid cells

J. Diehl, M. Hannink, 1994, Molecular and cellular biology.

The Cyclin D1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB·MCM7 Binding*

J. Diehl, A. Gladden, Andrew B Gladden, 2003, The Journal of Biological Chemistry.

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

M. Roussel, D. Beach, C. Sherr, 1999, Oncogene.

Type I interferons mediate pancreatic toxicities of PERK inhibition

J. Kushner, Angela K. Brice, S. Fuchs, 2015, Proceedings of the National Academy of Sciences.

Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.

Amy R. Peck, H. Rui, P. Yu, 2021, The Journal of clinical investigation.

Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes

M. Herlyn, A. Rustgi, H. Nakagawa, 2008, Cell cycle.

Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities

C. Koumenis, J. Diehl, L. Bradley, 2022, Cancer Immunology, Immunotherapy.

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors

G. Hardiman, E. Hazard, K. Knudsen, 2019, Science Advances.

SLC 36 A 1-mTORC 1 signaling drives acquired resistance to CDK 4 / 6 inhibitors .

G. Hardiman, E. Hazard, K. Knudsen, 2019 .

CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response

J. Diehl, Zihai Li, C. Davies, 2017, Nature Structural &Molecular Biology.

SCFFbx4/αB-crystallin E3 ligase: When one is not enough

O. Barbash, J. Diehl, 2008 .

SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough.

O. Barbash, J. Diehl, 2008, Cell cycle.

Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

A. Bass, Kwok-Kin Wong, C. Der, 2022, Nature Communications.

Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins

T. McKinsey, J. Diehl, M. Hannink, 1993, Molecular and cellular biology.

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

P. Yu, A. Minn, S. Fuchs, 2022, Nature Cancer.

C-terminal Sequences Direct Cyclin D1-CRM1 Binding*

S. Benzeno, J. Diehl, J. Alan Diehl, 2004, Journal of Biological Chemistry.

Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis

C. Bassing, D. Lin, J. Diehl, 2007, Oncogene.

The Cyclin D3 Knockout: A Pound of Redundancy with a Dash of Tissue Specificity

J. Diehl, 2004, Cancer biology & therapy.

A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.

P. Gimotty, M. Herlyn, H. Nakagawa, 2011, Cancer research.

ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes.

A. Weljie, C. Koumenis, V. Tomar, 2022, Cell metabolism.

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.

J. Diehl, W. Rozpędek, D. Pytel, 2019, Current Alzheimer research.

Inhibition of cyclin D 1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Charles J. Sherr, J. Alan Diehl, F. Zindy, 2007 .

Phosphorylation of MCM 3 on Ser-112 regulates its incorporation into the MCM 2 – 7 complex

D. Lin, J. Diehl, P. Aggarwal, 2008 .

KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.

H. Ji, A. Bass, A. Moreira, 2022, Cancer cell.

A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumor progression

P. Howe, J. Diehl, V. Palanisamy, 2017, Nature Cell Biology.

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

J. Diehl, D. Pytel, Radosław Wojtczak, 2020, International journal of molecular sciences.

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

J. Diehl, W. Rozpędek, D. Pytel, 2016, Current molecular medicine.

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.

Zachary T. Giaccone, A. Raj, Qi Long, 2018, Cancer research.

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

D. Baker, S. Fuchs, C. Koumenis, 2013, Oncogene.

Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway

M. Herlyn, A. Rustgi, K. Smalley, 2008, Molecular Cancer Therapeutics.

HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

J. Clements, M. Zink, J. Mankowski, 2017, The American journal of pathology.

CELL INJURY , REPAIR , AGING , AND APOPTOSIS HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via b-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation

J. Clements, M. Zink, J. Mankowski, 2016 .

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

John D Gordan, Cheng-Jun Hu, Jessica A. Bertout, 2007, Cancer cell.

PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development

J. Diehl, Yiwen Bu, 2016, Journal of cellular physiology.

Faculty Opinions recommendation of Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.

J. Diehl, 2017 .

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response.

L. Hendershot, J. Diehl, Yanjun Ma, 2002, Journal of molecular biology.

11 – Regulation of the Cell Cycle

O. Barbash, J. Diehl, Yan Li, 2008 .

Cyclin D1, cancer progression, and opportunities in cancer treatment

J. Diehl, Shuo Qie, 2016, Journal of Molecular Medicine.

Cycling to Cancer with Cyclin D1

J. Diehl, 2002, Cancer biology & therapy.

Location, location, location: The role of cyclin D1 nuclear localization in cancer

J. Diehl, A. Gladden, J Alan Diehl, 2005, Journal of cellular biochemistry.

CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

A. Bass, Kwok-Kin Wong, A. Rustgi, 2017, Nature Communications.

Nuclear cyclin D1: An oncogenic driver in human cancer

J. Diehl, Jong Kyong Kim, 2009, Journal of cellular physiology.

Cyclin D1: polymorphism, aberrant splicing and cancer risk

C. Haiman, K. Knudsen, E. Knudsen, 2006, Oncogene.

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.

A. Rustgi, C. Bassing, D. Lin, 2007, Genes & development.

Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor suppressor activities

A. Bass, P. Gimotty, Kwok-Kin Wong, 2014, Oncogene.

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

H. Rui, J. Kirkwood, P. Lehner, 2019, Cancer cell.

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

Z. Ignatova, Jiangbin Ye, D. Ruggero, 2019, Nature Cell Biology.

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Jiangbin Ye, Haiyan Zhang, C. Koumenis, 2010, The EMBO journal.

Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

Amy R. Peck, H. Rui, E. Puré, 2017, Cancer cell.

Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines

P. Howe, A. Yoshida, J. Diehl, 2017, PloS one.

GATA-1-Mediated Proliferation Arrest during Erythroid Maturation

L. Chodosh, J. Welch, G. Blobel, 2003, Molecular and Cellular Biology.

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

I. Mills, A. Koong, D. Ruggero, 2012, The Journal of clinical investigation.

Targeting wild-type KRAS amplified gastroesophageal cancer through combined MEK and SHP2

James M. McFarland, S. Carr, R. Beroukhim, 2018, Nature Medicine.

A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase

C. Sherr, J. Diehl, C J Sherr, 1997, Molecular and cellular biology.

MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer

G. Hardiman, Sean M Courtney, E. Hazard, 2018, Clinical Cancer Research.

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs

P. Howe, J. Diehl, V. Palanisamy, 2018, Molecular Cancer Research.

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

A. Redig, H. Ji, P. Hammerman, 2017, Nature Communications.

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells

G. Ginsberg, A. Bass, S. Natsugoe, 2018, Cellular and molecular gastroenterology and hepatology.

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

A. Bass, Kwok-Kin Wong, S. Natsugoe, 2017, Nature Communications.

Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells.

M. Herlyn, H. Nakagawa, J. Diehl, 2010, Carcinogenesis.

Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1

S. Friedman, D. Germain, G. Narla, 2004, Cancer Research.

Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.

Ju-Seog Lee, A. Rustgi, J. Diehl, 2011, Cancer cell.

The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

J. Harper, Jianping Jin, J. Diehl, 2004, Molecular and Cellular Biology.

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

O. Fernandez-Capetillo, J. Diehl, E. Brown, 2012, The Journal of clinical investigation.

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.

R. Hamanaka, J. Diehl, S. Cullinan, 2005, Molecular biology of the cell.

Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.

M. Herlyn, A. Rustgi, H. Nakagawa, 2010, Cancer research.

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.

Brian Keith, Bo Li, J. Ochocki, 2015, Cancer discovery.

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.

M. Roussel, C. Sherr, M. Cheng, 1998, Genes & development.

Structural basis of selective ubiquitination of TRF1 by SCFFbx4.

Xuedong Liu, Yong Chen, M. Lei, 2010, Developmental cell.

The Cyclin D 1-dependent Kinase Associates with the Pre-replication Complex and Modulates RB MCM 7 Binding *

J. Diehl, A. Gladden, 2003 .

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

R. Beroukhim, A. Dulak, A. Bass, 2018, Nature Medicine.

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

S. Fuchs, C. Koumenis, J. Diehl, 2016, Nature Communications.

The FBXO4 Tumor Suppressor Functions as a Barrier to BrafV600E-Dependent Metastatic Melanoma

M. Herlyn, K. Nathanson, O. Barbash, 2013, Molecular and Cellular Biology.

Identification and Characterization of a Potent Activator of p53-Independent Cellular Senescence via a Small-Molecule Screen for Modifiers of the Integrated Stress Response

Nancy L. Maas, A. Koong, C. Koumenis, 2013, Molecular Pharmacology.

Identification and Characterization of a Potent Activator of p53-Independent Cellular Senescence via a Small-Molecule Screen for Modifiers of the Integrated Stress Response s

Nancy L. Maas, A. Koong, C. Koumenis, 2013 .

Microsoft Word-12278828-file00.docx

Nancy L. Maas, A. Koong, C. Koumenis, 2012 .

Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity*

Alexander J. Valvezan, J. Diehl, P. S. Klein, 2011, The Journal of Biological Chemistry.

Use of small-molecule inhibitory compound of PERK-dependent signaling pathway as a promising target-based therapy for colorectal cancer.

J. Diehl, W. Rozpędek, D. Pytel, 2020, Current cancer drug targets.

Wnt1 and MEK1 Cooperate to Promote Cyclin D1 Accumulation and Cellular Transformation*

J. Diehl, R. Rimerman, Anna Gellert-Randleman, 2000, The Journal of Biological Chemistry.

Ubiquitin and cancer: new discussions for a new journal.

D. Haines, S. Fuchs, J. Diehl, 2010, Genes & cancer.

CDK4/6 inhibitor: from quiescence to senescence

A. Yoshida, J. Diehl, 2015, Oncoscience.

Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression

H. Nakagawa, D. S. St. Clair, Kazuhide Yamamoto, 2014, Oncogene.

ANOTCH3-MediatedSquamousCellDifferentiationProgram Limits Expansion of EMT-Competent Cells That Express the

M. Herlyn, H. Nakagawa, J. Diehl, 2011 .

Transcription Factors Expansion of EMT-Competent Cells That Express the ZEB A NOTCH 3-Mediated Squamous Cell Differentiation Program Limits

M. Herlyn, H. Nakagawa, J. Diehl, 2011 .

Tumor and Stem Cell Biology ANOTCH 3-MediatedSquamousCell DifferentiationProgram Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors

P. Gimotty, M. Herlyn, H. Nakagawa, 2011 .

Cyclin-Dependent Kinase Inhibition by the KLF 6 Tumor Suppressor Protein through Interaction with Cyclin D 1

S. Friedman, D. Germain, G. Narla, 2004 .

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum

J. Diehl, A. McQuiston, 2017, F1000Research.

Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas

G. Weinstein, P. Gimotty, M. Herlyn, 2011, Cell cycle.

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.

P. Nowell, P. Włodarski, M. Wasik, 2006, Blood.

An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.

J. Diehl, A. Gladden, F. Lu, 2003, Cancer research.

Award Number: W81XWH-09-1-0056 TITLE: Investigating the Role of Cyclin D1 in the Promotion of Genomic Instability and Breast Cancer

J. Diehl, Lauren L. Pontano, 2011 .

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

Amy R. Peck, H. Rui, T. Butt, 2018, Proceedings of the National Academy of Sciences.

Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor.

R. Hamanaka, S. Fuchs, J. Diehl, 2009, Cell host & microbe.

HIV-1 Vif promotes the G₁- to S-phase cell-cycle transition.

Debra K. Shivers, J. Diehl, Xiao-Fang Yu, 2011, Blood.

EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas

G. Weinstein, P. Gimotty, M. Herlyn, 2013, Molecular Cancer Therapeutics.

Cancer Therapeutics Insights EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas

G. Weinstein, P. Gimotty, M. Herlyn, 2013 .

A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion

A. Bass, Kwok-Kin Wong, A. Rustgi, 2013, Cancer biology & therapy.

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

N. Palanisamy, J. Diehl, V. Palanisamy, 2016, PLoS genetics.

Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6

J. Diehl, Shuo Qie, 2019, Molecular & cellular oncology.

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.

M. Herlyn, A. Rustgi, H. Nakagawa, 2010, Cancer cell.

Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability

C. Bassing, O. Barbash, J. Diehl, 2008, Molecular and Cellular Biology.

Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1

J. Herman, A. Rustgi, S. Benzeno, 2006, Oncogene.

Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma

M. Wasik, J. Diehl, A. Gladden, 2006, Oncogene.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

A. Bass, Kwok-Kin Wong, A. Rustgi, 2019, Nature Communications.

Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss

G. Leone, A. Yoshida, J. Diehl, 2022, Oncogene.

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.

A. Mancuso, J. Diehl, E. Bobrovnikova-Marjon, 2013, Genes & development.

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification.

M. Herlyn, A. Rustgi, Jose-Luiz Figueiredo, 2008, The Journal of clinical investigation.

Mechanism of cell-cycle control: ligating the ligase.

D. Lin, J. Diehl, 2004, Trends in biochemical sciences.

Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function.

S. Mehrotra, J. Diehl, D. Pytel, 2022, Cancer research.

A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

C. Dang, D. Ruggero, S. McMahon, 2017, Nature Cell Biology.

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

Jiangbin Ye, C. Koumenis, J. Diehl, 2010, Oncogene.

Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs

E. Puré, T. Mak, J. Kirkwood, 2020, Nature Cancer.

Advances in Brief An Alternatively Spliced Cyclin D 1 Isoform , Cyclin D 1 b , Is a Nuclear Oncogene 1

J. Diehl, A. Gladden, F. Lu, 2003 .

Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.

P. Gimotty, M. Herlyn, H. Nakagawa, 2012, American journal of cancer research.

The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling

M. Riese, Rohan Joshi, G. Koretzky, 2013, Science Signaling.

Regulatory T Cell Development and TCR-Mediated Ras Signaling The { zeta } Isoform of Diacylglycerol Kinase Plays a Predominant Role in

M. Riese, Rohan Joshi, G. Koretzky, 2013 .

Involvement of lipid mediators on cytokine signaling and induction of secretory phospholipase A2 in immortalized astrocytes (DITNC)

J. Diehl, M. Hannink, W. Tong, 1999, Journal of Molecular Neuroscience.

Phosphorylation-dependent regulation of SCFFbx4 dimerization and activity involves a novel component, 14-3-3ε

O. Barbash, J. Diehl, Eric K. Lee, 2010, Oncogene.

EVIDENCE FOR MESENCHYMAL-LIKE SUBPOPULATIONS WITHIN SQUAMOUS CELL CARCINOMAS POSSESSING CHEMORESISTANCE AND PHENOTYPIC PLASTICITY

G. Weinstein, M. Herlyn, Gao Zhang, 2010, Oncogene.

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

A. Bass, Kwok-Kin Wong, S. Natsugoe, 2017, Nature Communications.

Interplay between Notch 1 and Notch 3 promotes EMT and tumor initiation in squamous cell carcinoma

A. Bass, Kwok-Kin Wong, S. Natsugoe, 2017 .

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

A. Bass, Kwok-Kin Wong, A. Rustgi, 2019, Nature Communications.

SCFs in the new millennium

J. Diehl, E. Lee, EK Lee, 2014, Oncogene.

Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities

C. Koumenis, J. Diehl, L. Bradley, 2022, Cancer Immunology, Immunotherapy.

Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59v-rel

J. Diehl, M. Hannink, 1993, Journal of virology.

A PERK-miR211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

G. Wertheim, C. Dang, D. Ruggero, 2017, Nature Cell Biology.

Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

J. Diehl, J. Foskett, C. Cárdenas, 2016, Cell reports.

Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8

J. Diehl, H. Jin, Sagar Bajpai, 2022, Cancer biology & therapy.

ALDH2 dysfunction accelerates ESCC pathogenesis

H. Nakagawa, J. Diehl, D. Mochly‐Rosen, 2023, bioRxiv.

Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation

J. Diehl, Laura L Pontano, 2008, Cell Division.

Pan-ERBB kinase inhibition augments CDK4/6 inhibitor efficacy in oesophageal squamous cell carcinoma

Henry W. Long, M. Meyerson, A. Bass, 2021, Gut.

GSK3β Coordinates Cyclin D1 Phosphorylation and Ubiquitylation by SCFFbx4/αB-crystallin Ligase at the G1/S Transition

O. Barbash, J. Diehl, 2008 .

Molecular Basis of Human Diseases and Targeted Therapy Based on Small-Molecule Inhibitors of ER Stress-Induced Signaling Pathways.

J. Diehl, W. Rozpędek, D. Pytel, 2017, Current molecular medicine.

The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease

J. Diehl, W. Rozpędek, D. Pytel, 2016 .

Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

J. Diehl, J. Foskett, C. Cárdenas, 2016, Cell reports.

Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor*

D. Baker, S. Fuchs, C. Koumenis, 2011, The Journal of Biological Chemistry.

Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor*

D. Baker, C. Koumenis, J. Diehl, 2009, The Journal of Biological Chemistry.

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

L. P. Vaites, M. Riese, G. Koretzky, 2012, Molecular and Cellular Biology.

Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3

A. Yoshida, J. Diehl, Shuo Qie, 2020, Oncogene.

Cyclin D1, cancer progression, and opportunities in cancer treatment

J. Alan Diehl, J. Diehl, Shuo Qie, 2016, Journal of Molecular Medicine.

Coping with stress : ATF6α takes the stage

J. Diehl, E. Bobrovnikova-Marjon, M. Abramson, 2007 .

The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment

J. Diehl, D. Pytel, I. Majsterek, 2021, International journal of molecular sciences.

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

S. Carr, R. Beroukhim, A. Dulak, 2018, Nature Medicine.

PRMT5-dependent p53 escape in tumorigenesis

J. Diehl, Yan Li, 2015, Oncoscience.

Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.

J. Diehl, W. Rozpędek, D. Pytel, 2017, Polski przeglad chirurgiczny.

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

D. Lin, O. Barbash, J. Diehl, 2007, Cell Division.

Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression

P. Howe, J. Diehl, V. Palanisamy, 2017, Nature Cell Biology.

Selective Vulnerability of C ancer Cells by Inhibition of Ca 2 + Transfer from Endoplasmic Reticulum to Mitochondria Graphical

J. Diehl, J. Foskett, C. Cárdenas, 2016 .

An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.

Karlyne M. Reilly, K. Broman, K. Reilly, 2006, Cancer research.

Tumor-derived CCL5 recruits cancer-associated fibroblasts and promotes tumor cell proliferation in esophageal squamous cell carcinoma.

A. Rustgi, H. Nakagawa, J. Diehl, 2023, Molecular cancer research : MCR.

Cyclin D Degradation by E3 Ligases in Cancer Progression and Treatment.

J. Diehl, Shuo Qie, J. Alan Diehl, 2020, Seminars in cancer biology.

FFA‐Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways

Haiyan Xu, J. Diehl, Jie Ma, 2011, Obesity.

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

Y. Peterson, P. Howe, J. Diehl, 2017, Nature Communications.

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

O. Fernandez-Capetillo, J. Diehl, M. Murga, 2012, The Journal of clinical investigation.

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment.

Zachary T. Giaccone, A. Raj, Qi Long, 2018, Cancer Research.

Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor.

R. Hamanaka, J. Diehl, K. G. S. Kumar, 2009, Cell host & microbe.

Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.

M. Herlyn, A. Rustgi, H. Nakagawa, 2010, Cancer research.

Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma

M. Herlyn, W. Pear, H. Nakagawa, 2011 .