Yadan Huang

The immunomodulatory role of PDEs inhibitors in immune cells: therapeutic implication in rheumatoid arthritis.

Yufei He, Yadan Huang, Chu-tian Mai, 2020, Pharmacological research.

Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease.

Yadan Huang, Hai-bin Luo, Jinhui Hu, 2018, ACS chemical neuroscience.

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

Yadan Huang, Hai-bin Luo, Chen Zhang, 2018, Acta pharmaceutica Sinica. B.

Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension.

Yadan Huang, Hai-bin Luo, Deyan Wu, 2017, Journal of medicinal chemistry.

Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

Yadan Huang, Hai-bin Luo, Zhe Li, 2022, Acta pharmaceutica Sinica. B.

Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.

Yadan Huang, Hai-bin Luo, Zhe Li, 2020, Journal of medicinal chemistry.

Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.

Yadan Huang, Hai-bin Luo, Zhe Li, 2018, Journal of medicinal chemistry.

Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer's Disease.

Yadan Huang, Hai-bin Luo, Deyan Wu, 2017, ACS chemical neuroscience.

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

Yadan Huang, Hai-bin Luo, Qian Zhou, 2017, Journal of enzyme inhibition and medicinal chemistry.