M. Diaz-Meco

发表

Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.

A. Durán, M. Diaz-Meco, J. Moscat, 2003, The EMBO journal.

Essential role of RelA Ser311 phosphorylation by ζPKC in NF‐κB transcriptional activation

A. Durán, M. Diaz-Meco, J. Moscat, 2003 .

MEK5, a New Target of the Atypical Protein Kinase C Isoforms in Mitogenic Signaling

M. Diaz-Meco, J. Moscat, 2001, Molecular and Cellular Biology.

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Aleksey A. Porollo, Aleksey Porollo, Shadi Abu-Baker, 2011, Molecular cell.

Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1)

M. Serrano, C. Martínez-A, M. Diaz-Meco, 2009, European journal of immunology.

PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.

M. Tschöp, Ji Young Kim, M. Diaz-Meco, 2010, Cell metabolism.

Signal integration and diversification through the p62 scaffold protein.

M. Diaz-Meco, J. Moscat, M. W. Wooten, 2007, Trends in biochemical sciences.

Atypical protein kinase C (aPKCζ and aPKCλ) is dispensable for mammalian hematopoietic stem cell activity and blood formation

A. Durán, M. Diaz-Meco, J. Moscat, 2011, Proceedings of the National Academy of Sciences.

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Mark Ellisman, G. Perkins, M. Karin, 2016, Cell.

The interaction of p62 with RIP links the atypical PKCs to NF‐κB activation

M. Diaz-Meco, J. Moscat, L. Sanz, 1999, The EMBO journal.

NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype

M. Diaz-Meco, J. Moscat, G. Bjørkøy, 1994 .

p62 links β-adrenergic input to mitochondrial function and thermogenesis.

A. Walch, M. Aichler, J. Speakman, 2013, The Journal of clinical investigation.

NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype

M. Diaz-Meco, J. Moscat, G. Bjørkøy, 1994, Molecular and cellular biology.

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

W. Zong, K. Ozato, M. Diaz-Meco, 2016, Molecular cell.

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.

T. Deerinck, S. Vandenberg, J. Kleeff, 2013, The Journal of clinical investigation.

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

J. Auwerx, M. Serrano, M. Champy, 2006, Cell metabolism.

Evidence for a role of phosphatidylcholine‐hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.

M. Diaz-Meco, J. Moscat, T. Johansen, 1990, The EMBO journal.

AWARD NUMBER: W81XWH-13-1-0353 TITLE: “Targeting the Adipocyte-Tumor Cell Interaction in Prostate Cancer Treatment” PRINCIPAL INVESTIGATOR:

M. Diaz-Meco, 2014 .

Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway

M. Diaz-Meco, M. Vandenplas, M. W. Wooten, 2001, Molecular and Cellular Biology.

Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals

M. Diaz-Meco, J. Moscat, I. Dominguez, 1992, Molecular and cellular biology.

Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes

M. Diaz-Meco, J. Moscat, I. Dominguez, 1992, Molecular and cellular biology.

Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes

M. Diaz-Meco, J. Moscat, I. Dominguez, 1992 .

Protein Kinase C (cid:2) Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo (cid:1) †

A. Durán, M. Diaz-Meco, J. Moscat, 2008 .

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.

Christian M. Metallo, M. Karin, L. Roberts, 2020, Cancer cell.

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.

M. Diaz-Meco, J. Moscat, Zhaokai Wang, 2017, Molecular cell.

Loss of PKCλ/ι impairs Th2 establishment and allergic airway inflammation in vivo

A. Durán, M. Diaz-Meco, J. Moscat, 2009, Proceedings of the National Academy of Sciences.

The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

S. Woods, M. Tschöp, W. Thaiss, 2020, Nature Communications.

Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance

P. Pfluger, M. Tschöp, M. Diaz-Meco, 2012, Adipocyte.

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

L. Sanz, M. Diaz-Meco, J. Moscat, 1994, The Journal of biological chemistry.

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.

W. Zong, K. Ozato, M. Diaz-Meco, 2016, Molecular cell.

The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies.

M. Diaz-Meco, J. Moscat, 2002, Advances in enzyme regulation.

Molecular characterization of a novel transcription factor that controls stromelysin expression

M. Diaz-Meco, J. Moscat, L. Sanz, 1995, Molecular and cellular biology.

Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation.

M. Diaz-Meco, J. Moscat, P. Sanchez, 2001, Advances in enzyme regulation.

Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.

M. Serrano, I. Garcia-Cao, P. Fernández-Marcos, 2007, Cancer research.

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.

Christian M. Metallo, M. Karin, A. Lowy, 2021, Cancer cell.

Control of T helper 2 cell function and allergic airway inflammation by PKCzeta.

Pilar Martín, C. Martínez-A, Á. Zaballos, 2005, Proceedings of the National Academy of Sciences of the United States of America.

PKCζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways

M. Diaz-Meco, J. Moscat, P. Rennert, 2006, Cell Death and Differentiation.

The p62 Scaffold Regulates Nerve Growth Factor-induced NF-κB Activation by Influencing TRAF6 Polyubiquitination*

M. Diaz-Meco, J. Moscat, M. W. Wooten, 2005, Journal of Biological Chemistry.

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

J. Asara, E. Henske, M. Sahin, 2017, Cancer research.

Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes

M. Diaz-Meco, J. Moscat, I. Dominguez, 1993, Molecular and cellular biology.

NF-KB-Like Activity in Xenopus laevis Oocytes

M. Diaz-Meco, I. Dominguez, F. Arenzana‐Seisdedos, 2022 .

The Atypical Protein Kinase C-interacting Protein p62 Is a Scaffold for NF-κB Activation by Nerve Growth Factor*

P. Barker, M. Diaz-Meco, J. Moscat, 2001, The Journal of Biological Chemistry.

Edinburgh Research Explorer The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation

A. Krainer, M. Diaz-Meco, J. Moscat, 2017 .

To aggregate or not to aggregate? A new role for p62

M. Diaz-Meco, J. Moscat, 2009, EMBO reports.

Role of zeta PKC in B-cell signaling and function.

Pilar Martín, A. Durán, M. Diaz-Meco, 2002, The EMBO journal.

Par-4 Keeps the Atypical PKCs at Bay

M. Diaz-Meco, J. Moscat, 2003, Cell cycle.

review NF-κB activation by protein kinase C isoforms and B-cell function

M. Diaz-Meco, J. Moscat, P. Rennert, 2003 .

Protein kinase C zeta isoform is critical for mitogenic signal transduction.

M. Diaz-Meco, J. Moscat, I. Dominguez, 1993, Cell.

PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways.

M. Diaz-Meco, J. Moscat, P. Rennert, 2006, Cell death and differentiation.

Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction

G. Cooper, M. Diaz-Meco, J. Moscat, 1992, Molecular and cellular biology.

Crosstalk between PKCζ and the IL4/Stat6 pathway during T‐cell‐mediated hepatitis

Pilar Martín, M. Serrano, J. Flores, 2004, The EMBO journal.

Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation

Ramars Amanchy, M. Diaz-Meco, J. Moscat, 2011, Molecular and Cellular Biology.

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

L. Sanz, M. Diaz-Meco, J. Moscat, 1994, The Journal of biological chemistry.

ArticleThe Atypical PKC-Interacting Protein p 62 Is an Important Mediator of RANK-Activated Osteoclastogenesis

Jacques P. Brown, M. Serrano, J. Flores, 2004 .

Gαq Acts as an Adaptor Protein in Protein Kinase Cζ (PKCζ)-mediated ERK5 Activation by G Protein-coupled Receptors (GPCR)*♦

M. Diaz-Meco, J. Moscat, C. Ribas, 2010, The Journal of Biological Chemistry.

Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes

M. Diaz-Meco, J. Moscat, I. Dominguez, 1993, Journal of virology.

Hydrolysis Activates NF-KBandIncreases HumanImmunodeficiency VirusReplication inHuman Monocytes andT Lymphocytes

Dominique Thomas, M. Diaz-Meco, J. Moscat, 1993 .

Supplemental Data The Signaling Adaptor p 62 Is an Important NF-κ B Mediator in Tumorigenesis

J. Flores, A. Durán, M. Diaz-Meco, 2008 .

zeta PKC induces phosphorylation and inactivation of I kappa B‐alpha in vitro.

P. Dent, T. Sturgill, R. Hay, 1994, The EMBO journal.

Protein Kinase C (cid:2) Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo (cid:1) †

A. Durán, M. Diaz-Meco, J. Moscat, 2008 .

Genetic inactivation of Par4 results in hyperactivation of NF‐κB and impairment of JNK and p38

M. Serrano, I. Garcia-Cao, M. Diaz-Meco, 2003, EMBO reports.

The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation

Pilar Martín, M. Diaz-Meco, J. Moscat, 2006, The EMBO journal.

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.

Shailaja N Hegde, M. Diaz-Meco, J. Moscat, 2020, Blood.

OPR, PC and AID: all in the PB1 family.

C. Ponting, F. Inagaki, M. Diaz-Meco, 2002, Trends in biochemical sciences.

Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine‐hydrolysing phospholipase C.

F. McCormick, M. Diaz-Meco, J. Moscat, 1991, The EMBO journal.

Protein kinase C zeta

M. Diaz-Meco, J. Moscat, 2005 .

Regulation of mature T lymphocyte proliferation and differentiation by Par‐4

Pilar Martín, M. Serrano, I. Garcia-Cao, 2003, The EMBO journal.

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

M. Diaz-Meco, J. Moscat, J. Lozano, 1996, Cell.

Evidence for a Bifurcation of the Mitogenic Signaling Pathway Activated by Ras and Phosphatidylcholine-hydrolyzing Phospholipase C (*)

M. Diaz-Meco, J. Moscat, T. Johansen, 1995, The Journal of Biological Chemistry.

Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.

A. Durán, M. Diaz-Meco, J. Moscat, 2020, Developmental cell.

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

Junmin Peng, M. Diaz-Meco, J. Moscat, 2008, Journal of neurochemistry.

Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists.

M. Diaz-Meco, J. Moscat, P. Barreno, 1989, The Biochemical journal.

Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation

Ramars Amanchy, Ramars Amanchy, M. Diaz-Meco, 2010, Molecular and Cellular Biology.

DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila

M. Diaz-Meco, J. Moscat, S. Campuzano, 2004, The Journal of cell biology.

A functional role for the p62–ERK1 axis in the control of energy homeostasis and adipogenesis

P. Pfluger, M. Tschöp, J. Pouysségur, 2010, EMBO reports.

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins*

Junmin Peng, Junmin Peng, M. Diaz-Meco, 2008, Journal of Biological Chemistry.

Cell signaling and function organized by PB1 domain interactions.

M. Diaz-Meco, J. Moscat, S. Campuzano, 2006, Molecular cell.

The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.

J. Flores, A. Durán, M. Diaz-Meco, 2008, Cancer cell.

Cleavage of ζPKC but Not λ/ιPKC by Caspase-3 during UV-induced Apoptosis*

M. Diaz-Meco, J. Moscat, S. Frutos, 1999, The Journal of Biological Chemistry.

The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway*

M. Diaz-Meco, J. Moscat, E. Berra, 1998, The Journal of Biological Chemistry.

Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade

M. Diaz-Meco, J. Moscat, E. Berra, 1997, Molecular and cellular biology.

The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

A. Krainer, M. Diaz-Meco, J. Moscat, 2000, The Journal of cell biology.

PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.

M. Loda, G. Inghirami, A. Cuervo, 2021, Molecular cell.

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

M. Diaz-Meco, J. Moscat, Jorge Moscat, 2009, Cell.

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction

G. Cooper, J. Troppmair, U. Rapp, 1993, Molecular and cellular biology.

Award Number: W81XWH-09-1-0490 TITLE: Inflammation in Prostate Carcinogenesis: Role of the Tumor Suppressor Par-4 PRINCIPAL INVESTIGATOR:

M. Diaz-Meco, 2012 .

Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex

M. Diaz-Meco, J. Moscat, M. W. Wooten, 2009, Cell Death and Differentiation.

Nephrin deficiency activates NF-kappaB and promotes glomerular injury.

P. Scambler, M. Serrano, M. Diaz-Meco, 2009, Journal of the American Society of Nephrology : JASN.

The downregulation of the pro‐apoptotic protein Par‐4 is critical for Ras‐induced survival and tumor progression

M. Serrano, M. Barradas, M. Diaz-Meco, 1999, The EMBO journal.

The Drosophila Atypical Protein Kinase C-Ref(2)P Complex Constitutes a Conserved Module for Signaling in the Toll Pathway

M. Diaz-Meco, J. Moscat, N. Silverman, 2002, Molecular and Cellular Biology.

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

Juan F. García, Pilar Martín, A. Durán, 2001 .

The Par-4/PTEN connection in tumor suppression

M. Diaz-Meco, Shadi Abu-Baker, 2009, Cell cycle.

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma

M. Serrano, M. Collado, M. Diaz-Meco, 2009, Proceedings of the National Academy of Sciences.

Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis

M. Diaz-Meco, J. Moscat, T. Johansen, 1990, Cell.

Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.

M. Diaz-Meco, J. Moscat, I. Dominguez, 1991, The Journal of biological chemistry.

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.

M. Karin, D. Tarin, M. Valasek, 2017, Cancer cell.

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

G. Cooper, U. Rapp, M. Diaz-Meco, 1997, Molecular and cellular biology.

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.

A. Durán, M. Diaz-Meco, J. Moscat, 2001, Molecular cell.

Nephrin Deficiency Activates NF- B and Promotes Glomerular Injury

P. Scambler, M. Serrano, M. Diaz-Meco, 2009 .

Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes

G. Bren, C. Payá, M. Diaz-Meco, 1996, Journal of virology.

Atypical PKCs, NF-κB, and Inflammation

M. Diaz-Meco, J. Moscat, 2010 .

Activation of IκB Kinase β by Protein Kinase C Isoforms

G. Bren, C. Payá, M. Diaz-Meco, 1999, Molecular and Cellular Biology.

Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis*

M. Diaz-Meco, J. Moscat, M. Lallena, 1999, The Journal of Biological Chemistry.

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

M. Diaz-Meco, J. Moscat, E. Berra, 1995, The EMBO journal.

Akt regulation and lung cancer: A novel role and mechanism of action for the tumor suppressor Par-4

M. Diaz-Meco, J. Moscat, 2008, Cell cycle.

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation

Lozano, C. Payá, M. Diaz-Meco, 1993, Molecular and cellular biology.

Protein Kinase C (PKC)ζ-mediated Gαq Stimulation of ERK5 Protein Pathway in Cardiomyocytes and Cardiac Fibroblasts*

M. Diaz-Meco, J. Moscat, L. Boscá, 2012, The Journal of Biological Chemistry.

The atypical PKC‐interacting protein p62 channels NF‐κB activation by the IL‐1–TRAF6 pathway

H. Nakano, M. Diaz-Meco, J. Moscat, 2000, The EMBO journal.

AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62

R. Huganir, M. Diaz-Meco, Myoung-Goo Kang, 2009, Hippocampus.

An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis

A. Durán, M. Diaz-Meco, J. Moscat, 2020, STAR protocols.

Stress-Activated NRF 2-MD M 2 Cascade Controls Neoplastic Progression in Pancreas Graphical

M. Karin, D. Tarin, M. Valasek, 2017 .

The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

Manuel Serrano, Jacques P. Brown, Sylvain Picard, 2004, Developmental cell.

The atypical protein kinase Cs

M. Diaz-Meco, J. Moscat, J Moscat, 2000, EMBO reports.

Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62

M. Diaz-Meco, J. Moscat, I. Sandoval, 1998, Molecular and Cellular Biology.

Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element.

M. Diaz-Meco, J. Moscat, I. Dominguez, 1994, The Journal of biological chemistry.

Identification of Heterogeneous Ribonucleoprotein A1 as a Novel Substrate for Protein Kinase C ζ (*)

M. Diaz-Meco, J. Moscat, J. Lozano, 1995, The Journal of Biological Chemistry.

Protein kinase C ζ isoform is critical for mitogenic signal transduction

M. Diaz-Meco, J. Moscat, I. Dominguez, 1993, Cell.

Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade.

M. Diaz-Meco, J. Moscat, I. Díaz-Laviada, 1990, The Journal of biological chemistry.

Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C.

M. Diaz-Meco, J. Moscat, J. Saus, 1991, The Journal of biological chemistry.

Polarized Subcellular Localization of JAK/STAT Components Is Required for Efficient Signaling

M. Diaz-Meco, J. Moscat, J. C. Hombría, 2008, Current Biology.

Protein Kinase Cζ Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications*

I. Rahman, M. Diaz-Meco, J. Moscat, 2009, The Journal of Biological Chemistry.

The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-κB signaling

A. Davies, H. Gutierrez, M. Segura, 2004, The Journal of cell biology.

c-Myc phosphorylation by PKCζ represses prostate tumorigenesis

L. Brill, M. Medvedovic, Ji Young Kim, 2013, Proceedings of the National Academy of Sciences.

Fine tuning NF-κB: new openings for PKC-ζ

M. Diaz-Meco, J. Moscat, 2010, Nature Immunology.

Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum

A. Durán, M. Diaz-Meco, J. Moscat, 2021, STAR protocols.

Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?

M. Diaz-Meco, J. Moscat, Y. Nakanishi, 2023, Journal of gastroenterology.

Protein Kinase C-zMediates NF-kB Activation in Human Immunodeficiency Virus-Infected Monocytes

G. Bren, M. Diaz-Meco, J. Moscat, 1996 .

Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C.

M. Diaz-Meco, J. Moscat, T. Johansen, 1991, The Journal of biological chemistry.

Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo

M. Diaz-Meco, J. Moscat, J. Lozano, 1996, Molecular and cellular biology.

NF-kappaB activation by protein kinase C isoforms and B-cell function.

M. Diaz-Meco, J. Moscat, P. Rennert, 2003, EMBO reports.

Role of ζPKC in B‐cell signaling and function

Pilar Martín, A. Durán, M. Diaz-Meco, 2002 .

The interplay between PRKCI/PKCλ/ι, SQSTM1/p62, and autophagy orchestrates the oxidative metabolic response that drives liver cancer

M. Diaz-Meco, J. Moscat, 2020, Autophagy.

The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

S. Woods, M. Tschöp, W. Thaiss, 2020, Nature Communications.

Cross-talk between Different Enhancer Elements during Mitogenic Induction of the Human Stromelysin-1 Gene*

M. Diaz-Meco, J. Moscat, J. Saus, 1996, The Journal of Biological Chemistry.

NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ

A. Saltiel, A. Durán, M. Diaz-Meco, 2021, Nature Communications.

The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.

J. Flores, A. Durán, M. Diaz-Meco, 2008, Cancer cell.

Loss of PKCλ/ι impairs Th2 establishment and allergic airway inflammation in vivo

A. Durán, M. Diaz-Meco, J. Moscat, 2009, Proceedings of the National Academy of Sciences of the United States of America.

Atypical protein kinase C (aPKCζ and aPKCλ) is dispensable for mammalian hematopoietic stem cell activity and blood formation

A. Durán, M. Diaz-Meco, J. Moscat, 2011, Proceedings of the National Academy of Sciences.

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Aleksey A. Porollo, Ramars Amanchy, A. Durán, 2011, Molecular cell.

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

J. Asara, E. Henske, M. Sahin, 2017, Cancer research.

Protein Kinase C Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications*

I. Rahman, M. Diaz-Meco, J. Moscat, 2010 .

PKCzeta-mediated GalphaQ stimulation of the ERK5 pathway plays a key role in cardiac hypertrophy

M. Diaz-Meco, J. Moscat, C. Ribas, 2007 .

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

S. Ogawa, K. Obama, N. Sheibani, 2023, Nature communications.

Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

J. Asara, M. Sahin, M. Diaz-Meco, 2020, Cancer Research.

DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila

M. Diaz-Meco, J. Moscat, S. Campuzano, 2004, The Journal of cell biology.

Polarized Subcellular Localization Required for Efficient Signaling

M. Diaz-Meco, J. Moscat, J. C. Hombría, 2022 .