I. Aronchik

发表

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.

M. Lindvall, A. Jefferson, Abran Q. Costales, 2014, Bioorganic & medicinal chemistry letters.

B Transcriptional Activity in Human Breast Cancer Cells κa CD40-TRAF Regulatory Cascade That Disrupts NF- Direct Inhibition of Elastase Activity by Indole-3-Carbinol

G. Firestone, I. Aronchik, L. Bjeldanes, 2010 .

Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

G. Firestone, I. Aronchik, L. Bjeldanes, 2010, Cancer research.

Clinical activity of CC‐90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies

R. Plummer, G. Curigliano, E. Baudin, 2022, Cancer.

DEVD‐NucView488: a novel class of enzyme substrates for real‐time detection of caspase‐3 activity in live cells

G. Firestone, Fei Mao, I. Aronchik, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation

G. Firestone, I. Aronchik, Aishwarya Kundu, 2014, Molecular Cancer Research.

Target protein interactions of indole‐3‐carbinol and the highly potent derivative 1‐benzyl‐I3C with the C‐terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling

Kathleen A. Durkin, G. Firestone, M. Preobrazhenskaya, 2012, Molecular carcinogenesis.

Indole‐3‐carbinol inhibits MDA‐MB‐231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity

G. Firestone, I. Aronchik, C. Brew, 2009, International journal of cancer.

Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

M. Lindvall, E. Venetsanakos, Jiong Lan, 2014, Molecular Cancer Research.

Extracellular pH Controls NHE1 expression in epidermis and keratinocytes: implications for barrier repair.

P. Elias, K. Feingold, T. Mauro, 2005, The Journal of investigative dermatology.

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing

Hanh H. Nguyen, G. Brar, G. Firestone, 2008, Proceedings of the National Academy of Sciences.

Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier disease

A. Hovnanian, T. Mauro, I. Aronchik, 2006, Journal of Cell Science.

secretory pathway Ca2+-ATPase Characterization of Cos-7 cells overexpressing the rat

J. Goff, A. Hovnanian, T. Mauro, 2007 .

Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.

T. Pozzan, T. Mauro, I. Aronchik, 2003, The Journal of investigative dermatology.

Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes.

T. Pozzan, T. Mauro, I. Aronchik, 2003, The Journal of investigative dermatology.

Trotabresib (CC-90010) in combination with adjuvant temozolomide or concomitant temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma

M. J. van den Bent, M. Zuraek, I. Aronchik, 2022, Neuro-oncology advances.

50P A phase Ib study of CC-90011, a potent, reversible, oral LSD1 inhibitor, plus etoposide and cisplatin (EP) or carboplatin (EC) in patients (Pts) with first-line (1L) extensive-stage (ES) small cell lung cancer (SCLC): Updated results

L. Paz-Ares, I. Aronchik, M. Provencio, 2021 .

18O CC-90011 in patients (Pts) with advanced solid tumors (STs) and relapsed/refractory non-Hodgkin lymphoma (R/R NHL): Updated results of a phase I study

R. Plummer, F. D. De Braud, G. Curigliano, 2020 .

Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function.

E. Gratton, P. Elias, T. Mauro, 2003, The Journal of investigative dermatology.

Phase I Study of Lysine-Specific Demethylase 1 Inhibitor, CC-90011, in Patients with Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma

R. Plummer, G. Curigliano, E. Baudin, 2020, Clinical Cancer Research.

Indole‐3‐carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4‐1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells

Kathleen A. Durkin, G. Firestone, S. Lavrenov, 2017, Biochemical pharmacology.

Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells

G. Firestone, I. Aronchik, Kevin M. Poindexter, 2016, Cell Biology and Toxicology.

Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance

K. Mavrommatis, I. Aronchik, L. Qiao, 2018, Molecular Cancer Research.

Phase I study of CC-90010, a reversible, oral BET inhibitor in patients with advanced solid tumors and relapsed/refractory non-Hodgkin lymphoma.

I. Braña, M. Zuraek, I. Aronchik, 2020, Annals of oncology : official journal of the European Society for Medical Oncology.

Indole‐3‐carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

R. Dickson, G. Firestone, I. Aronchik, 2006, International journal of cancer.

BET inhibitor trotabresib in heavily pretreated patients with solid tumors and diffuse large B-cell lymphomas

A. Italiano, I. Braña, I. Aronchik, 2023, Nature Communications.

Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, “window-of-opportunity” study

M. Vogelbaum, D. Reardon, M. Zuraek, 2022, Neuro-oncology.

A phase Ia study of CC-90003, a selective extracellular signal regulated kinase (ERK) inhibitor, in patients with relapsed or refractory BRAF or RAS-mutant tumors.

Edward S. Kim, P. LoRusso, J. Bendell, 2017 .

Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells

G. Firestone, I. Aronchik, Kevin M. Poindexter, 2016, Cell Biology and Toxicology.

Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

M. Lindvall, E. Venetsanakos, Jiong Lan, 2014, Molecular Cancer Research.