J. Cancelas

发表

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

David A. Williams, A. Sánchez-Aguilera, X. Agirre, 2012, Blood.

Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives

Alexander R. Pico, Larsson Omberg, Winston Hide, 2017, Scientific Data.

High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells.

J. Briones, M. Nadal, J. Cancelas, 1997, Blood.

Diffusion Dynamics of Glycine Receptors Revealed by Single – Quantum Dot Tracking

David A. Williams, D. Kwiatkowski, J. Cancelas, 2012 .

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

N. Salomonis, R. Levine, Yi Zheng, 2018, Cell reports.

Structure-function based design of small molecule inhibitors targeting Rho family GTPases.

David A. Williams, N. Nassar, Yi Zheng, 2006, Current topics in medicinal chemistry.

The purified vepoloxamer prevents haemolysis in 42-day stored, DEHP/PVC-free red blood cell units.

J. Cancelas, D. Mckenzie, N. Rugg, 2017, Blood transfusion = Trasfusione del sangue.

Additive solution‐7 reduces the red blood cell cold storage lesion

Alan H. Siegel, J. Cancelas, J. Hess, 2015, Transfusion.

Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (RBC) additive solutions on in vitro RBC measures

D. Devine, R. Cardigan, J. Cancelas, 2011, Transfusion.

IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

Edward J Merino, N. Nassar, Shailaja N Hegde, 2020, PloS one.

In premature infants there is no decrease in 24‐hour posttransfusion allogeneic red blood cell recovery after 42 days of storage

J. Widness, R. Strauss, J. Cancelas, 2018, Transfusion.

The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh‐frozen plasma prepared within eight hours of collection

Alan H. Siegel, J. Cancelas, J. Hess, 2015, Transfusion.

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.

D. Largaespada, D. Levy, A. Stemmer-Rachamimov, 2016, Cell reports.

Rho GTPases in hematopoietic stem cell functions

David A. Williams, J. Cancelas, 2009, Current opinion in hematology.

Children are not little adults: just ask their hematopoietic stem cells.

David A. Williams, J. Cancelas, Haiming Xu, 2006, The Journal of clinical investigation.

Atypical protein kinase C (aPKCζ and aPKCλ) is dispensable for mammalian hematopoietic stem cell activity and blood formation

A. Durán, M. Diaz-Meco, J. Moscat, 2011, Proceedings of the National Academy of Sciences.

Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers

G. Shaw, D. Stroncek, J. Reems, 2017, Scientific Reports.

Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.

A. Stemmer-Rachamimov, D. Witte, N. Ratner, 2008, Cancer cell.

Dissecting the metabolic pathways controlling platelet survival in vivo: are our platelets what they eat?

Shailaja N Hegde, J. Cancelas, 2016, Transfusion.

Off the Shelf Third Party Virus Specific T-Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplant Recipients

P. Hanley, C. Bollard, J. Cancelas, 2021, Transplantation and Cellular Therapy.

FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia.

N. Salomonis, J. Cancelas, H. Geiger, 2020, Blood advances.

Aging of the hematopoietic stem cell niches

K. Chang, J. Cancelas, 2015 .

Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced‐based analysis and recommendations

J. Widness, R. Strauss, J. Cancelas, 2018, Transfusion.

Measurement of posttransfusion red cell survival with the biotin label.

C. Lindsell, J. Widness, R. Strauss, 2014, Transfusion medicine reviews.

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

David A. Williams, B. Druker, A. Cox, 2007, Cancer cell.

Rac2‐Deficient Hematopoietic Stem Cells Show Defective Interaction with the Hematopoietic Microenvironment and Long‐Term Engraftment Failure

David A. Williams, J. Cancelas, Feng-Chun Yang, 2005, Stem cells.

Characterization and first‐in‐human clinical dose‐escalation safety evaluation of a next‐gen human freeze‐dried plasma

J. Cancelas, N. Rugg, Shawnagay Nestheide, 2021, Transfusion.

Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data

J. Cancelas, 2019, Transfusion.

Red blood cells derived from whole blood treated with riboflavin and ultraviolet light maintain adequate survival in vivo after 21 days of storage

J. Cancelas, S. Slichter, N. Rugg, 2017, Transfusion.

A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.

David A. Williams, D. Schindler, S. Batish, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Stem Cell Collection and Gene Transfer in Fanconi Anemia.

David A. Williams, J. Cancelas, A. Auerbach, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice.

J. Cancelas, G. Wagemaker, A. Limón, 1998, Blood.

A syntactic and contextual edge detector and application of a rewriting rules set to improve detection

R. González, J. Cancelas, A. Diez, 1994, Proceedings of IECON'94 - 20th Annual Conference of IEEE Industrial Electronics.

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

H. Grimes, Shailaja N Hegde, J. Cancelas, 2021, eLife.

p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.

B. Aronow, A. Durán, J. Moscat, 2014, Cell reports.

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.

G. Fishman, M. Gunzer, A. Sengupta, 2012, Blood.

Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models

Y. Hayashi, X. An, J. Cancelas, 2017, Haematologica.

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.

M. Weirauch, K. Komurov, J. Maciejewski, 2014, Cell reports.

Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis

R. Hegde, N. Ratner, J. Cancelas, 2009, Oncogene.

progenitor cell proliferation and engraftment Inhibition of RhoA GTPase activity enhances hematopoietic stem and

David A. Williams, Yi Zheng, J. Cancelas, 2013 .

Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression

David E. Muench, B. Aronow, N. Salomonis, 2018, The Journal of experimental medicine.

Plasma Protein Timings: Relative Contributions of Storage Time, Donor Age and Donation Season

J. Cancelas, N. Rugg, 2016, EBioMedicine.

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis

Ashutosh Kumar Singh, A. Barski, N. Nassar, 2022, Nature Communications.

Involvement of RhoH GTPase in the Development of B-Cell Chronic Lymphocytic Leukemia

David A. Williams, J. Byrd, A. Sánchez-Aguilera, 2009, Leukemia.

Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice.

J. Cancelas, F. McCormack, J. Gardner, 2017, Experimental hematology.

Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020

David A Hildeman, J. Molkentin, J. Cancelas, 2021, medRxiv.

Enhanced Expression of α(1,3)-Fucosyltransferase Genes Correlates with E-selectin-mediated Adhesion and Metastatic Potential of Human Lung Adenocarcinoma Cells

J. Cancelas, M. Martín-Satué, J. Blanco, 1998 .

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging

T. Hökfelt, J. Kehr, J. Mulder, 2021, Science Advances.

AWARD NUMBER: W81XWH-11-1-0296 TITLE: Gap Junction Intercellular Communication in Bone Marrow Failure

Principal Investigator, J. Cancelas, 2013 .

M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling

J. Cancelas, B. Mackenzie, J. Gardner, 2022, Scientific Reports.

Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis

David A. Williams, D. Williams, J. Cancelas, 2008, Leukemia.

Leukaemia: Niche retreats for stem cells

David A. Williams, J. Cancelas, 2006, Nature.

Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

Eric A. Smith, J. Cancelas, H. Geiger, 2017, Experimental hematology.

Infusion of P‐Capt prion‐filtered red blood cell products demonstrate acceptable in vivo viability and no evidence of neoantigen formation

J. Cancelas, N. Rugg, R. Davenport, 2011, Transfusion.

Multi‐institutional randomized control study of haemolysis in stored red cell units prepared manually or by an automated system

J. Cancelas, N. Rugg, R. Vassallo, 2010, Vox sanguinis.

Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy.

P. Hanley, C. Bollard, J. Cancelas, 2020, Blood advances.

Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients.

P. Hanley, C. Bollard, J. Cancelas, 2020, Blood advances.

Stem cell mobilization by β2-agonists

David A. Williams, J. Cancelas, 2006, Nature Medicine.

Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.

David A. Williams, A. Sengupta, S. Dunn, 2010, Blood.

c-Fos and Dusp1 confer non-oncogene addiction in BCR-ABL induced leukemia

K. Komurov, Zachary Kincaid, H. Grimes, 2017, Nature medicine.

Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence.

J. Cancelas, J. Serrano-López, 2016, Cell stem cell.

Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings.

J. Sperry, E. Angelantonio, Jasmine Schwartz, 2019, Anesthesiology.

Current Concepts on the Pathogenesis of the Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia

J. Cancelas, Yoshiyuki Yamada, M. Rothenberg, 2006, Translational oncogenomics.

The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease.

David A. Williams, J. Cancelas, Yoshiyuki Yamada, 2006, Blood.

Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFRα initiated chronic eosinophilic leukemia/systemic mastocytosis.

J. Cancelas, Yoshiyuki Yamada, M. Rothenberg, 2014, Methods in molecular biology.

FIP1L1/PDGFRα-Associated Systemic Mastocytosis

J. Cancelas, Yoshiyuki Yamada, 2010, International Archives of Allergy and Immunology.

Murine Model of Hypereosinophilic Syndromes/Chronic Eosinophilic Leukemia

J. Cancelas, Yoshiyuki Yamada, M. Rothenberg, 2009, International Archives of Allergy and Immunology.

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma.

K. Golan, O. Kollet, T. Lapidot, 2020, Blood.

Decrease in serum antibodies to SARS‐CoV‐2 in convalescent plasma donors over time

J. Cancelas, Kristina M. Prus, C. Alquist, 2021, Transfusion.

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

Yi Zheng, J. Cancelas, G. Thomas, 2013, Haematologica.

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

G. Fishman, Bhuvana Murali, M. Madhu, 2012, Proceedings of the National Academy of Sciences.

Bone Marrow Connexin-43 Expression Is Critical for Hematopoietic Regeneration After Chemotherapy

G. Fishman, J. Cancelas, Yoshiyuki Yamada, 2005, Cell communication & adhesion.

High plasma levels of plasminogen activator inhibitor 1 (PAI-1) in polycythemia vera and essential thrombocythemia are associated with thrombosis.

J. Cancelas, L. J. García‐Frade, Á. García-Avello, 1994, Thrombosis research.

High F1.2 fragment of prothrombin, thrombin-antithrombin III complex (TAT) and soluble fibrin plasma levels demonstrate hypercoagulability induced during loco-regional thrombolytic therapy with rt-PA.

J. Cancelas, J. Ocaña, L. J. García‐Frade, 1994, Thrombosis research.

Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

J. Whitsett, H. Grimes, K. Chang, 2013, Nature Communications.

Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell‐biotin dose

J. Widness, R. Strauss, J. Cancelas, 2017, Transfusion.

Myeloablation enhances engraftment of transduced murine hematopoietic cells, but does not influence long-term expression of the transgene

J. Cancelas, T. Puig, A. Limón, 2002, Gene Therapy.

Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.

David A. Williams, D. Witte, J. Cancelas, 2008, Blood.

Rac 1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells

David A. Williams, D. Witte, J. Cancelas, 2008 .

Granulocyte transfusion: questions remain.

J. Cancelas, 2015, Blood.

Study of Antiphospholipid Antibodies in a Patient With Sneddon's Syndrome and Her Family

J. Cancelas, J. Gobernado, A. Pardo, 1994, Stroke.

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.

Shailaja N Hegde, M. Diaz-Meco, J. Moscat, 2020, Blood.

A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide–frozen autologous platelets in healthy volunteers

Alan H. Siegel, S. Dunn, J. Cancelas, 2013, Transfusion.

Angiotensin receptor signaling in sickle cell anemia has a reno‐protective effect on urine concentrating ability but results in sickle glomerulopathy

B. Aronow, T. Rizvi, K. Chang, 2018, American journal of hematology.

In vitro and in vivo quality of leukoreduced apheresis platelets stored in a new platelet additive solution

J. Cancelas, K. Friedman, Z. Szczepiorkowski, 2013, Transfusion.

Evaluation of the overnight hold of whole blood at room temperature, before component processing: platelets (PLTs) from PLT‐rich plasma

J. Cancelas, J. Hess, N. Rugg, 2011, Transfusion.

Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted.

A. Sette, P. Hanley, C. Bollard, 2021, Blood advances.

Ubiquitination is not omnipresent in myeloid leukemia

J. Cancelas, R. Nayak, 2019, Haematologica.

Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells.

A. Sengupta, M. Madhu, A. Ficker, 2012, Blood.

Bmi 1 reprograms CML B-lymphoid progenitors to become BALL – initiating cells

A. Sengupta, M. Madhu, A. Ficker, 2012 .

Optical Flow Calculation Using Look-Up Tables

R. González, J. Otero, J. Cancelas, 1998 .

Novel blood derived hemostatic agents for bleeding therapy and prophylaxis

Shailaja N Hegde, J. Cancelas, Y. Zheng, 2022, Current opinion in hematology.

Freeze‐dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies

T. Hervig, J. Cancelas, Z. Szczepiorkowski, 2021, American journal of hematology.

Antioxidant prevents clearance of hemostatically competent platelets after long‐term cold storage

Shailaja N Hegde, Yi Zheng, J. Cancelas, 2020, Transfusion.

Frozen Platelets-Development and Future Directions.

J. Cancelas, Z. Szczepiorkowski, N. Rugg, 2020, Transfusion medicine reviews.

Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia

M. Valiyaveettil, J. Cancelas, N. Dunbar, 2018, Transfusion.

Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026)

B. Custer, S. Glynn, S. Kleinman, 2019, Transfusion.

Stored red blood cell viability is maintained after treatment with a second‐generation S‐303 pathogen inactivation process

Alan H. Siegel, J. Cancelas, L. Corash, 2011, Transfusion.

Overnight, room temperature hold of whole blood followed by 42‐day storage of red blood cells in additive solution‐7

J. Cancelas, J. Hess, Z. Szczepiorkowski, 2015, Transfusion.

In vivo viability of stored red blood cells derived from riboflavin plus ultraviolet light–treated whole blood

S. Dunn, J. Cancelas, N. Rugg, 2011, Transfusion.

Hypoxic storage of red blood cells improves metabolism and post‐transfusion recovery

J. Cancelas, T. Nemkov, Tatsuro Yoshida, 2020, Transfusion.

Red blood cell concentrates treated with the amustaline (S‐303) pathogen reduction system and stored for 35 days retain post‐transfusion viability: results of a two‐centre study

J. Cancelas, N. Huang, L. Corash, 2017, Vox sanguinis.

Successful in vivo recovery and extended storage of additive solution (AS)‐5 red blood cells after deglycerolization and resuspension in AS‐3 for 15 days with an automated closed system

Edward L Snyder, Richard Kowalsky, J. Cancelas, 2007, Transfusion.

In vitro and in vivo evaluation of LEUKOSEP HRC‐600‐C leukoreduction filtration system for red cells

J. Cancelas, J. AuBuchon, N. Rugg, 2006, Transfusion.

Antibodies against biotin‐labeled red blood cells can shorten posttransfusion survival

S. Stowell, J. Widness, R. Strauss, 2022, Transfusion.

Fanca−/− hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766

Yi Zheng, J. Cancelas, Andrew W. Lee, 2009, Haematologica.

hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC 23766

Yi Zheng, J. Cancelas, Andrew W. Lee, 2022 .

Rho GTPases in hematopoiesis and hemopathies.

Yi Zheng, J. Cancelas, M. Filippi, 2010, Blood.

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

Patrick J. Paddison, B. Aronow, P. Paddison, 2015, The Journal of clinical investigation.

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

David A. Williams, D. Kwiatkowski, J. Cancelas, 2003, Science.

The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor positive breast cancers

J. Cancelas, L. P. Privette Vinnedge, S. Wells, 2014, Oncogene.

Signaling and cytoskeletal requirements in erythroblast enucleation.

Stefanos Manganaris, David A. Williams, Yi Zheng, 2012, Blood.

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors

R. Lang, Yi Zheng, J. Cancelas, 2013, The Journal of experimental medicine.

NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation

Lisa J. Martin, P. Andreassen, M. Wallace, 2019, Acta Neuropathologica.

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition

R. Dunn, G. Bollag, N. Ratner, 2012, Acta Neuropathologica.

Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.

A. Stemmer-Rachamimov, N. Ratner, T. Rizvi, 2011, Cancer research.

Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium

Adam A. Margolin, Elias T. Zambidis, A. Margolin, 2016, Stem cell reports.

Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.

T. Crombleholme, J. Cancelas, Y. Saeki, 2008, Cancer research.

Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance

J. Cancelas, A. Singh, 2020, International journal of molecular sciences.

P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis

N. Ratner, T. Rizvi, J. Cancelas, 2022, eLife.

An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system

K. Komurov, N. Ratner, J. Cancelas, 2017, Scientific Reports.

Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells

F. Kirchhoff, J. Cancelas, H. Geiger, 2017, The EMBO journal.

R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration, Homing, and Mobilization*

N. Ratner, A. Ficker, Yi Zheng, 2011, The Journal of Biological Chemistry.

Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus

N. Ratner, J. Cancelas, Y. Saeki, 2009, PloS one.

Mitochondria Transfer in Bone Marrow Hematopoietic Activity

J. Cancelas, A. Singh, 2021, Current Stem Cell Reports.

Mitochondria Transfer in Bone Marrow Hematopoietic Activity

J. Cancelas, A. Singh, 2021, Current Stem Cell Reports.

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.

David A. Williams, Linda Yang, Yi Zheng, 2007, Blood.

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia

M. Ahmadian, N. Nassar, Shailaja N Hegde, 2021, Leukemia.

Lack of communication rusts and ages stem cells

J. Cancelas, E. Ishikawa, 2012, Cell cycle.

Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis

N. Ratner, T. Rizvi, J. Cancelas, 2021, bioRxiv.

Chapter 14 – Animal Models of Human Pathology

James J. Lee, J. Cancelas, Yoshiyuki Yamada, 2013 .

c-Fos and Dusp1 confer non-oncogene addiction in BCR-ABL induced leukemia

K. Komurov, Zachary Kincaid, H. Grimes, 2017, Nature Medicine.

Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia

K. Komurov, Zachary Kincaid, H. Grimes, 2017, Nature Medicine.

Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo

J. Cancelas, C. Lutzko, A. M. Wellendorf, 2019, Stem cells translational medicine.

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

J. Manis, J. Cancelas, Shin-Young Park, 2021, Science Translational Medicine.

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.

N. Zeleznik-Le, B. Aronow, A. Jegga, 2014, The Journal of clinical investigation.

Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation

J. Cancelas, X. Shang, K. Funk, 2007, Journal of thrombosis and haemostasis : JTH.

Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies

J. Cancelas, Y. Zheng, H. Akbar, 2023, International journal of molecular sciences.

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

K. Stegmaier, K. Komurov, G. Alexe, 2018, Oncotarget.

Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States.

T. Jenkins, J. Cancelas, J. Nathan, 2020, Journal of pediatric surgery.

Redefining the Significance of Aneuploidy in the Prognostic Assessment of Colorectal Cancer

V. Moreno, G. Capellá, M. Peinado, 2001, Laboratory Investigation.

Rac guanosine triphosphatases represent a potential target in AML

D. Williams, J. Cancelas, Y. Gu, 2008, Leukemia.

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Yi Zheng, Sara Alvarez, Michael Jansen, 2008, Cancer cell.

Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.

K. Chang, J. Cancelas, R. Nayak, 2015, International review of cell and molecular biology.

Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells.

J. Cancelas, E. Rombouts, R. Ploemacher, 2000, Blood.

Regulation of the Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease

K. Chang, J. Cancelas, R. Nayak, 2015 .

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

N. Ratner, T. Rizvi, J. Cancelas, 2008, Cell stem cell.

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor population and confers tumorigenic potential

N. Ratner, J. Cancelas, Y. Mukouyama, 2008, International Journal of Developmental Neuroscience.

Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

H. Grimes, Shailaja N Hegde, J. Cancelas, 2021, bioRxiv.

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow

Linda Yang, Yi Zheng, J. Cancelas, 2007, Proceedings of the National Academy of Sciences.

Rho GTPases and regulation of hematopoietic stem cell localization.

David A. Williams, Yi Zheng, J. Cancelas, 2008, Methods in enzymology.

Towards increasing shelf life and haemostatic potency of stored platelet concentrates

Shailaja N Hegde, Yi Zheng, J. Cancelas, 2018, Current opinion in hematology.

Rho GTPases control specific cytoskeleton‐dependent functions of hematopoietic stem cells

K. Chang, J. Cancelas, R. Nayak, 2013, Immunological reviews.

On how Rac controls hematopoietic stem cell activity

J. Cancelas, 2011, Transfusion.

Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen

David A. Williams, Yi Zheng, J. Cancelas, 2010, Haematologica.

The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization.

David A. Williams, J. Cancelas, M. Jansen, 2006, Experimental hematology.

Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous Leukemia

J. Cancelas, 2008 .

Award Number: W81XWH-07-1-0297 TITLE: Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous Leukemia

J. Cancelas, 2008 .

Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T‐cell subpopulations

J. Reems, J. Cancelas, D. McKenna, 2017, Transfusion.

Continuous CD34+ cell collection by a new device is safe and more efficient than by a standard collection procedure: results of a two‐center, crossover, randomized trial

E. Scott, J. Cancelas, Jerry Bill, 2016, Transfusion.

Prognostic Factors of Peripheral Blood Stem Cell Mobilization with Cyclophosphamide and Filgrastim (r-metHuG-CSF): The CD34+ Cell Dose Positively Affects the Time to Hematopoietic Recovery and Supportive Requirements after High-Dose Chemotherapy

R. Salazar, J. Tabernero, J. Cancelas, 1999 .

Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial

J. Cancelas, N. Rugg, A. Padmanabhan, 2015, Transfusion.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms

S. Corey, S. Salipante, H. Grimes, 2014 .

Myelopoiesis From Induced Pluripotent Stem Cells Reveals The Role Of Elastase Activity In The Pathogenesis Of Severe Congenital Neutropenia

H. Grimes, J. Cancelas, C. Lutzko, 2013 .

From MPOX to the next epidemic: Words matter when talking about equity‐deserving groups

J. Cancelas, J. Holmberg, Matthew T S Yan, 2023, Transfusion.

Cancer stem cells: A stride towards cancer cure?

A. Sengupta, J. Cancelas, 2010, Journal of cellular physiology.

Masthead and Table of Contents

J. Cancelas, M. Busch, J. Acker, 2019, Transfusion.

Bone Marrow Transplantation: Prognostic Factors of Peripheral Blood Stem Cell Mobilization with Cyclophosphamide and Filgrastim (r-metHuG-CSF): The CD34+ Cell Dose Positively Affects the Time to Hematopoietic Recovery and Supportive Requirements after High-Dose Chemotherapy.

R. Salazar, J. Tabernero, J. Cancelas, 1999, Hematology.

Masthead and Table of Contents

J. Cancelas, M. Busch, J. Acker, 2019, Transfusion.

Procoagulant Activity of T Lymphoblastoid Cells due to Exposure of Negatively Charged Phospholipid

J. Cancelas, Jordi Félez, M. Jardí, 2002, Thrombosis and Haemostasis.

Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.

David A. Williams, Yi Zheng, J. Cancelas, 2008, Blood.

Third party and patient-specific donor-derived virus-specific T cells demonstrate similar efficacy and safety for management of viral infections after hematopoietic stem cell transplant in children and young adults.

P. Hanley, C. Bollard, J. Cancelas, 2023, Transplantation and cellular therapy.

M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling

J. Cancelas, B. Mackenzie, J. Gardner, 2022, Scientific Reports.

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

David A. Williams, Yi Zheng, J. Cancelas, 2005, Nature Medicine.

Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.

David A. Williams, Yi Zheng, J. Cancelas, 2006, Blood.

Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant

P. Hanley, C. Bollard, J. Cancelas, 2022, Blood advances.

Twisting the bone marrow stem cell niche

J. Cancelas, Haixia Niu, 2018, Haematologica.

Structure–Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents

J. Cancelas, Y. Zheng, W. Seibel, 2023, International journal of molecular sciences.

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

J. Moscat, J. Perentesis, J. Cancelas, 2019, Nature Communications.

Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization

M. Gunzer, N. Ratner, A. Sengupta, 2010, Nature Medicine.

Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature

A. Stemmer-Rachamimov, C. Vorhees, N. Ratner, 2013, Cell reports.

Vasculopathy associated hyperangiotensinemia mobilizes hematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation

K. Chang, Yi Zheng, J. Cancelas, 2014, Nature Communications.

Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging

J. Cancelas, A. Singh, M. Althoff, 2018, Current Stem Cell Reports.

Stem cell collection and gene transfer in Fanconi anemia.

David A. Williams, C. von Kalle, J. Cancelas, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Rational design and applications of a Rac GTPase-specific small molecule inhibitor.

David A. Williams, Yi Zheng, J. Cancelas, 2006, Methods in enzymology.

Pharmacological targeting of the thrombomodulin–protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2012, Nature Medicine.

Pharmacological targeting of the thrombomodulin – activated protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2022 .

Enhanced expression of alpha(1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells.

J. Cancelas, M. Martín-Satué, J. Blanco, 1998, Cancer research.

Evaluation of amotosalen and UVA pathogen‐reduced apheresis platelets after 7‐day storage

J. Cancelas, B. Shaz, R. Benjamin, 2022, Transfusion.

p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment

Sachin Kumar, J. Cancelas, M. Filippi, 2013, Leukemia.

Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells

F. Kirchhoff, J. Cancelas, H. Geiger, 2017, The EMBO journal.

A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome

M. Huber-Lang, J. Cancelas, H. Geiger, 2022, Shock.

Precision transfusion medicine: a new spin.

J. Cancelas, 2022, Blood.

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα+/Sca-1-/CD48dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

T. Suda, K. Golan, T. Itkin, 2016 .

FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome.

David A. Williams, A. Sánchez-Aguilera, F. Finkelman, 2008, Blood.

FIP 1 L 1 / PDGFR α synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia / hypereosinophilic syndrome Running title : FIP 1 L 1-PDGFRA-induced systemic mastocytosis

David A. Williams, A. Sánchez-Aguilera, F. Finkelman, 2008 .

Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.

K. Chang, J. Cancelas, R. Nayak, 2015, International review of cell and molecular biology.

Speed measurement using rotary encoders for high performance AC drives

Fernando Briz, Alberto B. Diez, J. A. Cancelas, 1994, Proceedings of IECON'94 - 20th Annual Conference of IEEE Industrial Electronics.

Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.

K. Chang, J. Cancelas, R. Nayak, 2015, International review of cell and molecular biology.

erythropoiesis Cdc42 critically regulates the balance between myelopoiesis and

David A. Williams, Linda Yang, Yi Zheng, 2013 .

Cdc 42 Critically Regulates the Balance Between Myelopoiesis and Erythropoiesis Running title : Cdc 42 in myelopoiesis and erythropoiesis

David A. Williams, Linda Yang, Yi Zheng, 2007 .

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis.

J. Welch, N. Salomonis, J. Cancelas, 2022, Blood.

Rac1 and Rac2 GTPases Play Distinct Roles and Are Essential for Full Osteoclast Differentiation.

David A. Williams, R. Faccio, J. Cancelas, 2005 .

Masthead and Table of Contents

J. Cancelas, M. Busch, P. Ness, 2017 .

Multi-kernel deconvolution for contrast improvement in a full field imaging system with engineered PSFs using conical diffraction

Rafael C. González, Jose M. Enguita, Ignacio Álvarez, 2018 .

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

G. Fishman, Bhuvana Murali, J. Cancelas, 2012, Proceedings of the National Academy of Sciences.

Atypical protein kinase C (aPKCζ and aPKCλ) is dispensable for mammalian hematopoietic stem cell activity and blood formation

A. Durán, M. Diaz-Meco, J. Moscat, 2011, Proceedings of the National Academy of Sciences.

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

David A. Williams, X. Agirre, M. Deininger, 2012, Blood.

Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.

T. Crombleholme, J. Cancelas, Y. Saeki, 2008, Cancer research.

c-Fos and Dusp1 confer non-oncogene addiction in BCR-ABL induced leukemia

K. Komurov, Zachary Kincaid, H. Grimes, 2017, Nature Medicine.

Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.

David A. Williams, A. Sengupta, Jorden L Arnett, 2010, Blood.

Signaling and cytoskeletal requirements in erythroblast enucleation.

David A. Williams, Yi Zheng, J. Cancelas, 2012, Blood.

Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis

J. Cancelas, Abhishek K. Singh, Parash Prasad, 2023, Frontiers in Cell and Developmental Biology.

Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors.

J. Cancelas, 2011, Methods in molecular biology.

Design of speed digital control interface to AC-drivers

Fernando Briz, Alberto B. Diez, J. A. Cancelas, 1991, [1991 Proceedings] 6th Mediterranean Electrotechnical Conference.

Fast stereo vision algorithm for robotic applications

J.C. Alvarez, J.A. Cancelas, R.C. Gonzalez, 1999, 1999 7th IEEE International Conference on Emerging Technologies and Factory Automation. Proceedings ETFA '99 (Cat. No.99TH8467).

Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions

N. Salomonis, J. Cancelas, Kairavee Thakkar, 2023, Journal of Experimental Medicine.