D. Cines

发表

uPA Modulates the Age-Dependent Effect of Brain Injury on Cerebral Hemodynamics through LRP and ERK MAPK

S. Stein, W. Armstead, D. Cines, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Urokinase plasminogen activator impairs SNP and PGE2 cerebrovasodilation after brain injury through activation of LRP and ERK MAPK.

W. Armstead, D. Cines, A. Higazi, 2008, Journal of neurotrauma.

Structural basis of interaction between urokinase-type plasminogen activator and its receptor.

D. Shaw, J. Lubkowski, A. Mazar, 2006, Journal of molecular biology.

Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.

J. George, G. Raskob, S. Woolf, 1996, Blood.

Endothelial cells in physiology and in the pathophysiology of vascular disorders.

J. Loscalzo, J. Pober, D. Cines, 1998, Blood.

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.

D. Cines, A. Higazi, R. Abramovitch, 2015, Blood.

Structure of Human Urokinase Plasminogen Activator in Complex with Its Receptor

D. Shaw, C. Bian, A. Mazar, 2006, Science.

Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy.

P. Weinreb, S. Violette, M. Baker, 2007, Journal of proteome research.

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.

L. Rauova, J. Weisel, D. Cines, 2014, Blood.

T2 Magnetic Resonance to Monitor Hemostasis

D. Cines, T. Lowery, A. Cuker, 2018, Seminars in thrombosis and hemostasis.

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability.

J. Weisel, D. Cines, K. Bdeir, 2019, Blood.

The emerging role for red blood cells in haemostasis: opportunity for intervention

C. Villa, V. Muzykantov, D. Cines, 2016 .

Rapid Evaluation of Platelet Function With T2 Magnetic Resonance

John W. Weisel, Holleh Husseinzadeh, Adam Cuker, 2016, American journal of clinical pathology.

T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept.

Mortimer Poncz, Adam Cuker, E. Thayer, 2014, Clinical chemistry.

Miniaturized T2MR Magnetic Resonance System for Analysis of Hemostasis and Detection of Impaired and Prothrombotic Blood Disorders

E. Thayer, L. Rauova, J. Weisel, 2012 .

real-time dynamic measurement of hemostasis and fibrinolysis and detection of hemostatic and prothrombotic blood disorders by T2 magnetic resonance : As 38.4

J. Weisel, D. Cines, M. Kowalska, 2013 .

α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol*

D. Cines, A. Higazi, G. Blum, 2015, The Journal of Biological Chemistry.

Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.

S. Vinogradov, T. Ganz, T. Allen, 2010, American journal of respiratory and critical care medicine.

Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature.

V. Muzykantov, B. Ding, D. Cines, 2005, Blood.

Delivery of Anti-Platelet-Endothelial Cell Adhesion Molecule Single-Chain Variable Fragment-Urokinase Fusion Protein to the Cerebral Vasculature Lyses Arterial Clots and Attenuates Postischemic Brain Edema

V. Muzykantov, B. Ding, D. Cines, 2007, Journal of Pharmacology and Experimental Therapeutics.

Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation.

V. Muzykantov, A. Fisher, B. Ding, 2009, American journal of respiratory and critical care medicine.

Advanced drug delivery systems for antithrombotic agents.

V. Muzykantov, C. Greineder, D. Cines, 2013, Blood.

ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model.

C. Villa, C. Esmon, V. Muzykantov, 2017, Blood advances.

Regulation of Single Chain Urokinase Binding, Internalization, and Degradation by a Plasminogen Activator Inhibitor 1-Derived Peptide*

D. Cines, A. Higazi, D. Strickland, 1997, The Journal of Biological Chemistry.

The kringle stabilizes urokinase binding to the urokinase receptor.

A. Mazar, D. Cines, K. Bdeir, 2003, Blood.

Blood Clearance and Activity of Erythrocyte-Coupled Fibrinolytics

Vladimir R Muzykantov, V. Muzykantov, D. Cines, 2005, Journal of Pharmacology and Experimental Therapeutics.

Fibrin Affinity of Erythrocyte-Coupled Tissue-Type Plasminogen Activators Endures Hemodynamic Forces and Enhances Fibrinolysis in Vivo

Scott L Diamond, Vladimir R Muzykantov, S. Diamond, 2006, Journal of Pharmacology and Experimental Therapeutics.

The Glycocalyx Protects Erythrocyte-Bound Tissue-Type Plasminogen Activator from Enzymatic Inhibition

Vladimir R Muzykantov, R. Westrick, V. Muzykantov, 2007, Journal of Pharmacology and Experimental Therapeutics.

Red Blood Cells-Coupled tPA Prevents Impairment of Cerebral Vasodilatory Responses and Tissue Injury in Pediatric Cerebral Hypoxia/Ischemia through Inhibition of ERK MAPK Activation

V. Muzykantov, Douglas H. Smith, W. Armstead, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury.

S. Stein, V. Muzykantov, Douglas H. Smith, 2009, Journal of neurotrauma.

Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile.

V. Muzykantov, D. Cines, A. Higazi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.

V. Muzykantov, J. Atkinson, M. Poncz, 2010, Blood.

The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte‐bound vs. free fibrinolytics

J. Weisel, V. Muzykantov, D. Cines, 2010, Journal of thrombosis and haemostasis : JTH.

Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig

V. Muzykantov, W. Armstead, D. Cines, 2011, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent.

J. Weisel, V. Muzykantov, D. Cines, 2011, Blood.

False normal von Willebrand factor activity by monoclonal antibody-based ELISA in a patient with type 2A(IID) von Willebrand disease

D. Cines, B. Konkle, A. Cuker, 2011, Thrombosis and Haemostasis.

Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA.

D. Weiner, L. Rosenfeld, J. Henkin, 1990, Blood.

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.

L. Rauova, M. Poncz, D. Cines, 2016, Blood.

Thrombocytopenia in pregnancy: Diagnosis and approach to management.

D. Cines, L. Levine, A. Pishko, 2019, Blood reviews.

Inhibition of pathologic retinal neovascularization by α-defensins

H. Hammes, K. Preissner, J. Lubkowski, 2005 .

Pathogenesis of Heparin-Induced Thrombocytopenia.

D. Cines, G. Arepally, 2020, Translational research : the journal of laboratory and clinical medicine.

Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia

L. Rauova, M. Poncz, D. Cines, 2017, The Journal of clinical investigation.

Role of monocytes and endothelial cells in heparin-induced thrombocytopenia

L. Rauova, M. Poncz, D. Cines, 2016, Thrombosis and Haemostasis.

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.

L. Rauova, M. Poncz, D. Cines, 2016, Blood advances.

thrombocytopenia pathogenesis: diagnostic and therapeutic implications Role of platelet surface PF4 antigenic complexes in heparin-induced

L. Rauova, M. Poncz, D. Cines, 2013 .

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

E. L. Luning Prak, D. Cines, K. McCrae, 2012, Blood.

thrombotic disorders Antigen and substrate withdrawal in the management of autoimmune

E. L. Prak, D. Cines, K. McCrae, 2012 .

Dynamic antibody-binding properties in the pathogenesis of HIT.

L. Rauova, J. Weisel, M. Poncz, 2012, Blood.

Heparin‐induced thrombocytopenia: An autoimmune disorder regulated through dynamic autoantigen assembly/disassembly

L. Rauova, M. Poncz, D. Cines, 2007, Journal of clinical apheresis.

Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.

M. Poncz, D. Cines, S. McKenzie, 2001, Blood.

Heparin-induced thrombocytopenia / thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcRIIA

Scott M. Taylor, M. Poncz, D. Cines, 2001 .

Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.

W. Kisiel, M. Poncz, D. Cines, 2000, Blood.

The Pathogenesis and Clinical Relevance of Heparin-Induced Autoantibodies

D. Cines, G. Arepally, 1999 .

Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia

Y. Shoenfeld, M. Poncz, D. Cines, 1998 .

Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis.

M. Poncz, D. Cines, S. McKenzie, 1997, Blood.

Heparin-associated Autoantibodies

D. Cines, G. Arepally, 1996 .

Tissue factor regulates plasminogen binding and activation.

I. Chaiken, D. Cines, P. Larson, 1998, Blood.

Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor.

H. Li, D. Cines, D. Strickland, 1994, The Journal of biological chemistry.

Single-chain urokinase alone or complexed to its receptor in tetracycline-induced pleuritis in rabbits.

W. Hadden, A. Mazar, D. Cines, 2002, American journal of respiratory and critical care medicine.

Regulation of urokinase-type plasminogen activator production by cultured human cytotrophoblasts.

D. Cines, J. Strauss, T. Golos, 1987, The Journal of biological chemistry.

RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis

V. Muzykantov, W. Armstead, D. Cines, 2011, Translational Stroke Research.

Platelets inhibit the lysis of pulmonary microemboli.

V. Muzykantov, A. Fisher, D. Cines, 2002, American journal of physiology. Lung cellular and molecular physiology.

Urokinase mediates fibrinolysis in the pulmonary microvasculature.

V. Muzykantov, D. Cines, K. Bdeir, 2000, Blood.

The antiphospholipid-protein syndrome

D. Cines, K. McCrae, 1995, Journal of Clinical Immunology.

Delivery of anti-PECAM scFv-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates post-ischemic brain edema

V. Muzykantov, B. Ding, D. Cines, 2007 .

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

J. Hoxie, D. Cines, G. Vilaire, 1983, Proceedings of the National Academy of Sciences of the United States of America.

TMA: beware of complements.

D. Ricklin, D. Cines, 2013, Blood.

Protamine-induced thrombocytopenia?

D. Cines, A. Cuker, 2013, Blood.

Compelling Evidence That Cd146

D. Cines, 2022 .

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

D. Cines, P. Declerck, A. Azghani, 2018, American journal of physiology. Lung cellular and molecular physiology.

American Society of Hematology 2019 guidelines for immune thrombocytopenia.

S. Vesely, J. George, D. Cines, 2019, Blood advances.

American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.

R. Mustafa, D. Cines, Y. Gruel, 2018, Blood advances.

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.

J. George, J. Bussel, V. Blanchette, 2009, Blood.

an international working group immune thrombocytopenic purpura of adults and children: report from Standardization of terminology, definitions and outcome criteria in

J. George, J. Bussel, D. Cines, 2009 .

Final results of the ReoPro readministration registry.

M. Effron, A. Lincoff, J. Tcheng, 2004, The American journal of cardiology.

Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond.

C. Villa, V. Muzykantov, D. Cines, 2017, Transfusion medicine reviews.

Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery.

W. Hauck, B. Mestichelli, S. Shapiro, 1997, Circulation.

Abciximab Readministration: Results of the ReoPro Readministration Registry

R. Jordan, M. Effron, A. Lincoff, 2001, Circulation.

Involvement of the Urokinase Kringle Domain in Lipopolysaccharide-Induced Acute Lung Injury1

E. Abraham, D. Cines, K. Bdeir, 2006, The Journal of Immunology.

Acute Lung Injury Domain in Lipopolysaccharide-Induced Involvement of the Urokinase Kringle Cines

E. Abraham, D. Cines, K. Bdeir, 2006 .

Characterization of urokinase receptor expression by human placental trophoblasts.

A. Mazar, J. Henkin, D. Cines, 1992, Blood.

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor (*)

J. Henkin, D. Cines, A. Higazi, 1995, The Journal of Biological Chemistry.

Carboxy-terminal processing of the urokinase receptor: implications for substrate recognition and glycosylphosphatidylinositol anchor addition.

D. Cines, T. Kieber‐Emmons, J. Aceto, 1999, Biochemistry.

Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation.

J. Breuss, J. Bussel, R. Hofer-Warbinek, 2002, Blood.

Protamine-induced thrombocytopenia?

D. Cines, A. Cuker, 2013, Blood.

Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery.

M. Poncz, D. Cines, B. Konkle, 2001, The Annals of thoracic surgery.

How I treat heparin-induced thrombocytopenia.

D. Cines, A. Cuker, 2012, Blood.

The HIT Expert Probability (HEP) Score: a novel pre‐test probability model for heparin‐induced thrombocytopenia based on broad expert opinion

T. Ortel, K. Propert, D. Cines, 2010, Journal of thrombosis and haemostasis : JTH.

Determinants of PF4/heparin immunogenicity.

M. Poncz, D. Cines, M. Wiesner, 2007, Blood.

PF4/heparin complexes are T cell-dependent antigens.

Emily K. E. McCracken, L. Rauova, M. Poncz, 2005, Blood.

Towards a diagnosis of heparin‐induced thrombocytopenia after cardiopulmonary bypass

D. Cines, W. Matthai, W. H. Matthai, 2004, Journal of thrombosis and haemostasis : JTH.

Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia.

A. Jawad, M. Poncz, D. Cines, 1995, American journal of clinical pathology.

Pathogenesis of heparin-induced thrombocytopenia and thrombosis.

D. Cines, G. Arepally, 2002, Autoimmunity reviews.

Immune Vascular Injury in Heparin- Induced Thrombocytopenia

M. Poncz, D. Cines, G. Arepally, 2003 .

Urokinase-type Plasminogen Activator (uPA) Induces Pulmonary Microvascular Endothelial Permeability through Low Density Lipoprotein Receptor-related Protein (LRP)-dependent Activation of Endothelial Nitric-oxide Synthase*

D. Cines, K. Bdeir, A. Higazi, 2011, The Journal of Biological Chemistry.

LRP and αvβ3 mediate tPA activation of smooth muscle cells

D. Cines, A. Higazi, M. Tarshis, 2006 .

LRP and alphavbeta3 mediate tPA activation of smooth muscle cells.

D. Cines, A. Higazi, M. Tarshis, 2006, American journal of physiology. Heart and circulatory physiology.

Erythrocytes Reveal Complement Activation in Patients with COVID-19

E. Wherry, M. Betts, J. Lambris, 2020, medRxiv.

Platelet‐Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury

M. Poncz, D. Cines, K. Bdeir, 2016, American journal of respiratory cell and molecular biology.

endothelial luminal surface : Presented in part as posters at the ICAM-directed vascular immunotargeting of antithrombotic agents to the

V. Muzykantov, D. Cines, S. Albelda, 2013 .

endothelial luminal surface ICAM-directed vascular immunotargeting of anti-thrombotic agents to

V. Muzykantov, D. Cines, S. Albelda, 2003 .

High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation.

A. Schmaier, D. Cines, G. Motta, 1998, Blood.

High-molecular-weight kininogen is exclusively membrane bound on endothelial cells to influence activation of vascular endothelium.

A. Schmaier, E. Jaffe, D. Cines, 1995, Blood.

Bradykinin regulates the expression of kininogen binding sites on endothelial cells.

A. Schmaier, D. Cines, J. Zini, 1993, Blood.

Catheter-delivered ultrasound potentiates in vitro thrombolysis.

R. Shlansky-Goldberg, C. Sehgal, D. Cines, 1996, Journal of vascular and interventional radiology : JVIR.

Viral infection of vascular endothelial cells alters production of colony-stimulating activity.

H. Friedman, D. Cines, S. Gerson, 1985, The Journal of clinical investigation.

Tissue-type plasminogen activator binding to human endothelial cells. Evidence for two distinct binding sites.

D. Cines, K. McCrae, E. Barnathan, 1988, The Journal of biological chemistry.

Pathobiology of Secondary Immune Thrombocytopenia

D. Cines, R. Stasi, H. Liebman, 2009, Seminars in Hematology.

Immune thrombocytopenic purpura [6] (multiple letters)

V. Blanchette, D. Cines, W. Dzik, 2002 .

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contribute to thrombus propagation.

L. Rauova, Junmei Chen, M. Poncz, 2020, Blood.

COVID-19–associated Acute Respiratory Distress Syndrome Clarified: A Vascular Endotype?

C. Hunter, D. Cines, N. Meyer, 2020, American Journal of Respiratory and Critical Care Medicine.

Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK–mediated pathway

E. Abraham, V. Ploplis, D. Cines, 2006, Thrombosis and Haemostasis.

How I treat heparin-induced thrombocytopenia (HIT) Short title: How I treat HIT

D. Cines, A. Cuker, 2016 .

Tissue-Type Plasminogen Activator-A296–299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor–Dependent Increase in cAMP and p38

W. Armstead, D. Cines, A. Higazi, 2016, Stroke.

Glycoprotein IIb/IIIa antagonists: potential induction and detection of drug-dependent antiplatelet antibodies.

D. Cines, 1998, American heart journal.

Isolation and characterization of monoclonal antibodies reactive with endothelial cells.

A. Hamburger, D. Cines, U. Ryan, 1985, Tissue & cell.

fibrinolysis plasminogen activator on circulating erythrocytes for prophylactic directed loading of tissue - Human complement receptor type 1

V. Muzykantov, D. Cines, P. Taylor, 2013 .

Compositions et methodes pour la dissolution selective de caillots sanguins intravasculaires naissants

D. Cines, Vladimir R. Muzykantov, Juan Carlos Murciano, 2004 .

Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line.

D. Cines, K. Karikó, E. Barnathan, 1993, Cancer research.

Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.

W. Armstead, D. Cines, A. Higazi, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPK

S. Stein, W. Armstead, D. Cines, 2008, Brain Research.

tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK

W. Armstead, D. Cines, A. Higazi, 2011, Brain Research.

tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK

W. Armstead, D. Cines, A. Higazi, 2011, Neurological research.

uPA Contributes To Initial Age Dependent Cerebrovascular Hyperemia After Brain Injury Through LRP and ERK MAPK

S. Stein, W. Armstead, D. Cines, 2006 .

Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils.

E. Abraham, Gang Liu, D. Cines, 2010, American journal of respiratory and critical care medicine.

The kringle domain of urokinase‐type plasminogen activator potentiates LPS‐induced neutrophil activation through interaction with αVβ3 integrins

E. Abraham, D. Cines, K. Bdeir, 2005 .

Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.

W. Armstead, D. Cines, A. Higazi, 2009, American journal of physiology. Heart and circulatory physiology.

Inhibition of integrin V 3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia / ischemia

W. Armstead, D. Cines, A. Higazi, 2009 .

Critical Role of Integrin α5β1 in Urokinase (uPA)/Urokinase Receptor (uPAR, CD87) Signaling*

R. Czekay, A. Mazar, Y. Takada, 2003, Journal of Biological Chemistry.

Disorders associated with antibodies to endothelial cells.

D. Cines, 1989, Reviews of infectious diseases.

tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.

W. Armstead, D. Cines, A. Higazi, 2013, Journal of neurotrauma.

tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

Douglas H. Smith, W. Armstead, D. Cines, 2012, Journal of neurotrauma.

FcRn augments induction of tissue factor activity by IgG-containing immune complexes.

L. Rauova, M. Poncz, D. Cines, 2020, Blood.

Urokinase-type Plasminogen Activator Receptor (CD87) Is a Ligand for Integrins and Mediates Cell-Cell Interaction*

A. Mazar, Y. Takada, D. Cines, 2001, The Journal of Biological Chemistry.

Crystallization of soluble urokinase receptor (suPAR) in complex with urokinase amino-terminal fragment (1-143).

A. Mazar, Mingdong Huang, D. Cines, 2005, Acta crystallographica. Section D, Biological crystallography.

Appendix Participating Institutions , Principal Investigators , and Study Coordinators

R. Jordan, M. Effron, A. Lincoff, 2001 .

Pathogenesis of immune thrombocytopenia.

D. Cines, J. Semple, A. Cuker, 2014, Presse medicale.

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

M. Greene, D. Cines, Zhiqiang Zhu, 2016, Autoimmunity reviews.

Autoantibodies in Heparin-Induced Thrombocytopenia

D. Cines, G. Arepally, A. Cuker, 2014 .

Antibody and immune complexes induce tissue factor production by human endothelial cells.

D. Cines, S. Tannenbaum, R. Finko, 1986, Journal of immunology.

Fc and C3 receptors induced by herpes simplex virus on cultured human endothelial cells.

H. Friedman, D. Cines, A. Lyss, 1982, The Journal of clinical investigation.

Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells.

D. Cines, S. Grobmyer, E. Barnathan, 1993, The Journal of biological chemistry.

How I treat idiopathic thrombocytopenic purpura (ITP).

J. Bussel, D. Cines, 2005, Blood.

Management of adult idiopathic thrombocytopenic purpura.

D. Cines, R. Mcmillan, 2005, Annual review of medicine.

Immune thrombocytopenic purpura.

V. Blanchette, D. Cines, 2002, The New England journal of medicine.

SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia

J. Bussel, D. Cines, 2021, The New England journal of medicine.

Interlaboratory agreement in the monitoring of unfractionated heparin using the anti‐factor Xa‐correlated activated partial thromboplastin time

D. Cines, B. Konkle, S. Pipe, 2009, Journal of thrombosis and haemostasis : JTH.

Human neutrophil peptide‐1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols

D. Cines, K. Bdeir, M. Renfrow, 2019, Journal of thrombosis and haemostasis : JTH.

Future research in ITP: an ICIS consensus

E. Neufeld, J. Zehnder, D. Cines, 2010, Annals of Hematology.

Antiphospholipid syndrome: intraoperative and postoperative anticoagulation in cardiac surgery.

T. Floyd, J. Detre, N. Narula, 2008, Journal of cardiothoracic and vascular anesthesia.

Controversies in the treatment of immune thrombocytopenia

D. Cines, A. Cuker, C. Neunert, 2016, Current opinion in hematology.

Can Immune Thrombocytopenia Be Cured with Medical Therapy?

E. L. Prak, D. Cines, A. Cuker, 2015, Seminars in Thrombosis & Hemostasis.

Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis

D. Cines, K. Bdeir, A. Higazi, 2020, PloS one.

Regulation of neovascularization by human neutrophil peptides (α‐defensins): a link between inflammation and angiogenesis

H. Hammes, K. Preissner, O. Liang, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Induction of Plasminogen Activator Inhibitor-1 by Urokinase in Lung Epithelial Cells*

S. Shetty, D. Cines, K. Bdeir, 2003, The Journal of Biological Chemistry.

From bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 23, 2013. For personal use only.

D. Eslin, D. Cines, K. Bdeir, 2002 .

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

L. Rauova, M. Kuchibhatla, M. Poncz, 2018, Blood.

Polyreactive IgM initiates complement activation by PF 4 / heparin complexes through the classical pathway Running Title : IgM involvement in the HIT Immune Response

Frank, L. Rauova, M. Kuchibhatla, 2018 .

Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein.

A. Schmaier, W. V. Van Nostrand, D. Cines, 1991, Biochemical and biophysical research communications.

PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.

W. Armstead, D. Cines, A. Higazi, 2010, American journal of physiology. Heart and circulatory physiology.

Plasminogen Activators Contribute to Impairment of Hypercapnic and Hypotensive Cerebrovasodilation After Cerebral Hypoxia/Ischemia in the Newborn Pig

W. Armstead, D. Cines, A. Higazi, 2005 .

Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.

T. Allen, D. Cines, A. Higazi, 2010, American journal of respiratory cell and molecular biology.

Heterogeneity of anti-phospholipid and anti-endothelial cell antibodies.

I. Chaiken, D. Cines, L. Silberstein, 1998, Journal of autoimmunity.

Infection of human endothelial cells by human T-cell leukemia virus type I.

J. Hoxie, D. Cines, D. Matthews, 1984, Proceedings of the National Academy of Sciences of the United States of America.

targeted to PECAM-1 in the pulmonary vasculature Prophylactic thrombolysis by thrombin-activated latent pro-urokinase

A. Fisher, B. Ding, D. Cines, 2013 .

A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo

A. Mazar, D. Cines, S. Rabbani, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The immune thrombocytopenia syndrome: a disorder of diverse pathogenesis and clinical presentation.

D. Cines, H. Liebman, 2009, Hematology/oncology clinics of North America.

Danazol treatment of myelodysplastic syndromes

P. Nowell, D. Cines, J. Abrahm, 1991, British journal of haematology.

Tissue-Type Plasminogen Activator-A 296 – 299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor – Dependent Increase in cAMP and p 38

W. Armstead, D. Cines, A. Higazi, 2016 .

Endogenous plasminogen activators mediate progressive intracranial hemorrhage after traumatic brain injury.

D. Cines, N. Hijazi, S. Yarovoi, 2015 .

Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice.

T. Allen, D. Cines, A. Higazi, 2011, American journal of respiratory cell and molecular biology.

tPA regulates pulmonary vascular activity through NMDA receptors.

T. Allen, D. Cines, K. Bdeir, 2011, American journal of physiology. Lung cellular and molecular physiology.

Glucagon protects against impaired NMDA-mediated cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A and inhibiting upregulation of tPA.

W. Armstead, D. Cines, A. Higazi, 2011, Journal of Neurotrauma.

NMDA receptors tPA regulates pulmonary vascular activity through

T. Allen, D. Cines, K. Bdeir, 2011 .

Plasminogen activators contribute to age-dependent impairment of NMDA cerebrovasodilation after brain injury.

W. Armstead, D. Cines, Abd Al-Roof Higazie, 2005, Brain research. Developmental brain research.

Danazol therapy in myelodysplasia.

D. Cines, J. Kiss, P. Cassileth, 1985, Annals of internal medicine.

Inhibition of pathologic retinal neovascularization by alpha-defensins.

H. Hammes, K. Preissner, J. Lubkowski, 2005, Blood.

Thrombopoietin receptor agonists in the treatment of chronic immune thrombocytopenic purpura

D. Cines, A. Cuker, E. Chiang, 2009 .

primary immune thrombocytopenia International consensus report on the investigation and management of

V. Blanchette, D. Cines, B. Chong, 2010 .

How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment.

J. Bussel, D. Cines, B. Godeau, 2012, Blood.

or a medical therapy as a second-line treatment How I treat immune thrombocytopenia: the choice between splenectomy

J. Bussel, D. Cines, B. Godeau, 2012 .

Immune thrombocytopenia.

D. Cines, A. Cuker, 2010, Hematology. American Society of Hematology. Education Program.

Long‐term safety and tolerability of romiplostim in patients with primary immune thrombocytopenia: a pooled analysis of 13 clinical trials

D. Cines, J. Viallard, A. Giagounidis, 2013, European journal of haematology.

Regulation of the single-chain urokinase-urokinase receptor complex activity by plasminogen and fibrin: novel mechanism of fibrin specificity.

D. Cines, A. Higazi, A. Kuo, 2005, Blood.

Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia.

Y. Shoenfeld, M. Poncz, D. Cines, 1998, Blood.

Congenital and acquired thrombocytopenia.

J. Zehnder, J. Bussel, D. Cines, 2004, Hematology. American Society of Hematology. Education Program.

The structure of lipoprotein(a) and ligand-induced conformational changes.

M. Koschinsky, J. Weisel, D. Cines, 2001, Biochemistry.

Heparin: do we understand its antithrombotic actions?

D. Cines, 1986, Chest.

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2.

A. Schmaier, D. Cines, Z. Shariat-Madar, 2013, American journal of physiology. Heart and circulatory physiology.

Posttranscriptional Regulation of uPAR Expression in Lipopolysaccharide-induced Acute Lung Injury

S. Shetty, Y. Bhandary, D. Cines, 2008 .

Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts

M. Poncz, M. Hughes, D. Cines, 2022, Scientific Reports.

Integrin (cid:1) M (cid:2) 2 Orchestrates and Accelerates Plasminogen Activation and Fibrinolysis by Neutrophils*

D. Cines, K. Bdeir, E. Plow, 2022 .

Effect of Anti P 1 M Antibody on Human Platelets

D. Cines, Schreiber, 2005 .

Antiplatelet antibody pregnant women testing in thrombocytopenic

K. Eddleman, J. Bussel, D. Cines, 2004 .

Mechanisms of Action of Therapeutics in Idiopathic Thrombocytopenic Purpura

D. Cines, D. Siegel, S. Mckenzie, 2003, Journal of pediatric hematology/oncology.

Antiplatelet antibody testing in thrombocytopenic pregnant women.

K. Eddleman, J. Bussel, D. Cines, 1996, American journal of obstetrics and gynecology.

Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia.

D. Cines, R. Aster, S. Murphy, 1985, Blood.

Presence of complement-fixing anti-endothelial cell antibodies in systemic lupus erythematosus.

D. Cines, M. Bina, A. Lyss, 1984, The Journal of clinical investigation.

Heparin enhances active site-dependent binding of tissue-type plasminogen activator to endothelial cells

J. Hirsh, L. Rosenfeld, D. Cines, 1992 .

Heparin enhances active site-dependent binding of tissue-type plasminogen activator to endothelial cells.

J. Hirsh, L. Rosenfeld, D. Cines, 1992, Blood.

Clinical trial opportunities in hemostasis and thrombosis: NHBLI State‐of‐the‐science symposium

J. Bussel, D. Cines, K. High, 2012, American journal of hematology.

Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.

L. Rosenfeld, J. Henkin, D. Cines, 1990, The Journal of biological chemistry.

Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist–oncologists

S. Vesely, J. George, D. Cines, 2018, Journal of Thrombosis and Thrombolysis.

Tissue Factor Regulates Plasminogen Binding and Activation

I. Chaiken, D. Cines, A. Higazi, 1998 .

Avoiding intuxication.

J. Bussel, D. Cines, 2012, Blood.

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro

E. Ostertag, D. Cines, D. Siegel, 2016, Transfusion.

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

M. Poncz, D. Cines, Dengju Li, 2015, Blood.

THROMBOSIS AND HEMOSTASIS Platelet-delivered ADAMTS 13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models

M. Poncz, D. Cines, Dengju Li, 2015 .

Urokinase‐derived peptides regulate vascular smooth muscle contraction in vitro and in vivo

A. Al-Mehdi, A. Mazar, D. Cines, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.

L. Rauova, J. Hirsch, M. Poncz, 2010, Blood.

In vitro binding of an IgE protein to human platelets.

A. Levinson, D. Cines, H. van der Keyl, 1986, Journal of immunology.

Soluble Human Urokinase Receptor Is Composed of Two Active Units*

A. Mazar, J. Henkin, D. Cines, 1997, The Journal of Biological Chemistry.

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

L. Rauova, M. Poncz, D. Cines, 2018, Blood.

Fc and C 3 Receptors Induced by Herpes Simplex Virus on Cultured Human Endothelial Cells

D. Cines, A. Lyss, 2022 .

Bad (or good) things come in small packages.

L. Rauova, D. Cines, 2013, Blood.

Thrombotic Thrombocytopenic Purpura: A Paradigm Shift?

D. Cines, B. Konkle, M. Furlan, 2000, Thrombosis and Haemostasis.

Minimal role for the alternative pathway in complement activation by HIT immune complexes

L. Rauova, B. Garcia, D. Cines, 2021, Journal of thrombosis and haemostasis : JTH.

Novel diagnostic assays for heparin-induced thrombocytopenia.

S. Watson, D. Cines, B. Konkle, 2012, Blood.

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

C. Ruppert, E. Abraham, S. Shetty, 2010, American journal of respiratory and critical care medicine.

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

L. Rauova, M. Poncz, D. Cines, 2018, Autoimmunity reviews.

Mesenchymal stromal cells enhance self-assembly of a HUVEC tubular network through uPA-uPAR/VEGFR2/integrin/NOTCH crosstalk.

P. Tyurin-Kuzmin, A. Mazar, D. Cines, 2021, Biochimica et biophysica acta. Molecular cell research.

Identification of the fibrinogen receptor on human platelets by photoaffinity labeling.

D. Cines, G. Vilaire, J. Bennett, 1982, The Journal of biological chemistry.

facilitates prophylactic thrombolysis in the pulmonary vasculature single-chain variable antibody fragment (scFv) with pro-urokinase Endothelial targeting of a recombinant construct fusing a PECAM-1

V. Muzykantov, B. Ding, D. Cines, 2013 .

Complexes Lysis of Plasma Clots by Urokinase-Soluble Urokinase Receptor

D. Cines, K. Bdeir, A. Higazi, 2013 .

Lysis of plasma clots by urokinase-soluble urokinase receptor complexes.

D. Cines, K. Bdeir, A. Higazi, 1998, Blood.

Lysis of plasma clots by urokinase-soluble urokinase receptor complexes.

D. Cines, K. Bdeir, A. Kuo, 1998, Blood.

Diagnosing HIT: the need for speed.

D. Cines, A. Cuker, 2020, Blood.

The risk of major bleeding in patients with suspected heparin‐induced thrombocytopenia

P. Gimotty, D. Cines, J. Guevara, 2019, Journal of thrombosis and haemostasis : JTH.

Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury

D. Atochin, C. Villa, C. Esmon, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis and expression of C1 inhibitor by human umbilical vein endothelial cells.

A. Schmaier, G. Heda, D. Cines, 1989, The Journal of biological chemistry.

Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling.

R. Czekay, A. Mazar, Y. Takada, 2003, The Journal of biological chemistry.

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

L. Rauova, M. Poncz, D. Cines, 2023, bioRxiv.

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

W. Armstead, D. Cines, A. Higazi, 2019, Translational Stroke Research.

The Role of Surface PF4: Glycosaminoglycan Complexes in the Pathogenesis of Heparin-Induced Thrombocytopenia (HIT)

L. Rauova, M. Poncz, D. Cines, 2006, Pathophysiology of Haemostasis and Thrombosis.

A mouse model for heparin-induced thrombocytopenia.

Y. Shoenfeld, M. Blank, D. Cines, 1999, Seminars in hematology.

Cerebrovascular Thromboprophylaxis in Mice by Erythrocyte-Coupled Tissue-Type Plasminogen Activator

D. Atochin, S. Kasner, Paul L Huang, 2008, Circulation.

The expression of high molecular weight kininogen on human umbilical vein endothelial cells.

A. Schmaier, D. Cines, A. Kuo, 1988, The Journal of biological chemistry.

Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by Surface Plasmon Resonance (BiaCore)

R. Colman, D. Cines, K. Bdeir, 2011, Thrombosis and Haemostasis.

Mapping the Cell Binding Site on High Molecular Weight Kininogen Domain 5 (*)

A. Schmaier, D. Cines, H. Herwald, 1995, The Journal of Biological Chemistry.

Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors

D. Cines, V. Krymskaya, Y. Parfyonova, 2017, The Journal of Biological Chemistry.

Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression*

P. Jayaraman, V. Tkachuk, D. Cines, 2016, The Journal of Biological Chemistry.

Regulation of single chain urokinase by small peptides.

D. Cines, Higazi A al-R, Abd A I Roof Higazi, 1996, Thrombosis research.

Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications.

L. Rauova, M. Poncz, D. Cines, 2006, Blood.

Heparin-induced thrombocytopenia and thrombosis

D. Cines, G. Arepally, D. Cines, 1998, Clinical reviews in allergy & immunology.

Thrombocytopenia in pregnancy.

D. Cines, L. Levine, 2017, Hematology. American Society of Hematology. Education Program.

International consensus report on the investigation and management of primary immune thrombocytopenia.

Drew Provan, Robert McMillan, Shirley Watson, 2010, Blood.

The ITP syndrome: pathogenic and clinical diversity.

E. L. Luning Prak, J. Bussel, D. Cines, 2009, Blood.

Thrombocytopenia following Pfizer and Moderna SARS‐CoV‐2 vaccination

Eun-Ju Lee, J. Bussel, C. Kessler, 2021, American journal of hematology.

Blood clot contraction differentially modulates internal and external fibrinolysis

J. Weisel, D. Cines, R. Litvinov, 2019, Journal of thrombosis and haemostasis : JTH.

Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells

R. Eisenberg, G. Cohen, H. Friedman, 1984, Nature.

Functional consequence of variation in melanoma antigen expression

D. Guerry, M. Herlyn, D. Cines, 2004, Cancer Immunology, Immunotherapy.

Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.

A. Vorotnikov, V. Tkachuk, R. Wait, 2012, The Biochemical journal.

1 receptor is relatively resistant to plasminogen activator inhibitor type Single-chain urokinase-type plasminogen activator bound to its

A. Mazar, J. Henkin, D. Cines, 2011 .

Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins.

K. Preissner, J. Henkin, D. Cines, 1996, Blood.

Single-chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1.

A. Mazar, J. Henkin, D. Cines, 1996, Blood.

Biosynthesis of phosphatidylinositol-glycan (PI-G)-anchored membrane proteins in cell-free systems: PI-G is an obligatory cosubstrate for COOH-terminal processing of nascent proteins.

E. Yeh, K. Kodukula, S. Udenfriend, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets.

D. Eslin, M. Poncz, D. Cines, 2003, Blood.

Binding of Urokinase to Low Density Lipoprotein-related Receptor (LRP) Regulates Vascular Smooth Muscle Cell Contraction*

A. Mazar, D. Cines, K. Bdeir, 2002, The Journal of Biological Chemistry.

The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis.

D. Rader, T. Ganz, K. Williams, 2000, Blood.

Biosynthesis of phosphatidylinositol-glycan (PI-G)-anchored membrane proteins in cell-free systems: cleavage of the nascent protein and addition of the PI-G moiety depend on the size of the COOH-terminal signal peptide.

K. Kodukula, S. Udenfriend, D. Cines, 1992, Proceedings of the National Academy of Sciences of the United States of America.

clinical commentarY Heparin : Do We Understand Its Antithrombotic Actions ? *

D. Cines, 2022 .

Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

C. Villa, V. Muzykantov, D. Cines, 2015, Therapeutic delivery.

Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment.

R. Doms, L. Rauova, M. Poncz, 2016, AIDS research and human retroviruses.

Nuclear translocation of urokinase-type plasminogen activator.

M. Marks, V. Tkachuk, D. Cines, 2008, Blood.

Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways.

J. Hoxie, D. Cines, K. Karikó, 1993, Circulation research.

Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature.

V. Muzykantov, A. Fisher, B. Ding, 2008, Blood.

The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli

J. Weisel, D. Cines, R. Litvinov, 2020, Scientific Reports.

Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood.

J. Weisel, D. Cines, R. Litvinov, 2016, Blood.

Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection

M. Feldman, D. Cines, K. Bdeir, 2021, British journal of haematology.

Pathogenesis of chronic immune thrombocytopenic purpura

D. Cines, R. Mcmillan, 2007, Current opinion in hematology.

A closer look at intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP).

J. Bussel, D. Cines, E. Grabowski, 2007, Blood.

The child with immune thrombocytopenia: to treat or not to treat, is that still the question?

D. Cines, N. Cooper, 2019, Haematologica.

Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group.

J. Bussel, V. Blanchette, D. Cines, 2013, Blood.

SARS-CoV-2 Vaccination and Immune Thrombocytopenia in de novo and pre-existing ITP patients

Eun-Ju Lee, J. Bussel, C. Kessler, 2021, Blood.

cell surface endocytic itinerary, resulting in retention of low-density lipoprotein on the Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the

M. Poncz, K. Williams, D. Cines, 2013 .

Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface.

M. Poncz, K. Williams, D. Cines, 2002, Blood.

Thrombocytopenia in pregnancy

M. Druzin, J. Bussel, D. Cines, 1991, The Lancet.

Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells

D. Coulter, D. Cines, D. Lynch, 2021, Scientific Reports.

Thermotaxis of human trophoblastic cells.

D. Cines, D. Kniss, E. Barnathan, 1996, Placenta.

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).

L. Rauova, G. Kelsoe, M. Poncz, 2016, Blood.

Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin.

L. Rauova, D. Eslin, M. Poncz, 2004, Blood.

Mapping the Interaction between High Molecular Mass Kininogen and the Urokinase Plasminogen Activator Receptor*

A. Schmaier, D. Cines, A. Kuo, 2004, Journal of Biological Chemistry.

Safety of the thrombopoiesis-stimulating agents for the treatment of immune thrombocytopenia.

D. Cines, A. Cuker, E. Chiang, 2009, Current Drug Safety.

Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia

M. Steurer, D. Cines, B. Chong, 2017, Haematologica.

Antibodies reactive with surface membranes of cellular elements in the blood.

D. Cines, 1983, Human pathology.

Erythrocytes identify complement activation in patients with COVID-19

E. Wherry, M. Betts, J. Lambris, 2021, American journal of physiology. Lung cellular and molecular physiology.

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

D. Cines, K. Bdeir, S. Seeholzer, 2016, Blood.

Innate and adaptive immunity in immune thrombocytopenia.

D. Cines, A. Lazarus, J. Semple, 2013, Seminars in hematology.

Urokinase induces activation of STAT3 in lung epithelial cells.

S. Shetty, D. Cines, K. Bdeir, 2006, American journal of physiology. Lung cellular and molecular physiology.

INTRAPLEURAL LOW-MOLECULAR-WEIGHT UROKINASE OR TISSUE PLASMINOGEN ACTIVATOR VERSUS SINGLE-CHAIN UROKINASE IN TETRACYCLINE-INDUCED PLEURAL LOCULATION IN RABBITS

T. Allen, A. Mazar, D. Cines, 2007, Experimental lung research.

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer

S. Asuthkar, C. Gondi, J. S. Rao, 2013, Molecular biology of the cell.

Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema

K. Sarva, D. Cines, A. Azghani, 2020, bioRxiv.

Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury.

E. Abraham, S. Shetty, Y. Bhandary, 2009, American journal of respiratory and critical care medicine.

Divergent impacts of tocilizumab and colchicine in COVID‐19‐associated coagulopathy: the role of alpha‐defensins

D. Cines, K. Bdeir, A. Higazi, 2021, British Journal of Haematology.

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

C. Villa, V. Muzykantov, C. Greineder, 2018, Blood advances.

Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin αvβ3 induces signal transduction and enhances plasminogen activation

J. Takagi, A. Mazar, Y. Takada, 2006, Thrombosis and Haemostasis.

Exploring biomolecular recognition using optical biosensors.

Gabriela Canziani, I. Chaiken, D. Cines, 1999, Methods.

of heparin-induced thrombocytopenia Ultralarge complexes of PF4 and heparin are central to the pathogenesis

L. Rauova, M. Poncz, D. Cines, 2010 .

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.

L. Rauova, J. Weisel, M. Poncz, 2005, Blood.

Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody.

M. Poncz, D. Cines, Weiyi Liu, 2002, Blood.

Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic Escherichia coli challenge

D. Cines, K. Bdeir, R. Fairchild, 2022, Proceedings of the National Academy of Sciences of the United States of America.

COVID-19 vaccination and immune thrombocytopenia

J. Bussel, D. Cines, A. Pishko, 2021, Nature Medicine.

A Region in Domain II of the Urokinase Receptor Required for Urokinase Binding*

A. Mazar, D. Cines, K. Bdeir, 2000, The Journal of Biological Chemistry.

Defensin promotes the binding of lipoprotein(a) to vascular matrix.

M. Koschinsky, J. Weisel, T. Ganz, 1999, Blood.

α-Defensins: Potential Link between Inflammation, Thrombosis and Atherosclerosis

D. Cines, K. Bdeir, A. Higazi, 2001 .

of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin induces signal transduction and enhances plasminogen activation.

J. Takagi, A. Mazar, Y. Takada, 2006 .

Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation.

J. Takagi, A. Mazar, Y. Takada, 2006, Thrombosis and haemostasis.

ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface.

V. Muzykantov, D. Cines, S. Albelda, 2003, Blood.

Evidence-based mini-review: Is indium-labeled autologous platelet scanning predictive of response to splenectomy in patients with chronic immune thrombocytopenia?

D. Cines, A. Cuker, 2010, Hematology. American Society of Hematology. Education Program.

ITP: time to “bug off”?

D. Cines, 2007 .

Atomic description of the immune complex involved in heparin-induced thrombocytopenia

L. Rauova, M. Greene, M. Poncz, 2015, Nature Communications.

Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis.

Vladimir R Muzykantov, V. Muzykantov, D. Cines, 2006, Blood.

Platelet Glycoprotein IIb/IIIa Inhibitors and Thrombocytopenia: Possible Link between Platelet Activation, Autoimmunity and Thrombosis

D. Cines, C. Abrams, 2002, Thrombosis and Haemostasis.

Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytes

Vladimir R Muzykantov, D. Eslin, V. Muzykantov, 2003, Nature Biotechnology.

Neutrophil accumulation and NET release contribute to thrombosis in HIT.

L. Rauova, M. Poncz, D. Cines, 2018, JCI insight.

Immunohistochemical localization of defensin in human coronary vessels.

T. Ganz, D. Cines, E. Barnathan, 1997, The American journal of pathology.

Neutralizing the neurotoxic effects of exogenous and endogenous tPA

Douglas H. Smith, W. Armstead, D. Cines, 2006, Nature Neuroscience.

PAI-1-Derived Peptide EEIIMD Prevents Hypoxia/Ischemia-Induced Aggravation of Endothelin- and Thromboxane-Induced Cerebrovasoconstriction

W. Armstead, D. Cines, A. Higazi, 2014, Neurocritical Care.

Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders

V. Muzykantov, W. Armstead, D. Cines, 2010, Journal of neurochemistry.

Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages

L. Rauova, M. Poncz, D. Cines, 2015, Journal of thrombosis and haemostasis : JTH.

Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters

R. Fairman, E. Mohler, J. Hunt, 2003, Thrombosis and Haemostasis.

Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils.

D. Cines, K. Bdeir, E. Plow, 2004, The Journal of biological chemistry.

Complement mediates binding and procoagulant effects of ultra-large HIT immune complexes.

L. Rauova, J. Lambris, M. Poncz, 2021, Blood.

Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells.

D. Rader, T. Ganz, D. Cines, 1997, Blood.

THROMBOSIS AND HEMOSTASIS Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS 13 : a potential link of in fl ammation to TTP

D. Cines, K. Bdeir, S. Seeholzer, 2016 .

Interactions of platelet factor 4 with the vessel wall.

M. Poncz, D. Cines, M. Kowalska, 2004, Seminars in Thrombosis and Hemostasis.

Sars-Cov-2 Vaccination in Patients with Pre-Existing Immune Thrombocytopenia

J. Bussel, C. Kessler, D. Cines, 2021, Blood.

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.

C. Esmon, V. Muzykantov, J. Atkinson, 2012, Blood.

A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation.

V. Muzykantov, M. Poncz, D. Cines, 2015, The Journal of clinical investigation.

Fibrin Generation in Heparin-Induced Thrombocytopenia (HIT): Pathomechanistic Background for Novel Therapy and Prophylaxis

L. Rauova, J. Weisel, M. Poncz, 2012 .

Conflicting impacts of tocilizumab and colchicine in COVID-19-associated coagulop.

D. Cines, K. Bdeir, A. Higazi, 2021, British journal of haematology.

RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis

V. Muzykantov, W. Armstead, D. Cines, 2012, Translational Stroke Research.

Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis

Vladimir R Muzykantov, Mortimer Poncz, V. Muzykantov, 2010, Journal of Pharmacology and Experimental Therapeutics.

Blood–brain barrier permeability and tPA-mediated neurotoxicity

Anwar Rayan, D. Cines, A. Higazi, 2010, Neuropharmacology.

Factor IXa inhibition by protease nexin-2/amyloid beta-protein precursor on phospholipid vesicles and cell membranes.

A. Schmaier, W. V. Van Nostrand, D. Cines, 1995, Biochemistry.

polyhedra and redistribution of platelets and fibrin Clot contraction: compression of erythrocytes into tightly packed

L. Rauova, J. Weisel, D. Cines, 2014 .

THROMBOSIS AND HEMOSTASIS Clot contraction : compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fi brin

L. Rauova, J. Weisel, D. Cines, 2014 .

The carboxyl terminus of bradykinin and amino terminus of the light chain of kininogens comprise an endothelial cell binding domain.

A. Schmaier, J. Zhang, D. Cines, 1994, The Journal of biological chemistry.

Platelet Factor 4 Enhances the Binding of Oxidized Low-density Lipoprotein to Vascular Wall Cells*

M. Poncz, D. Cines, K. Bdeir, 2003, The Journal of Biological Chemistry.

The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli

J. Weisel, D. Cines, R. Litvinov, 2020, Scientific Reports.

Defensin Modulates Tissue-type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells*

T. Ganz, D. Cines, A. Higazi, 1996, The Journal of Biological Chemistry.

Pumping out platelets

D. Cines, 2007 .

Thrombocytopenia after treatment with platelet glycoprotein IIb/IIIa inhibitors.

D. Cines, C. Abrams, 2004, Current hematology reports.

Contact with stroke.

D. Cines, A. Higazi, 2012, Blood.

Variability in the expression of urokinase receptor (CD87) mutants on cells: relevance to cell adhesion

K. Preissner, D. Cines, K. Bdeir, 2004, Cell biochemistry and function.

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT.

L. Rauova, J. Esko, M. Poncz, 2011, Blood.

Putting the “Tux” on ITP

D. Cines, 2006 .

Distinct Specificity and Single-molecule Kinetics Characterize the Interaction of Pathogenic and Non-pathogenic Antibodies against Platelet Factor 4-Heparin Complexes with Platelet Factor 4*

L. Rauova, J. Weisel, V. Barsegov, 2013, The Journal of Biological Chemistry.

Pathogenic vs . non-pathogenic anti-PF 4 / heparin antibodies 1 Distinct Specificity and Single-molecule Kinetics of the Interaction of Pathogenic and Non-Pathogenic antiPlatelet Factor 4 / Heparin Antibodies with Platelet Factor 4 *

L. Rauova, J. Weisel, V. Barsegov, 2013 .

Polyhedrocytes: Compressed Polyhedral Erythrocytes In Contracted Blood Clots and Thrombi

L. Rauova, J. Weisel, D. Cines, 2013 .

tPA variant tPA‐A296–299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET‐1

W. Armstead, D. Cines, A. Higazi, 2018, Journal of neuroscience research.

Combination therapy with glucagon and a novel plasminogen activator inhibitor-1-derived peptide enhances protection against impaired cerebrovasodilation during hypotension after traumatic brain injury through inhibition of ERK and JNK MAPK

W. Armstead, D. Cines, A. Higazi, 2012, Neurological research.

Plasminogen Activators Contribute to Impairment of Hypercapnic and Hypotensive Cerebrovasodilation After Cerebral Hypoxia/Ischemia in the Newborn Pig

W. Armstead, D. Cines, A. Higazi, 2005 .

Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia.

D. Cines, M. Crowther, G. Arepally, 2018, Blood advances.

Thrombocytopenia in pregnancy.

D. Cines, L. Levine, 2017, Hematology. American Society of Hematology. Education Program.

Thrombotic microangiopathy during pregnancy.

D. Cines, K. McCrae, D. Cines, 1997, Seminars in hematology.

Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

S. Watson, D. Cines, J. Rux, 2012, Blood.

Altered NO function contributes to impairment of uPA and tPA cerebrovasodilation after brain injury.

W. Armstead, D. Cines, A. Al-Roof Higazi, 2004, Journal of neurotrauma.

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

W. Armstead, D. Cines, A. Higazi, 2019, Translational Stroke Research.

Regulation of Single Chain Urokinase Binding, Internalization, and Degradation by a Plasminogen Activator Inhibitor 1-Derived Peptide*

D. Cines, A. Higazi, D. Strickland, 1997, The Journal of Biological Chemistry.

Nuclear Translocation of Urokinase-type Plasminogen Activator Lentivirus-based Nucleolin Rna Interference

D. Cines, K. Bdeir, S. Tkachuk, 2022 .

tPA regulates pulmonary vascular activity through NMDA receptors.

T. Allen, D. Cines, K. Bdeir, 2011, American journal of physiology. Lung cellular and molecular physiology.

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

C. Ruppert, E. Abraham, S. Shetty, 2010, American journal of respiratory and critical care medicine.

Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by Surface Plasmon Resonance (BiaCore)

D. Cines, K. Bdeir, B. Ghebrehiwet, 2011, Thrombosis and Haemostasis.

Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors

D. Cines, V. Krymskaya, Y. Parfyonova, 2017, The Journal of Biological Chemistry.

Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis

V. Muzykantov, J. Atkinson, M. Poncz, 2010, Journal of Pharmacology and Experimental Therapeutics.

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability.

J. Weisel, D. Cines, K. Bdeir, 2019, Blood.

The ITP syndrome: pathogenic and clinical diversity.

E. L. Luning Prak, J. Bussel, D. Cines, 2009, Blood.

Neutrophil accumulation and NET release contribute to thrombosis in HIT.

L. Rauova, M. Poncz, D. Cines, 2018, JCI insight.

Minimal role for the alternative pathway in complement activation by HIT immune complexes

L. Rauova, B. Garcia, D. Cines, 2022, Journal of thrombosis and haemostasis : JTH.

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension

P. Wolters, H. DeLisser, M. Poncz, 2023, bioRxiv.

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

D. Cines, K. Bdeir, S. Seeholzer, 2016, Blood.

Clot penetration and retention by plasminogen activators promote fibrinolysis.

R. Shlansky-Goldberg, V. Muzykantov, D. Cines, 2013, Biochemical pharmacology.

The immune thrombocytopenia syndrome: a disorder of diverse pathogenesis and clinical presentation.

D. Cines, H. Liebman, 2009, Hematology/oncology clinics of North America.

Thrombosis: Dissociation between Anticoagulant and Antithrombotic Transgenic Mice Studies Demonstrate a Role for Platelet Factor 4 In

L. Rauova, M. Poncz, D. Cines, 2022 .

D. Cines, K. Bdeir, A. Higazi, 2011, The Journal of Biological Chemistry.