A. Higazi

发表

uPA Modulates the Age-Dependent Effect of Brain Injury on Cerebral Hemodynamics through LRP and ERK MAPK

S. Stein, W. Armstead, D. Cines, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Urokinase plasminogen activator impairs SNP and PGE2 cerebrovasodilation after brain injury through activation of LRP and ERK MAPK.

W. Armstead, D. Cines, A. Higazi, 2008, Journal of neurotrauma.

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.

D. Cines, A. Higazi, R. Abramovitch, 2015, Blood.

α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol*

D. Cines, A. Higazi, G. Blum, 2015, The Journal of Biological Chemistry.

Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.

S. Vinogradov, T. Ganz, T. Allen, 2010, American journal of respiratory and critical care medicine.

Red Blood Cells-Coupled tPA Prevents Impairment of Cerebral Vasodilatory Responses and Tissue Injury in Pediatric Cerebral Hypoxia/Ischemia through Inhibition of ERK MAPK Activation

V. Muzykantov, Douglas H. Smith, W. Armstead, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile.

V. Muzykantov, D. Cines, A. Higazi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig

V. Muzykantov, W. Armstead, D. Cines, 2011, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis

V. Muzykantov, W. Armstead, D. Cines, 2011, Translational Stroke Research.

α-Defensin: Link between inflammation and atherosclerosis

K. Bdeir, A. Higazi, E. Lavi, 2007 .

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor (*)

J. Henkin, D. Cines, A. Higazi, 1995, The Journal of Biological Chemistry.

Distribution of natural radioactivity around mechanized and non-mechanized mining regions

A. Higazi, I. Salih, H. Idriss, 2019, Acta Geophysica.

Urokinase-type Plasminogen Activator (uPA) Induces Pulmonary Microvascular Endothelial Permeability through Low Density Lipoprotein Receptor-related Protein (LRP)-dependent Activation of Endothelial Nitric-oxide Synthase*

D. Cines, K. Bdeir, A. Higazi, 2011, The Journal of Biological Chemistry.

LRP and αvβ3 mediate tPA activation of smooth muscle cells

D. Cines, A. Higazi, M. Tarshis, 2006 .

LRP and alphavbeta3 mediate tPA activation of smooth muscle cells.

D. Cines, A. Higazi, M. Tarshis, 2006, American journal of physiology. Heart and circulatory physiology.

Human α-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor–related protein/α2-macroglobulin receptor

A. Al-Mehdi, R. Bar-Shavit, K. Bdeir, 2002 .

Tissue-Type Plasminogen Activator-A296–299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor–Dependent Increase in cAMP and p38

W. Armstead, D. Cines, A. Higazi, 2016, Stroke.

Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.

W. Armstead, D. Cines, A. Higazi, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPK

S. Stein, W. Armstead, D. Cines, 2008, Brain Research.

tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK

W. Armstead, D. Cines, A. Higazi, 2011, Brain Research.

tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK

W. Armstead, D. Cines, A. Higazi, 2011, Neurological research.

Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.

W. Armstead, D. Cines, A. Higazi, 2009, American journal of physiology. Heart and circulatory physiology.

Inhibition of integrin V 3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia / ischemia

W. Armstead, D. Cines, A. Higazi, 2009 .

tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.

W. Armstead, D. Cines, A. Higazi, 2013, Journal of neurotrauma.

tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

Douglas H. Smith, W. Armstead, D. Cines, 2012, Journal of neurotrauma.

Crystallization of soluble urokinase receptor (suPAR) in complex with urokinase amino-terminal fragment (1-143).

A. Mazar, Mingdong Huang, D. Cines, 2005, Acta crystallographica. Section D, Biological crystallography.

Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

A. Al-Mehdi, R. Bar-Shavit, K. Bdeir, 2002, Blood.

Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis

D. Cines, K. Bdeir, A. Higazi, 2020, PloS one.

Regulation of neovascularization by human neutrophil peptides (α‐defensins): a link between inflammation and angiogenesis

H. Hammes, K. Preissner, O. Liang, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.

W. Armstead, D. Cines, A. Higazi, 2010, American journal of physiology. Heart and circulatory physiology.

Plasminogen Activators Contribute to Impairment of Hypercapnic and Hypotensive Cerebrovasodilation After Cerebral Hypoxia/Ischemia in the Newborn Pig

W. Armstead, D. Cines, A. Higazi, 2005 .

Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.

T. Allen, D. Cines, A. Higazi, 2010, American journal of respiratory cell and molecular biology.

Tissue-Type Plasminogen Activator-A 296 – 299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor – Dependent Increase in cAMP and p 38

W. Armstead, D. Cines, A. Higazi, 2016 .

Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice.

T. Allen, D. Cines, A. Higazi, 2011, American journal of respiratory cell and molecular biology.

tPA regulates pulmonary vascular activity through NMDA receptors.

T. Allen, D. Cines, K. Bdeir, 2011, American journal of physiology. Lung cellular and molecular physiology.

Glucagon protects against impaired NMDA-mediated cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A and inhibiting upregulation of tPA.

W. Armstead, D. Cines, A. Higazi, 2011, Journal of Neurotrauma.

Regulation of the single-chain urokinase-urokinase receptor complex activity by plasminogen and fibrin: novel mechanism of fibrin specificity.

D. Cines, A. Higazi, A. Kuo, 2005, Blood.

Tissue Factor Regulates Plasminogen Binding and Activation

I. Chaiken, D. Cines, A. Higazi, 1998 .

Complexes Lysis of Plasma Clots by Urokinase-Soluble Urokinase Receptor

D. Cines, K. Bdeir, A. Higazi, 2013 .

Lysis of plasma clots by urokinase-soluble urokinase receptor complexes.

D. Cines, K. Bdeir, A. Higazi, 1998, Blood.

The fibrinolytic system attenuates vascular tone: effects of tissue plasminogen activator (tPA) and aminocaproic acid on renal microcirculation

A. Higazi, S. Rosen, S. Heyman, 2004, British journal of pharmacology.

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

W. Armstead, D. Cines, A. Higazi, 2019, Translational Stroke Research.

Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate.

A. Higazi, S. Heyman, N. Hijazi, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Regulation of Single Chain Urokinase Binding, Internalization, and Degradation by a Plasminogen Activator Inhibitor 1-Derived Peptide*

D. Cines, A. Higazi, D. Strickland, 1997, The Journal of Biological Chemistry.

In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone.

K. Bdeir, A. Higazi, S. Heyman, 2004, Blood.

Binding of Urokinase to Low Density Lipoprotein-related Receptor (LRP) Regulates Vascular Smooth Muscle Cell Contraction*

A. Mazar, D. Cines, K. Bdeir, 2002, The Journal of Biological Chemistry.

Novel Interactions between Urokinase and Its Receptor*

J. Weisel, A. Mazar, K. Bdeir, 2000, The Journal of Biological Chemistry.

Nuclear translocation of urokinase-type plasminogen activator.

M. Marks, V. Tkachuk, D. Cines, 2008, Blood.

Neuroprotection by glucagon: role of gluconeogenesis.

G. Goelman, A. Higazi, S. Heyman, 2011, Journal of neurosurgery.

Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection

M. Feldman, D. Cines, K. Bdeir, 2021, British journal of haematology.

Divergent impacts of tocilizumab and colchicine in COVID‐19‐associated coagulopathy: the role of alpha‐defensins

D. Cines, K. Bdeir, A. Higazi, 2021, British Journal of Haematology.

A Region in Domain II of the Urokinase Receptor Required for Urokinase Binding*

A. Mazar, D. Cines, K. Bdeir, 2000, The Journal of Biological Chemistry.

Neutralizing the neurotoxic effects of exogenous and endogenous tPA

Douglas H. Smith, W. Armstead, D. Cines, 2006, Nature Neuroscience.

PAI-1-Derived Peptide EEIIMD Prevents Hypoxia/Ischemia-Induced Aggravation of Endothelin- and Thromboxane-Induced Cerebrovasoconstriction

W. Armstead, D. Cines, A. Higazi, 2014, Neurocritical Care.

Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders

V. Muzykantov, W. Armstead, D. Cines, 2010, Journal of neurochemistry.

Conflicting impacts of tocilizumab and colchicine in COVID-19-associated coagulop.

D. Cines, K. Bdeir, A. Higazi, 2021, British journal of haematology.

RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis

V. Muzykantov, W. Armstead, D. Cines, 2012, Translational Stroke Research.

Blood–brain barrier permeability and tPA-mediated neurotoxicity

Anwar Rayan, D. Cines, A. Higazi, 2010, Neuropharmacology.

Defensin Modulates Tissue-type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells*

T. Ganz, D. Cines, A. Higazi, 1996, The Journal of Biological Chemistry.

Contact with stroke.

D. Cines, A. Higazi, 2012, Blood.

tPA variant tPA‐A296–299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET‐1

W. Armstead, D. Cines, A. Higazi, 2018, Journal of neuroscience research.

Combination therapy with glucagon and a novel plasminogen activator inhibitor-1-derived peptide enhances protection against impaired cerebrovasodilation during hypotension after traumatic brain injury through inhibition of ERK and JNK MAPK

W. Armstead, D. Cines, A. Higazi, 2012, Neurological research.