K. Chang

Jae Heun Lee, H. Seo, K. Chang, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.

Jae Heun Lee, Y. M. Kim, K. Chang, 2012, Journal of ethnopharmacology.

YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1.

Jae Heun Lee, H. Seo, K. Chang, 2008, Life sciences.

PPARδ promotes wound healing by up-regulating TGF-β1-dependent or -independent expression of extracellular matrix proteins

Jae Heun Lee, Hyun Joon Kim, E. S. Kang, 2009, Journal of cellular and molecular medicine.

Degradation of histone deacetylase 4 via the TLR4/JAK/STAT1 signaling pathway promotes the acetylation of high mobility group box 1 (HMGB1) in lipopolysaccharide‐activated macrophages

E. Park, Y. M. Kim, K. Chang, 2018, FEBS open bio.

Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.

Jae Heun Lee, E. Park, Y. M. Kim, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals.

Jae Heun Lee, E. Park, K. Tsoyi, 2012, Antioxidants & redox signaling.

Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2011, British journal of pharmacology.

β₁-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice.

Jae Heun Lee, Y. M. Kim, H. Seo, 2011, Biochemical pharmacology.

DIRECT EFFECT OF DEXMEDETOMIDINE ON RAT ISOLATED AORTA INVOLVES ENDOTHELIAL NITRIC OXIDE SYNTHESIS AND ACTIVATION OF THE LIPOXYGENASE PATHWAY

K. Chang, H. Kim, Chang-Shin Park, 2009, Clinical and experimental pharmacology & physiology.

Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat.

Jae Heun Lee, Y. M. Kim, H. Seo, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.

Min Young Kim, Chang Woo Han, Jae Heun Lee, 2011, Biochemical and biophysical research communications.

Akt-dependent heme oxygenase-1 induction by NS-398 in C6 glial cells: A potential role for CO in prevention of oxidative damage from hypoxia

Jae Heun Lee, Y. M. Kim, H. Seo, 2007, Neuropharmacology.

Luteolin activates ERK1/2- and Ca2+-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and mitigates acute lung injury of endotoxin mice

E. Park, Y. M. Kim, K. Chang, 2018, Inflammation Research.

Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.

Jae Heun Lee, E. S. Kang, H. Seo, 2005, The international journal of biochemistry & cell biology.

P2Y2R activation by nucleotides promotes skin wound‐healing process

Jae Heun Lee, K. Chang, H. Kim, 2014, Experimental dermatology.

IL-1β enhances vascular smooth muscle cell proliferation and migration via P2Y2 receptor-mediated RAGE expression and HMGB1 release.

K. Chang, H. Kim, S. Park, 2015, Vascular pharmacology.

Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kappaB activation.

Jae Heun Lee, Y. M. Kim, H. Seo, 2009, Life sciences.

Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.

Jae Heun Lee, C. Yabe-Nishimura, E. S. Kang, 2007, Free radical biology & medicine.

Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB.

Min Young Kim, Jae Heun Lee, E. S. Kang, 2008, Pharmacological research.

Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes.

K. Chang, H. Kim, S. Park, 2014, Journal of ethnopharmacology.

Anthocyanins from soybean seed coat inhibit the expression of TNF‐α‐induced genes associated with ischemia/reperfusion in endothelial cell by NF‐κB‐dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo

S. Shin, J. Chung, K. Chang, 2006, FEBS letters.

Anthocyanins from black soybean seed coats preferentially inhibit TNF-alpha-mediated induction of VCAM-1 over ICAM-1 through the regulation of GATAs and IRF-1.

Jae Heun Lee, S. Shin, Y. M. Kim, 2009, Journal of agricultural and food chemistry.

Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells

Jae Heun Lee, Soon-Chan Hong, E. S. Kang, 2010, Neuroscience Letters.

Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells.

Jae Heun Lee, S. Shin, Y. M. Kim, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals.

S. Kim, E. Park, Y. M. Kim, 2015, Biochemical pharmacology.

Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants.

Jae Heun Lee, Hyung-Ryong Kim, H. Seo, 2007, International immunopharmacology.

EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells.

Jae Heun Lee, H. Seo, K. Chang, 2009, Biochemical and biophysical research communications.

Indigo carmine enhances phenylephrine-induced contractions in an isolated rat aorta

K. Chang, H. Kim, Y. Ha, 2011, Korean journal of anesthesiology.

Anti‐inflammatory effects of anthocyanins from black soybean seed coat on the keratinocytes and ischemia‐reperfusion injury in rat skin flaps

S. Shin, J. Chung, K. Chang, 2012, Microsurgery.

Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages.

Cheorl-Ho Kim, H. Seo, K. Chang, 2003, Life sciences.

Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo.

E. Park, K. Chang, H. Kim, 2014, International immunopharmacology.

(+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction.

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2011, Journal of ethnopharmacology.

Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction.

Jae Heun Lee, Y. M. Kim, H. Seo, 2011, Journal of ethnopharmacology.

Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.

Jae Heun Lee, Y. M. Kim, H. Seo, 2009, Atherosclerosis.

Activation of PPAR-γ by Carbon Monoxide from CORM-2 Leads to the Inhibition of iNOS but not COX-2 Expression in LPS-Stimulated Macrophages

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2009, Inflammation.

Regulation of Lipopolysaccharide-Induced Inducible Nitric-Oxide Synthase Expression through the Nuclear Factor-κB Pathway and Interferon-β/Tyrosine Kinase 2/Janus Tyrosine Kinase 2-Signal Transducer and Activator of Transcription-1 Signaling Cascades by 2-Naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahyd

Jae Heun Lee, K. Tsoyi, H. Seo, 2007, Journal of Pharmacology and Experimental Therapeutics.

Regulation of Lipopolysaccharide-Induced Inducible Nitric-Oxide Synthase Expression through the Nuclear Factor- (cid:1) B Pathway and Interferon- (cid:2) /Tyrosine Kinase 2/Janus Tyrosine Kinase 2-Signal Transducer and Activator of Transcription-1 Signaling Cascades by 2-Naphthylethyl-6,7-dihydroxy-

Jae Heun Lee, K. Tsoyi, H. Seo, 2007 .

Selective activation of adrenergic β1 receptors induces heme oxygenase 1 production in RAW264.7 cells

Jae Heun Lee, H. Seo, K. Chang, 2005, FEBS letters.

NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition

Jae Heun Lee, H. Seo, K. Chang, 2009, Archives of pharmacal research.

Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo.

Y. M. Kim, H. Seo, K. Chang, 2009, European journal of pharmacology.

Carbon Monoxide From CORM-2 Reduces HMGB1 Release Through Regulation of IFN-&bgr;/JAK2/STAT-1/INOS/NO Signaling But Not COX-2 in TLR-Activated Macrophages

Jae Heun Lee, K. Tsoyi, H. Seo, 2010, Shock.

Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264.7 cells and endotoxemic mice.

E. Park, Y. M. Kim, K. Chang, 2018, Biochemical and biophysical research communications.

Ran suppresses paclitaxel-induced apoptosis in human glioblastoma cells

Chang Woo Han, Jae Heun Lee, H. Seo, 2008, Apoptosis.

Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities

S. Ryter, Hyo Jeong Kim, K. Chang, 2012, Journal of Pharmacology and Experimental Therapeutics.

Is α-adrenoceptor blockade responsible for atropine flush?

K. Chang, K. Hahn, 1995 .

Protective effect of anthocyanins from black soybean seed coats on UVB-induced apoptotic cell death in vitro and in vivo.

Jae Heun Lee, S. Shin, K. Tsoyi, 2008, Journal of agricultural and food chemistry.

Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues.

K. Chang, Y. Jin, J. Jung, 2008, The journal of sexual medicine.

YS 51, 1-(beta-naphtylmethyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1.

Jae Heun Lee, H. Seo, K. Chang, 2007, Biochemical pharmacology.

CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN.

E. Park, K. Tsoyi, Y. M. Kim, 2014, Life sciences.

Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation.

K. Chang, H. Yun-Choi, M. Pyo, 2007, Thrombosis research.

Suppression of tumor necrosis factor-alpha and inducible nitric oxide synthase gene expression by THI 52, a new synthetic naphthyl-benzylisoquinoline alkaloid.

H. Seo, K. Chang, Y. Kang, 2003, Biochemical pharmacology.

A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock.

K. Chang, Y. Kang, S. Seo, 2002, The Journal of pharmacology and experimental therapeutics.

Transforming Growth Factor- (cid:1) 1 Is a Molecular Target for the Peroxisome Proliferator-Activated Receptor (cid:2)

C. Yabe-Nishimura, H. Seo, K. Chang, 2008 .

Transforming Growth Factor- 1 Is a Molecular Target for the Peroxisome Proliferator-Activated Receptor

C. Yabe-Nishimura, H. Seo, K. Chang, 2008 .

13-Ethylberberine reduces HMGB1 release through AMPK activation in LPS-activated RAW264.7 cells and protects endotoxemic mice from organ damage.

K. Chang, H. Kim, Y. Ko, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice.

K. Chang, 2015, Thrombosis research.

(S)‐1‐α‐naphthylmethyl‐6,7‐dihydroxy‐1,2,3,4‐tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO‐1 induction in human dermal fibroblasts and mouse skin

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2013, British journal of pharmacology.

Nootkatone from the Rhizomes of Cyperus rotundus Protects Against Ischemia-reperfusion Mediated Acute Myocardial Injury in the Rat

K. Chang, Dong-Ung Lee, 2016 .

C-Jun NH2-Terminal Kinase Contributes to Dexmedetomidine-Induced Contraction in Isolated Rat Aortic Smooth Muscle

K. Chang, H. Kim, Seong-chun Kwon, 2011, Yonsei medical journal.

Peroxisome Proliferator-Activated Receptor &dgr; Regulates Extracellular Matrix and Apoptosis of Vascular Smooth Muscle Cells Through the Activation of Transforming Growth Factor-β1/Smad3

Min Young Kim, Jae Heun Lee, Hyun Joon Kim, 2009, Circulation research.

Peroxisome Proliferator-Activated Receptor (cid:1) Regulates Extracellular Matrix and Apoptosis of Vascular Smooth Muscle Cells Through the Activation of Transforming Growth Factor- (cid:2) 1/Smad3

Jae Heun Lee, Hyun Joon Kim, S. Kang, 2009 .

Heme oxygenase-1 induction through p 38 MAPK / Nrf 2 activation by ethanol extract of Artemisia capillaries inhibits LPS-activated iNOS , COX-2 , and HMGB 1 in RAW 264 . 7 cells

Jae Heun Lee, E. Park, Y. M. Kim, 2013 .

Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation.

K. Chang, Ji-hye Lee, H. Yun-Choi, 2008, Bioorganic & medicinal chemistry letters.

Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo.

H. Seo, K. Chang, H. Kim, 2009, Vascular pharmacology.

A Supraclinical Dose of Tramadol Stereoselectively Attenuates Endothelium-Dependent Relaxation in Isolated Rat Aorta

K. Chang, J. Sohn, Il-Woo Shin, 2006, Anesthesia and analgesia.

P2Y(2)R activation by nucleotides released from oxLDL-treated endothelial cells (ECs) mediates the interaction between ECs and immune cells through RAGE expression and reactive oxygen species production.

Jae Heun Lee, K. Chang, H. Kim, 2014, Free radical biology & medicine.

Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells.

Jae Heun Lee, H. Seo, K. Chang, 2011, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

LPS potentiates nucleotide-induced inflammatory gene expression in macrophages via the upregulation of P2Y2 receptor.

Jae Heun Lee, K. Chang, H. Kim, 2014, International immunopharmacology.

Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1.

Y. M. Kim, K. Chang, H. Kim, 2015, International immunopharmacology.

Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.

Jae Heun Lee, Jong Sil Lee, H. Seo, 2008, Carcinogenesis.

Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells.

Jae Heun Lee, H. Seo, K. Chang, 2008, International journal of oncology.

Tanshinone IIA inhibits TNF-α-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1.

Jae Heun Lee, Y. M. Kim, K. Chang, 2012, International immunopharmacology.

Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat

K. Chang, Y. Kang, J. Ryu, 1998 .

Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats.

Yong Chun Jin, Jae Heun Lee, H. Seo, 2008, Planta medica.

Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells.

K. Chang, H. Kim, Yeong Shik Kim, 2008, International immunopharmacology.

Radioresistant breast cancer cells exhibit increased resistance to chemotherapy and enhanced invasive properties due to cancer stem cells.

Jong Sil Lee, K. Chang, H. Kim, 2018, Oncology reports.

Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity.

Jae Heun Lee, E. S. Kang, H. Seo, 2006, Biochemical and biophysical research communications.

Expression of a Peroxisome Proliferator-Activated Receptor γ1 Splice Variant that Was Identified in Human Lung Cancers Suppresses Cell Death Induced by Cisplatin and Oxidative Stress

Jae Heun Lee, W. Choi, C. Yabe-Nishimura, 2007, Clinical Cancer Research.

HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

Jae Heun Lee, Hee-Jeong Cho, K. Tsoyi, 2008, Cellular signalling.

Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.

Jae Heun Lee, K. Tsoyi, H. Seo, 2011, Antioxidants & redox signaling.

P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment

K. Chang, H. Kim, S. Park, 2014, Oncotarget.

Honokiol exerts an anticancer effect in T98G human glioblastoma cells through the induction of apoptosis and the regulation of adhesion molecules.

Jae Heun Lee, K. Chang, H. Kim, 2012, International journal of oncology.

P2Y2receptor activation by nucleotides released from highly metastatic breast cancer cells increases tumor growth and invasion via crosstalk with endothelial cells

Hana Jin, Jae Heun Lee, Jong Sil Lee, 2014, Breast Cancer Research.

Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta.

K. Chang, H. Kim, S. Ok, 2012, Canadian journal of physiology and pharmacology.

Diazepam Attenuates Phenylephrine-Induced Contractions in Rat Aorta

K. Chang, S. Park, J. Sohn, 2006, Anesthesia and analgesia.

Inhibitory effect of tramadol on vasorelaxation mediated by ATP-sensitive K+ channels in rat aorta

K. Chang, J. Sohn, Il-Woo Shin, 2007, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages

Y. Lee, K. Chang, Y. Kang, 1999, British journal of pharmacology.

Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition.

Jae Heun Lee, K. Chang, H. Kim, 2014, International journal of oncology.

TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential.

Hana Jin, Jae Heun Lee, W. Choi, 2011, Cancer letters.

Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways.

K. Chang, H. Kim, Yeong Shik Kim, 2007, International immunopharmacology.

Transforming Growth Factor- (cid:1) 1 Is a Molecular Target for the Peroxisome Proliferator-Activated Receptor (cid:2)

C. Yabe-Nishimura, H. Seo, K. Chang, 2008 .

The proximal tubular α7 nicotinic acetylcholine receptor attenuates ischemic acute kidney injury through Akt/PKC signaling-mediated HO-1 induction

K. Chang, H. Kim, S. Park, 2018, Experimental & Molecular Medicine.

The proximal tubular α7 nicotinic acetylcholine receptor attenuates ischemic acute kidney injury through Akt/PKC signaling-mediated HO-1 induction

K. Chang, H. Kim, S. Park, 2018, Experimental & Molecular Medicine.

Resveratrol induces hepatic mitochondrial biogenesis through the sequential activation of nitric oxide and carbon monoxide production.

S. Ryter, Jin Han, G. Cho, 2014, Antioxidants & redox signaling.

Role of heme oxygenase in preserving vascular bioactive NO.

K. Chang, H. Jeong, Hun-taeg Chung, 2010, Nitric oxide : biology and chemistry.

Iron Released by Sodium Nitroprusside Contributes to Heme Oxygenase-1 Induction via the cAMP-Protein Kinase A-Mitogen-Activated Protein Kinase Pathway in RAW 264.7 Cells

Jae Heun Lee, H. Seo, K. Chang, 2006, Molecular Pharmacology.

MKP-7, a negative regulator of JNK, regulates VCAM-1 expression through IRF-1.

Jae Heun Lee, Y. M. Kim, K. Chang, 2012, Cellular signalling.

PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells.

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2010, Atherosclerosis.

Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression.

Y. M. Kim, K. Chang, H. Kim, 2008, International immunopharmacology.

Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury.

Jae Heun Lee, H. Seo, K. Chang, 2006, Journal of ethnopharmacology.

Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo.

Min Young Kim, Jae Heun Lee, G. Roh, 2011, Atherosclerosis.

Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury

Jae Heun Lee, H. Seo, K. Chang, 2006, Apoptosis.

Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophages.

E. Park, Y. M. Kim, K. Chang, 2016, International immunopharmacology.

The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain.

Jae Heun Lee, H. Seo, K. Chang, 2008, Biochemical and biophysical research communications.

Effects of Two Tetrahydroisoquinolines (YS-49 and YS-51) on Experimental Disseminated Intravascular Coagulation Induced by Lipopolysaccharide in Rats

K. Chang, H. Yun-Choi, M. Pyo, 2004, Arzneimittelforschung.

DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells.

W. Choi, W. Paik, K. Chang, 2009, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation.

Jae Heun Lee, C. Yabe-Nishimura, E. S. Kang, 2011, Free radical biology & medicine.

Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways

Min Young Kim, Jae Heun Lee, Y. M. Kim, 2012, Apoptosis.

Inhibition of lipopolysaccharide-induced inducible nitric oxide (iNOS) mRNA expression and nitric oxide production by higenamine in murine peritoneal macrophages

H. W. Lee, E. Kim, K. Chang, 1999, Archives of pharmacal research.

7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells.

Jae Heun Lee, Y. M. Kim, H. Seo, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes.

K. Chang, H. Kim, S. Park, 2015, Toxicology and applied pharmacology.

Biochemical investigation of Amm3, an unusual flavin-dependent tryptophan halogenase involved in the cryptic biosynthesis of the ammosamides

K. Chang, 2017 .

Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells

E. Jeong, B. Jeon, Dong Hoon Lee, 2011, Anatomy & cell biology.

Role of Thrombotic and Fibrinolytic Disorders in the Etiology of Perthes’ Disease

Hae-Ryong Song, K. Chang, Y. Ha, 2002, Clinical orthopaedics and related research.

13-Ethylberberine Induces Apoptosis through the Mitochondria-Related Apoptotic Pathway in Radiotherapy-Resistant Breast Cancer Cells

K. Chang, H. Kim, S. Park, 2019, Molecules.

Valsartan independent of AT1 receptor inhibits tissue factor, TLR-2 and-4 expression by regulation of Egr-1 through activation of AMPK in diabetic conditions

E. Park, K. Chang, H. Kim, 2014, Journal of cellular and molecular medicine.

Relaxation of canine corporal smooth muscle relaxation by ginsenoside saponin Rg3 is independent from eNOS activation.

K. Chang, Y. Kang, J. Sohn, 2005, Life Science.

Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.

Jae Heun Lee, Y. M. Kim, H. Seo, 2011, Journal of ethnopharmacology.

Transforming growth factor-beta1 is a molecular target for the peroxisome proliferator-activated receptor delta.

C. Yabe-Nishimura, H. Seo, K. Chang, 2008, Circulation research.

Etomidate attenuates phenylephrine-induced contraction in isolated rat aorta

K. Chang, J. Sohn, Il-Woo Shin, 2005, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Calcium channel blocking and α-adrenoceptor blocking action of Coptidis rhizoma extracts and their alkaloid components in rat aorta

K. Chang, Dong Ung Lee, 1996 .

The effects of higenamine on LPS-induced experimental disseminated intravascular coagulation (DIC) in rats.

K. Chang, H. Yun-Choi, M. Pyo, 2002, Planta medica.

Ethanol Extract of Prunella vulgaris var. lilacina Inhibits HMGB1 Release by Induction of Heme Oxygenase‐1 in LPS‐activated RAW 264.7 Cells and CLP‐induced Septic Mice

Jae Heun Lee, E. Park, Y. M. Kim, 2012, Phytotherapy research : PTR.

Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells.

Jae Heun Lee, E. S. Kang, H. Seo, 2006, Biochemical and biophysical research communications.

P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells.

K. Chang, H. Kim, S. Park, 2015, Oncology reports.

P 2 Y 2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells

K. Chang, H. Kim, S. Park, 2015 .

NS-398, a selective COX-2 inhibitor, inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1.

K. Chang, H. Choi, H. Kim, 2008, Biochemical and biophysical research communications.

Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain.

Jae Heun Lee, H. Seo, K. Chang, 2008, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells.

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2009, Atherosclerosis.

P2Y2receptor activation by nucleotides released from highly metastatic breast cancer cells increases tumor growth and invasion via crosstalk with endothelial cells

Jae Heun Lee, K. Chang, H. Kim, 2014, Breast Cancer Research.

High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor.

Jae Heun Lee, H. Seo, K. Chang, 2009, Cancer letters.

Tristetraprolin Mediates Anti-inflammatory Effects of Nicotine in Lipopolysaccharide-stimulated Macrophages*

Hyo Jeong Kim, W. Lee, Jeong Woo Park, 2011, The Journal of Biological Chemistry.

Up-regulation of Heme Oxygenase-1 Expression by cAMP-elevating Agents in RAW 264.7 cells

H. Seo, K. Chang, Y. Kang, 2002 .

Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-α and IL-1β

Jae Heun Lee, E. S. Kang, H. Seo, 2005 .

Calcium sensitization involved in dexmedetomidine-induced contraction of isolated rat aorta.

K. Chang, H. Kim, Seong-chun Kwon, 2011, Canadian journal of physiology and pharmacology.

Honokiol inhibits U 87 MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition

Jae Heun Lee, K. Chang, H. Kim, 2013 .

(S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation.

E. Park, Y. M. Kim, K. Chang, 2016, European journal of pharmacology.

Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening.

Min Young Kim, Jae Heun Lee, H. Seo, 2008, Biochemical and biophysical research communications.

13-Methylberberine reduces HMGB1 release in LPS-activated RAW264.7 cells and increases the survival of septic mice through AMPK/P38 MAPK activation.

K. Chang, H. Kim, Dong-Ung Lee, 2016, International immunopharmacology.

Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

Jae Heun Lee, K. Tsoyi, Y. M. Kim, 2011, British journal of pharmacology.

Jae Heun Lee, K. Tsoyi, H. Seo, 2009, Molecular Pharmacology.

Anti-Apoptotic Effect of Magnolol in Myocardial Ischemia and Reperfusion Injury Requires Extracellular Signal-Regulated Kinase1/2 Pathways in Rat In Vivo

Jae Heun Lee, Y. M. Kim, H. Seo, 2008, Experimental biology and medicine.

Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation

H. J. Kim, Jae Heun Lee, C. Yabe-Nishimura, 2005, Cellular and Molecular Life Sciences CMLS.

Transforming Growth Factor-&bgr;1 Is a Molecular Target for the Peroxisome Proliferator-Activated Receptor &dgr;

C. Yabe-Nishimura, K. Chang, S. A. Ham, 2008 .

Carbon Monoxide From CORM-2 Reduces HMGB1 Release Through Regulation of IFN-&bgr;/JAK2/STAT-1/INOS/NO Signaling But Not COX-2 in TLR-Activated Macrophages

Jae Heun Lee, K. Tsoyi, H. Seo, 2010, Shock.

7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells.

Jae Heun Lee, Y. M. Kim, H. Seo, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.

Jae Heun Lee, E. Park, Y. M. Kim, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN.

E. Park, K. Tsoyi, Y. M. Kim, 2014, Life sciences.

Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals.

S. Kim, E. Park, Y. M. Kim, 2015, Biochemical pharmacology.

Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes.

C. Yabe-Nishimura, H. Seo, K. Chang, 2002, Molecular pharmacology.

EPA Downregulate COX-2 Expression through Suppression of NF-κ B Activity in LPS-treated Human Umbilical Vein Endothelial Cells

W. Choi, W. Paik, K. Chang, 2009 .

Anti‐inflammatory effects of anthocyanins from black soybean seed coat on the keratinocytes and ischemia‐reperfusion injury in rat skin flaps

S. Shin, J. Chung, K. Chang, 2012, Microsurgery.