C. Yun

发表

Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.

V. Yang, Raluca Rusovici, A. Ghaleb, 2007, Biochimica et biophysica acta.

The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.

C. Yun, Peijian He, Luqing Zhao, 2016, American journal of physiology. Renal physiology.

Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor.

F. Lang, C. Yun, Dongsheng Wang, 2007, American journal of physiology. Cell physiology.

Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse.

F. Artunc, F. Lang, D. Alessi, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Unique Regulation of Human Na+/H+ Exchanger 3 (NHE3) by Nedd4-2 Ligase That Differs from Non-primate NHE3s*

C. Yun, Peijian He, Y. No, 2014, The Journal of Biological Chemistry.

Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe

M. Amiri, C. Yun, U. Seidler, 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Regulation of NHE 3 by lysophosphatidic acid is mediated by phosphorylation of NHE 3 by RSK 2

C. Yun, Peijian He, B. K. Yoo, 2015 .

Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.

C. Yun, Peijian He, Y. No, 2015, American journal of physiology. Cell physiology.

Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.

C. Yun, Peijian He, Sei-Jung Lee, 2011, American journal of physiology. Cell physiology.

Ubiquitin‐specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity

C. Yun, Yiran Han, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Nedd4-2–dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli

C. Yun, K. Jenkin, Peijian He, 2021, Cellular and molecular gastroenterology and hepatology.

Regulation of the Na/H Exchanger Regulatory Factor in OK Cells

S. Shenolikar, C. Yun, E. Weinman, 1999, Mineral and Electrolyte Metabolism.

Coexpression of MAST 205 inhibits the activity of Na / H exchanger NHE 3

C. Yun, P. Walden, Dongsheng Wang, 2005 .

LPA 2 receptor mediates mitogenic signals in human colon cancer cells

Hong Sun, Raluca Rusovici, H. Shim, 2005 .

Lysophosphatidic Acid Facilitates Proliferation of Colon Cancer Cells via Induction of Krüppel-like Factor 5*

V. Yang, Raluca Rusovici, H. Shim, 2007, Journal of Biological Chemistry.

Protein Inhibitor of Activated STAT1 Interacts with and Up-regulates Activities of the Pro-proliferative Transcription Factor Krüppel-like Factor 5*

V. Yang, C. Yun, C. Yun, 2007, Journal of Biological Chemistry.

NHE2 contains subdomains in the COOH terminus for growth factor and protein kinase regulation.

M. Donowitz, C. Yun, C. Tse, 1999, American journal of physiology. Cell physiology.

cGMP Inhibition of Na+/H+ Antiporter 3 (NHE3) Requires PDZ Domain Adapter NHERF2, a Broad Specificity Protein Kinase G-anchoring Protein*

S. Lohmann, M. Cavet, M. Donowitz, 2005, Journal of Biological Chemistry.

Glucocorticoid Activation of Na+/H+Exchanger Isoform 3 Revisited

F. Lang, C. Yun, Yueping Chen, 2002, The Journal of Biological Chemistry.

Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library.

H. Shim, C. Yun, Y. Oum, 2017, European journal of medicinal chemistry.

Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1.

F. Lang, C. Yun, H. Embark, 2003, Biochemical and biophysical research communications.

The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.

P. Cohen, F. Lang, D. Pearce, 2002, Journal of the American Society of Nephrology : JASN.

Differential Association of the Na+/H+ Exchanger Regulatory Factor (NHERF) Family of Adaptor Proteins with the Raft- and the Non-Raft Brush Border Membrane Fractions of NHE3

M. Donowitz, C. Yun, W. Xia, 2013, Cellular Physiology and Biochemistry.

Mechanisms of the Regulation of the Intestinal Na+/H+Exchanger NHE3

C. Yun, Peijian He, C. Yun, 2009, Journal of biomedicine & biotechnology.

GLAST stability and activity are enhanced by interaction with the PDZ scaffold NHERF-2

C. Yun, M. Asay, Stefanie L. Ritter, 2011, Neuroscience Letters.

Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids

F. Lang, C. Yun, A. Náray-Fejes-Tóth, 2011, Molecular biology of the cell.

Impaired intestinal NHE 3 activity in the PDK 1 hypomorphic mouse

F. Artunc, F. Lang, D. Alessi, 2006 .

Acute activation of Na + / H + exchanger NHE 3 by dexamethasone correlates with activation of SGK 1 and requires a functional glucocorticoid receptor

F. Lang, C. Yun, Dongsheng Wang, 2006 .

Na+–H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST

D. Pow, C. Yun, D. Hryciw, 2007, Glia.

Regulation of Albumin Endocytosis by PSD95/Dlg/ZO-1 (PDZ) Scaffolds

C. Yun, R. Parton, J. Ekberg, 2006, Journal of Biological Chemistry.

Evidence for Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) Self-association through PDZ-PDZ Interactions*

R. Doctor, C. Yun, L. Fouassier, 2000, The Journal of Biological Chemistry.

Two Histidine Residues in the Juxta-Membrane Cytoplasmic Domain of Na+/H+ Exchanger Isoform 3 (NHE3) Determine the Set Point

M. Donowitz, C. Yun, B. Cha, 2003, The Journal of Membrane Biology.

Molecular Studies of Members of the Mammalian Na+/H+ Exchanger Gene Family

S. Brant, J. Pouysségur, M. Donowitz, 1996 .

Molecular Properties, Kinetics and Regulation of Mammalian Na+/H+ Exchangers

S. Brant, J. Pouysségur, M. Donowitz, 1994 .

Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1.

F. Lang, Hong Sun, C. Yun, 2005, American journal of physiology. Cell physiology.

Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling

C. Yun, Peijian He, Zhongxing Liang, 2022, Cellular and molecular gastroenterology and hepatology.

Autotaxin determines colitis severity in mice and is secreted by B cells in the colon

T. Denning, C. Yun, B. El-Rayes, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The mammalian Na+/H+ exchanger gene family--initial structure/function studies.

S. Brant, J. Pouysségur, M. Donowitz, 1993, Journal of the American Society of Nephrology : JASN.

Compensatory Upregulation of LPA2 and Activation of the PI3K-Akt Pathway Prevent LPA5-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids

C. Yun, Zhongxing Liang, 2022, Cells.

Concerted Roles of SGK1 and the Na+/H+ Exchanger Regulatory Factor 2 (NHERF2) in Regulation of NHE3

C. Yun, 2003, Cellular Physiology and Biochemistry.

Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice

M. Manns, C. Yun, U. Seidler, 2007, Pflügers Archiv - European Journal of Physiology.

The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa.

K. Lackner, H. Rossmann, M. Gregor, 2005, Biochemistry.

Oral Sessions

Capasso, A. Cantone, F. Artunc, 2014 .

Loss of PDZ‐adaptor protein NHERF2 affects membrane localization and cGMP‐ and [Ca2+]‐ but not cAMP‐dependent regulation of Na+/H+ exchanger 3 in murine intestine

M. Donowitz, C. Yun, Gang Chen, 2010, The Journal of physiology.

P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2

Y. Smith, C. Yun, S. Traynelis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

IRBIT, Inositol 1,4,5-Triphosphate (IP3) Receptor-binding Protein Released with IP3, Binds Na+/H+ Exchanger NHE3 and Activates NHE3 Activity in Response to Calcium*

C. Yun, Peijian He, Huanchun Zhang, 2008, Journal of Biological Chemistry.

Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family

S. Brant, J. Pouysségur, M. Donowitz, 1993, The Journal of Membrane Biology.

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

M. Donowitz, C. Yun, U. Lehmann, 2009, The Journal of clinical investigation.

Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF‐2) in mouse brain

Y. Smith, M. Kuwajima, C. Yun, 2006, The Journal of comparative neurology.

Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.

G. Grigoryan, H. Shim, C. Yun, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells.

C. Yun, Peijian He, Y. No, 2015, Cellular signalling.

Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer

C. Yun, 2019, Cancers.

Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia

C. Yun, Peijian He, M. Yoshida, 2016, PloS one.

Regulation of Hypoxia-inducible Factor 1α (HIF-1α) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Krüppel-like Factor 5*

D. Dang, V. Yang, H. Shim, 2013, The Journal of Biological Chemistry.

Role of Lysophosphatidic Acid (LPA) in the Intestine

C. Yun, Peijian He, 2013 .

Colorectal cancer cells - Proliferation, survival and invasion by lysophosphatidic acid.

C. Yun, Sei-Jung Lee, 2010, The international journal of biochemistry & cell biology.

Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα‐dependent manner

S. Srinivasan, C. Yun, Peijian He, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Protein Kinase Cε-dependent Regulation of Cystic Fibrosis Transmembrane Regulator Involves Binding to a Receptor for Activated C Kinase (RACK1) and RACK1 Binding to Na+/H+ Exchange Regulatory Factor*

C. Yun, C. Liedtke, Dandan Wang, 2002, The Journal of Biological Chemistry.

Postnatal developmental expression of the PDZ scaffolds Na+-H+ exchanger regulatory factors 1 and 2 in the rat cochlea

M. Bellingham, C. Yun, D. Hryciw, 2005, Cell and Tissue Research.

Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na+/H+ exchanger 3 in SAMP1/Fc mice.

C. Yun, F. Cominelli, Peijian He, 2018, American journal of physiology. Gastrointestinal and liver physiology.

The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.

J. Chun, H. Shim, C. Yun, 2010, American journal of physiology. Gastrointestinal and liver physiology.

mutation in the intestine MinApc tumorigenesis by The absence of LPA receptor 2 reduces the

J. Chun, H. Shim, C. Yun, 2010 .

Distinct Phospholipase C-β Isozymes Mediate Lysophosphatidic Acid Receptor 1 Effects on Intestinal Epithelial Homeostasis and Wound Closure

J. Chun, G. Leoni, C. Yun, 2013, Molecular and Cellular Biology.

HIF1α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5

C. Yun, Ajay Kumar, Y. No, 2015, PloS one.

The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.

J. Chun, V. Yang, A. Ghaleb, 2009, Gastroenterology.

HIF 1 α-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN 5

C. Yun, Ajay Kumar, Sei-Jung Lee, 2022 .

Diverse roles of LPA signaling in the intestinal epithelium.

C. Yun, Ajay Kumar, 2015, Experimental cell research.

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis

C. Yun, A. Bleich, D. Bruder, 2014, Pflügers Archiv - European Journal of Physiology.

Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3.

M. Yanda, C. Yun, Y. No, 2012, American journal of physiology. Gastrointestinal and liver physiology.

L-Glutamine in intestinal sodium absorption: lessons for physiology, pathobiology, and therapy for diarrhea.

M. Donowitz, C. Yun, C. Tse, 1994, Gastroenterology.

Regulation of Hypoxia-inducible Factor 1 alpha (HIF-1 alpha) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Kruppel-like Factor 5

D. Dang, V. Yang, H. Shim, 2022 .

Development of a Unique Small Molecule Modulator of CXCR4

J. Snyder, H. Grossniklaus, M. Goodman, 2012, PloS one.

Systematic family‐wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins

C. Yun, Soojung Lee, I. Choi, 2014, Physiological reports.

Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3.

C. Yun, P. Walden, Dongsheng Wang, 2006, American journal of physiology. Renal physiology.

Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1.

C. Yun, C. Liedtke, V. Raghuram, 2004, American journal of physiology. Cell physiology.

Role of a PDZ 1 domain of NHERF 1 in the binding of airway epithelial RACK 1 to NHERF 1

C. Yun, C. Liedtke, V. Raghuram, 2004 .

PSD-95 Interacts with NBCn1 and Enhances Channel-like Activity without Affecting Na/HCO3 Cotransport

Y. Smith, C. Yun, Soojung Lee, 2012, Cellular Physiology and Biochemistry.

The PDZ Scaffold NHERF-2 Interacts with mGluR5 and Regulates Receptor Activity*

Y. Smith, H. Inuzuka, C. Yun, 2006, Journal of Biological Chemistry.

MAGI-3 regulates LPA-induced activation of Erk and RhoA.

Hong Sun, C. Yun, Dongsheng Wang, 2007, Cellular signalling.

Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5

Lei Dong, C. Yun, Peijian He, 2021, Cellular and molecular gastroenterology and hepatology.

Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na+/H+ exchanger 3 by lysophosphatidic acid in vivo.

C. Yun, K. Jenkin, Peijian He, 2018, American journal of physiology. Gastrointestinal and liver physiology.

Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.

J. Chun, M. Donowitz, C. Yun, 2010, Gastroenterology.

Metformin Inhibits Na+/H+ Exchanger NHE3 Resulting in Intestinal Water Loss

C. Yun, Yiran Han, 2022, Frontiers in Physiology.

Activation of Na+/H+ Exchanger NHE3 by Angiotensin II Is Mediated by Inositol 1,4,5-Triphosphate (IP3) Receptor-binding Protein Released with IP3 (IRBIT) and Ca2+/Calmodulin-dependent Protein Kinase II*

C. Yun, C. Yun, Peijian He, 2010, The Journal of Biological Chemistry.

Muscarinic-induced Recruitment of Plasma Membrane Ca2+-ATPase Involves PSD-95/Dlg/Zo-1-mediated Interactions*

C. Yun, P. Poronnik, G. Monteith, 2009, Journal of Biological Chemistry.

Regulation of Expression and Function of Scavenger Receptor Class B, Type I (SR-BI) by Na+/H+ Exchanger Regulatory Factors (NHERFs)*

C. Yun, F. Kraemer, W. Shen, 2013, The Journal of Biological Chemistry.

Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss.

S. Srinivasan, C. Yun, R. De Giorgio, 2015, The Journal of clinical investigation.

Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain

Y. Smith, C. Yun, E. Weinman, 2017, Neuroscience.

Alimentary Tract

H. Shim, C. Yun, Sei-Jung Lee, 2022 .

Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis.

C. Yun, K. Jenkin, Peijian He, 2017, The American journal of pathology.

LPA2 receptor mediates mitogenic signals in human colon cancer cells.

Hyunsuk Shim, Hong Sun, Raluca Rusovici, 2005, American journal of physiology. Cell physiology.

The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange.

M. Gregor, C. Yun, H. Kalbacher, 2002, Biochemistry.

Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons

C. Yun, Peijian He, I. Rajbhandari, 2009, The European journal of neuroscience.

Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2.

S. Ryu, P. Suh, C. Yun, 2000, Journal of Biological Chemistry.

cAMP-mediated inhibition of the epithelial brush border NayH exchanger, NHE3, requires an associated regulatory protein (sodium–hydrogen antiporterypH regulationysignal transductionyNa1 absorption)

Edward, M. Donowitz, C. Yun, 1997 .

Coming out of the NHERF family

Y. Kurachi, M. Donowitz, C. Yun, 2005 .

MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells

H. Shim, C. Yun, Sei-Jung Lee, 2022 .

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

M. Donowitz, C. Yun, U. Lehmann, 2009, The Journal of clinical investigation.

Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.

G. Grigoryan, H. Shim, C. Yun, 2016, American journal of physiology. Gastrointestinal and liver physiology.