Dan Li

发表

Protein preparation, crystallization and preliminary X-ray analysis of the C-terminal domain of human RSK1 serine/threonine protein kinase.

T. Fu, Dan Li, J. Nan, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure-based design of functional amyloid materials.

E. M. Jones, D. Eisenberg, Stuart A. Sievers, 2014, Journal of the American Chemical Society.

Crystal structure of B. subtilis YjcG characterizing the YjcG‐like group of 2H phosphoesterase superfamily

Dan Li, Lan-fen Li, X. Su, 2008, Proteins.

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Zhijun Liu, Dan Li, Cong Liu, 2020, Nature Communications.

Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases

Dan Li, Cong Liu, 2022, Nature Reviews Neuroscience.

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

Dan Li, X. Su, Yaoyang Zhang, 2020, Cell Research.

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

Dan Li, X. Su, Yaoyang Zhang, 2020, Cell Research.

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

Xueming Li, Dan Li, X. Su, 2019, bioRxiv.

Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders

Dan Li, Yaoyang Zhang, Cong Liu, 2022, Cell Research.

The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3

Dan Li, Cong Liu, Bing Li, 2021, Proceedings of the National Academy of Sciences.

Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

Dan Li, Cong Liu, Lin He, 2022, Nature Communications.

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

R. Zhai, Dan Li, Yaoyang Zhang, 2022, bioRxiv.

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

T. Dawson, V. Dawson, Renxiao Wang, 2021, Proceedings of the National Academy of Sciences.

Membrane association of VAMP2 SNARE motif in cells and its regulation by different lipid phases of synaptic vesicle membrane

Zhijun Liu, Dan Li, Cong Liu, 2019, bioRxiv.

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

Zhijun Liu, Dan Li, X. Gui, 2020, Nature Structural & Molecular Biology.

Molecular structure of an amyloid fibril formed by FUS low-complexity domain

Dan Li, Cong Liu, Yichen Li, 2021, iScience.

Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation

Dan Li, Yanshan Fang, Yichen Li, 2022, iScience.

Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia.

Dan Li, Shuyi Zeng, Jun Liu, 2022, Cell reports.

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion

Jie Chen, Yi Liang, Dan Li, 2022, Nature Communications.

Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases

Dan Li, Jiang Bian, Cong Liu, 2022, Fundamental research.

Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis.

Dan Li, X. Gui, Cong Liu, 2022, Developmental cell.

Protein preparation and preliminary X-ray crystallographic analysis of a putative glucosamine 6-phosphate deaminase from Streptococcus mutants.

Dan Li, Lan-fen Li, X. Su, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Preparation, crystallization and preliminary X-ray analysis of protein YtlP from Bacillus subtilis.

Dan Li, Lan-fen Li, X. Su, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Preparation, crystallization and preliminary X-ray analysis of YjcG protein from Bacillus subtilis.

Xiaofeng Zheng, Dan Li, Lan-fen Li, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.

Jidong Zhu, Shoulai Gu, Dan Li, 2017, Journal of medicinal chemistry.

Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect–based chemical-enrichment method

Z. Liu, M. Ye, Dan Li, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation.

Dan Li, Cong Liu, Shengnan Zhang, 2020, The Journal of biological chemistry.

Structural genomics studies of human caries pathogen Streptococcus mutans

Dan Li, J. Nan, Lan-fen Li, 2014, Journal of Structural and Functional Genomics.

Designed amyloid fibers as materials for selective carbon dioxide capture

D. Eisenberg, H. Furukawa, Dan Li, 2013, Proceedings of the National Academy of Sciences.

The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein

Dan Li, Yaoyang Zhang, Cong Liu, 2021, Nature Communications.

Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles

Zhijun Liu, Dan Li, Cong Liu, 2020, Proceedings of the National Academy of Sciences.

Faculty Opinions recommendation of Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.

Jidong Zhu, Jingjing Xie, Dan Li, 2020, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

Renxiao Wang, Dan Li, X. Gui, 2020, Nature Communications.

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

Xueming Li, Minglei Zhao, Dan Li, 2019, Nature Communications.

Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.

T. Fu, Dan Li, J. Nan, 2012, Acta crystallographica. Section D, Biological crystallography.

Structural diversity of amyloid fibrils and advances in their structure determination.

Dan Li, Cong Liu, 2020, Biochemistry.

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

Xueming Li, Dan Li, X. Gui, 2018, Cell Research.

Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation

D. Eisenberg, J. Nowick, Dan Li, 2019, Front. Mol. Neurosci..

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

Jie Chen, Yi Liang, Dan Li, 2020, Nature Structural & Molecular Biology.

Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.

Dan Li, Jian Wang, Cong Liu, 2022, Structure.

Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease

Dan Li, Cong Liu, 2021, Nature Chemical Biology.

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

Xueming Li, Dan Li, X. Su, 2020, Nature Communications.

Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

Dan Li, Cong Liu, Yan‐Mei Li, 2020, Proceedings of the National Academy of Sciences.

Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity

Xueming Li, Dan Li, Cong Liu, 2019, The Journal of Biological Chemistry.

Different Heat Shock Proteins Bind α-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation

Dan Li, Shengnan Zhang, Zhenying Liu, 2019, Front. Neurosci..

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

Dan Li, Cong Liu, Tongzhou Li, 2018, The Journal of Biological Chemistry.

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

Xueming Li, Minglei Zhao, Dan Li, 2019, Nature Communications.

Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

Jie Chen, Yi Liang, Dan Li, 2021, bioRxiv.

Protein amyloid aggregate: Structure and function

Dan Li, Cong Liu, Yunpeng Sun, 2023, Aggregate.

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

Xueming Li, Minglei Zhao, Dan Li, 2018, Nature Structural & Molecular Biology.

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

Xueming Li, Minglei Zhao, Dan Li, 2018, Nature Structural & Molecular Biology.

Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier

Jun Hu, Xiang Zhang, Guanghong Wei, 2015, Proceedings of the National Academy of Sciences.

The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins

Dan Li, Yaoyang Zhang, Cong Liu, 2022, The Journal of biological chemistry.

Versatile Structures of α-Synuclein

Dan Li, Cong Liu, J. Diao, 2016, Front. Mol. Neurosci..

Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding

Dan Li, Cong Liu, K. Zhao, 2021, Proceedings of the National Academy of Sciences.

SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation

Xiaozhong Peng, Dan Li, Cong Liu, 2022, Protein & Cell.

Bloom Syndrome Helicase Compresses Single-Stranded DNA into Phase-Separated Condensates.

Dan Li, Cong Liu, X. Xi, 2022, Angewandte Chemie.

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

Zhijun Liu, Dan Li, X. Gui, 2020, Nature Structural & Molecular Biology.

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

Dan Li, Cong Liu, Yanshan Fang, 2021, Cell Research.

Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation

Dan Li, Cong Liu, Shengnan Zhang, 2020, The Journal of Biological Chemistry.

Ultrasensitive Homogeneous Electrochemiluminescence Biosensor for Transcription Factor based on Target-modulated Proximity Hybridization and Exonuclease III-powered Recycling Amplification.

Dan Li, Bin Qiu, Zhenyu Lin, 2020, Analytical chemistry.

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

Dan Li, X. Su, Yaoyang Zhang, 2020, Cell Research.

Better Together: A Hybrid Amyloid Signals Necroptosis

Dan Li, Cong Liu, 2018, Cell.

A novel partially open state of SHP2 points to a “multiple gear” regulation mechanism

Jidong Zhu, J. Xie, X. Fang, 2021, The Journal of biological chemistry.

Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks.

Dan Li, Cong Liu, 2021, Trends in cell biology.

Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Zhijun Liu, Dan Li, Cong Liu, 2020, Nature Communications.

Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein.

Liang Wang, Dan Li, Jie Song, 2023, ACS nano.

Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure

Dan Li, W. Le, Zhengtao Liu, 2022, iScience.

Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly

Minghua Zhang, Jinbiao Ma, Dan Li, 2023, Molecular Biomedicine.

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

Jie Chen, Yi Liang, Dan Li, 2020, Nature Structural & Molecular Biology.

Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

Jie Chen, Yi Liang, Dan Li, 2021, Science advances.

In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau

Zhijun Liu, Dan Li, Cong Liu, 2018, International journal of molecular sciences.

A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation

Dan Li, Yichen Li, Jinge Gu, 2022, Cell Reports Physical Science.

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

Jie Chen, Yi Liang, Dan Li, 2023, bioRxiv.

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

Jie Chen, Yi Liang, Dan Li, 2021, bioRxiv.

Different structures and pathologies of α-synuclein fibrils derived from preclinical and postmortem patients of Parkinson’s disease

Dan Li, Cong Liu, Jianjun Wu, 2021 .

Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

Dan Li, Cong Liu, Yan‐Mei Li, 2023, bioRxiv.

Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.

Dan Li, Cong Liu, Chaowei Shi, 2023, Journal of the American Chemical Society.

Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies

Jenny J. Yang, L. Bu, Y. Guan, 2023, Cell.

Rational design of functional amyloid fibrillar assemblies.

Dan Li, Xinyu Wang, Cong Liu, 2023, Chemical Society reviews.

Solution structure and conformational heterogeneity of acylphosphatase from Bacillus subtilis

C. Jin, Dan Li, X. Su, 2010, FEBS letters.

Cellular and animal models to investigate pathogenesis of amyloid aggregation in neurodegenerative diseases

Dan Li, Shuyi Zeng, Houfang Long, 2022, Biophysics reports.

Structural insights of Fe3+ induced α-synuclein fibrillation in Parkinson's disease.

Dan Li, Cong Liu, K. Zhao, 2022, Journal of molecular biology.

Molecular rules governing the structural polymorphism of amyloid fibrils in neurodegenerative diseases.

Dan Li, Cong Liu, 2023, Structure.

Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

R. Zhai, Dan Li, Yaoyang Zhang, 2020, eLife.

Mechanistic insights into NAD synthase NMNAT chaperoning phosphorylated Tau from pathological aggregation

R. Zhai, Dan Li, Yaoyang Zhang, 2019, bioRxiv.

Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules

Xueming Li, Dan Li, Cong Liu, 2019, bioRxiv.

Structural mechanism for specific binding of chemical compounds to amyloid fibrils

Dan Li, Cong Liu, Ying Li, 2023, Nature Chemical Biology.

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.

Xueming Li, Minglei Zhao, Dan Li, 2018 .

Structure-based design of functional amyloid materials.

D. Eisenberg, Stuart A. Sievers, M. Ivanova, 2014, Journal of the American Chemical Society.

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

Xueming Li, Dan Li, X. Gui, 2018, Cell Research.

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

Xueming Li, Dan Li, X. Su, 2020, Nature Communications.

Hsp 70 chaperons TDP-43 in dynamic , liquid-like phase and prevents it 1 from amyloid aggregation 2 3

Dan Li, Cong Liu, Yanshan Fang, 2020 .

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

Xueming Li, Minglei Zhao, Dan Li, 2018, Nature Structural & Molecular Biology.

CryoEM Reconstruction of Hsp104 N728A Hexamer

Dan Li, Cong Liu, Shengnan Zhang, 2019 .

Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.

Dan Li, Cong Liu, Qinyue Zhao, 2024, Proceedings of the National Academy of Sciences of the United States of America.

Biomolecular condensates and disease pathogenesis.

Dan Li, Qing Lu, Boxun Lu, 2024, Science China. Life sciences.

A Tau PET tracer PBB3 binds to TMEM106B amyloid fibril in brain

Dan Li, Cong Liu, Qinyue Zhao, 2024, Cell discovery.

Tracing TMEM106B fibril deposition in aging and Parkinson’s disease with dementia brains

Dan Li, Cong Liu, Jian Wang, 2024, Life Medicine.