T. Bellido

发表

Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation*

S. Manolagas, L. Plotkin, J. I. Aguirre, 2005, Journal of Biological Chemistry.

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.

A. Parfitt, S. Manolagas, L. Plotkin, 2005, American journal of physiology. Cell physiology.

PTH Receptor Signaling in Osteocytes Governs Periosteal Bone Formation and Intracortical Remodeling

G. Passeri, C. O’Brien, L. Plotkin, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

6 – Bone structure and function

D. Burr, K. White, T. Bellido, 2015 .

The phospholipid and fatty acid composition of skeletal muscle cells during culture in the presence of vitamin D-3 metabolites.

T. Bellido, R. Boland, A. R. de Boland, 1987, Biochimica et biophysica acta.

Apoptosis of Bone Cells

M. Almeida, R. Weinstein, R. Jilka, 2008 .

Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits

D. Burr, L. Plotkin, T. Bellido, 2012, Calcified Tissue International.

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin.

P. Roberson, A. Parfitt, R. Weinstein, 1999, The Journal of clinical investigation.

Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity

J. Helms, M. Vigolo, G. Roodman, 2021, Cancer Research.

Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice.

A. Robling, C. Turner, T. Bellido, 2011, Endocrinology.

Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss

A. Parfitt, R. Weinstein, S. Manolagas, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover

M. Ivan, L. Plotkin, T. Bellido, 2020, The FEBS journal.

Reversal of loss of bone mass in old mice treated with mefloquine.

L. Plotkin, T. Bellido, M. Allen, 2018, Bone.

Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

M. Ivan, T. Yoneda, L. Plotkin, 2017, Aging cell.

Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner

L. Plotkin, T. Bellido, T. Wallace, 2016, Nutrients.

Protection From Glucocorticoid‐Induced Osteoporosis by Anti‐Catabolic Signaling in the Absence of Sost/Sclerostin

L. Plotkin, T. Bellido, M. Allen, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading*

L. Plotkin, T. Bellido, M. Allen, 2015, The Journal of Biological Chemistry.

Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice.

L. Plotkin, T. Bellido, Xiaolin Tu, 2014, Bone.

Comment on Osteocytes: Masters Orchestrators of Bone

L. Plotkin, T. Bellido, 2014, Calcified Tissue International.

Role of osteocytes in multiple myeloma bone disease

G. Roodman, T. Bellido, J. Delgado-Calle, 2014, Current opinion in supportive and palliative care.

OSTEOCYTES AND THEIR ROLE IN BONE REMODELING

T. Bellido, 2013 .

Osteocyte-Driven Bone Remodeling

T. Bellido, 2013, Calcified Tissue International.

Beyond gap junctions: Connexin43 and bone cell signaling.

L. Plotkin, T. Bellido, 2013, Bone.

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

G. Passeri, L. Plotkin, T. Bellido, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability.

L. Plotkin, T. Bellido, 2011, Bone.

A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice.

L. Plotkin, T. Bellido, N. Bivi, 2011, Bone.

Antagonistic interplay between mechanical forces and glucocorticoids in bone: A tale of kinases

T. Bellido, 2010, Journal of cellular biochemistry.

Regulation of the Executive Cells of Bone Remodeling by Osteocytes-the Sclerostin Paradigm

T. Bellido, 2009 .

Why to Keep Osteocytes Alive and How

T. Bellido, 2009 .

Glucocorticoids Induce Osteocyte Apoptosis by Blocking Focal Adhesion Kinase-mediated Survival

S. Manolagas, T. Bellido, L. Plotkin, 2007, Journal of Biological Chemistry.

Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness

T. Bellido, 2007 .

Meeting report from the 28th annual meeting of the American society for bone and mineral research

C. Turner, L. Mccauley, T. Bellido, 2006 .

Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids.

R. Landes, A. Parfitt, R. Weinstein, 2002, The Journal of clinical investigation.

Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.

R. Weinstein, C. O’Brien, S. Manolagas, 2004, Endocrinology.

Chapter 14 – Osteocyte Biology

L. Bonewald, T. Bellido, P. Pajevic, 2018 .

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

M. Bouxsein, A. Robling, C. Turner, 2008, PloS one.

Response to Windahl et al.

Li Han, R. Weinstein, R. Jilka, 2006, The Journal of clinical investigation.

Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids

A. Parfitt, Li Han, R. Weinstein, 2002, Science.

Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases

T. Zimmers, L. Plotkin, T. Bellido, 2017, Endocrinology.

Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling.

L. Plotkin, T. Bellido, K. Condon, 2019, Endocrinology.

Glucocorticoid Excess in Bone and Muscle

T. Bellido, M. Peacock, Amy Y Sato, 2018, Clinical Reviews in Bone and Mineral Metabolism.

Connexin 43 Is Required for the Anti‐Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo

R. Weinstein, S. Manolagas, L. Plotkin, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.

David, D. Crabb, S. Manolagas, 1994, The Journal of clinical investigation.

Effects of PTH on osteocyte function.

T. Bellido, P. Pajevic, V. Saini, 2013, Bone.

Detection of apoptosis of bone cells in vitro.

L. Plotkin, T. Bellido, 2008, Methods in molecular biology.

Poster abstracts from the 34 th Meeting of the International Sun Valley Workshop on Skeletal Tissue Biology 1-4 August 2004 , Sun Valley , Idaho , USA Program Chairman :

A. Parfitt, P. Campbell, R. Weinstein, 2004 .

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

A. Robling, L. Plotkin, T. Bellido, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia

K. White, T. Bellido, M. Allen, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Role of TGF‐β in a Mouse Model of High Turnover Renal Osteodystrophy

P. Dechow, S. Ledbetter, T. Bellido, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines

A. Parfitt, R. Weinstein, R. Jilka, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo

R. Jilka, S. Manolagas, T. Bellido, 2005, Osteoporosis International.

Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.

S. Manolagas, L. Plotkin, T. Bellido, 2006, Bone.

Nongenotropic, Anti-Apoptotic Signaling of 1α,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes

M. Almeida, Li Han, S. Manolagas, 2005, Journal of Biological Chemistry.

Calbindin-D28k Is Expressed in Osteoblastic Cells and Suppresses Their Apoptosis by Inhibiting Caspase-3 Activity*

S. Manolagas, T. Bellido, S. Christakos, 2000, The Journal of Biological Chemistry.

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

C. Galmarini, G. Roodman, N. Kurihara, 2019, Oncotarget.

Connexin43 interacts with βarrestin: A pre‐requisite for osteoblast survival induced by parathyroid hormone

L. Plotkin, T. Bellido, N. Bivi, 2011, Journal of cellular biochemistry.

The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.

T. Bellido, R. Shahar, Y. Gabet, 2014, Endocrinology.

Klotho expression in osteocytes regulates bone metabolism and controls bone formation.

R. Baron, B. Lanske, N. Ide, 2017, Kidney international.

CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4.

L. Bonewald, L. Plotkin, T. Bellido, 2003, Endocrinology.

Overexpression of WNT16 Does Not Prevent Cortical Bone Loss Due to Glucocorticoid Treatment in Mice

M. Econs, T. Bellido, Rita L. Gerard-O’Riley, 2018, JBMR plus.

Modulation of calcium uptake in cultured cardiac muscle cells by 1,25-dihydroxyvitamin D3.

T. Bellido, R. Boland, J. Sellés, 1994, Journal of molecular and cellular cardiology.

Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

H. Broxmeyer, R. Jilka, S. Manolagas, 1995, The Journal of clinical investigation.

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

M. Kwiatkowski, H. Schlüter, A. V. van Wijnen, 2019, Nature Communications.

New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130.

R. Jilka, S. Manolagas, T. Bellido, 1995, International journal of immunopharmacology.

Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.

S. C. Lin, C. O’Brien, S. Manolagas, 1997, The Journal of clinical investigation.

Ex Vivo Organ Cultures as Models to Study Bone Biology

T. Bellido, J. Delgado-Calle, 2020, JBMR plus.

Vitamin D and the hematolymphopoietic tissue: a 1994 update.

S. Manolagas, T. Bellido, G. Girasole, 1994, Seminars in nephrology.

Erratum: Down-regulation of NF-κB protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3 (Proceedings of the National Academy of Sciences of the United States of America (November 21, 1995) 24 (524))

S. Manolagas, T. Bellido, Xiao-peng Yu, 1996 .

Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion

J. Helms, T. Bellido, X. Liu, 2020, Journal of dental research.

High Bone Mass–Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo

A. Robling, M. Warman, T. Bellido, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

M. Taketo, T. Bellido, Xiaolin Tu, 2022, Bioactive materials.

Regulation of the gp 80 and gp 130 Subunits of the IL-6 Receptor by Sex Steroids in the Murine Bone Marrow

C. O’Brien, S. Manolagas, T. Bellido, 2013 .

Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo.

E. Farrow, K. White, L. Plotkin, 2011, Bone.

Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.

L. Plotkin, T. Bellido, M. Allen, 2014, Endocrinology.

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma.

J. Chirgwin, T. Yoneda, K. Mohammad, 2016, Cancer research.

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

D. Burr, M. Taketo, L. Plotkin, 2015, Proceedings of the National Academy of Sciences.

Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis.

J. Helms, T. Bellido, Liao Wang, 2019, Bone.

IL‐17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH‐Induced Bone Loss and Enhances Osteocytic RANKL Production

T. Bellido, R. Pacifici, M. Weitzmann, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

β-arrestin/connexin 43 complex anchors ERKs outside the nucleus: a pre-requisite for bisphosphonate anti-apoptotic effect mediated by CX43/ERK in osteocytes

L. Plotkin, T. Bellido, A. Gortázar, 2016 .

THE IMMUNOMODULATING PROPERTIES OF VITAMIN D: RECEPTORS AND MECHANISMS OF BIOLOGIC ACTION

D. Crabb, S. Manolagas, T. Bellido, 1991 .

The Notch pathway regulates the bone gain induced by PTH anabolic signaling

G. Roodman, T. Bellido, R. K. Boeckman, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Estrogens, cytokines, and the pathophysiology of osteoporosis

G. Passeri, R. Jilka, S. Manolagas, 1994 .

Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

T. Bellido, Subhadip Ghatak, C. Sen, 2022, npj Regenerative Medicine.

MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production

J. Riancho, T. Bellido, J. Tonra, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effects of 1,25-dihydroxy-vitamin D3 on phosphate accumulation by myoblasts.

T. Bellido, R. Boland, 1991, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice

A. Robling, L. Plotkin, T. Bellido, 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Transcriptional Activation of the p21 WAF1,CIP1,SDI1 Gene by Interleukin-6 Type Cytokines

P. Roberson, C. O’Brien, S. Manolagas, 1998, The Journal of Biological Chemistry.

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone.

P. Roberson, A. Parfitt, R. Weinstein, 1999, The Journal of clinical investigation.

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.

Matthew R Allen, Yumie Rhee, Alexander G Robling, 2012, Bone.

A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion.

J. Helms, T. Bellido, Xue Yuan, 2019, Journal of endodontics.

Stat3 in osteocytes mediates osteogenic response to loading

Joseph M. Wallace, T. Bellido, Hongkang Zhou, 2019, Bone reports.

Transcriptional Activation of the p21 Gene by Interleukin-6 Type Cytokines A PREREQUISITE FOR THEIR PRO-DIFFERENTIATING AND ANTI-APOPTOTIC EFFECTS ON HUMAN OSTEOBLASTIC CELLS*

P. Roberson, C. O’Brien, S. Manolagas, 1998 .

A Novel Ligand-independent Function of the Estrogen Receptor Is Essential for Osteocyte and Osteoblast Mechanotransduction*

C. O’Brien, S. Manolagas, L. Plotkin, 2007, Journal of Biological Chemistry.

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin*

Matthew R Allen, Alexander G Robling, Sara M. Mantila, 2008, Journal of Biological Chemistry.

Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age

G. McCabe, D. Burr, C. Weaver, 2017, PloS one.

Printed in U.S.A. Copyright © 1997 by The Endocrine Society Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes

P. Roberson, S. Manolagas, T. Bellido, 2022 .

Role and mechanism of action of sclerostin in bone.

T. Bellido, J. Delgado-Calle, Amy Y. Sato, 2017, Bone.

Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids*

P. Roberson, A. Parfitt, M. Almeida, 2007, Journal of Biological Chemistry.

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

B. Katzenellenbogen, P. Roberson, J. Katzenellenbogen, 2001, Cell.

Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT*

M. Almeida, Li Han, S. Manolagas, 2005, Journal of Biological Chemistry.

Transduction of Cell Survival Signals by Connexin-43 Hemichannels*

S. Manolagas, L. Plotkin, T. Bellido, 2002, The Journal of Biological Chemistry.

Skeletal cell YAP and TAZ combinatorially promote bone development

A. Robling, T. Bellido, G. Vigil, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Skeletal cell YAP and TAZ redundantly promote bone development by regulation of collagen I 1 expression and organization . 2 3

A. Robling, T. Bellido, S. Howard, 2017 .

Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma.

S. Manolagas, L. Plotkin, S. Kousteni, 2004, Kidney international. Supplement.

Basic Aspects of Osteocyte Function

T. Bellido, J. Delgado-Calle, 2020 .

Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.

G. Yancopoulos, N. Stahl, S. Manolagas, 1996, The Journal of clinical investigation.

Induction of Osteoblast Differentiation by Selective Activation of Kinase-Mediated Actions of the Estrogen Receptor

M. Almeida, Li Han, R. Jilka, 2006, Molecular and Cellular Biology.

Prevention of Glucocorticoid‐Induced Apoptosis in Osteocytes and Osteoblasts by Calbindin‐D28k

Yan Liu, Sylvia Christakos, T. Bellido, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.

M. Almeida, Li Han, S. Manolagas, 2003, The Journal of clinical investigation.

Osteocytic signalling pathways as therapeutic targets for bone fragility

L. Plotkin, T. Bellido, 2016, Nature Reviews Endocrinology.

Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH‐Induced Bone Formation

A. Robling, L. Plotkin, T. Bellido, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signalling

M. Muckenthaler, A. Petzold, S. Colucci, 2019, Nature Metabolism.

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling

M. Muckenthaler, L. Hofbauer, S. Colucci, 2018, Nature Metabolism.

Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.

S. Manolagas, T. Bellido, T Bellido, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Osteocytes and Skeletal Pathophysiology

T. Bellido, J. Delgado-Calle, 2015, Current Molecular Biology Reports.

Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin

W. R. Thompson, Yong Li, L. Bonewald, 2023, International journal of molecular sciences.

Genetic Deletion of Sost or Pharmacological Inhibition of Sclerostin Prevent Multiple Myeloma-induced Bone Disease without Affecting Tumor Growth

G. Roodman, L. Plotkin, T. Bellido, 2017, Leukemia.

Summary - Osteocyte control of bone formation via Sost/sclerostin

T. Bellido, T. Bellido, 2006 .

Bone Cells

L. Plotkin, T. Bellido, A. Bruzzaniti, 2019, Basic and Applied Bone Biology.

Targeting Bone Remodeling for the Treatment of Osteoporosis: Summary of the Proceedings of an ASBMR Workshop

R. Recker, S. Khosla, J. Bilezikian, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

M. Kwiatkowski, H. Schlüter, A. V. van Wijnen, 2019, Nature Communications.

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

G. Loots, A. Robling, T. Bellido, 2019, iScience.

Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

A. Parfitt, Li Han, R. Weinstein, 2003, Science.

Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth

T. Bellido, Jiangdong Ni, Fanxin Long, 2017, Bone Research.

Role of Osteoblasts in Cancer-Induced Bone Disease

G. Roodman, T. Bellido, S. Marino, 2019 .

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner.

D. Chen, T. Manshouri, S. Verstovsek, 2014, Cell stem cell.

New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots

T. Bellido, J. Delgado-Calle, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice

L. Plotkin, T. Bellido, S. Harris, 2018, JBMR plus.

Decrease in protein tyrosine phosphorylation is associated with F‐actin reorganization by retinoic acid in human endometrial adenocarcinoma (RL95‐2) cells

T. Bellido, C. A. Carter, 1999, Journal of cellular physiology.

Osteocyte Estrogen Receptor β (Ot‐ERβ) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice

R. Main, C. Ohlsson, Haisheng Yang, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Evidence for the participation of protein kinase C and 3′,5′-cyclic AMP-dependent protein kinase in the stimulation of muscle cell proliferation by 1,25-dihydroxy-vitamin D3

T. Bellido, R. Boland, S. Morelli, 1993, Molecular and Cellular Endocrinology.

Transient Versus Sustained Phosphorylation and Nuclear Accumulation of ERKs Underlie Anti-Versus Pro-apoptotic Effects of Estrogens*

Li Han, R. Jilka, S. Manolagas, 2005, Journal of Biological Chemistry.

Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3.

G. Passeri, R. Jilka, S. Manolagas, 1993, Endocrinology.

A Scaffold-Free Multicellular Three-Dimensional In Vitro Model of Osteogenesis

Umut A. Gurkan, U. Gurkan, O. Akkus, 2011, Calcified Tissue International.

Mechanobiology of the Skeleton

Stuart J Warden, Alexander G Robling, Iwona Jasiuk, 2009, Science Signaling.

Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.

L. Plotkin, T. Bellido, M. Allen, 2015, Bone.

Crosstalk between Caveolin-1/Extracellular Signal-regulated Kinase (ERK) and β-Catenin Survival Pathways in Osteocyte Mechanotransduction*

M. Martín-Millán, L. Plotkin, T. Bellido, 2013, The Journal of Biological Chemistry.

Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response

G. McCabe, C. Nakatsu, D. Burr, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Resorption Controls Bone Anabolism Driven by Parathyroid Hormone (PTH) Receptor Signaling in Osteocytes*

L. Plotkin, T. Bellido, M. Allen, 2013, The Journal of Biological Chemistry.

Contribution of Rankl Regulation to Bone Resorption Induced by Pth Receptor Activation in Osteocytes

L. Plotkin, T. Bellido, M. Allen, 2012 .

Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts

P. Roberson, R. Weinstein, R. Jilka, 2003, Journal of Biological Chemistry.

The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration.

T. Bellido, H. Turkkahraman, Xue Yuan, 2023, Journal of periodontal research.

Extracellular Signal‐Regulated Kinases and Calcium Channels Are Involved in the Proliferative Effect of Bisphosphonates on Osteoblastic Cells In Vitro

L. Plotkin, T. Bellido, I. Mathov, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic RANKL but it does not Stop Bone Resorption or the Loss of Bone Induced by Unloading.*

L. Plotkin, T. Bellido, M. Allen, 2015 .

Chapter 2 – Bone Cells

L. Plotkin, T. Bellido, A. Bruzzaniti, 2014 .

Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL‐6‐type cytokines

C. O’Brien, S. Manolagas, T. Bellido, 2000, Journal of cellular biochemistry.

Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

I. Nookaew, G. Roodman, N. Kurihara, 2022, Neoplasia.

PTHrP‐Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading

P. Esbrit, L. Plotkin, T. Bellido, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits

D. Burr, L. Plotkin, T. Bellido, 2012, Calcified Tissue International.

Comment on Osteocytes: Masters Orchestrators of Bone

L. Plotkin, T. Bellido, 2014, Calcified Tissue International.

Sex steroids, cytokines and the bone marrow: new concepts on the pathogenesis of osteoporosis.

R. Jilka, S. Manolagas, T. Bellido, 1995, Ciba Foundation symposium.

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells.

L. Calvi, T. Bellido, Y. Rhee, 2012, Blood.

YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling

Jennifer C. Coulombe, A. Robling, V. Ferguson, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Osteocyte as a Signaling Cell.

T. Bellido, J. Delgado-Calle, 2021, Physiological reviews.

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis.

R. Jilka, C. O’Brien, S. Manolagas, 2005, Endocrinology.

Reversal of the diabetic bone signature with anabolic therapies in mice

I. Nookaew, T. Bellido, Shenyang Li, 2023, Bone research.

Mechanical stimulation in vivo reduces osteocyte expression of sclerostin.

A. Robling, C. Turner, T. Bellido, 2006, Journal of musculoskeletal & neuronal interactions.

Osteocytes remodel bone by TGF-β-induced YAP/TAZ signaling

Jennifer C. Coulombe, A. Robling, V. Ferguson, 2019, bioRxiv.

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling

M. Muckenthaler, S. Colucci, G. Schett, 2018, Nature Metabolism.

The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice.

T. Bellido, R. Shahar, R. Dresner-Pollak, 2014, Endocrinology.

High Bone Mass–Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo

A. Robling, M. Warman, T. Bellido, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice.

L. Plotkin, T. Bellido, Xiaolin Tu, 2015, Bone.

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

G. Passeri, L. Plotkin, T. Bellido, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43

L. Plotkin, T. Bellido, T. Bellido, 2001, Cell communication & adhesion.

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.

A. Robling, C. Turner, M. Stolina, 2012, Bone.

Klotho expression in osteocytes regulates bone metabolism and controls bone formation

R. Baron, B. Lanske, N. Ide, 2018, Yearbook of Paediatric Endocrinology.

Loss of Nmp4 enhances bone gain from sclerostin antibody administration.

A. Robling, L. Plotkin, T. Bellido, 2023, Bone.

Skeletal cell YAP and TAZ redundantly promote bone development by regulation of collagen I expression and organization

A. Robling, T. Bellido, S. Howard, 2017, bioRxiv.