C. K. Chu

发表

A neuroprotective role of extracellular signal-regulated kinase in n-acetyl-o-methyldopamine-treated hippocampal neurons after exposure to in vitro and in vivo ischemia

B. Volpe, T. Joh, E. Park, 2004, Neuroscience.

Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.

R. Schinazi, C. K. Chu, J. R. Babu, 1990, Antiviral research.

Antiviral Activity of Nucleoside Analogues against SARS-coronavirus (SARS-CoV)

S. Olgen, H. Choo, C. K. Chu, 2006, Antiviral chemistry & chemotherapy.

Studies of molecular mechanism of tenofovir against 3TC- and AZT-resistance mutant HIV-1 reverse transcriptase.

C. K. Chu, Y. Chong, Nagaraju Akula, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and Anti-HIV Activity of β-D-3′-Azido-2′,3′-unsaturated Nucleosides and β-D-3′-Azido-3′-deoxyribofuranosylnucleosides

R. Schinazi, C. K. Chu, Srinivas Gadthula, 2005 .

Characterization of Hepatitis B Virus Inhibition by Novel 2′-Fluoro-2′,3′-Unsaturated Beta-D- and l-nucleosides

R. Schinazi, C. K. Chu, Junxing Shi, 2005, Antiviral chemistry & chemotherapy.

CHAPTER 1 – RECENT ADVANCES IN ANTIVIRAL NUCLEOSIDES

C. K. Chu, Yongseok Choi, G. Gumina, 2003 .

Synthesis and anti-HIV activity of l-2′-fluoro-2′,3′-unsaturated purine nucleosides

R. Schinazi, C. K. Chu, Yongseok Choi, 1998 .

Anti-human immunodeficiency virus type-1 (HIV-1) and anti-hepatitis B virus (HBV) activities of (2,3-dideoxy-2-fluoro-β-L-threo-pentofuranosyl)nucleosides

Yung-chi Cheng, R. Schinazi, C. K. Chu, 1995 .

Asymmetric synthesis of enantiomerically pure (−)-(1′R,4′R)-dioxolane-thymine and its anti-HIV activity.

R. Schinazi, P. Roey, S. Ahn, 1991 .

Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.

R. Schinazi, C. K. Chu, D. Cannon, 1988, Biochemical pharmacology.

Nucleosides and Nucleotides as Antitumor and Antiviral Agents

C. K. Chu, D. Baker, Antiviral Agents, 1993, Springer US.

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

R. Schinazi, C. K. Chu, L. Jeong, 1992, Antimicrobial Agents and Chemotherapy.

Lymphatic Targeting of anti-HIV Nucleosides: Distribution of 3′-azido-3′-deoxythymidine (AZT) and 3′-azido-2′,3′-dideoxyuridine (AZdU) after Administration of Dipalmitoylphosphatidyl Prodrugs to Mice

L. Kotra, R. Schinazi, C. K. Chu, 1995 .

Metabolism and effects of 5-(beta-D-ribofuranosyl)isocytosine in P815 cells.

J. Burchenal, T. Chou, C. K. Chu, 1979, Cancer research.

Nucleoside and Nucleotide Prodrugs

C. K. Chu, J. Cooperwood, F. D. Boudinot, 2002 .

Fluorinated Nucleosides: Synthesis and Biological Implication.

C. K. Chu, P. Liu, Ashoke Sharon, 2008, Journal of fluorine chemistry.

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

M. Otto, L. Stuyver, R. Schinazi, 2003, Journal of Virology.

Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.

C. K. Chu, Ashoke Sharon, Young Ah Kim, 2007, Biochemical pharmacology.

6-Benzylthioinosine analogues: promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es).

J. Buolamwini, C. K. Chu, V. Yadav, 2005, Biochemical pharmacology.

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

C. K. Chu, Y. A. Kim, O. N. Al Safarjalani, 2005, Biochemical pharmacology.

Hybrid Pharmacokinetic Models to Describe Anti-HIV Nucleoside Brain Disposition Following Parent and Prodrug Administration in Mice

C. K. Chu, J. Gallo, F. D. Boudinot, 1991, Pharmaceutical Research.

Anti-Epstein-Barr Virus (EBV) Activity of β-l-5-Iododioxolane Uracil Is Dependent on EBV Thymidine Kinase

Yung-chi Cheng, C. K. Chu, Ju-sheng Lin, 2000, Antimicrobial Agents and Chemotherapy.

Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.

M. Kukhanova, Y. Cheng, C. K. Chu, 1996, Biochemical pharmacology.

Pharmacokinetics and saturable renal tubular secretion of zidovudine in rats.

C. K. Chu, F. D. Boudinot, B. Patel, 1989, Journal of pharmaceutical sciences.

Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.

Y. Cheng, C. K. Chu, Shwu-Huey Liu, 1995, Cancer research.

Antiviral activity of clevudine [L‐FMAU, (1‐(2‐fluoro‐5‐methyl‐β, L‐arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax)

C. K. Chu, J. Jacob, B. Tennant, 2001, Hepatology.

Synthesis of β-Enantiomers of N4-Hydroxy-3′-Deoxy-Pyrimidine Nucleosides and Their Evaluation against Bovine Viral Diarrhoea Virus and Hepatitis C Virus in Cell Culture

L. Stuyver, R. Schinazi, H. Choo, 2004, Antiviral chemistry & chemotherapy.

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

M. Otto, L. Stuyver, R. Schinazi, 2003, Antimicrobial Agents and Chemotherapy.

Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil

Y. L. Zhu, Y. Cheng, C. K. Chu, 1996, Antimicrobial agents and chemotherapy.

Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N‐acetyl‐O‐methyldopamine: Protein kinase a–dependent mechanism

T. Joh, E. Park, C. K. Chu, 2001, Glia.

Inhibition of estrogen stimulated mitogenesis by 3-phenylacetylamino-2,6-piperidinedione and its Para-hydroxy analog

J. Copland, C. K. Chu, J. C. Wood, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.

R. Schinazi, C. K. Chu, K. Rapp, 2007, Journal of medicinal chemistry.

Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS.

C. K. Chu, R. Sidwell, E. Kern, 2006, Journal of medicinal chemistry.

Antiviral nucleosides : chiral synthesis and chemotherapy

C. K. Chu, 2003 .

Pharmacology and Pharmacokinetics of the Antiviral Agent β-d-2′,3′-Dideoxy-3′-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys

H. McClure, R. Schinazi, C. K. Chu, 2005, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.

H. McClure, R. Schinazi, C. K. Chu, 1999, AIDS research and human retroviruses.

Lymphatic Targeting of Anti-Human Immunodeficiency Virus Nucleosides: Pharmacokinetics of G′-Deoxy-2′,3′-Didehydrothymidine after Intravenous and Oral Administration of Dipalmitoylphosphatidyl Prodrug to Mice

R. Schinazi, C. K. Chu, F. D. Boudinot, 1997 .

Preclinical pharmacokinetics of β-L-dioxolane-cytidine, a novel anticancer agent, in rats

C. K. Chu, F. D. Boudinot, L. Moore, 1997, Cancer Chemotherapy and Pharmacology.

Dose-Dependent Pharmacokinetics of 3′-azido-2′,3′-dideoxyuridine in Rats

R. Schinazi, C. K. Chu, F. D. Boudinot, 1991 .

Pharmacokinetics of 3′-azido-2′,3′-dideoxy-5-methylcytidine in Rats

R. Schinazi, C. K. Chu, F. D. Boudinot, 1990 .

Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.

R. Schinazi, C. K. Chu, J. Gallo, 1990, Journal of pharmacobio-dynamics.

3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.

H. McClure, R. Schinazi, C. K. Chu, 1990, AIDS research and human retroviruses.

Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice.

D. Smee, C. K. Chu, R. Sidwell, 2007, Antiviral research.

Natural Products as Antiviral Agents

C. K. Chu, H. Cutler, 1992, Springer US.

Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships.

A. Matsuda, M. Chun, C. K. Chu, 1983, Journal of medicinal chemistry.

A novel serotonin antagonist 2,2'-bis[3-(2-N,N-dimethylaminoethyl)indolyl]sulfide (BDIS)

C. K. Chu, J. Wander, J. Schmitz, 1984 .

Some nucleoside analogs with anti-human immunodeficiency virus activity inhibit replication of Epstein-Barr virus.

C. K. Chu, J. Lin, E. Mar, 1995, Antiviral research.

Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent.

Y. Cheng, C. K. Chu, B. Tennant, 1998, Antiviral therapy.

Determination of 3'-azido-2',3'-dideoxyuridine in maternal plasma, amniotic fluid, fetal and placental tissues by high-performance liquid chromatography.

C. K. Chu, M. Bartlett, C. White, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Anti-human immunodeficiency and anti-hepatitis B virus activities of β-l-2′,3′-dideoxy purine nucleosides

R. Schinazi, C. K. Chu, Ju-sheng Lin, 1996 .

Synthesis of enantiomerically pure cyclopropyl carbocyclic nucleosides

R. Schinazi, C. K. Chu, Yufen Zhao, 1994 .

Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.

R. Schinazi, C. K. Chu, L. Jeong, 1993, Journal of medicinal chemistry.

Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.

J. Burchenal, C. K. Chu, T. O'Toole, 1976, Cancer Research.

Stereoselective synthesis of 3-azido-2,3-dideoxy-D-ribose derivatives and its utilization for the synthesis of anti-HIV nucleosides†‡

C. K. Chu, L. Jeong, J. Beach, 1993 .

Antiretroviral Activity, Biochemistry, and Pharmacokinetics of 3′‐Azido‐2′,3′‐Dideoxy‐5‐Methylcytidine a

H. McClure, R. Schinazi, C. K. Chu, 1990, Annals of the New York Academy of Sciences.

An efficient total synthesis of 3′-azido-3′-deoxythymidine (AZT) and 3′-azido-2′,3′-dideoxyuridine (AZDDU, CS-87) from D-mannitol

C. K. Chu, J. Beach, G. Ullas, 1988 .

Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.

D. Smee, C. K. Chu, J. Morrey, 2010, Antiviral research.

Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine.

D. Smee, C. K. Chu, R. Bowen, 2008, Antiviral research.

Recent Advances in Nucleosides: Chemistry and Chemotherapy

C. K. Chu, 2002 .

human lymphocytes. human immunodeficiency virus type 1 in 2',3'-dideoxy-3'-thiacytidine (BCH-189) against Activities of the four optical isomers of

C. K. Chu, L. Jeong, D. Cannon, 2014 .

Pharmacological Reversal of Histone Methylation Presensitizes Pancreatic Cancer Cells to Nucleoside Drugs: In Vitro Optimization and Novel Nanoparticle Delivery Studies

Y. Bhutia, C. K. Chu, S. Dhar, 2013, PloS one.

PAMAM Dendrimers and Branched Polyethyleneglycol (Nanoparticles) Prodrugs of (-)-β-D-(2R, 4R)-dioxolane-thymine (DOT) and Their Anti-HIV Activity

R. Schinazi, C. K. Chu, K. Rapp, 2006, Antiviral chemistry & chemotherapy.

β-L-1-[5-(E-2-Bromovinyl)-2-(Hydroxymethyl)-1,3-Dioxolan-4-yl)] Uracil (L-BHDU) Inhibits Varicella Zoster Virus Replication by Depleting the Cellular dTTP Pool

C. K. Chu, Dongmei Liu, J. Moffat, 2020, bioRxiv.

Current status of anti-HBV chemotherapy

C. K. Chu, Yongseok Choi, B. Chun, 1998, Archives of pharmacal research.

Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus).

C. K. Chu, J. Huggins, Peng Liu, 2003, The Journal of organic chemistry.

Pharmacokinetics of 1 -(2-Deoxy-2-fluoro-β-L-arabino-furanosyl)-5-methyluracil (L-FMAU) in Rats

C. K. Chu, F. D. Boudinot, Jennifer D. Wright, 1995, Pharmaceutical Research.

Pharmacokinetics of the anticancer agent 2-chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine in rats

C. K. Chu, J. Gallo, M. Qian, 2004, Cancer Chemotherapy and Pharmacology.

Pharmacokinetic Evaluation of 3′-Azido-2′, 3′-Dideoxyuridine-5′-O-Valinate-Hydrochloride as a Prodrug of the Anti-HIV Nucleoside 3′-Azido-2′, 3′-Dideoxyuridine

C. K. Chu, J. Cooperwood, F. D. Boudinot, 2003, Antiviral chemistry & chemotherapy.

Pharmacokinetics of Bis(t-butyl-SATE)-AZTMP, a Bispivaloylthioethyl Prodrug for Intracellular Delivery of Zidovudine Monophosphate, in Mice

C. K. Chu, J. Imbach, F. D. Boudinot, 2000, Antiviral chemistry & chemotherapy.

Pharmacokinetics of 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uracil in woodchucks

C. K. Chu, B. Tennant, F. D. Boudinot, 1997, Antimicrobial agents and chemotherapy.

Biotransformation and pharmacokinetics of prodrug 9-(β-d-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(β-d-1,3-dioxolan-4-yl)guanine in mice

R. Schinazi, C. K. Chu, F. D. Boudinot, 1997 .

Lymphatic targeting of anti-HIV nucleosides: distribution of 2',3'-dideoxyinosine after intravenous and oral administration of dipalmitoylphosphatidyl prodrug in mice.

R. Schinazi, C. K. Chu, F. D. Boudinot, 1997, Antiviral research.

Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys

H. McClure, R. Schinazi, C. K. Chu, 1996, Antimicrobial agents and chemotherapy.

Pharmacokinetics of (-)-β-D-2,6-Diaminopurine Dioxolane and its Metabolite, Dioxolane Guanosine, in Woodchucks (Marmota Monax)

R. Schinazi, C. K. Chu, B. Tennant, 1996 .

Brain Targeting of anti-HIV Nucleosides: in vitro and in vivo Evaluation of 6-chloro-2′,3′-dideoxypurine, a Lipophilic Prodrug of 2′,3′-dideoxyinosine

R. Schinazi, C. K. Chu, J. Gallo, 1994 .

Brain Targeting of anti-HIV Nucleosides: Ether Prodrugs of 3′-Azido-2′,3′-Dideoxyuridine (AZdU) and 3′-Azido-3′-Deoxythymidine (AZT)

R. Schinazi, C. K. Chu, J. Gallo, 1993 .

Synthesis of Entecavir and Its Novel Class of Analogs

C. K. Chu, R. Rawal, Srinivas Gadthula, 2011, Current protocols in nucleic acid chemistry.

CHAPTER 1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES : SYNTHESIS AND BIOLOGICAL ACTIVITY

C. K. Chu, R. Rawal, Jianing Wang, 2011 .

Synthesis and anti-HIV activity of (−)-β- d-(2 R,4 R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (−)-β- d-(2 R,4 R)-1,3-dioxolane guanosine (DXG) prodrugs

R. Schinazi, C. K. Chu, Ashoke Sharon, 2007 .

Interaction of 2′-deoxyguanosine Triphosphate Analogue Inhibitors of HIV Reverse Transcriptase with Human Mitochondrial DNA Polymerase γ

K. Anderson, R. Schinazi, C. K. Chu, 2007, Antiviral chemistry & chemotherapy.

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

R. Schinazi, C. K. Chu, Jagadeeshwar R. Rao, 2006, Bioorganic & Medicinal Chemistry.

Enantiomeric synthesis of carbocyclic analogs of D- and L-6-azapyrimidine ribonucleosides

C. K. Chu, P. Liu, 2006 .

Mechanism of Anti-Human Immunodeﬁciency Virus Activity of (cid:2) - D -6-Cyclopropylamino-2 (cid:3) ,3 (cid:3) -Didehydro-2 (cid:3) ,3 (cid:3) -Dideoxyguanosine

K. Anderson, R. Schinazi, C. K. Chu, 2005 .

Synthesis and anti-HIV activity of l-β-3′-C-cyano-2′,3′-unsaturated nucleosides and l-3′-C-cyano-3′-deoxyribonucleosides

Wei Zhu, R. Schinazi, C. K. Chu, 2003 .

2′-Fluoro-4′-thio-2′,3′-unsaturated Nucleosides: Anti-HIV Activity, Resistance Profile, and Molecular Modeling Studies

R. Schinazi, H. Choo, C. K. Chu, 2003, Nucleosides, nucleotides & nucleic acids.

Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)

R. Baker, C. K. Chu, J. Huggins, 2002, Bioorganic & medicinal chemistry letters.

CHAPTER 3 – OXATHIOLANE AND DIOXOLANE NUCLEOSIDES: SYNTHESIS AND ANTIVIRAL ACTIVITY

C. K. Chu, J. Cooperwood, G. Gumina, 2003 .

Nucleoside and Nucleotide Prodrugs

C. K. Chu, J. Cooperwood, F. D. Boudinot, 2003 .

Efficient and practical synthesis of d-cyclopent-2-enone, the key intermediate for the synthesis of carbocyclic nucleosides

C. K. Chu, Yun H. Jin, 2002 .

L-Nucleosides as chemotherapeutic agents.

C. K. Chu, G. Gumina, G. Song, 2001, FEMS microbiology letters.

UNDERSTANDING THE MODE OF ACTION OF L-NUCLEOSIDES AS ANTIVIRAL AGENTS: A MOLECULAR MODELING APPROACH

C. K. Chu, Y. Chong, K. Lee, 2001, Nucleosides, nucleotides & nucleic acids.

A divergent synthesis of d- and l-carbocyclic 4′-fluoro-2′,3′-dideoxynucleosides as potential antiviral agents

C. K. Chu, Y. Chong, G. Gumina, 2000 .

Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.

R. Schinazi, Y. Cheng, C. K. Chu, 1999, Journal of medicinal chemistry.

Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.

S. Olgen, R. Schinazi, H. Choo, 2002, Organic letters.

Synthesis of 2′-C-α-Methyl-2′,3′-dideoxynucleosides

C. K. Chu, P. Bolon, I. Giri, 1996 .

Stereoselective Synthesis of 2′,3′-Dideoxy-and 2,3′-Didehydro-2′,3′-dideoxy-nucleosides

C. K. Chu, L. Jeong, H. Kim, 1991 .

A Practical Synthesis of 2′-Deoxyuridine from Uridine

C. K. Chu, Haoqiang Huang, 1990 .

NEW C-NUCLEOSIDE ISOSTERES OF SOME NUCLEOSIDE ANTIBIOTICS*

C. K. Chu, R. Klein, J. Hwang, 1978 .

Nucleosides XCII. A facile synthesis of 5-(β-d-ribofuranosyl)- isocytosine (ψ-isocytidine)

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1975 .

2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.

K. Anderson, R. Schinazi, C. K. Chu, 2004, Bioorganic & medicinal chemistry letters.

Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

R. Schinazi, C. Tsai, Y. Cheng, 1992, The Journal of biological chemistry.

5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.

R. Schinazi, C. K. Chu, Ashoke Sharon, 2009, Bioorganic & medicinal chemistry.

Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.

R. Schinazi, C. K. Chu, Yuzeng Liang, 2006, Bioorganic & medicinal chemistry.

In Vitro Selection and Analysis of Human Immunodeficiency Virus Type 1 Resistant to Derivatives of β-2′,3′-Didehydro-2′,3′-Dideoxy-5-Fluorocytidine

J. Mellors, R. Schinazi, C. K. Chu, 2005, Antimicrobial Agents and Chemotherapy.

Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.

R. Schinazi, C. K. Chu, Y. Chong, 2005, Journal of medicinal chemistry.

Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents.

R. Schinazi, C. K. Chu, Wen Zhou, 2002, Journal of medicinal chemistry.

In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.

L. Kotra, R. Schinazi, C. K. Chu, 1996, Journal of Medicinal Chemistry.

Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.

R. Schinazi, C. K. Chu, J. Gallo, 1994, Journal of medicinal chemistry.

SYNTHESIS OF NOVEL D-2',3'-DIDEOXY-2',3'-ENDO-METHYLENE NUCLEOSIDES

C. K. Chu, B. Chun, J. Hong, 1998 .

New classes of fluorinated L-nucleosides; synthesis and antiviral activity.

R. Schinazi, C. K. Chu, K. Lee, 1999, Nucleosides & nucleotides.

Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.

R. Schinazi, Y. Cheng, C. K. Chu, 1999, Journal of medicinal chemistry.

Nucleosides. 100. General synthesis of pyrimidine C-5 cucleosides related to pseudouridine. Synthesis of 5-(beta-D-ribofuranosyl) isocytosine (pseudoisocytidine),5-(beta-D-ribofuranosyl)-2-thiouracil(2-thiopseudouridine) and 5-(beta-D-ribofuranosyl)uracil(pseudouridine).

C. K. Chu, K. Watanabe, J. Fox, 1976, The Journal of organic chemistry.

2′,3′-Didehydro-2′,3′-dideoxynucleosides Are Degraded to Furfuryl Alcohol under Acidic Conditions.

K. Anderson, R. Schinazi, C. K. Chu, 2004 .

Clevudine Inhibits Hepatitis Delta Virus Viremia: a Pilot Study of Chronically Infected Woodchucks

C. K. Chu, B. Tennant, J. Casey, 2005, Antimicrobial Agents and Chemotherapy.

Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents.

Y. L. Zhu, Y. Cheng, C. K. Chu, 1996, Journal of medicinal chemistry.

Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus

Y. Cheng, C. K. Chu, J. Sommadossi, 1995, Antimicrobial agents and chemotherapy.

Infected Woodchucks Viremia : a Pilot Study of Chronically Clevudine Inhibits Hepatitis Delta Virus

C. K. Chu, B. Tennant, J. Casey, 2005 .

Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA-ligand complexes

J. Copland, C. K. Chu, V. Mahesh, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

A Stereochemical Rationale for the Activity of Anti-HIV Nucleosides

R. Schinazi, C. K. Chu, E. Taylor, 1990 .

β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism.

C. K. Chu, Dongmei Liu, J. Moffat, 2014, Antiviral research.

Synthesis and anti-human immunodeficiency virus (HIV-1) activity of 3'-deoxy-3'-(triazol-1-yl)thymidines and 2',3'-dideoxy-3'-(triazol-1-yl)uridines and inhibition of reverse transcriptase by their 5'-triphosphates.

Y. Kitade, R. Schinazi, C. K. Chu, 1990, Chemical and pharmaceutical bulletin.

Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.

R. Schinazi, C. K. Chu, M. Bennett, 2005, Journal of medicinal chemistry.

Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.

R. Schinazi, H. Choo, C. K. Chu, 2001, Journal of medicinal chemistry.

Stereocontrolled syntheses of carbocyclic C-nucleosides and related compounds.

C. K. Chu, B. Chun, G. Song, 2001, The Journal of organic chemistry.

Enantiomeric synthesis of 3′-fluoro-apionucleosides using Claisen rearrangement

C. K. Chu, Yongseok Choi, J. Hong, 1998 .

Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies.

C. K. Chu, Y. Chong, Youhoon Chong, 2002, Bioorganic & medicinal chemistry letters.

Potent anti-HIV and anti-HBV activities of (−)-L-β-dioxolane-C and (+)-L-β-dioxolane-T and their asymmetric syntheses.

R. Schinazi, C. K. Chu, L. Jeong, 1992 .

Chemistry and antiviral activities of acyclonucleosides

C. K. Chu, S. Cutler, 1986 .

Pyrimido[5,4-b]quinolines. III. Synthesis of 10-alkyl-substituted 10-deazaalloxazines

C. K. Chu, T. Bardos, 1977 .

Synthesis of neplanocin F analogues as potential antiviral agents.

R. Schinazi, C. K. Chu, Hong-wang Zhang, 2006, Bioorganic & medicinal chemistry.

Synthesis, Structure−Activity Relationships, and Drug Resistance of β-d-3‘-Fluoro-2‘,3‘-Unsaturated Nucleosides as Anti-HIV Agents

R. Schinazi, C. K. Chu, Y. Chong, 2004 .

Synthesis and anti-HIV activity of D- and L-thietanose nucleosides.

R. Schinazi, H. Choo, C. K. Chu, 2006, Journal of medicinal chemistry.

L-nucleosides: antiviral activity and molecular mechanism.

H. Choo, C. K. Chu, Y. Chong, 2002, Current topics in medicinal chemistry.

Recent advances in L-nucleosides: chemistry and biology.

C. K. Chu, J. Cooperwood, J. Hong, 1998, Antiviral research.

Determination of the Anomeric Configuration of C-Nucleosides by 1H and 13C NMR Spectroscopy

C. K. Chu, B. Thompson, F. M. El-kabbani, 1984 .

(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).

D. Smee, C. K. Chu, D. Barnard, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, Structure−Activity Relationships, and Mechanism of Drug Resistance of d- and l-β-3‘-Fluoro-2‘,3‘-unsaturated-4‘-thionucleosides as Anti-HIV Agents

R. Schinazi, H. Choo, C. K. Chu, 2004 .

4-Azido-2-pyrimidinone Nucleosides and Related Chemistry.

L. Kotra, C. K. Chu, PingPing Wang, 1997, The Journal of organic chemistry.

Nucleosides. 116. 1-(beta-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides.

C. K. Chu, K. Watanabe, J. Fox, 1980, Journal of medicinal chemistry.

Nucleosides XCVII. Synthesis of an 8‐(d‐ribofuranosyl)pyrazolo[1,5‐a]‐1,3,5‐triazine. A new type of C‐Nucleoside

C. K. Chu, R. Klein, F. Heras, 1976 .

Pyrimidines. 16. Novel s-triazine to pyrimidine ring transformation reaction

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1979 .

Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

R. Schinazi, C. K. Chu, L. Jeong, 1992 .

An efficient synthesis of enantiomerically pure (+)-(2S,5R)-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine [(+)-BCH-189] from d-galactose

Sean W. Carrigan, C. K. Chu, L. Jeong, 1992 .

Enantiomeric synthesis of (+)-BCH-189 [(+)-(2S,5R)-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine] from D-mannose and its anti-HIV activity

R. Schinazi, C. K. Chu, L. Jeong, 1991 .

Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks

R. Schinazi, C. K. Chu, B. Tennant, 1996, Antimicrobial agents and chemotherapy.

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

R F Schinazi, J. Mellors, R. Schinazi, 1993, Antimicrobial Agents and Chemotherapy.

Asymmetric synthesis of (2′R,4′R) and (2′S,4′S)-1,3-dioxolanyl triazole C-nucleosides

C. K. Chu, M. Newton, Jinfa Du, 1999 .

Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.

R. Schinazi, C. K. Chu, S. Chu, 1996, Biochemical pharmacology.

Pharmacokinetics of (2)-29-39-Dideoxy-39-Thiacytidine in Woodchucks

R. Schinazi, C. K. Chu, B. Tennant, 1996 .

Novel C-nucleoside analogs of 1,3-dioxolane: Synthesis of enantiomeric (2′R,4′S)- and (2′S,4′R)-2-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-1,3-thiazol-4-carboxamide

C. K. Chu, Q. Teng, Y. Xiang, 1995 .

Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.

Y. Cheng, C. K. Chu, E. Gullen, 2000, Journal of medicinal chemistry.

CHAPTER 2 – CHIRAL SYNTHESIS OF ANTIVIRAL NUCLEOSIDES FROM CARBOHYDRATE TEMPLATES

C. K. Chu, S. Ölgen, G. Gumina, 2003 .

Synthesis of 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides.

L. Kotra, C. K. Chu, M. Newton, 1998, Carbohydrate research.

Syntheses of 2″,3″-Dideoxy-L-Glycero-Pentofuranosyl C-Nucleosides

C. K. Chu, Jinfa Du, Chang Soo Lee, 1996 .

ASYMMETRIC SYNTHESIS OF (1'S,2'R)-CYCLOPROPYL CARBOCYCLIC NUCLEOSIDES

C. K. Chu, Yufen Zhao, M. Newton, 1995 .

Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).

R. Schinazi, W. Prusoff, C. K. Chu, 1988, Journal of medicinal chemistry.

NUCLEOSIDES. 98. DIRECT INTRODUCTION OF AN ACETAMIDO GROUP INTO THE SUGAR MOIETY OF NUCLEOSIDE EPOXIDES

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1976 .

Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

M. Otto, L. Stuyver, R. Schinazi, 2002, Antimicrobial Agents and Chemotherapy.

Regioselective synthesis of 3-deazacarbovir and its 3-deaza-adenosine analogues

C. K. Chu, Ashoke Sharon, A. Jha, 2009 .

Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity

C. K. Chu, R. Rawal, Jianing Wang, 2011 .

SYNTHESIS OF NOVEL 3'-C-METHYL-4'-THIO APIONUCLEOSIDES VIA HIGHLY ENANTIOSELECTIVE ELABORATION OF QUATERNARY CARBON BY 3,3-SIGMATROPIC REARRANGEMENT

C. K. Chu, J. Hong, M. Gao, 1999 .

Synthesis and antiviral activity of oxaselenolane nucleosides.

S. Olgen, R. Schinazi, Y. Cheng, 2000, Journal of medicinal chemistry.

A Highly Stereoselective Synthesis of Anti‐HIV 2′,3′‐Dideoxy‐ and 2′,3′ ‐Didehydro‐2′,3′‐dideoxynucleosides.

Soon Kil Ahn, J. W. Beach, S. Ahn, 1992 .

A highly stereoselective synthesis of anti-HIV 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxynucleosides

S. Ahn, C. K. Chu, L. Jeong, 1992 .

Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides

C. K. Chu, L. Jeong, Hea Ok Kim, 1993 .

Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.

L. Kotra, R. Schinazi, C. K. Chu, 1996, Journal of medicinal chemistry.

Synthesis of 1-(β-D-ribofuranosyl)indol-3-acetic acid

C. K. Chu, H. Cutler, Jungjin Suh, 1986 .

Nucleosides. 98. Direct introduction of an acetamido group into the sugar moiety of nucleoside epoxides.

C. K. Chu, K. Watanabe, J. Fox, 1976, The Journal of organic chemistry.

Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution.

R. Schinazi, C. K. Chu, G. Gumina, 2004, Organic letters.

Synthesis of L-oxetanocin.

C. K. Chu, G. Gumina, 2002, Organic letters.

Synthesis of pyrimidine 3'-allyl-2',3'-dideoxyribonucleosides by free-radical coupling

P. Roey, C. K. Chu, B. Doboszewski, 1989 .

NUCLEOSIDES. 107. SYNTHESIS OF 5-(β-D-ARABINOFURANOSYL)ISOCYTOSINE AND RELATED C-NUCLEOSIDES

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1978 .

Nucleosides. 107. Synthesis of 5-(beta-D-arabinofuranosyl)isocytosine and related C-nucleosides.

C. K. Chu, K. Watanabe, J. Fox, 1978, Journal of medicinal chemistry.

General syntheses of 2',3'-dideoxynucleosides and 2',3'-didehydro-2',3'-dideoxynucleosides

P. Roey, C. K. Chu, Z. Gu, 1989 .

Synthesis of C-nucleoside analogs of 2',3'-dideoxycytidine, 3'-azido-2',3'-dideoxyuridine (CS-87), and 2',3'-dideoxy-2',3'-didehydrocytidine

C. K. Chu, H. Halbeek, B. Doboszewski, 1988 .

Synthesis and structure-activity relationships of 6-substituted 2',3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents.

R. Schinazi, C. K. Chu, L. Jeong, 1990, Journal of medicinal chemistry.

Synthesis of Pyrimidine 3′-Allyl-2′,3′-dideoxyribonucleosides by Free-Radical Coupling.

P. Roey, C. K. Chu, B. Doboszewski, 1989 .

Hydrolysis products of dibutyltin dichlorides

C. K. Chu, J. D. Murray, 1971 .

Comparison of cytotoxicity of the (-)- and (+)-enantiomer of 2',3'-dideoxy-3'-thiacytidine in normal human bone marrow progenitor cells.

R. Schinazi, C. K. Chu, J. Sommadossi, 1992, Biochemical pharmacology.

Synthesis of [4-(hydroxy)tetrahydrofuran-2-yl]nucleosides as a novel class of uridine phosphorylase inhibitors

L. Kotra, C. K. Chu, Q. Teng, 1995 .

β-L-1-[5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)] uracil (L-BHDU) effectiveness against varicella-zoster virus and herpes simplex virus type 1 depends on thymidine kinase activity

D. Depledge, C. K. Chu, Dongmei Liu, 2020, bioRxiv.

Pharmacokinetics of the Anti-Human Immunodeficiency Virus Agent 1-(β-d-Dioxolane)Thymine in Rhesus Monkeys

H. McClure, R. Schinazi, C. K. Chu, 2007, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of the Anti-Human Immunodeﬁciency Virus Agent 1-( (cid:2) - D -Dioxolane)Thymine in Rhesus Monkeys (cid:1) †

H. McClure, R. Schinazi, C. K. Chu, 2007 .

Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides.

R. Schinazi, C. K. Chu, J. Sommadossi, 1992, Biochemical pharmacology.

Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.

R. Schinazi, C. K. Chu, Z. Gu, 1989, Journal of medicinal chemistry.

Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid.

C. K. Chu, T. Bardos, 1977, Journal of medicinal chemistry.

1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.

R. Schinazi, C. K. Chu, L. Jeong, 1993, Journal of medicinal chemistry.

Synthesis and Antiviral Activities of Enantiomeric 1-[2-(Hydroxymethyl) Cyclopropyl] Methyl Nucleosides

S. Olgen, R. Schinazi, C. K. Chu, 2000, Nucleosides, Nucleotides & Nucleic Acids.

A practical synthesis of L-FMAU from L-arabinose.

Joon Hee Hong, C. K. Chu, K. Lee, 1999, Nucleosides & nucleotides.

SYNTHESES OF 2′,3′-DIDEOXY-D-C-NUCLEOSIDES FROM γ-LACTONE

C. K. Chu, Y. Xiang, Jinfa Du, 1996 .

Chiral Synthesis of Carbocyclic Analogues of l-ribofuranosides

C. K. Chu, L. Agrofoglio, Peiyuan Wang, 1999 .

Syntheses of 2′,3′-Dideoxy-D-C-nucleosides from γ-Lactone.

C. K. Chu, Y. Xiang, Jinfa Du, 1997 .

Nucleosides. 104. Synthesis of 4-amino-5-(D-ribofuranosyl)pyrimidine C-nucleosides from 2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile.

C. K. Chu, K. Watanabe, J. Fox, 1977, Journal of Organic Chemistry.

Synthesis of L-ribofuranosyl C-nucleosides.

C. K. Chu, J. Cooperwood, J. Du, 1997, Carbohydrate research.

Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.

R. Schinazi, C. K. Chu, M. Murray, 2009, Journal of medicinal chemistry.

Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).

C. K. Chu, Hyo-Joong Kim, E. Kern, 2006, Bioorganic & medicinal chemistry letters.

A Convergent Approach for the Synthesis of Ara-Neplanocin a Analogues Under Subzero Microwave Assisted Conditions

M. Radi, C. K. Chu, A. Jha, 2009, Nucleosides, nucleotides & nucleic acids.

Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.

C. K. Chu, Jakyung Yoo, Ashoke Sharon, 2010, Bioorganic & medicinal chemistry.

Enantiomeric synthesis of carbocyclic d-4′-C-methylribonucleosides as potential antiviral agents

C. K. Chu, P. Liu, Ashoke Sharon, 2006 .

Solid phase synthesis of carbocyclic l-2'-deoxynucleosides.

H. Choo, C. K. Chu, Y. Chong, 2001, Organic letters.

Chiral Synthesis of Carbocyclic Analogues of L‐Ribofuranosides.

C. K. Chu, L. Agrofoglio, M. Newton, 1999 .

Asymmetric synthesis of L-cyclopentyl carbocyclic nucleosides

C. K. Chu, L. Agrofoglio, M. Newton, 1997 .

A facile synthesis of 8-(β-D-ribofuranosyl)-4-thioxo-3H-pyrazolo[1,5-a]-1,3,5-triazine and its α-anomer

C. K. Chu, 1984 .

Acyclopyrimidine C-nucleosides. Synthesis of acyclopseudoisocytidine and its derivatives

C. K. Chu, 1984 .

Nucleosides. 117. Synthesis of 4‐oxo‐8‐(β‐D‐ribofuranosyl)‐3H‐pyrazolo[1,5‐a]‐1,3,5‐triazine (OPTR) via 3‐amino‐2N‐carbamoyl‐4‐(β‐D‐ribofuranosyl)pyrazole (ACPR) derivatives

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1980 .

NUCLEOSIDES. 104. SYNTHESIS OF 4-AMINO-5-(D-RIBOFURANOSYL)PYRIMIDINE C-NUCLEOSIDES FROM 2-(2,3-O-ISOPROPYLIDENE-5-O-TRITYL-D-RIBOFURANOSYL)ACETONITRILE

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1977 .

NUCLEOSIDES. CIX. 2′-DEOXY-Ψ-ISOCYTIDINE, 2′-DEOXY-Ψ-URIDINE, AND 2′DEOXY-1-METHYL-Ψ-URIDINE. ISOSTERES OF DEOXYCYTIDINE, DEOXYURIDINE AND THYMIDINE

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1978 .

Short communication Physicochemical properties, bioconversion and disposition of lipophilic prodrugs of 2 1,3

C. K. Chu, 1996 .

Synthesis and Antiviral Activities of Enantiomeric 1‐[2‐(Hydroxymethyl)cyclopropyl]methyl Nucleosides.

S. Olgen, R. Schinazi, C. K. Chu, 2000 .

Enantiomeric Synthesis of L-(or 1'R,2'S)-Carbocyclic Cyclopropyl Nucleosides.

C. K. Chu, Mi Gyoung Lee, J. Du, 1997, The Journal of organic chemistry.

Enantioselective synthesis of cyclopropyl carbocyclic L-nucleosides

M. Chun, C. K. Chu, Yufen Zhao, 1995 .

Understanding the molecular basis of HBV drug resistance by molecular modeling.

C. K. Chu, Ashoke Sharon, 2008, Antiviral research.

Antiviral Effect of Orally Administered (−)-β-d-2-Aminopurine Dioxolane in Woodchucks with Chronic Woodchuck Hepatitis Virus Infection

R. Schinazi, C. K. Chu, B. Tennant, 2007, Antimicrobial Agents and Chemotherapy.

Mechanism of Antiviral Activities of 3′-Substituted L-Nucleosides against 3Tc-Resistant HBV Polymerase: A Molecular Modelling Approach

M. Otto, L. Stuyver, R. Schinazi, 2003, Antiviral chemistry & chemotherapy.

Effect of β-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells

R. Schinazi, C. K. Chu, G. R. Revankar, 1996 .

Synthesis of 2',3'-dideoxy-3'-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol.

R. Schinazi, Y. Cheng, C. K. Chu, 2000, Carbohydrate research.

Correlation of Molecular Conformation and Activity of Reverse Transcriptase Inhibitors a

R. Schinazi, P. Roey, C. K. Chu, 1990, Annals of the New York Academy of Sciences.

Inhibitory Effect of 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyl-Uracil on Duck Hepatitis B Virus Replication

M. Chevallier, F. Zoulim, C. Borel, 1998, Antimicrobial Agents and Chemotherapy.

Understanding the molecular mechanism of drug resistance of anti-HIV nucleosides by molecular modeling.

C. K. Chu, Y. Chong, 2004, Frontiers in bioscience : a journal and virtual library.

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

K. Anderson, R. Schinazi, C. K. Chu, 2001, Antimicrobial Agents and Chemotherapy.

High-performance liquid chromatographic determination of (-)-β-D-2-aminopurine dioxolane and (-)-β-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-β-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid

H. McClure, R. Schinazi, C. K. Chu, 1997 .

Biotransformation and pharmacokinetics of prodrug 9-(beta-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine in mice.

R. Schinazi, C. K. Chu, F. D. Boudinot, 1997, Antiviral Research.

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.

K. Anderson, R. Schinazi, C. K. Chu, 2001, Antimicrobial agents and chemotherapy.

and Epstein-Barr virus. l as a novel antiviral agent for hepatitis B virus 2'-fluoro-5-methyl-beta-L-arabinofuranosyluraci Use of

C. K. Chu, J. Sommadossi, Y. Xiang, 2013 .

Efficient synthesis of 2-deoxy-L-erythro-pentose (2-deoxy-L-ribose) from L-arabinose.

C. K. Chu, Y. Chong, 2002, Carbohydrate research.

Anticancer Activity of /3-L-Dioxolane-cytidine, a Novel Nucleoside Analogue with the Unnatural L Configuration1

C. K. Chu, Liu, Zhi-hua Gao, 2006 .

Clevudine, to Treat Hepatitis B Viral Infection

C. K. Chu, Ashoke Sharon, A. Jha, 2010 .

SYNTHESIS AND IN VITRO ANTI-HCV ACTIVITY OF β-D- and L-2′-DEOXY-2′-FLUORORIBONUCLEOSIDES

M. Otto, L. Stuyver, R. Schinazi, 2005 .

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

M. Otto, L. Stuyver, R. Schinazi, 2005, Bioorganic & medicinal chemistry.

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.

R. Schinazi, S. Ahn, C. K. Chu, 1992, Journal of medicinal chemistry.

Pharmacokinetics of the Antiviral Agent β-l-3′-Fluoro-2′,3′-Didehydro-2′,3′-Dideoxycytidine in Rhesus Monkeys

H. McClure, R. Schinazi, C. K. Chu, 2005, Antimicrobial Agents and Chemotherapy.

Synthesis of 2′,3′-Dideoxy-3′-fluoro-L-ribonucleosides as Potential Antiviral Agents from D-Sorbitol.

R. Schinazi, C. K. Chu, B. Chun, 2000 .

Nucleosides. CXXXV. Synthesis of some 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purines and their biological activities.

J. Burchenal, T. Chou, C. K. Chu, 1989, Chemical & pharmaceutical bulletin.

Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents.

Y. Cheng, C. K. Chu, E. Gullen, 1999, Journal of medicinal chemistry.

Structure-activity relationships of 2'-deoxy-2',2'-difluoro-L-erythro-pentofuranosyl nucleosides.

L. Kotra, R. Schinazi, Y. Cheng, 1997, Journal of medicinal chemistry.

Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase.

C. K. Chu, Ashoke Sharon, Y. A. Kim, 2008, Journal of medicinal chemistry.

Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.

C. K. Chu, V. Yadav, V. Guarcello, 2004, Journal of medicinal chemistry.

The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).

H. Choo, C. K. Chu, Y. Chong, 2003, Bioorganic & medicinal chemistry letters.

Antiviral Activity and Pharmacokinetics of 1-(2,3-Dideoxy-2-Fluoro-β-l-Glyceropent-2-Enofuranosyl)Cytosine

H. McClure, R. Schinazi, C. K. Chu, 2003, Antimicrobial Agents and Chemotherapy.

Synthesis and anti-HIV activities of 2′-deoxy-2′,2″-difluoro-β-L-ribofuranosyl-pyrimidine and -purine nucleosides

L. Kotra, R. Schinazi, C. K. Chu, 1995 .

Metabolism of the Anti-Hepatitis C Virus Nucleoside β-d-N4-Hydroxycytidine in Different Liver Cells

L. Stuyver, R. Schinazi, C. K. Chu, 2004, Antimicrobial Agents and Chemotherapy.

Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus.

C. K. Chu, Ashoke Sharon, R. Rawal, 2011, Bioorganic & medicinal chemistry letters.

Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis.

K. Anderson, R. Schinazi, C. K. Chu, 2003, Biochemistry.

Molecular Mechanism of DAPD/DXG against Zidovudine- and Lamivudine- Drug Resistant Mutants: A Molecular Modelling Approach

R. Schinazi, C. K. Chu, Y. Chong, 2002, Antiviral chemistry & chemotherapy.

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

K. Anderson, H. McClure, R. Schinazi, 2005, Antimicrobial Agents and Chemotherapy.

Probing the Mechanistic Consequences of 5-Fluorine Substitution on Cytidine Nucleotide Analogue Incorporation by HIV-1 Reverse Transcriptase

K. Anderson, R. Schinazi, C. K. Chu, 2003, Antiviral chemistry & chemotherapy.

Novel Use of a Guanosine Prodrug Approach To Convert 2',3'-Didehydro-2',3'-Dideoxyguanosine into a Viable Antiviral Agent

K. Anderson, C. K. Chu, Zhenjun Yang, 2002, Antimicrobial Agents and Chemotherapy.

Beta-L-(-)-dioxolane Cytidine (β-L-(-)-OddC) as a Potent Compound for the Treatment of Cancer

M. Kukhanova, C. K. Chu, Shwu-Huey Liu, 1997 .

L- and D-Enantiomers of 2′,3′-Dideoxycytidine 5′-Triphosphate Analogs as Substrates for Human DNA Polymerases

M. Kukhanova, C. K. Chu, Shwu-Huey Liu, 1995, The Journal of Biological Chemistry.

L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.

R. Schinazi, C. K. Chu, L. Jeong, 1993, Journal of medicinal chemistry.

Molecular Modeling Approach to Understanding the Mode of Action of l-Nucleosides as Antiviral Agents

C. K. Chu, Kyeong Lee, 2001, Antimicrobial Agents and Chemotherapy.

Potent Anti‐HIV and Anti‐HBV Activities of (‐)‐L‐β‐Dioxolane‐C and (+)‐L‐β‐Dioxolane‐T and Their Asymmetric Syntheses.

R. Schinazi, C. K. Chu, L. Jeong, 1993 .

Molecular mechanism of dioxolane nucleosides against 3TC resistant M184V mutant HIV.

C. K. Chu, Y. Chong, 2004, Antiviral research.

Effects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase.

H. Choo, C. K. Chu, Y. Chong, 2004, Bioorganic & Medicinal Chemistry Letters.

Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine.

R. Schinazi, C. K. Chu, P. Wang, 1998, Bioorganic & medicinal chemistry letters.

1,3-Dioxolane C-Nucleosides: Asymmetric Synthesis of Four Stereoisomers of 2-[2-(Hydroxymethyl)-1,3-Dioxolan-S-yl)-1,3-Thiazole-4-Carboxamide

C. K. Chu, M. Newton, Jinfa Du, 1995 .

Dioxolane cytosine nucleosides as anti-hepatitis B agents

M. Chun, C. K. Chu, S. Pai, 1995 .

Crystal Structures and Molecular Conformations of Anti-HIV Nucleosides

P. Roey, C. K. Chu, 1993 .

Nucleosides. CIX. 2′-Deoxy-ψ-isocytidine, 2 -deoxy-ψ-uridine, and 2′-deoxy-l-methyl-ψ-uridine. Isosteres of deoxycytidine, deoxyuridine and thymidine

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1977 .

Enantiomeric syntheses of conformationally restricted D- and L-2', 3'-dideoxy-2',3'-endo-methylene nucleosides from carbohydrate chiral templates.

S. Olgen, C. K. Chu, M. Newton, 2000, The Journal of organic chemistry.

Synthesis of L-3′-Hydroxymethylribonucleosides

C. K. Chu, J. Cooperwood, G. Gumina, 2000, Nucleosides, nucleotides & nucleic acids.

Synthesis of novel 3'-C-methyl-apionucleosides: an asymmetric construction of a quaternary carbon by Claisen rearrangement.

R. Schinazi, Y. Cheng, C. K. Chu, 2000, Carbohydrate research.

Activity and Mechanism of Action of HDVD, a Novel Pyrimidine Nucleoside Derivative with High Levels of Selectivity and Potency against Gammaherpesviruses

J. J. van den Oord, Y. Cheng, C. K. Chu, 2013, Journal of Virology.

Metabolism and mode of inhibition of varicella-zoster virus by L-beta-5-bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil is dependent on viral thymidine kinase.

Y. Cheng, C. K. Chu, E. Gullen, 2000, Molecular pharmacology.

Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.

C. K. Chu, V. Yadav, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and Anti-Hepatitis B Virus Activity of 9-(2-Deoxy-2-fluoro-. beta.-L-arabinofuranosyl)purine Nucleosides.

C. K. Chu, M. Newton, Y.‐C. Cheng, 1997 .

Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.

Chuo, R. Schinazi, P. Roey, 1989, Proceedings of the National Academy of Sciences of the United States of America.

19F NMR study of the uptake of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil in erythrocytes: evidence of transport by facilitated and nonfacilitated pathways.

C. K. Chu, R. London, A. Xu, 1998, Biochemical pharmacology.

Synthesis and anti-hepatitis B virus activity of 9-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl) purine nucleosides.

Y. Cheng, C. K. Chu, M. Newton, 1997, Journal of Medicinal Chemistry.

Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.

R. Schinazi, M. Chun, C. K. Chu, 1993, Journal of medicinal chemistry.

Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.

R. Schinazi, C. K. Chu, Xin Chen, 2004, Journal of Organic Chemistry.

2′‐Fluoro‐6′‐methylene carbocyclic adenosine and its phosphoramidate prodrug: A novel anti‐HBV agent, active against drug‐resistant HBV mutants

C. K. Chu, Varughese A. Mulamoottil, U. Singh, 2018, Medicinal research reviews.

The Crystal and Molecular Structure of the Complex of 2′3′-Didehydro-2′3′-Dideoxyguanosine with Pyridine

P. Roey, C. K. Chu, 1992 .

l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.

R. Schinazi, C. K. Chu, Y. Chong, 2003, Journal of medicinal chemistry.

Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides.

R. Schinazi, Y. Cheng, C. K. Chu, 1997, Journal of Medicinal Chemistry.

Structure‐Activity Relationships of 1‐(2‐Deoxy‐2‐fluoro‐β‐L‐ arabinofuranosyl)pyrimidine Nucleosides as anti‐Hepatitis B Virus Agents.

Y. L. Zhu, C. K. Chu, H. Kim, 1996 .

Metabolism of the Anti-Hepatitis C Virus Nucleoside β-d-N4-Hydroxycytidine in Different Liver Cells

L. Stuyver, R. Schinazi, C. K. Chu, 2004, Antimicrobial Agents and Chemotherapy.

Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.

R. Schinazi, C. K. Chu, J. Gallo, 1989, Drug Metabolism And Disposition.

In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.

G. Peters, M. Radi, C. K. Chu, 2007, Journal of medicinal chemistry.

Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.

R. Schinazi, Y. Cheng, C. K. Chu, 1999, Nucleosides & nucleotides.

Synthesis of an Anti-hepatitis B Agent, 2'-Fluoro-6'-methylene-carbocyclic Adenosine (FMCA) and Its Phosphoramidate (FMCAP).

C. K. Chu, Varughese A. Mulamoottil, U. Singh, 2018, The Journal of organic chemistry.

Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.

R. Schinazi, H. Choo, C. K. Chu, 2003, Journal of Medicinal Chemistry.

Nucleosides—XCV: Total synthesis of pentopyranamine D, the nucleoside moiety of blasticidin H

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1976 .

Acetylation of Nucleosides by Acetylsalicylic Acid (Aspirin)1

C. K. Chu, 1983 .

C(2')-substituted purine nucleoside analogs. Interactions with adenosine deaminase and purine nucleoside phosphorylase and formation of analog nucleotides.

M. Ikehara, C. K. Chu, R. Parks, 1982, Biochemical pharmacology.

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.

M. Otto, L. Stuyver, R. Schinazi, 2005, Nucleosides, Nucleotides & Nucleic Acids.

Stereoselective Synthesis and Antiviral Activity of d-2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluoro-4‘-thionucleosides

R. Schinazi, H. Choo, C. K. Chu, 2002 .

Asymmetric Synthesis and anti-HIV Activity of L-Carbocyclic 2′,3′-Didehydro-2′,3′-dideoxyadenosine.

R. Schinazi, C. K. Chu, Peiyuan Wang, 1998 .

1,3-Dioxolane C-Nucleosides: Asymmetric Synthesis of Four Stereoisomers of 2-(2-(Hydroxymethyl)-1,3-dioxolan-5-yl)-1,3-thiazole- 4-carboxamide.

C. K. Chu, M. Newton, J. Du, 2010 .

Nucleosides XCIX. 2-Acetoxybenzoyl Chloride, A Reagent for the Direct Synthesis of 2,2′-Anhydro-pyrimidine Nucleosides

C. K. Chu, K. Watanabe, J. Fox, 1976 .

A highly stereoselective glycosylation of 2-(phenylselenenyl)-2,3-dideoxyribose derivative with thymine: synthesis of 3'-deoxy-2',3'-didehydrothymidine and 3'-deoxythymidine

S. Ahn, C. K. Chu, L. Jeong, 1990 .

A General Synthetic Method for 2′,3′-Dideoxynucleosldes: Total Synthetic Approach

C. K. Chu, R. Raghavachari, J. Beach, 1989 .

Nucleosides CIII. Anhydropyrimidine-C-nueleosides. Synthesis of 4,2′-anhydro-5-(β-D-arabinofuranosyl)- and 5-(β-D-arabinofuranosyl)pyrimidine C-nucleosides

C. K. Chu, Kyoichi A. Watanabe, J. Fox, 1976 .

A Highly Stereoselective Glycosylation of 2-(Phenylselenenyl)-2,3-dideoxyribose Derivative with Thymine: Synthesis of 3′-Deoxy-2′,3′-didehydrothymidine and 3′-Deoxythymidine.

S. Ahn, C. K. Chu, L. Jeong, 1990 .

Solid-state conformation of anti-human immunodeficiency virus type-1 agents: Crystal structures of three 3'-azido-3'-deoxythymidine analogs

William L. Duax, Patrick Van Roey, Raymond F. Schinazi, 1988 .

NUCLEOSIDES. 123. SYNTHESIS OF ANTIVIRAL NUCLEOSIDES: 5-SUBSTITUTED 1-(2-DEOXY-2-HALOGENO-β-D-ARABINOFURANOSYL)CYTOSINES AND -URACILS. SOME STRUCTURE-ACTIVITY RELATIONSHIPS

A. Matsuda, M. Chun, C. K. Chu, 1983 .

Metabolism and Eftects of 5-(fJ-D-Ribofuranosyl)isocytosinein P815 Cells

J. Burchenal, T. Chou, C. K. Chu, 2006 .

Synthesis of thymidine derivatives 3'-modified with a polar three-atom group as potential anti-HIV-1 agents

Y. Kitade, R. Schinazi, C. K. Chu, 1992 .

Ring transformation reactions of C-nucleosides: facile synthesis of pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]triazine C-nucleosides

C. K. Chu, S. Cutler, Jungjin Suh, 1986 .

Nucleosides. CVI. Syntheses of 1-N-methyl-5-(beta-D-ribofuranosyl)uracil (1-N-methyl-phi-uridine) and its identity with a metabolite elaborated by Streptomyces platensis var. clarensis.

C. K. Chu, J. Fox, K. Hirota, 1977, The Journal of antibiotics.

Troxacitabine Prodrugs for Pancreatic Cancer

M. Radi, C. K. Chu, G. Peters, 2007, Nucleosides, nucleotides & nucleic acids.

Enantiomeric Syntheses of Conformationally Restricted D‐ and L‐2′,3′‐Dideoxy‐2′,3′‐endo‐methylene Nucleosides from Carbohydrate Chiral Templates.

C. K. Chu, M. Newton, S. Ölgen, 2000 .

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.

K. Anderson, R. Schinazi, C. K. Chu, 2002, Biochemistry.

Synthesis of Novel 3′‐C‐Methyl‐apionucleosides: An Asymmetric Construction of a Quaternary Carbon by Claisen Rearrangement.

R. Schinazi, C. K. Chu, Yongseok Choi, 2000 .

Asymmetric synthesis of car☐yclic C-nucleoside, (−)-9-deazaaristeromycin

C. K. Chu, B. Chun, 1999 .

Chiral Synthesis of Antiviral Nucleosides from Carbohydrate Templates

C. K. Chu, S. Ölgen, G. Gumina, 2004 .

Nucleoside conjugates. 15. Synthesis and biological activity of anti-HIV nucleoside conjugates of ether and thioether phospholipids.

C. K. Chu, C. West, K. Manouilov, 1996, Journal of medicinal chemistry.

Acyclopyrimidine C-nucleosides: Synthesis of 5-[(2,3-dihydroxy-1-propoxy)methyl]pyrimidines†

C. K. Chu, Jungjin Suh, 2009 .

2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.

M. Sugiyama, Yasuhito Tanaka, C. K. Chu, 2013, Bioorganic & medicinal chemistry letters.

Structure-Activity Relationships of β-D-(2S,5R)- and α-D-( 2S,5S)-1,3-Oxathiolanyl Nucleosides as Potential Anti-HIV Agents.

R. Schinazi, M. Chun, C. K. Chu, 1993 .

Conformational Analysis of 2′,3′‐Didehydro‐2′,3′‐dideoxypyrimidine Nucleosides

Raymond F. Schinazi, R. Schinazi, P. Roey, 1993 .

Structure determination of 4-azido-2-pyrimidinone nucleoside analogs using mass spectrometry.

L. Kotra, C. K. Chu, M. Bartlett, 1999, Journal of mass spectrometry : JMS.

Practical Synthesis of AZT and AZDU from Xylose: Efficient Deoxygenation via Nucleoside 2′-Xanthates

C. K. Chu, J. Bauman, Yaoquan Chen, 1992 .

Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.

R. Schinazi, C. K. Chu, J. Sommadossi, 1990, Molecular pharmacology.

Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.

R. Schinazi, C. K. Chu, J. Gallo, 1990, Journal of medicinal chemistry.

Simultaneous determination of 3'-azido-2',3'-dideoxyuridine and novel prodrugs in rat plasma by liquid chromatography.

C. K. Chu, J. Cooperwood, F. D. Boudinot, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis of 2′,3′-Dideoxy-2′-fluoro-L-threo-pentofuranosyl Nucleosides as Potential Antiviral Agents.

R. Schinazi, C. K. Chu, Y. Xiang, 2000 .

Determination of acyclovir in maternal plasma, amniotic fluid, fetal and placental tissues by high-performance liquid chromatography.

Stacy D. Brown, C. K. Chu, M. Bartlett, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Conformational Analysis of 2',3'-Didehydro-2',3'-dideoxypyrimidine Nucleosides.

R. Schinazi, P. Roey, C. K. Chu, 1993 .

Nucleosides. 120. Syntheses of 2'-deoxy-.psi.-isocytidine and 2'-deoxy-1-methyl-.psi.-uridine from .psi.-uridine

A. Matsuda, C. K. Chu, Kyoichi A. Watanabe, 1981 .

Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants.

M. Sugiyama, Yasuhito Tanaka, C. K. Chu, 2011, Bioorganic & medicinal chemistry letters.

In Vitro Selection of Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Decrease Susceptibility to (−)-β-d-Dioxolane-Guanosine and Suppress Resistance to 3′-Azido-3′-Deoxythymidine

J. Mellors, R. Schinazi, C. K. Chu, 2000, Antimicrobial Agents and Chemotherapy.

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

J. Karn, D. Margolis, K. Keedy, 2011, Journal of Virology.

Pyrimidines. Part 67. Synthesis and Antihuman Immunodeficiency Virus ( HIV-1) Activity of 3′-Deoxy-3′-(triazol-1-yl)thymidines and 2′,3′- Dideoxy-3′-(triazol-1-yl)uridines, and Inhibition of Reverse Transcriptase by Their 5′-Triphosphates.

Y. Kitade, R. Schinazi, C. K. Chu, 1991 .

Biochemical Studies on the Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to 1-(β-d-Dioxolane)Thymine Triphosphate

R. Schinazi, J. Lennerstrand, C. K. Chu, 2007, Antimicrobial Agents and Chemotherapy.

In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase

J. Mellors, R. Schinazi, C. K. Chu, 2005, Antimicrobial Agents and Chemotherapy.

Design of novel antiestrogens

J. Copland, C. K. Chu, J. C. Wood, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicities.

C. K. Chu, Y. A. Kim, O. N. Al Safarjalani, 2010, Biochemical pharmacology.

Blockade of Tetrahydrobiopterin Synthesis Protects Neurons after Transient Forebrain Ischemia in Rat: A Novel Role for the Cofactor

B. Volpe, T. Joh, C. K. Chu, 1999, The Journal of Neuroscience.

L-nucleoside analogues as potential antimalarials that selectively target Plasmodium falciparum adenosine deaminase.

A. M. Gero, C. K. Chu, A. Netting, 1999, Nucleosides & nucleotides.

An Efficient Total Synthesis of 3′-Azido-3′-deoxythymidine (AZT) and 3′-Azido-2′,3′-dideoxyuridine (AZDDU, CS-87) from D-Mannitol.

C. K. Chu, J. Beach, G. Ullas, 1989 .

Pharmacokinetics of 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (L-FMAU) in rats.

C. K. Chu, T. Ma, J. Wright, 1995, Pharmaceutical research.

Stereoselective synthesis of carbocyclic L-4'-fluoro-2',3'-dideoxyadenosine

Chu, C. K. Chu, Choi, 2000, Organic letters.

Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate

R. Schinazi, C. K. Chu, B. Eriksson, 1989, Antimicrobial Agents and Chemotherapy.

Advances in antiviral agents for hepatitis B virus.

C. K. Chu, G. Gumina, G. Song, 2001, Antiviral Chemistry & Chemotherapy.

SYNTHESIS OF CARBOCYCLIC OROTIDINE ANALOGS AS POTENTIAL OROTIDINE DECARBOXYLASE INHIBITORS

C. K. Chu, F. Naguib, G. Song, 2001, Nucleosides, nucleotides & nucleic acids.

1,3‐Dioxolanylpurine Nucleosides (2R,4R), e.g. (II), and (2R,4S) with Selective Anti‐HIV‐1 Activity in Human Lymphocytes.

R. Schinazi, C. K. Chu, L. Jeong, 1994 .

Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides.

R. Schinazi, C. K. Chu, Srinivas Gadthula, 2005, Nucleosides, Nucleotides & Nucleic Acids.

Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys.

H. McClure, R. Schinazi, C. K. Chu, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis of unsaturated fluoride containing D- and L-pyranosyl nucleosides

C. K. Chu, Wen Zhou, C. Momany, 2002 .

Asymmetric synthesis of oxazolidine nucleosides and related chemistry.

C. K. Chu, J. Du, 1998, Nucleosides & nucleotides.

NUCLEOSIDES PART 92, A FACILE SYNTHESIS OF 5‐(BETA‐D‐RIBOFURANOSYL)‐ISOCYTOSINE(PSI‐ISOCYTIDINE)

C. K. Chu, J. Fox, K. Watanabe, 1975 .

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

J. Mellors, C. K. Chu, N. Ilksoy, 1993, Antimicrobial Agents and Chemotherapy.

Solid-State Conformation of Anti-Human Immunodeficiency Virus Type-1 Agents: Crystal Structures of Three 3′-Azido-3′-deoxythymidine Analogues

R. Schinazi, P. Roey, W. Duax, 1988 .

Synthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase

C. K. Chu, Uma S. Singh, 2020, Nucleosides, nucleotides & nucleic acids.

Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase.

C. K. Chu, Ashoke Sharon, Y. A. Kim, 2008, Journal of medicinal chemistry.