T. Chambers

发表

The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide.

Cheryl Brantley-Finley, C. Lyle, Li-juan Du, 2003, Biochemical pharmacology.

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death

T. Chambers, J. Eichhorn, N. Sakurikar, 2013, Cell Death and Disease.

CDK1/2 toolbox in need of an upgrade

T. Chambers, Anisha Kothari, 2016, Cell cycle.

Subcellular localization as a limiting factor for utilization of decoy oligonucleotides.

T. Chambers, R. Kurten, Anca Bene, 2004, Nucleic acids research.

Small peptide substrates and high resolution peptide gels for the analysis of site-specific protein phosphorylation and dephosphorylation

T. Chambers, L. Battle, 2017, Journal of biological methods.

Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction

C. Lyle, Li-juan Du, T. Chambers, 2005, Oncogene.

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

T. Chambers, J. Jacobs, G. Eilon, 1990, The Journal of biological chemistry.

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

T. Chambers, B. Zheng, J. Kuo, 1992, Molecular pharmacology.

Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.

T. Chambers, J. Wietrzyk, D. Strand, 2018, European journal of medicinal chemistry.

H1 histone kinases from nuclei of Physarum polycephalum.

T. Chambers, E. Bradbury, H. Matthews, 1983, Biochemistry.

The c-Jun NH(2)-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine.

M. Birrer, M. Goodwin, T. Chambers, 2001, Cancer research.

Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine

T. Chambers, M. Upreti, R. Chu, 2008, Molecular Cancer Therapeutics.

Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified

T. Chambers, S. Mackintosh, S. Alford, 2016, Oncotarget.

Multidrug‐resistant human kb carcinoma cells are highly resistant to the protein phosphatase inhibitors okadaic acid and calyculin A. Analysis of potential mechanisms involved in toxin resistance

T. Chambers, J. Kuo, R. Raynor, 1993, International journal of cancer.

P‐Glycoprotein, Multidrug Resistance and Protein Kinase C

R. Fine, T. Chambers, C. Sachs, 1996, Stem cells.

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer

A. Tackett, T. Chambers, S. Piña‐Oviedo, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways

K. Raney, T. Chambers, G. Baldini, 2022, The Journal of biological chemistry.

Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives.

J. Tuszynski, J. Preto, T. Chambers, 2021, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents.

J. Tuszynski, J. Preto, T. Chambers, 2020, Bioorganic chemistry.

Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel.

T. Chambers, S. Piña‐Oviedo, Adam Huczyński, 2020, European journal of pharmacology.

Contrasting effects of microtubule destabilizers versus stabilizers on induction of death in G1 phase of the cell cycle

T. Chambers, Alicja Urbaniak, Magdalena Delgado, 2019, Biochemical pharmacology.

Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.

J. Tuszynski, J. Preto, T. Chambers, 2019, Bioorganic & medicinal chemistry.

Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase

T. Chambers, Magdalena Delgado, 2018, Cell cycle.

Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells.

W. Hittelman, T. Chambers, Anisha Kothari, 2016, Cancer research.

Identification of a mitotic death signature in cancer cell lines.

T. Chambers, J. Eichhorn, N. Sakurikar, 2014, Cancer letters.

Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis.

Xiao-Ming Yin, T. Chambers, W. Ding, 2009, Biochemical pharmacology.

Induction of apoptosis by vinblastine via c-Jun auto-amplification and p53-independent downregulation of p21

C. Lyle, T. Chambers, M. Upreti, 2007 .

Modulation of mitogen-activated protein kinases and phosphorylation of Bcl-2 by vinblastine represent persistent forms of normal fluctuations at G2-M1.

T. Chambers, K. Gilbert, M. Fan, 2000, Cancer research.

Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein.

T. Chambers, D. Glass, J. Pohl, 1994, The Biochemical journal.

Identification of SDecific Sites in Human P-glycoprotein Phosphorylated by Protein

T. Chambers, J. Kuo, R. Raynor, 1993 .

Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy.

T. Chambers, M. Fan, M. Fan, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Role of c-Jun in cellular sensitivity to the microtubule inhibitor vinblastine.

C. Lyle, T. Chambers, Toria B Obey, 2005, Biochemical and biophysical research communications.

Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation.

A. Kumar, K. Mehta, T. Chambers, 1997, Journal of lipid research.

Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells.

T. Chambers, A. Stone, A. A. Stone, 2000, Experimental cell research.

Differential Roles of Extracellular Signal-regulated Kinase-1/2 and p38MAPK in Interleukin-1β- and Tumor Necrosis Factor-α-induced Low Density Lipoprotein Receptor Expression in HepG2 Cells*

K. Mehta, T. Chambers, Amit Kumar, 1998, The Journal of Biological Chemistry.

p21 functions in a post-mitotic block checkpoint in the apoptotic response to vinblastine.

T. Chambers, Anca Bene, 2009, Biochemical and biophysical research communications.

Cyclin-dependent Kinase-1 (Cdk1)/Cyclin B1 Dictates Cell Fate after Mitotic Arrest via Phosphoregulation of Antiapoptotic Bcl-2 Proteins*

T. Chambers, J. Eichhorn, N. Sakurikar, 2012, The Journal of Biological Chemistry.

Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.

T. Chambers, R. Chu, D. Terrano, 2012, Biochemical pharmacology.

Two-drug combinations that increase apoptosis and modulate Bak and Bcl-XL expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase

K. E. Jones, M. Moyer, T. Chambers, 2000, Cancer Gene Therapy.

Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C.

T. Chambers, J. Pohl, J. Kuo, 1993, The Journal of biological chemistry.

Activity of resveratrol triesters against primary acute lymphoblastic leukemia cells.

T. Chambers, Alicja Urbaniak, K. Kacprzak, 2017, Bioorganic & medicinal chemistry letters.

Superhigh-sensitivity photothermal monitoring of individual cell response to antitumor drug.

V. Zharov, C. Lyle, T. Chambers, 2006, Journal of biomedical optics.

Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans.

T. Chambers, M. Upreti, K. Moon, 2009, Bioorganic & medicinal chemistry letters.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.

J. Tuszynski, T. Chambers, F. Bartl, 2018, Bioorganic chemistry.

Expression, subcellular distribution and response to phorbol esters of protein kinase C (PKC) isozymes in drug-sensitive and multidrug-resistant KB cells evidence for altered regulation of PKC-alpha.

T. Chambers, R. McMasters, B. A. Cloud-Heflin, 1996, European journal of biochemistry.

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

T. Chambers, M. Upreti, D. Terrano, 2009, Molecular and Cellular Biology.

BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells.

T. Chambers, H. M. Goselink, I. Jedema, 2015, Cancer research.

Vinblastine-induced Phosphorylation of Bcl-2 and Bcl-XL Is Mediated by JNK and Occurs in Parallel with Inactivation of the Raf-1/MEK/ERK Cascade*

Cheryl Brantley-Finley, M. Goodwin, T. Chambers, 2000, The Journal of Biological Chemistry.

c-Jun NH2-Terminal Kinase-Mediated Signaling Is Essential for Pseudomonas aeruginosa ExoS-Induced Apoptosis

H. Baker, T. Chambers, M. Chow, 2003, Infection and Immunity.

Molecular analysis of the multidrug transporter, P-glycoprotein

T. Chambers, U. Germann, 1998, Cytotechnology.

Effects of phosphorylation of P-glycoprotein on multidrug resistance

I. Pastan, M. Gottesman, S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Phorbol ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways

T. Chambers, L. M. Bell, A. Berry, 1999, Oncogene.

Vinblastine-induced Apoptosis Is Mediated by Discrete Alterations in Subcellular Location, Oligomeric Structure, and Activation Status of Specific Bcl-2 Family Members*

C. Lyle, Li-juan Du, T. Chambers, 2006, Journal of Biological Chemistry.

Translocation of cAMP-dependent protein kinase to the nucleus during development of Dictyostelium discoideum.

T. Chambers, K. Schaller, B. Leichtling, 1986, Developmental biology.

Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20‐oxo Analogues

T. Chambers, S. Piña‐Oviedo, Adam Huczyński, 2019, ChemMedChem.

1 BH 3 inhibitor sensitivity and Bcl-2 dependence in primary acute lymphoblastic leukemia cells

T. Chambers, I. Jedema, J. Eichhorn, 2015 .

Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells (*)

I. Pastan, M. Gottesman, S. Ambudkar, 1996, The Journal of Biological Chemistry.

Cyclin B1 Overexpression Induces Cell Death Independent of Mitotic Arrest

T. Chambers, J. Eichhorn, Anisha Kothari, 2014, PloS one.

Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance*

A. Tackett, T. Chambers, M. Upreti, 2008, Journal of Biological Chemistry.

Differential phosphorylation of sites in the linker region of P-glycoprotein by protein kinase C isozymes α, βi, βii, γ, δ, ϵ, η, and ζ

R. Fine, T. Chambers, C. Sachs, 1999 .

Identification of phosphorylation sites in human MDR1 P-glycoprotein.

T. Chambers, 1998, Methods in enzymology.

Role of the Stress-activated/c-Jun NH2-terminal Protein Kinase Pathway in the Cellular Response to Adriamycin and Other Chemotherapeutic Drugs*

T. Chambers, M. T. Osborn, 1996, The Journal of Biological Chemistry.

Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells—in vitro and ex vivo study

T. Chambers, S. Piña‐Oviedo, Adam Huczyński, 2020, Journal of biochemical and molecular toxicology.

The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study

T. Chambers, S. Piña‐Oviedo, T. Kieber‐Emmons, 2019, Oncology letters.

Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro.

T. Chambers, Adam Huczyński, Alicja Urbaniak, 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Inhibition of Cell Proliferation and Cell Cycle Progression by Specific Inhibition of Basal JNK Activity

C. Lyle, Li-juan Du, T. Chambers, 2004, Journal of Biological Chemistry.

BH 3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells

T. Chambers, H. M. Goselink, I. Jedema, 2015 .

Distinct signaling pathways of microtubule inhibitors – vinblastine and Taxol induce JNK‐dependent cell death but through AP‐1‐dependent and AP‐1‐independent mechanisms, respectively

K. Sabapathy, C. Lyle, T. Chambers, 2008, The FEBS journal.

AP-1 activation and altered AP-1 composition in association with increased phosphorylation and expression of specific Jun and Fos family proteins induced by vinblastine in KB-3 cells.

M. Goodwin, T. Chambers, C. Moran, 2001, Biochemical pharmacology.

Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use

T. Chambers, M. Pawłowska, E. Augustin, 2013, Drug Metabolism and Disposition.

Cytoskeletal Reorganization Induced by Retinoic Acid Treatment of Human Endometrial Adenocarcinoma (RL95-2) Cells Is Correlated with Alterations in Protein Kinase C-α

G. Parham, T. Chambers, C. A. Carter, 1998, Pathobiology.

Coordinating epidermal growth factor-induced motility promotes efficient wound closure.

C. Lyle, T. Chambers, R. Kurten, 2005, American journal of physiology. Cell physiology.

The lysine‐rich H1 histones from the slime moulds, Physarum polycephalum and Dictyostelium discoideum lack phosphorylation sites recognised by cyclic AMP‐dependent protein kinase in vitro

T. Chambers, R. Heads, H. V. Rickenberg, 1992, FEBS letters.

Activation of histone kinase in G2 phase of the cell cycle in Physarum Polycephalum

T. Chambers, K. Mitchelson, E. Bradbury, 1978, FEBS letters.

Identification of nuclear substrates of the cyclic AMP-dependent protein kinase in Dictyostelium discoideum.

T. Chambers, B. Leichtling, E. Spitz, 1987, Cell differentiation.

Purification and characterization of growth-associated H1 histone kinase from Novikoff hepatoma cells.

T. Chambers, T. Langan, 1990, The Journal of biological chemistry.

Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells.

T. Chambers, G. Eilon, I. Chalikonda, 1990, Biochemical and biophysical research communications.

Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein.

T. Chambers, B. Zheng, H. Gebel, 1994, The Journal of biological chemistry.

Purification and properties of growth-associated H1 histone kinase.

T. Chambers, T. Langan, 1991, Methods in enzymology.

Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival.

T. Chambers, J. Eichhorn, N. Sakurikar, 2014, Experimental cell research.

Pegylated IFN-α sensitizes melanoma cells to chemotherapy and causes premature senescence in endothelial cells by IRF-1-mediated signaling

T. Chambers, M. Upreti, R. Griffin, 2010, Cell Death and Disease.

Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition.

T. Chambers, B. Zheng, S. Chiou, 1993, Biochemistry.

Retracted: At diabetes‐like concentration, glucose down‐regulates the placental serotonin transport system in a cell‐cycle‐dependent manner

E. A. Reece, C. Lyle, T. Chambers, 2007, Journal of neurochemistry.

Electrophoretic mobility shift assay coupled with immunoblotting for the identification of DNA-binding proteins.

T. Chambers, B. Hurlburt, M. T. Osborn, 1999, BioTechniques.

Protein kinase domain of twitchin has protein kinase activity and an autoinhibitory region.

T. Chambers, G. Benian, J. Pohl, 1994, The Journal of biological chemistry.

Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest.

P. Brown, T. Chambers, Lingling Duan, 2007, Biochemical pharmacology.

Induction of Apoptosis by Vinblastine via c-Jun Autoamplification and p53-Independent Down-Regulation of p21WAF1/CIP1

C. Lyle, T. Chambers, M. Upreti, 2008, Molecular Pharmacology.

Induction of apoptosis by vinblastine via c-Jun autoamplification and p53-independent down-regulation of p21WAF1/CIP1.

C. Lyle, T. Chambers, M. Upreti, 2008, Molecular pharmacology.

Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines

T. Chambers, J. Eichhorn, S. Alford, 2013, Cell Death and Disease.

Photothermal evaluation of the influence of nicotine, antitumor drugs, and radiation on cellular absorbing structures

Vladimir P. Zharov, Valentin Galitovsky, Parimal Chowdhury, 2004, SPIE BiOS.

Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle

Charity L. Washam, Aaron J. Storey, A. Tackett, 2021, ACS omega.

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.

I. Pastan, S. Ambudkar, T. Chambers, 1995, Biochemistry.

Prostaglandin E2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: synergistic activation of differentiation, cell spreading, and fusion.

T. Chambers, Yongwon Choi, M. Wani, 1999, Endocrinology.

Abstract 14: Role of Cdk1 and Bcl-2 proteins in mitotic cell death

Stephen S. Taylor, T. Chambers, N. Sakurikar, 2011 .

P-Glycoprotein, Multidrug Resistance and Protein Kinase C.

R. Fine, T. Chambers, Fine, 1996, The oncologist.

Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.

T. Chambers, A. MacNicol, Megan R. Reed, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Intracellular Oxygen Concentration Determined By Mitochondrial Respiration Regulates Production of Reactive Oxygen Species.

T. Chambers, M. Higuchi, Sara E. Prior, 2017, Integrative cancer biology & research.

A novel succinyl dipeptide stimulates directed cell migration by modulating protein kinase C activity

T. Chambers, M. Gallo, R. Mascardo, 1990, Journal of cellular physiology.

Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance*

A. Tackett, T. Chambers, M. Upreti, 2008, Journal of Biological Chemistry.

Superhigh-sensitivity photothermal monitoring of individual cell response to antitumor drug.

V. Zharov, C. Lyle, T. Chambers, 2006, Journal of biomedical optics.

Modulation of mitogen-activated protein kinases and phosphorylation of Bcl-2 by vinblastine represent persistent forms of normal fluctuations at G2-M1.

Li-juan Du, T. Chambers, Kathleen M. Gilbert, 2000, Cancer research.