H. Gascan

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Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF

M. Peschanski, C. Monville, C. Fages, 2002, BMC Cell Biology.

Membranes of activated CD4+ T cells expressing T cell receptor (TcR) αβ or TcR γδ induce IgE synthesis by human B cells in the presence of interleukin‐4

H. Gascan, G. Aversa, J. D. de Vries, 1992 .

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

N. Gay, S. Tauszig-Delamasure, H. Gascan, 2003, Nature Immunology.

Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.

David Perret, S. Chevalier, C. Guillet, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Prokineticin 1 induces CCL4, CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells.

H. Gascan, V. Quillien, M. Samson, 2008, European cytokine network.

Cell kinetics in the fetal mouse thymus: precursor cell input, proliferation, and emigration.

F. Heuźe, H. Gascan, F. Jotereau, 1987, Journal of immunology.

Interleukin-27 and IFNγ regulate the expression of CXCL9, CXCL10, and CXCL11 in hepatitis

S. Chevalier, H. Gascan, M. Samson, 2015, Journal of Molecular Medicine.

Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture.

H. Gascan, J. Wijdenes, J. Froger, 2002, Cytokine.

gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses (*)

S. Chevalier, C. Guillet, H. Gascan, 1996, The Journal of Biological Chemistry.

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein*

S. Chevalier, H. Gascan, J. Wijdenes, 1996, The Journal of Biological Chemistry.

Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis.

H. Gascan, D. Guyader, F. Chalmel, 2014, Journal of hepatology.

Nerve growth factor is involved in the supportive effect by bone marrow--derived stromal cells of the factor-dependent human cell line UT-7.

S. Chevalier, W. Vainchenker, H. Gascan, 1996, Blood.

IL‐6 and soluble IL‐6 receptors (sIL‐6R and sgp130) in human pleural effusions: massive IL‐6 production independently of underlying diseases

P. Ingrand, H. Gascan, J. Wijdenes, 1997, Clinical and experimental immunology.

Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response*

S. Chevalier, H. Gascan, E. Lelièvre, 2000, The Journal of Biological Chemistry.

Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells.

S. Chevalier, G. Yancopoulos, P. Brachet, 1994, Blood.

Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells

S. Chevalier, G. Yancopoulos, P. Brachet, 1994 .

Characterization and NH2-terminal amino acid sequence of natural human interleukin for DA cells: leukemia inhibitory factor. Differentiation inhibitory activity secreted by a T lymphoma cell line.

V. Praloran, H. Gascan, R. Hewick, 1989, The Journal of biological chemistry.

Parameters of interaction of a novel monoclonal antibody (33B3.1) with the human IL2-receptors: interrelationship between 33B3.1, anti-Tac, and IL2 binding sites.

D. Olive, J. Moreau, H. Gascan, 1987, Human immunology.

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

S. Chevalier, J. Molès, H. Gascan, 2008, The Journal of Immunology.

Alanine Substitution for Thr268 and Asp269 of Soluble Ciliary Neurotrophic Factor (CNTF) Receptor α Component Defines a Specific Antagonist for the CNTF Response*

V. Praloran, H. Gascan, J. Froger, 1996, The Journal of Biological Chemistry.

Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation1

S. Chevalier, J. Molès, H. Gascan, 2007, The Journal of Immunology.

Activator Involved in Skin Inflammation Lymphocytes Is a Potent Keratinocyte Oncostatin M Secreted by Skin Infiltrating T

S. Chevalier, H. Gascan, H. Yssel, 2007 .

LymphocytesInfiltrated by Highly Differentiated Th17 Chronically Inflamed Human Tissues Are

S. Chevalier, J. Molès, H. Gascan, 2008 .

Regulation of Human IgE synthesis

H. Gascan, R. Waal Malefyt, H. Yssel, 1991, Annals of the New York Academy of Sciences.

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

H. Gascan, G. Aversa, J. D. de Vries, 1991, Journal of immunology.

Regulation of IgE synthesis by cytokines

H. Gascan, G. Aversa, J. Vries, 1992, Current Biology.

Neutrophils efficiently cross-prime naive T cells in vivo.

V. Barnaba, H. Gascan, P. Guermonprez, 2007, Blood.

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production

R. Coffman, H. Gascan, J. D. de Vries, 1990, The Journal of experimental medicine.

Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro.

S. Chevalier, D. Chappard, C. Guillet, 2007, Biochemical pharmacology.

Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle.

C. Guillet, H. Gascan, B. Fraysse, 2000, Journal of applied physiology.

Changes in CNTF receptor alpha expression in rat skeletal muscle during the recovery period after hindlimb suspension.

C. Guillet, H. Gascan, C. Huchet-Cadiou, 1998, Acta physiologica Scandinavica.

Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis

H. Gascan, F. Chalmel, J. Girard, 2017, Mediators of inflammation.

Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2+CD4+ lymphocytes.

H. Gascan, A. L'helgoualc'h, M. Samson, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Interleukin-33 overexpression is associated with liver fibrosis in mice and humans

H. Gascan, Katia Bourd-Boittin, A. L'helgoualc'h, 2009, Journal of cellular and molecular medicine.

Characterization of a factor produced by human T cell clones exhibiting eosinophil-activating and burst-promoting activities.

M. Bonneville, J. Moreau, H. Gascan, 1987, Journal of immunology.

Regulation of IgE synthesis by cytokines.

H. Gascan, G. Aversa, J. Vries, 1991 .

Modulation of IL-4 induced germline ε RNA synthesis in human B cells by tumor necrosis factor-α, anti-CD40 monoclonal antibodies or transforming growth factor-β correlates with levels of IgE production

H. Gascan, G. Aversa, J. Vries, 1992 .

The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps

C. Garlanda, A. Mantovani, H. Gascan, 2007, The Journal of experimental medicine.

Membranes of activated CD4+ T cells expressing T cell receptor (TcR) alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4.

H. Gascan, G. Aversa, J. D. de Vries, 1992, European journal of immunology.

Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor α Chain*

S. Chevalier, C. Guillet, H. Gascan, 2008, Journal of Biological Chemistry.

Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4+ T cells.

R. de Waal Malefyt, H. Gascan, J. D. de Vries, 1992, Journal of immunology.

Functional Interaction of STAT3 Transcription Factor with the Cell Cycle Inhibitor p21 WAF1/CIP1/SDI1 *

H. Gascan, O. Coqueret, 2000, The Journal of Biological Chemistry.

Binding Interactions of Leukemia Inhibitory Factor and Ciliary Neurotrophic Factor with the Different Subunits of Their High Affinity Receptors

S. Chevalier, V. Praloran, H. Gascan, 1996, Journal of neurochemistry.

Interleukin-27 and IFNγ regulate the expression of CXCL9, CXCL10, and CXCL11 in hepatitis

S. Chevalier, H. Gascan, M. Samson, 2015, Journal of Molecular Medicine.

Biochemical characterization and purification of HILDA, a human lymphokine active on eosinophils and bone marrow cells.

J. Moreau, H. Gascan, J. Soulillou, 1988, Blood.

Regulation of human IgE synthesis: the role of CD4+ and CD8+ T-cells and the inhibitory effects of interferon-alpha.

H. Gascan, J. D. de Vries, M. Roncarolo, 1991, The European respiratory journal. Supplement.

ELISA Detection of Circulating Levels of LIF, OSM, and CNTF in Septic Shock

S. Chevalier, C. Guillet, H. Gascan, 1995, Annals of the New York Academy of Sciences.

IL-2 and a contact-mediated signal provided by TCR alpha beta + or TCR gamma delta + CD4+ T cells induce polyclonal Ig production by committed human B cells. Enhancement by IL-5, specific inhibition of IgA synthesis by IL-4.

R. de Waal Malefyt, H. Gascan, J. D. de Vries, 1992, Journal of immunology.

Regulation of interleukin 6 expression by cardiotrophin 1.

S. Chevalier, H. Gascan, D. Pennica, 1997, Cytokine.

functional changes in rat soleus muscle Ciliary neurotrophic factor prevents unweighting-induced

C. Guillet, H. Gascan, B. Fraysse, 2000 .

The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to cardiotrophin‐like cytokine

S. Chevalier, C. Guillet, H. Gascan, 2001, The EMBO journal.

Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones

H. Gascan, J. D. de Vries, M. Roncarolo, 1991, The Journal of experimental medicine.

Molecular and Functional Characterization of a Soluble Form of Oncostatin M/Interleukin-31 Shared Receptor*>

S. Chevalier, H. Gascan, E. Vénéreau, 2006, Journal of Biological Chemistry.

Signaling of Type II Oncostatin M Receptor*

C. Guillet, H. Gascan, P. Auguste, 1997, The Journal of Biological Chemistry.

Reversal of some viral IL‐6 electrostatic properties compared to IL‐6 contributes to a loss of alpha receptor component recruitment

H. Gascan, V. Tran, F. Rousseau, 2005, Proteins.

Response of murine IL3-sensitive cell lines to cytokines of human and murine origin.

J. Moreau, H. Gascan, J. Soulillou, 1989, Lymphokine research.

Ciliary Neurotrophic Factor is a Regulator of Muscular Strength in Aging

W. Mayo, C. Guillet, H. Gascan, 1999, The Journal of Neuroscience.

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses.

P. Distefano, G. Yancopoulos, N. Stahl, 1993, Science.

CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

S. Chevalier, C. Guillet, H. Gascan, 2000, Nature Neuroscience.

Signaling of the Cardiotrophin-1 Receptor

S. Chevalier, C. Guillet, H. Gascan, 1997, The Journal of Biological Chemistry.

Constitutive production of human interleukin for DA cells/leukemia inhibitory factor by human tumor cell lines derived from various tissues.

V. Praloran, H. Gascan, I. Anegon, 1990, Journal of immunology.

Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling.

S. Chevalier, H. Gascan, J. Froger, 2004, European cytokine network.

Signaling Pathways Recruited by the Cardiotrophin-like Cytokine/Cytokine-like Factor-1 Composite Cytokine

S. Chevalier, C. Guillet, H. Gascan, 2001, The Journal of Biological Chemistry.

Receptor Recognition Sites of Cytokines Are Organized as Exchangeable Modules

S. Rose-John, D. Aasland, H. Gascan, 1999, The Journal of Biological Chemistry.

Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor*

S. Chevalier, H. Gascan, E. Lelièvre, 2003, Journal of Biological Chemistry.

Involvement of gp130/interleukin‐6 receptor transducing component in interleukin‐11 receptor

S. Chevalier, H. Gascan, J. Lebrun, 1994, European journal of immunology.

Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor.

C. Guillet, H. Gascan, J. Bonnefoy, 2002, European journal of biochemistry.

Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

S. Chevalier, H. Gascan, D. Heymann, 2012, Stem cells.

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

H. Gascan, R. Ghozzi, A. Trautmann, 2020, Frontiers in Medicine.

Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling

H. Rohrer, R. Parlato, G. Schütz, 2006, Development.

Direct Stimulation of Human T Cells via TLR5 and TLR7/8: Flagellin and R-848 Up-Regulate Proliferation and IFN-γ Production by Memory CD4+ T Cells1

H. Gascan, G. Caron, Y. Delneste, 2005, The Journal of Immunology.

Induction of bone formation by activated monocytes / macrophages depends on Oncostatin M signaling

S. Chevalier, H. Gascan, D. Heymann, 2012 .

Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities.

S. Chevalier, H. Gascan, Angélique Guay-Giroux, 2004, European cytokine network.

Cyclin D1 Represses STAT3 Activation through a Cdk4-independent Mechanism*

H. Gascan, O. Coqueret, Frédéric Bienvenu, 2001, The Journal of Biological Chemistry.

Definition and Characterization of an Inhibitor for Interleukin-31*

S. Chevalier, H. Gascan, E. Vénéreau, 2010, The Journal of Biological Chemistry.

Cardiotrophin-like cytokine labelling using Bir A biotin ligase: a sensitive tool to study receptor expression by immune and non-immune cells.

S. Chevalier, H. Gascan, G. Magistrelli, 2005, Journal of immunological methods.

Neonatal and adult microglia cross‐present exogenous antigens

H. Gascan, P. Guermonprez, Y. Delneste, 2008, Glia.

Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells.

H. Gascan, M. Hebbar, N. Ifrah, 2007, Blood.

differentiation into tumor-associated macrophage-like cells Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte

H. Gascan, M. Hebbar, N. Ifrah, 2013 .

GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor*

S. Chevalier, C. Guillet, H. Gascan, 2003, Journal of Biological Chemistry.

Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture

M. Baslé, H. Gascan, M. Fourcin, 2000, Molecular and Cellular Endocrinology.

Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

H. Gascan, A. Herbelin, J. Gangneux, 2012, PloS one.

High circulating leukaemia inhibitory factor (LIF) in patients with giant cell arteritis: independent regulation of LIF and IL‐6 under corticosteroid therapy

S. Chevalier, H. Gascan, F. Morel, 1993, Clinical and experimental immunology.

Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a*

H. Gascan, O. Coqueret, D. Heery, 2002, The Journal of Biological Chemistry.

Structureand Expression of Germline E Transcripts in Human B CellsInduced by Interleukin4 to Switch to IgE Production By Jean-Franyois Gauchat,DeborahA.Lebman,

H. Gascan, 1990 .

IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants

S. Chevalier, H. Gascan, F. Rousseau, 2010, Proceedings of the National Academy of Sciences.

Two Different Contact Sites Are Recruited by Cardiotrophin-like Cytokine (CLC) to Generate the CLC/CLF and CLC/sCNTFRα Composite Cytokines*

C. Guillet, H. Gascan, M. Chabbert, 2004, Journal of Biological Chemistry.

Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression*

P. Heinrich, I. Behrmann, H. Hermanns, 2002, The Journal of Biological Chemistry.

Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

S. Chevalier, C. Guillet, H. Gascan, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Rapid protein kinase C‐dependent reduction of rat skeletal muscle voltage‐gated sodium channels by ciliary neurotrophic factor

J. Pennec, C. Guillet, H. Gascan, 2005, The Journal of physiology.

Molecular Dissection of Human Interleukin-31-mediated Signal Transduction through Site-directed Mutagenesis*

S. Chevalier, H. Gascan, S. Le Saux, 2009, The Journal of Biological Chemistry.

Serum cytokine and cytokine receptor levels in patients with giant cell arteritis during corticotherapy.

H. Gascan, J. Wijdenes, E. Lelièvre, 1996, The Journal of rheumatology.

Monoclonal Antibodies Define Different Functional Epitopes on gp130 Signal Transducer

H. Gascan, J. Wijdenes, O. Robledo, 1995, Annals of the New York Academy of Sciences.

Induction of leukemia inhibitory factor secretion by interleukin-1 in a human T lymphoma cell line.

H. Gascan, J. Lemetayer, 1991, Lymphokine and cytokine research.

Cell Communication and Signaling

H. Gascan, Damien Derouet, O. Delapeyrière, 2014 .

Inducible production of macrophage colony-stimulating factor (CSF-1) by malignant and normal human T cells.

S. Chevalier, V. Praloran, H. Gascan, 1990, Leukemia.

Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

S. Chevalier, H. Gascan, D. Heymann, 2012, Stem cells.

clc is co-expressed with clf or cntfr in developing mouse

H. Gascan, Damien Derouet, G. Elson, 2006 .

Astroglial Expression of the P-glycoprotein Is Controlled by Intracellular Cntf. Bmc Cell Biology Astroglial Expression of the P-glycoprotein Is Controlled by Intracellular Cntf

C. Monville, A. Feyens, A. Vernallis, 2022 .

Bmc Cell Biology Astroglial Expression of the P-glycoprotein Is Controlled by Intracellular Cntf

C. Monville, A. Feyens, A. Vernallis, 2022 .

Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated-macrophage-like cells Short title: LIF and IL-6 induce TAM-like cells

H. Gascan, L. Preisser, Y. Delneste, 2007 .