Daohong Zhou

发表

Phosphatidylinositol-3-Kinase–Akt Kinase and p42/p44 Mitogen-Activated Protein Kinases Mediate Neurotrophic and Excitoprotective Actions of a Secreted Form of Amyloid Precursor Protein

M. Mattson, G. Cheng, Zaifang Yu, 2002, Experimental Neurology.

Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks

Daohong Zhou, W. Du, Yingying Wang, 2016, Radiation Research.

Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: Mesenchymal cells and fibrocytes

R. A. Schmiedt, Daohong Zhou, H. Minamiguchi, 2006, The Journal of comparative neurology.

Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

J. Campisi, Daohong Zhou, F. Xia, 2020, Scientific Reports.

NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system

Daohong Zhou, Lijian Shao, Yi Luo, 2018, Cell & Bioscience.

Hematopoietic stem cell injury induced by ionizing radiation.

Daohong Zhou, Daohong Zhou, Lijian Shao, 2014, Antioxidants & redox signaling.

Korey R. Johnson, Takuji Tanaka, Y. Hannun, 2022 .

Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases

M. Boerma, Daohong Zhou, Yingying Wang, 2016, Radiation Research.

PARP1 is required for chromosomal translocations.

R. Hromas, D. Weinstock, E. Williamson, 2013, Blood.

MYELOID NEOPLASIA PARP 1 is required for chromosomal translocations

R. Hromas, D. Weinstock, E. Williamson, 2013 .

Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy

Yan Cao, Daohong Zhou, Yixuan Fang, 2017, Scientific Reports.

Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration.

Daohong Zhou, Junling Zhang, Jianhui Chang, 2011, Journal of radiation research.

Total body irradiation selectively induces murine hematopoietic stem cell senescence.

Yong Wang, Daohong Zhou, Daohong Zhou, 2006, Blood.

28Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis.

J. Raber, Daohong Zhou, Antiño R. Allen, 2017, Life sciences in space research.

Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice

M. Boerma, X. Mao, V. Sridharan, 2017, International journal of radiation biology.

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice.

D. Citrin, Daohong Zhou, Junling Zhang, 2017, International journal of radiation oncology, biology, physics.

Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice

M. Boerma, X. Mao, V. Sridharan, 2017, PloS one.

Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice

M. Boerma, X. Mao, V. Sridharan, 2016, PloS one.

Whole-Body Proton Irradiation Causes Long-Term Damage to Hematopoietic Stem Cells in Mice

I. Koturbash, J. Raber, Daohong Zhou, 2015, Radiation research.

Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation

Daohong Zhou, Junling Zhang, A. Meng, 2015, Cell & Bioscience.

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.

N. Sharpless, Daohong Zhou, Lijian Shao, 2014, Blood.

CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence.

Daohong Zhou, Jie Wang, P. Zou, 2013, Leukemia research.

The Effects of p38 MAPK Inhibition Combined with G-CSF Administration on the Hematoimmune System in Mice with Irradiation Injury

F. Fan, Daohong Zhou, Junling Zhang, 2013, PloS one.

A Sensitive and Quantitative Polymerase Chain Reaction-Based Cell Free In Vitro Non-Homologous End Joining Assay for Hematopoietic Stem Cells

B. Chen, Daohong Zhou, Lijian Shao, 2012, PloS one.

Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells

Daohong Zhou, Jie Wang, P. Zou, 2012, Annals of Hematology.

Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.

S. Pazhanisamy, Daohong Zhou, I. Batinic-Haberle, 2011, Free radical biology & medicine.

Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury

Daohong Zhou, Yong Wang, Lingbo Liu, 2011, Radiation research.

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability.

S. Pazhanisamy, Daohong Zhou, I. Batinic-Haberle, 2011, Mutagenesis.

Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion.

Daohong Zhou, Yong Wang, Lingbo Liu, 2011, Stem cells and development.

Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells.

S. Pazhanisamy, Daohong Zhou, A. Meng, 2009, Free radical biology & medicine.

Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway.

Daohong Zhou, Yong Wang, Virginia Probin, 2007, Free radical biology & medicine.

Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Injury

Daohong Zhou, B. A. Schulte, Yong Wang, 2006, Cell cycle.

Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms.

Daohong Zhou, A. Meng, G. van Zant, 2003, Experimental hematology.

Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells.

Daohong Zhou, A. Meng, G. van Zant, 2003, Cancer research.

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Daohong Zhou, Yingying Wang, Jianhui Chang, 2016, Aging.

Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene[S]

K. Bhalla, Daohong Zhou, Xiao-fei Yang, 2013, Journal of Lipid Research.

Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice

Jinze Liu, Chi Wang, T. Gao, 2017, Stem cell reports.

Activation of Nuclear Factor κB In vivo Selectively Protects the Murine Small Intestine against Ionizing Radiation-Induced Damage

R. A. Schmiedt, Daohong Zhou, A. Meng, 2004, Cancer Research.

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

Kwok-Kin Wong, N. Sharpless, Daohong Zhou, 2010, The Journal of clinical investigation.

PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

Daohong Zhou, Guangrong Zheng, Sajid Khan, 2020, Exploration of targeted anti-tumor therapy.

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

J. Elisseeff, J. Campisi, M. Almeida, 2020, Nature Communications.

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity.

Daohong Zhou, Yaxia Yuan, Guangrong Zheng, 2020, European journal of medicinal chemistry.

Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL.

Daohong Zhou, Guangrong Zheng, Dinesh Thummuri, 2019, Chemical communications.

Cellular senescence and radiation-induced pulmonary fibrosis.

P. Okunieff, D. Citrin, Daohong Zhou, 2019, Translational research : the journal of laboratory and clinical medicine.

Cellular Senescence: Defining a Path Forward

C. Schmitt, M. Serrano, P. Robbins, 2019, Cell.

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

J. Campisi, Daohong Zhou, Guangrong Zheng, 2020, Aging cell.

Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells

I. Koturbash, Daohong Zhou, M. Hauer-Jensen, 2021, International journal of molecular sciences.

Busulfan Selectively Induces Cellular Senescence but Not Apoptosis in WI38 Fibroblasts via a p53-Independent but Extracellular Signal-Regulated Kinase-p38 Mitogen-Activated Protein Kinase-Dependent Mechanism

Daohong Zhou, A. Bai, Yong Wang, 2006, Journal of Pharmacology and Experimental Therapeutics.

Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation.

Daohong Zhou, Yingying Wang, H. Hendrickson, 2018, Bioorganic & medicinal chemistry.

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL–Specific Degrader DT2216

A. Loguinov, C. Vulpe, R. Hromas, 2021, Molecular Cancer Therapeutics.

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

B. Kennedy, N. Sharpless, S. Melov, 2017, Cancer discovery.

Nuclear Factor κB Deficiency Is Associated with Auditory Nerve Degeneration and Increased Noise-Induced Hearing Loss

R. A. Schmiedt, S. Spicer, Daohong Zhou, 2006, The Journal of Neuroscience.

Unmyelinated auditory type I spiral ganglion neurons in congenic Ly5.1 mice

R. A. Schmiedt, Daohong Zhou, A. Larue, 2010, The Journal of comparative neurology.

Senescence-associated hyper-activation to inflammatory stimuli in vitro

T. Foster, Daohong Zhou, Yonghan He, 2021, Aging.

Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis

M. Mattson, M. Nikolova-Karakashian, G. Cheng, 2000, Journal of Molecular Neuroscience.

Synthesis and Liver Microsomal Metabolic Stability Studies of a Fluorine‐Substituted δ‐Tocotrienol Derivative

Daohong Zhou, H. Hendrickson, Yaxia Yuan, 2020, ChemMedChem.

Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development

Q. Kong, L. Hu, Daohong Zhou, 2022, Frontiers in Cell and Developmental Biology.

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy

Stephen L. Brown, C. N. Coleman, C. Coleman, 2021, Journal of the National Cancer Institute.

OP-JNCI210063 1285..1298

C. Coleman, S. Lowe, C. Schmitt, 2021 .

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.

Shaoguang Li, S. Lensing, Zhifu Xiang, 2016, Blood.

Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice

M. Almeida, E. Ambrogini, Li Han, 2020, Aging cell.

Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses

S. Authier, Daohong Zhou, M. Hauer-Jensen, 2015, BMC Genomics.

Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss.

R. A. Schmiedt, S. Spicer, Daohong Zhou, 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice

R. Hromas, M. Almeida, Daohong Zhou, 2021, The Journal of biological chemistry.

of activity selectively eliminates senescent cells in part via restoration of p53 activity.

J. Campisi, Daohong Zhou, Guangrong Zheng, 2020 .

Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice

J. Campisi, M. Almeida, Li Han, 2019, Aging cell.

The curcumin analog EF24 is a novel senolytic agent

Daohong Zhou, Guangrong Zheng, Rongping Zhang, 2019, Aging.

Cellular senescence, geroscience, cancer and beyond

G. Ferbeyre, F. Rodier, Daohong Zhou, 2018, Aging.

Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

Y. Fujiwara, M. Almeida, Li Han, 2020, JCI insight.

The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress.

Daohong Zhou, Lijian Shao, W. Feng, 2012, Free radical biology & medicine.

Marrow damage and hematopoietic recovery following allogeneic bone marrow transplantation for acute leukemias: Effect of radiation dose and conditioning regimen.

R. Corvò, G. Storme, K. Dusenbery, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers

F. Kaye, S. Kopetz, C. Allegra, 2022, Journal of Hematology & Oncology.

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy

C. N. Coleman, C. Coleman, S. Lowe, 2021 .

M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion.

I. Bernstein, P. Emanuel, Y. L. Liu, 2018, Blood advances.

IKKβ Regulates the Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation in MCF-7 Breast Cancer Cells

S. Pazhanisamy, S. Miyamoto, Daohong Zhou, 2011, PloS one.

C/EBPδ Deficiency Sensitizes Mice to Ionizing Radiation-Induced Hematopoietic and Intestinal Injury

M. Boerma, Daohong Zhou, E. Sterneck, 2014, PloS one.

Cellular origin of ionizing radiation‐induced NF‐κB activation in vivo and role of NF‐κB in ionizing radiation‐induced lymphocyte apoptosis

Daohong Zhou, A. Meng, J. Thompson, 2003 .

Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.

P. Crooks, M. Boerma, Daohong Zhou, 2016, Tetrahedron.

The curcumin analog EF24 is highly active against chemotherapy-resistant melanoma cells.

Daohong Zhou, Wen Li, Yonghan He, 2021, Current cancer drug targets.

IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis.

Alexis N. Peña, J. Elisseeff, D. Pardoll, 2020, The Journal of clinical investigation.

Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts.

Yong Wang, Daohong Zhou, Daohong Zhou, 2004, Experimental cell research.

Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy.

Yong Wang, Daohong Zhou, Daohong Zhou, 2006, Current cancer therapy reviews.

Bone Marrow Transplantation Helps Restore the Intestinal Mucosal Barrier after Total Body Irradiation in Mice

M. Boerma, Daohong Zhou, M. Hauer-Jensen, 2014, Radiation research.

Prodrug Modification Increases Potassium Tricyclo[5.2.1.02,6]-decan-8-yl Dithiocarbonate (D609) Chemical Stability and Cytotoxicity against U937 Leukemia Cells

Y. Hannun, Daohong Zhou, G. P. Meier, 2004, Journal of Pharmacology and Experimental Therapeutics.

Ionizing Radiation and Busulfan Induce Premature Senescence in Murine Bone Marrow Hematopoietic Cells 1

Daohong Zhou, A. Meng, G. Zant, 2003 .

The Role of Endotoxins in Burns: Anomalies in Cytokine Regulation of Immunity*

Daohong Zhou, R. Winchurch, A. Munster, 1993 .

Can molecular targeting the TNFα-ERK-ETS1-IL27Rα pathway keep us young and healthy by protecting HSCs from aging?

Daohong Zhou, Yonghan He, 2020, Blood science.

Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin.

M. Boerma, Daohong Zhou, M. Berbée, 2011, International journal of radiation oncology, biology, physics.

Faculty Opinions recommendation of A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia.

Daohong Zhou, 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

OP-JNCI210063 1285..1298

Stephen L. Brown, C. N. Coleman, C. Coleman, 2021 .

Gene expression profiling in non-human primate jejunum, ileum and colon after total-body irradiation: a comparative study of segment-specific molecular and cellular responses

S. Authier, Daohong Zhou, M. Hauer-Jensen, 2015, BMC Genomics.

Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells.

Y. Hannun, Daohong Zhou, A. Meng, 2004, Experimental cell research.

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance

Chi Wang, Yi Zheng, Daohong Zhou, 2019, Haematologica.

MicroRNA regulation of ionizing radiation-induced premature senescence.

G. Calin, Daohong Zhou, C. Neumann, 2011, International journal of radiation oncology, biology, physics.

Cellular senescence in lymphoid organs and immunosenescence

T. Foster, Daohong Zhou, Vivekananda Budamagunta, 2021, Aging.

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.

Daohong Zhou, Yingying Wang, Jianhui Chang, 2013, Translational cancer research.

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

N. Sharpless, J. Campisi, Daohong Zhou, 2015, Nature Medicine.

Sustained fetal hematopoiesis causes juvenile death from leukemia: evidence from a dual-age-specific mouse model.

Erich A. Peterson, D. Johann, S. Lensing, 2020, Blood advances.

Total Body Irradiation in the “Hematopoietic” Dose Range Induces Substantial Intestinal Injury in Non-Human Primates

S. Authier, Daohong Zhou, M. Hauer-Jensen, 2015, Radiation research.

Reactive oxygen species in normal and tumor stem cells.

Daohong Zhou, D. Spitz, Lijian Shao, 2014, Advances in cancer research.

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair

T. Beißbarth, R. Hromas, A. Jaiswal, 2015, PLoS genetics.

GWAS of 972 autologous stem cell recipients with multiple myeloma identifies 11 genetic variants associated with chemotherapy-induced oral mucositis

O. Stephens, E. Anaissie, V. Raj, 2015, Supportive Care in Cancer.

PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells

Zhiyan Zhan, Yanxin Li, Daohong Zhou, 2021, Signal Transduction and Targeted Therapy.

Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.

Z. Ju, Daohong Zhou, Q. Hou, 2013, Free radical biology & medicine.

Reactive oxygen species and hematopoietic stem cell senescence

S. Pazhanisamy, Daohong Zhou, Lijian Shao, 2011, International journal of hematology.

Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition.

Daohong Zhou, Nan Hua, Yaxia Yuan, 2021, Journal of medicinal chemistry.

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

Daohong Zhou, Yaxia Yuan, Guangrong Zheng, 2020, Oncogene.

Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation

I. Koturbash, R. Landes, A. Tackett, 2017, International journal of molecular sciences.

Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2

G. Glazko, G. Childs, Daohong Zhou, 2017, Scientific Reports.

Dependence on PI3K/Akt signaling for malignant rhabdoid tumor cell survival

Daohong Zhou, Yong Wang, C. Wright, 2009, Cancer Chemotherapy and Pharmacology.

The complete mitochondrial genome sequence and mutations of the Lung cancer model inbred rat strain (Muridae; Rattus)

Daohong Zhou, Qingfeng Lu, Dan-dan Zhu, 2016, Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis.

Lack of the p50 Subunit of Nuclear Factor-κB Increases the Vulnerability of Hippocampal Neurons to Excitotoxic Injury

M. Mattson, A. Bruce-Keller, Zaifang Yu, 1999, The Journal of Neuroscience.

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

R. Hromas, Daohong Zhou, Yaxia Yuan, 2020, Journal of Hematology & Oncology.

Biomedical Applications of Gut Stem Cells: Gaining First- Hand Insights for Developing Therapy for the Future

Upendra K. Kar, Daohong Zhou, U. Kar, 2016 .

Assays and technologies for developing proteolysis targeting chimera degraders

Daohong Zhou, Yaxia Yuan, Guangrong Zheng, 2020, Future medicinal chemistry.

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

A. Ferrando, M. Konopleva, P. Houghton, 2019, Nature Medicine.

Effects of NF-κB1 (p50) targeted gene disruption on ionizing radiation-induced NF-κB activation and TNFα, IL-1α, IL-1β and IL-6 mRNA expression in vivo

M. Mattson, Zaifang Yu, Daohong Zhou, 2001 .

CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

Andrew P. Voigt, S. Zheng, Rhonda Bacher, 2021, Nature Communications.

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

M. Almeida, Li Han, R. Jilka, 2017, Aging cell.

Neuroprotective role for the p50 subunit of NF-κB in an experimental model of Huntington’s disease

M. Mattson, G. Cheng, Zaifang Yu, 2000, Journal of Molecular Neuroscience.

Oxidation resistance 1 is a novel senolytic target

A. Tackett, J. Campisi, Daohong Zhou, 2018, Aging cell.

Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

James D. Kang, P. Robbins, J. Campisi, 2019, Aging cell.

Systemic clearance of p16 INK4a ‐ positive senescent cells mitigates age ‐ associated intervertebral disc degeneration

James D. Kang, P. Robbins, J. Campisi, 2019 .

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

R. Koch, D. Weinstock, Daohong Zhou, 2020, Journal of Hematology & Oncology.

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

J. Downing, Linheng Li, D. Scadden, 2018, Nature Communications.

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

J. Elisseeff, J. Campisi, M. Almeida, 2020, Nature Communications.

BMS-345541 Sensitizes MCF-7 Breast Cancer Cells to Ionizing Radiation by Selective Inhibition of Homologous Recombinational Repair of DNA Double-Strand Breaks

Daohong Zhou, M. Hauer-Jensen, Jianhui Chang, 2012, Radiation research.

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines.

Daohong Zhou, J. Pei, Yaxia Yuan, 2020, European journal of medicinal chemistry.

Targeting anti-apoptotic BCL-2 family proteins for cancer treatment.

Daohong Zhou, Guangrong Zheng, Xingui Liu, 2020, Future medicinal chemistry.

An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.

P. Newburger, D. Faller, Daohong Zhou, 2017, Blood cells, molecules & diseases.

Autophagy Promotes the Repair of Radiation-Induced DNA Damage in Bone Marrow Hematopoietic Cells via Enhanced STAT3 Signaling

Yan Cao, Daohong Zhou, Yixuan Fang, 2017, Radiation Research.

Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner

Jing Zou, Yi Luo, Jie Wang, 2011, Experimental Gerontology.

Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation

E. Tian, Daohong Zhou, M. Hauer-Jensen, 2019, Scientific Reports.

Cancer cell-intrinsic function of CD177 in attenuating β-Catenin signaling

R. Weigel, A. Bellizzi, Daohong Zhou, 2020, Oncogene.

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase.

Daohong Zhou, Lijian Shao, Lixian Wu, 2012, Translational cancer research.

Exposure to Low-Dose 56Fe-Ion Radiation Induces Long-Term Epigenetic Alterations in Mouse Bone Marrow Hematopoietic Progenitor and Stem Cells

I. Koturbash, J. Raber, Daohong Zhou, 2014, Radiation research.

Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells

S. Zheng, Daohong Zhou, yang-xin fu, 2021, Nature Communications.

Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents.

G. Storme, P. Alaei, Daohong Zhou, 2017, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

M. Konopleva, R. Hromas, S. Weintraub, 2021, Nature Communications.

Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice

Daohong Zhou, Junling Zhang, Yingying Wang, 2015, Free radical biology & medicine.

Lawrence Berkeley National Laboratory Recent Work Title Systemic clearance of p 16 INK 4 a-positive senescent cells mitigates age-associated intervertebral disc degeneration

James D. Kang, P. Robbins, J. Campisi, 2019 .

DyScore: A Boosting Scoring Method with Dynamic Properties for Identifying True Binders and Non-binders in Structure-based Drug Discovery

Daohong Zhou, Xiaoling Li, Yaxia Yuan, 2021, bioRxiv.

Senolytic Drug Development

Daohong Zhou, Guangrong Zheng, Yonghan He, 2020 .

Pharmacological targeting of the thrombomodulin–protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2012, Nature Medicine.

Pharmacological targeting of the thrombomodulin – activated protein C pathway mitigates radiation toxicity

José A Fernández, A. Schambach, L. Fink, 2022 .

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

D. Duong, Liang Zhou, Daohong Zhou, 2019, Nature Communications.

The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM)

Daohong Zhou, M. Hauer-Jensen, Sanchita P. Ghosh, 2016, International journal of molecular sciences.

Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome

D. McKinzie, Daohong Zhou, A. Bhatwadekar, 2023, Radiation Research.

NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system

Daohong Zhou, Lijian Shao, Yi Luo, 2018, Cell & bioscience.

Busulfan Selectively Induces Cellular Senescence Via a p53-Independent but Erk-p38 MAPK-Dependent Mechanism.

Daohong Zhou, A. Bai, Yong Wang, 2006 .

Thrombomodulin Contributes to Gamma Tocotrienol-Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice

M. Boerma, Daohong Zhou, M. Hauer-Jensen, 2015, PloS one.

Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.

P. Crooks, Daohong Zhou, H. Hendrickson, 2020, Bioorganic & medicinal chemistry.