M. Marshall

发表

Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.

H. Nakshatri, A. King, V. Gelfanov, 2001, Blood.

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

A. King, M. Marshall, B. Diaz, 1997, Molecular and cellular biology.

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

A. King, M. Marshall, B. Diaz, 1998, Nature.

Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase

A. Fox, A. Depaoli-Roach, M. Marshall, 2003, BMC Neuroscience.

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

X. F. Zhang, J. Avruch, M. Marshall, 1994, Molecular and cellular biology.

Activation of Raf-1 Signaling by Protein Kinase C through a Mechanism Involving Raf Kinase Inhibitory Protein*

E. Eves, M. Rosner, M. Marshall, 2003, The Journal of Biological Chemistry.

Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma

Lang Li, Shan Tang, K. Pollok, 2020, Cancers.

Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

Lang Li, K. Pollok, M. Marshall, 2019, BMC Medical Genomics.

Abstract A49: Circulating tumor cell (CTC) assay development for detection of H2AX as a clinical pharmacodynamic (PD) marker for Chk1 kinase inhibitors.

J. Dempsey, R. Beckmann, M. Marshall, 2011 .

Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.

D. Heilman, M. Marshall, D. Barnard, 2000, Carcinogenesis.

Abstract 1776: Antitumor activity of Chk1 inhibitor LY2606368 as a single agent in SW1990 human pancreas orthotopic tumor model

Chen Bi, R. Beckmann, M. Marshall, 2012 .

Abstract A108: LY2606368, a second generation Chk1 inhibitor, inhibits growth of ovarian carcinoma xenografts either as monotherapy or in combination with standard-of-care agents.

T. Burke, R. Beckmann, M. Marshall, 2011 .

Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.

M. Marshall, A. Lin, M. Yip-Schneider, 2001, Biochemical and biophysical research communications.

Protein isoprenylation in suspension-cultured tobacco cells.

M. Marshall, D. Crowell, S. Randall, 1993, The Plant cell.

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

D. Clawson, M. Marshall, B. Diaz, 1998, Oncogene.

Involvement of H-ras in erythroid differentiation of TF1 and human umbilical cord blood CD34 cells.

H. Broxmeyer, M. Marshall, L. Lu, 1998, Blood cells, molecules & diseases.

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

R. Dixon, S. Moores, V. Garsky, 1990, Journal of Biological Chemistry.

Amino Acid Residues That Define Both the Isoprenoid and CAAX Preferences of the Saccharomyces cerevisiae Protein Farnesyltransferase

Y. Ohya, M. Marshall, B. Caplin, 1998, The Journal of Biological Chemistry.

Mutagenesis and biochemical analysis of recombinant yeast prenyltransferases.

M. Marshall, B. Caplin, 1995, Methods in enzymology.

Genetic analysis of the molecular basis for β‐adrenergic receptor subtype specificity

C. Strader, R. Dixon, I. Sigal, 1989, Proteins.

An adenylate cyclase from Saccharomyces cerevisiae that is stimulated by RAS proteins with effector mutations

E. Scolnick, I. Sigal, M. Marshall, 1988, Molecular and cellular biology.

Regulatory function of the Saccharomyces cerevisiae RAS C-terminus

E. Scolnick, I. Sigal, M. Marshall, 1987, Molecular and cellular biology.

Regulatory Function oftheSaccharomyces cerevisiae RASC-Terminus

E. Scolnick, I. Sigal, M. Marshall, 1987 .

Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.

M. Marshall, C. Sweeney, M. Yip-Schneider, 2001, The Journal of pharmacology and experimental therapeutics.

Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Shobha N. Bhattachar, R. Campbell, Y. Qian, 2019, Molecular Cancer Therapeutics.

Previously unreported somatic variants in two patients with pleuropulmonary blastoma with metastatic brain recurrence

J. Ivanovich, M. Marshall, T. Vik, 2020, Pediatric blood & cancer.

Ras-Raf complexes in vitro.

X. F. Zhang, J. Avruch, M. Marshall, 1995, Methods in enzymology.

Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor

D. Clawson, M. Marshall, D. Barnard, 2014, Investigational New Drugs.

Identification of amino acid residues required for Ras p21 target activation

E. Scolnick, L. Davis, M. Marshall, 1991, Molecular and cellular biology.

CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase.

M. Marshall, B. Caplin, M. Mayer, 1992, The Journal of biological chemistry.

Characterization of Ras effector mutant interactions with the NF1-GAP related domain.

M. Marshall, L. Hettich, 1993, Oncogene.

Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression.

M. Marshall, C. Mantel, H. Broxmeyer, 1995, Journal of immunology.

Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine‐hydrolysing phospholipase C.

F. McCormick, M. Diaz-Meco, J. Moscat, 1991, The EMBO journal.

Title: LY2606368 causes replication catastrophe and anti-tumor effects through CHK1-dependent mechanisms

J. Dempsey, R. Beckmann, M. Marshall, 2015 .

The ras Oncogene Protein

R. Dixon, E. Scolnick, I. Sigal, 1989 .

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

S. Elledge, J. Settleman, J. Avruch, 1993, Nature.

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms

J. Dempsey, R. Beckmann, M. Marshall, 2015, Molecular Cancer Therapeutics.

Title : LY 2606368 causes replication catastrophe and anti-tumor effects through CHK 1-dependent mechanisms

J. Dempsey, R. Beckmann, M. Marshall, 2015 .

Causes Replication Catastrophe and Antitumor Effects through CHK 1-Dependent Mechanisms

J. Dempsey, R. Beckmann, M. Marshall, 2015 .

The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.

T. Pawson, H. Broxmeyer, M. Marshall, 1994, The Journal of biological chemistry.

Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis

J. Deddens, J. Graff, M. Marshall, 2004, Clinical Cancer Research.

Hyperactivation of P21ras and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro

David A. Williams, R. Shivakumar, A. King, 2001, The Journal of experimental medicine.

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

M. H. Cobb, J. S. Brugge, J. A. Frost, 2000, Current Biology.

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP).

J B Gibbs, R. Dixon, E. Scolnick, 1990, The Journal of biological chemistry.

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

P. J. Belshaw, J. Avruch, G. Tzivion, 1996, Nature.

Cloning of bovine GAP and its interaction with oncogenic ras p21

Irving S. Sigal, R. Dixon, E. Scolnick, 1988, Nature.

CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae.

L. C. Robinson, I. Sigal, M. Marshall, 1987, Science.

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein

M. Nakafuku, Kunihiro Matsumoto, M. Marshall, 1990, Cell.

A C‐terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

R. Dixon, E. Scolnick, I. Sigal, 1989, The EMBO journal.

PDGF induction of tyrosine phosphorylation of GTPase activating protein

T. Fleming, S. Aaronson, C. Molloy, 1989, Nature.

Integrative Multi-OMICs Identifies Therapeutic Response Biomarkers and Confirms Fidelity of Clinically Annotated, Serially Passaged Patient-Derived Xenografts Established from Primary and Metastatic Pediatric and AYA Solid Tumors

E. Petricoin, Kun Huang, J. Zhang, 2022, Cancers.

Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity

Morag Park, M. Marshall, Zhong-Qing Shi, 2000, Molecular and Cellular Biology.

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

A. King, M. Marshall, Huaiyu Sun, 2000, Current Biology.

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/“effector” domain

D. Stacey, M. Marshall, J. Gibbs, 1991, Cell.

Ras target proteins in eukaryotic cells

M. Marshall, Mark S. Marshall, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The ras oncogene--an important regulatory element in lower eucaryotic organisms

M. Marshall, J. Gibbs, 1989, Microbiological reviews.

Purification and Molecular Cloning of Bovine GAP

R. Dixon, E. Scolnick, I. Sigal, 1989 .

LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models

T. Burke, R. Beckmann, M. Marshall, 2016, Investigational New Drugs.

Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase.

M. Marshall, L. Hettich, B. Caplin, 1994, Biochimica et biophysica acta.

Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

M. Marshall, D. Barnard, A. Lin, 1999, International journal of oncology.

The effector interactions of p21ras.

M. Marshall, Mark S. Marshall, 1993, Trends in biochemical sciences.

Structure/function studies of the ras protein.

J B Gibbs, E. Scolnick, I. Sigal, 1988, Cold Spring Harbor symposia on quantitative biology.

p120 Ras GTPase-activating Protein Interacts with Ras-GTP through Specific Conserved Residues*

M. Marshall, Wenyan Miao, L. Eichelberger, 1996, The Journal of Biological Chemistry.

Phosphorylation site specificity of the Pak‐mediated regulation of Raf‐1 and cooperativity with Src

A. King, M. Marshall, M. Hamilton, 2001, FEBS letters.

Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.

G. Tzivion, M. Marshall, D. Barnard, 2000, The Biochemical journal.

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

J. Avruch, M. Marshall, Z. Luo, 1997, Molecular and cellular biology.

Molecular Biology of GAP and its Interaction with Oncogenic ras p21

R. Dixon, E. Scolnick, I. Sigal, 1989 .

Sustained Complete Response to Palbociclib in a Refractory Pediatric Sarcoma With BCOR-CCNB3 Fusion and Germline CDKN2B Variant

J. Ivanovich, M. Marshall, Michael J Ferguson, 2020, JCO precision oncology.

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

J. Parsons, A. Catling, S. T. Eblen, 2003, The Journal of cell biology.

Sequence dependence of protein isoprenylation.

S. Moores, V. Garsky, M. Marshall, 1991, The Journal of biological chemistry.

Identification of the sites of interaction between c-Raf-1 and Ras-GTP.

X. F. Zhang, J. Avruch, M. Marshall, 1995, Oncogene.

Interactions between Ras and Raf: Key regulatory proteins in cellular transformation

M. Marshall, 1995, Molecular Reproduction and Development.

In vitro inhibition of Ras-Raf association by short peptides.

M. Marshall, D. Barnard, H. Sun, 1998, Biochemical and biophysical research communications.

Ras interaction with the GTPase‐activating protein (GAP)

E. Scolnick, V. Garsky, I. Sigal, 1989, Proteins.

Characterization of the Ras binding domain of the RalGDS-related protein, RLF.

X. F. Zhang, M. Marshall, M. O'gara, 1997, Biochemical and biophysical research communications.

Preclinical analyses and phase I evaluation of LY2603618 administered in combination with Pemetrexed and cisplatin in patients with advanced cancer

P. Iversen, M. Marshall, D. Barnard, 2014, Investigational New Drugs.

Mutational analysis of theβ-subunit of yeast geranylgeranyl transferase I

Y. Anraku, Y. Ohya, J. Pringle, 1996, Molecular and General Genetics MGG.

Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.

R. Jove, M. Marshall, J. Gibbs, 1992, The Journal of biological chemistry.

Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function

H. Nakshatri, A. King, M. Marshall, 2004, British Journal of Cancer.

Interferon-inducible Protein 10 and Macrophage Inflammatory Protein-1α Inhibit Growth Factor Stimulation of Raf-1 Kinase Activity and Protein Synthesis in a Human Growth Factor-dependent Hematopoietic Cell Line (*)

H. Broxmeyer, M. Marshall, A. Sarris, 1995, The Journal of Biological Chemistry.

Interleukin-11 Induces Complex Formation of Grb2, Fyn, and JAK2 in 3T3L1 Cells (*)

M. Marshall, Yuh Cheng Yang, D. K. Fuhrer, 1995, The Journal of Biological Chemistry.

Identification of guanine nucleotides bound to ras-encoded proteins in growing yeast cells.

E. Scolnick, I. Sigal, M. Marshall, 1987, The Journal of biological chemistry.

Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

Lang Li, K. Pollok, M. Marshall, 2019, BMC Medical Genomics.

Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-κB pathway in pancreatic carcinoma cells

H. Nakshatri, M. Marshall, C. Sweeney, 2005, Molecular Cancer Therapeutics.

Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion

K. Pollok, J. Wulfkuhle, M. Marshall, 2023, Scientific reports.

Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue.

Liang Cheng, D. Heilman, M. Marshall, 2002, Cancer detection and prevention.

correction: The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

A. King, M. Marshall, B. Diaz, 2000, Nature.

Identification of amino acid residues required for Ras p21 target activation

E. Scolnick, L. Davis, M. Marshall, 1991, Molecular and cellular biology.

A Novel Role of p38α MAPK in Mitotic Progression Independent of Its Kinase Activity

Jian Du, M. Marshall, K. Blanchard, 2005 .

A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity.

Jian Du, M. Marshall, K. Blanchard, 2005, Cell cycle.

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.

D. Williams, M. Dinauer, A. King, 2000, Immunity.

Use of Precision Medicine Molecular Profiling of Baseline Tumor Specimen May Not Benefit Outcomes in Children With Relapsed or Refractory Pediatric Sarcomas

L. Cheng, K. Pollok, M. Marshall, 2017, Clinical pharmacology and therapeutics.

N-terminal Sequences Contained in the Src Homology 2 and 3 Domains of p120 GTPase-activating Protein Are Required for Full Catalytic Activity Toward Ras (*)

R. Jove, M. Marshall, Wenyan Miao, 1996, The Journal of Biological Chemistry.

Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae

J. Broach, A. Rose, M. Marshall, 1987, Molecular and cellular biology.

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

J. Parsons, A. Catling, S. T. Eblen, 2003, The Journal of cell biology.