D. Merry

发表

CREB-binding protein sequestration by expanded polyglutamine.

K. Fischbeck, H. Paulson, G. Sobue, 2000, Human molecular genetics.

A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.

D. Ferguson, G. Dressler, Zhigang Yu, 2012, Human molecular genetics.

Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy

D. Merry, A. Lieberman, Yuhong Liu, 2022, Acta Neuropathologica Communications.

Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy

D. Merry, Tamar R Berger, H. Montie, 2015, Brain Research.

The role of ubiquitination in spinal and bulbar muscular atrophy

D. Merry, Medha Sengupta, A. Pluciennik, 2022, Frontiers in Molecular Neuroscience.

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer

B. Leiby, M. Nevalainen, D. Merry, 2014, Molecular Cancer Therapeutics.

FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases

R. Kalb, M. Driscoll, R. Neve, 2009, The Journal of Neuroscience.

Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer

K. Knudsen, D. Merry, C. Burd, 2008, Oncogene.

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

G. Sobue, S. Yeh, Chawnshang Chang, 2007, Nature Medicine.

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy

D. Merry, A. Pluciennik, F. Arnold, 2019, Scientific Reports.

Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.

G. Sobue, D. Merry, A. Lieberman, 2014, Human molecular genetics.

Overexpression of Bcl‐2 is neuroprotective after experimental brain injury in transgenic mice

R. Raghupathi, D. Merry, T. Mcintosh, 1999, The Journal of comparative neurology.

Molecular Mechanisms and Therapeutics for SBMA/Kennedy’s Disease

D. Merry, F. Arnold, 2019, Neurotherapeutics.

Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase.

K. Fischbeck, H. Zoghbi, H. Orr, 1996, Human molecular genetics.

Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice

K. Fischbeck, E. Wilson, D. Merry, 1995, Nature Genetics.

Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.

D. Merry, Tamar R Berger, B. Paschal, 2015, Cell reports.

Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila.

N. Bonini, D. Merry, J. M. Warrick, 2002, Human molecular genetics.

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

J. Iñiguez-Lluhí, Zhigang Yu, D. Merry, 2015, The Journal of clinical investigation.

enhanced autophagy in spinobulbar muscular atrophy

G. Sobue, D. Merry, A. Lieberman, 2013 .

An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy*

E. Wilson, D. Merry, H. Montie, 2010, The Journal of Biological Chemistry.

Castration Restores Function and Neurofilament Alterations of Aged Symptomatic Males in a Transgenic Mouse Model of Spinal and Bulbar Muscular Atrophy

Huiyi Wang, D. Merry, A. Lieberman, 2004, The Journal of Neuroscience.

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects.

J. Olson, A. Young, D. Borchelt, 2002, Human molecular genetics.

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.

S. Finkbeiner, D. Merry, H. Montie, 2009, Human molecular genetics.

Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features

A. Zinn, M. Dalva, D. Merry, 2015, Genes, brain, and behavior.

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy.

H. Kampinga, D. Merry, C. Bailey, 2002, Human molecular genetics.

Molecular pathogenesis of spinal and bulbar muscular atrophy

D. Merry, 2001, Brain Research Bulletin.

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Catherine A. Collins, T. Komiyama, J. Gestwicki, 2012, Nature chemical biology.

Preventing the Androgen R eceptor N / C Interaction Delays Disease Onset in a Mouse Model of SBMA Graphical Abstract Highlights

D. Merry, Tamar R Berger, B. Paschal, 2015 .

Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis*

D. Merry, Tamar R Berger, C. Orr, 2015, The Journal of Biological Chemistry.

Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy

D. Merry, Erica S. Chevalier-Larsen, 2011, Disease Models & Mechanisms.

Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy.

K. Fischbeck, A. Taye, D. Merry, 1998, Human molecular genetics.

Characterization of an Expanded Glutamine Repeat Androgen Receptor in a Neuronal Cell Culture System

K. Fischbeck, H. Paulson, E. Wilson, 1997, Neurobiology of Disease.

Molecular Pathogenesis of the Polyglutamine Disease: Spinal and Bulbar Muscular Atrophy

D. Merry, Erica S. Chevalier-Larsen, 2007 .

Pathophysiology of Spinal and Bulbar Muscular Atrophy

D. Merry, 2001 .

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

Fumiaki Tanaka, Gen Sobue, Masahiko Yamamoto, 1998, Annals of neurology.

Soluble Androgen Receptor Oligomers Underlie Pathology in a Mouse Model of Spinobulbar Muscular Atrophy*

D. Merry, M. Diamond, Erica S. Chevalier-Larsen, 2007, Journal of Biological Chemistry.

Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor.

Xiaoling Wang, D. Merry, Erica S. Chevalier-Larsen, 2003, Human molecular genetics.

Ligand Promotes Intranuclear Inclusions in a Novel Cell Model of Spinal and Bulbar Muscular Atrophy*

J. Walcott, D. Merry, Jessica L. Walcott, 2002, The Journal of Biological Chemistry.

The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms

D. Merry, M. Rechsteiner, Erica S. Chevalier-Larsen, 2017, Front. Mol. Neurosci..

Animal models of Kennedy disease

D. Merry, 2005, NeuroRX.

Neurobiology of Disease Castration Restores Function and Neurofilament Alterations of Aged Symptomatic Males in a Transgenic Mouse Model of Spinal and Bulbar Muscular Atrophy

Huiyi Wang, D. Merry, A. Lieberman, 2004 .

Autophagy and access: Understanding the role of androgen receptor subcellular localization in SBMA

D. Merry, H. Montie, Heather L. Montie, 2009, Autophagy.

SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA

D. Merry, R. Pestell, H. Montie, 2011, The Journal of Neuroscience.

A Cell Culture Model for Androgen Effects in Motor Neurons

K. Fischbeck, H. Paulson, D. Kolson, 1998, Journal of neurochemistry.

Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy.

J. Walcott, D. Merry, Jessica L. Walcott, 2002, Vitamins and hormones.

The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/CCdh1 ubiquitin ligase complex

K. Fischbeck, D. Merry, N. Dantuma, 2016, Scientific Reports.

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.

S. Korsmeyer, D. Merry, S. Korsmeyer, 1994, Development.

Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

M. Pennuto, D. Merry, H. Montie, 2023, iScience.

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

Z. Oltvai, S. Korsmeyer, J. Shutter, 1993, Seminars in cancer biology.

Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner.

G. Sobue, D. Merry, Yasushi Kobayashi, 1998, Biochemical and biophysical research communications.

Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.

B. Davidson, W. Gu, D. Merry, 2020, The Journal of clinical investigation.

A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in Drosophila

D. Merry, A. Sujkowski, R. Wessells, 2023, bioRxiv.

Attacking the flank: targeting new pathways in SBMA

D. Merry, 2012, Nature Medicine.

Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice.

J. Walcott, D. Merry, J. Duda, 2001, Human molecular genetics.

Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention

D. Pleasure, A. Pekosz, D. Merry, 1996, Journal of virology.

Differentiating PC12 cells to evaluate neurite densities through live-cell imaging

D. Merry, J. Karliner, 2023, STAR protocols.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy*

E. Wilson, D. Merry, E. Bolzoni, 2010, The Journal of Biological Chemistry.

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.

S. Finkbeiner, D. Merry, Andrey S. Tsvetkov, 2009, Human molecular genetics.

SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA

D. Merry, R. Pestell, Heather L. Montie, 2011, The Journal of Neuroscience.

Cell biological approaches to investigate polyglutamine-expanded AR metabolism.

D. Merry, Lori Cooper, 2013, Methods in molecular biology.

Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features

A. Zinn, M. Dalva, D. Merry, 2015, Genes, brain, and behavior.

Differentially disrupted spinal cord and muscle energy metabolism in spinal and bulbar muscular atrophy

D. Merry, Elana Molotsky, Hsin-Yao Tang, 2024, JCI insight.

Corrigendum: Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice

K. Fischbeck, E. Wilson, D. Merry, 1995, Nature Genetics.

Blocking the dimerization of polyglutamine-expanded androgen receptor protects cells from DHT-induced toxicity by increasing AR turnover

D. Merry, Yuhong Liu, Allison Lisberg, 2024, The Journal of biological chemistry.