A. Pioszak

发表

New Insights into the Mechanism of the Kinase and Phosphatase Activities of Escherichia coli NRII (NtrB) and Their Regulation by the PII Protein

A. Ninfa, P. Jiang, M. R. Atkinson, 2003 .

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles.

A. Pioszak, D. Hay, 2016, Annual review of pharmacology and toxicology.

Biochemical characterization of G protein coupling to calcitonin gene–related peptide and adrenomedullin receptors using a native PAGE assay

A. Pioszak, A. Roehrkasse, M. L. Warner, 2020, The Journal of Biological Chemistry.

Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics.

K. Chung, A. Pioszak, J. Simms, 2020 .

N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.

A. Pioszak, D. Hay, Virginie H. Sjoelund, 2017, Biochemistry.

Calcitonin and amylin receptor peptide interaction mechanisms. INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.

A. Pioszak, D. Hay, Sangmin Lee, 2016, The Journal of Biological Chemistry.

Structure-function analysis of glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49) of Escherichia coli.

A. Ninfa, P. Jiang, A. Pioszak, 2007, Biochemistry.

Crystal structure of the C-terminal domain of the two-component system transmitter protein nitrogen regulator II (NRII; NtrB), regulator of nitrogen assimilation in Escherichia coli.

A. Ninfa, Zhaohui Xu, D. Peisach, 2004, Biochemistry.

Mechanism of the PII-activated phosphatase activity of Escherichia coli NRII (NtrB): how the different domains of NRII collaborate to act as a phosphatase.

A. Ninfa, A. Pioszak, 2003, Biochemistry.

Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.

A. Pioszak, D. Hay, A. Roehrkasse, 2018 .

Probing the Mechanism of Receptor Activity–Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists

A. Pioszak, D. Hay, A. Roehrkasse, 2018, Molecular Pharmacology.

Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation*

L. Miller, H. Xu, A. Pioszak, 2010, The Journal of Biological Chemistry.

Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides*

H. Xu, A. Pioszak, T. Gardella, 2009, The Journal of Biological Chemistry.

Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin.

D. Raleigh, C. Reynolds, A. Pioszak, 2018, ACS pharmacology & translational science.

Mutations Altering the N-Terminal Receiver Domain of NRI (NtrC) That Prevent Dephosphorylation by the NRII-PII Complex in Escherichia coli

A. Ninfa, A. Pioszak, 2004, Journal of bacteriology.

Structural Basis for Hormone Recognition by the Human CRFR2α G Protein-coupled Receptor*

H. Xu, K. Swaminathan, A. Pioszak, 2010, The Journal of Biological Chemistry.

Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1*

H. Xu, A. Pioszak, K. Suino-Powell, 2008, Journal of Biological Chemistry.

RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors.

A. Pioszak, D. Hay, 2020, Advances in pharmacology.

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

P. Sexton, A. Pioszak, D. Hay, 2016, Cell Discovery.

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

A. Pioszak, M. Brimble, R. Bill, 2015, Molecular cell.

Calcitonin Receptor N‐Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics

K. Chung, A. Pioszak, J. Simms, 2020, Journal of molecular biology.

Genetic and Biochemical Analysis of Phosphatase Activity of Escherichia coli NRII (NtrB) and Its Regulation by the PII Signal Transduction Protein

A. Ninfa, A. Pioszak, 2003, Journal of bacteriology.

Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors

H. Xu, K. Swaminathan, A. Pioszak, 2011, PloS one.

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

H. Xu, A. Pioszak, H. E. Xu, 2008, Proceedings of the National Academy of Sciences.

Picomolar affinity antagonist and sustained signaling agonist peptide ligands for the adrenomedullin and calcitonin gene-related peptide receptors

A. Pioszak, J. Booe, M. Warner, 2020, bioRxiv.

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.

G. Pairaudeau, C. Reynolds, A. Pioszak, 2020, ACS pharmacology & translational science.

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties

Christopher A. Reynolds, Margaret A. Brimble, Alex C. Conner, 2016, The Journal of Biological Chemistry.

Calcitonin and Amylin Receptor Peptide Interaction Mechanisms

A. Pioszak, D. Hay, Sangmin Lee, 2016, The Journal of Biological Chemistry.

Selective CGRP and adrenomedullin peptide binding by tethered RAMP‐calcitonin receptor‐like receptor extracellular domain fusion proteins

A. Pioszak, Heather E Moad, 2013, Protein science : a publication of the Protein Society.

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein–coupled receptor

A. Dickson, A. Pioszak, J. Lennon, 2023, The Journal of biological chemistry.

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor

A. Dickson, A. Pioszak, Katie M. Babin, 2023, bioRxiv.

Structure–function analyses reveal a triple β-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design

A. Pioszak, Sangmin Lee, A. Roehrkasse, 2018, The Journal of Biological Chemistry.

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.

A. Pioszak, Sangmin Lee, J. Booe, 2015, European journal of pharmacology.

Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling.

A. Pioszak, Heather Hill, 2013, Protein expression and purification.

Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.

A. Pioszak, Heather E Moad, 2013, Biochemistry.

Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine.

S. Yokoyama, M. Shirouzu, S. Kuramitsu, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides*

A. Pioszak, T. Gardella, N. Parker, 2009, The Journal of Biological Chemistry.

Time- and cost-efficient bacterial expression and purification of potato apyrase.

N. Lambert, A. Pioszak, Jordan A Karim, 2022, Protein expression and purification.

Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (22-32)

A. Pioszak, J. Simms, D. Poyner, 2020 .

The Escherichia coli PII signal transduction protein regulates the activities of the two-component system transmitter protein NRII by direct interaction with the kinase domain of the transmitter module.

A. Ninfa, P. Jiang, A. Pioszak, 2000, Biochemistry.

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

P. Sexton, A. Pioszak, D. Hay, 2016, Cell Discovery.

Engineering High-Potency R-spondin Adult Stem Cell Growth Factors

A. Pioszak, M. Warner, Tufica Bell, 2015, Molecular Pharmacology.

Molecular interaction of an antagonistic amylin analog with the extracellular domain of receptor activity-modifying protein 2 assessed by fluorescence polarization.

A. Pioszak, Sangmin Lee, 2020, Biophysical chemistry.