A. Beavil

发表

Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis

Dennis Bray, Thomas S. Shimizu, Nicolas Le Novère, 2000, Nature Cell Biology.

Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome

D. Mann, A. Beavil, Lu-Ning Liu, 2022, bioRxiv.

A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E Fc

Anthony H Keeble, S. Ameer-Beg, A. Beavil, 2012, The Journal of Biological Chemistry.

IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.

Robert J. Moore, D. Dombrowicz, F. Balkwill, 2007, Journal of immunology.

Human immunoglobulin E flexes between acutely bent and extended conformations

Benjamin P. Cossins, Anthony H Keeble, J. M. McDonnell, 2014, Nature Structural &Molecular Biology.

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab

Benjamin P. Cossins, T. Ceska, Anthony H Keeble, 2017, The Journal of Biological Chemistry.

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Kristina M. Ilieva, S. Tsoka, D. Dombrowicz, 2017, Cancer research.

Structural basis of the IgE-Fc epsilon RI interaction.

R. Owens, A. Beavil, B. Sutton, 1993, Biochemical Society transactions.

Bent domain structure of recombinant human IgE-Fc in solution by X-ray and neutron scattering in conjunction with an automated curve fitting procedure.

S. Perkins, A. Beavil, B. Sutton, 1995, Biochemistry.

Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the Fc epsilon RI alpha chain.

R. Owens, R. Ghirlando, S. Perkins, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI

R. Owens, B. Dhaliwal, J. M. McDonnell, 2011, Nature Structural &Molecular Biology.

Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI‐mediated basophil activation by a tumour‐specific IgE antibody to evaluate the risk of type I hypersensitivity

F. Nestle, S. Canevari, J. Spicer, 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition

L. James, A. Beavil, B. Sutton, 2018, Proceedings of the National Academy of Sciences.

Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody

A. Beavil, B. Sutton, R. Beavil, 2018, Scientific Reports.

Dodding, M. P. (2017). A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Proceedings of the National Academy of Sciences of the United States of America, 114(52),

R. Steiner, M. Parsons, A. Beavil, 2017 .

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution.

A. Beavil, B. Sutton, F. Saab, 2011, Organic & biomolecular chemistry.

The applicability of fluorescence lifetime to determine the time since the deposition of biological stains

A. Beavil, K. Suhling, B. Daniel, 2017 .

Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells

A. Beavil, B. Sutton, P. Hobson, 2012, The Journal of Immunology.

Homeostasis in Human B Cells Soluble CD23 Controls IgE Synthesis and

A. Beavil, P. Hobson, H. Gould, 2022 .

Mutagenesis within human FcepsilonRIalpha differentially affects human and murine IgE binding.

A. Beavil, B. Sutton, M. Hulett, 2002, Journal of immunology.

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application

F. Nestle, J. Spicer, A. Beavil, 2012, Cancer Immunology, Immunotherapy.

CD23/Fc epsilon RII: C-type lectin membrane protein with a split personality?

A. Beavil, B. Sutton, H. Gould, 1991, Monographs in allergy.

Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins.

A. Beavil, B. Sutton, H. Gould, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells

D. Dombrowicz, F. Balkwill, A. Beavil, 2007, Cancer Immunology, Immunotherapy.

Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI.

A. Beavil, B. Sutton, H. Gould, 1997, Biochemical Society transactions.

Structural basis of the IgE-FcɛRI interaction

R. Owens, A. Beavil, B. Sutton, 1993 .

Human IgE flips between two acutely bent structures via an ensemble of extended conformations

Benjamin P. Cossins, A. Beavil, B. Sutton, 2013 .

CLONING OF ANTIBODY GENES USING UNIQUE RESTRICTIONS SITES

A. Beavil, J. Hunt, S. Gan, 2009 .

Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.

A. Beavil, B. Sutton, B. Helm, 2012, The Journal of organic chemistry.

Enantioselective synthesis of (+)-aspercyclide A

A. Beavil, R. Leatherbarrow, A. Spivey, 2013 .

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether.

A. Beavil, B. Sutton, A. White, 2010, Chemical communications.

The biology of IGE and the basis of allergic disease.

David Fear, A. Beavil, B. Sutton, 2001, Annual review of immunology.

Monitoring the Systemic Human Memory B Cell Compartment of Melanoma Patients for Anti-Tumor IgG Antibodies

F. Nestle, J. Spicer, A. Beavil, 2011, PloS one.

Inhibition of allergen‐dependent IgE activity by antibodies of the same specificity but different class

S. Durham, L. James, A. Beavil, 2015, Allergy.

Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.

S. Durham, L. James, A. Beavil, 2012, The Journal of allergy and clinical immunology.

Identification of Contact Residues and Definition of the CAR-Binding Site of Adenovirus Type 5 Fiber Protein

Andrew J. Beavil, Brian J. Sutton, A. Beavil, 2000, Journal of Virology.

Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor

A. Beavil, B. Sutton, R. Korngold, 1996, Nature Structural Biology.

The structure of the IgE Cɛ2 domain and its role in stabilizing the complex with its high-affinity receptor FcɛRIα

David Cowburn, Andrew J. Beavil, Rebecca L. Beavil, 2001, Nature Structural Biology.

The crystal structure of rabbit IgG-Fc.

A. Beavil, B. Sutton, A. Davies, 2009, The Biochemical journal.

A tool kit for rapid cloning and expression of recombinant antibodies

L. James, A. Beavil, D. Josephs, 2014, Scientific Reports.

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI

B. Dhaliwal, A. Beavil, B. Sutton, 2012, Proceedings of the National Academy of Sciences.

Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.

Maddy Parsons, James Hunt, Andrew Beavil, 2006, The Journal of general virology.

Mutations in the DG Loop of Adenovirus Type 5 Fiber Knob Protein Abolish High-Affinity Binding to Its Cellular Receptor CAR

A. Beavil, B. Sutton, I. Kovesdi, 1999, Journal of Virology.

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

Kristina M. Ilieva, A. Tutt, J. Spicer, 2017, Front. Immunol..

Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells

T. Daniels, M. Penichet, F. Nestle, 2009, Cancer Immunology, Immunotherapy.

Cancer Cells Mechanisms of Eradication of Ovarian Solid Tumors: Cytotoxic and Phagocytic Ige-antibody-dependent Immunotherapy Of

D. Dombrowicz, F. Balkwill, A. Beavil, 2022 .

Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation

T. Vyse, A. Beavil, S. Lynham, 2021, The Journal of biological chemistry.

a-Helical coiled-coil stalks in the low-affinity receptor for IgE (FcERII/CD23) and related C-type lectins

A. Beavil, B. Sutton, H. Gould, 2022 .

Mutagenesis Within Human FcεRIα Differentially Affects Human and Murine IgE Binding1

A. Beavil, B. Sutton, M. Hulett, 2002, The Journal of Immunology.

IgE binds asymmetrically to its B cell receptor CD23

B. Dhaliwal, L. James, A. Beavil, 2017, Scientific Reports.

A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23

B. Dhaliwal, A. Beavil, B. Sutton, 2014, Acta crystallographica. Section F, Structural biology communications.

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23☆

B. Dhaliwal, A. Beavil, B. Sutton, 2013, Molecular immunology.

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E*

B. Dhaliwal, A. Beavil, B. Sutton, 2013, The Journal of Biological Chemistry.

Reviving lost binding sites: Exploring calcium‐binding site transitions between human and murine CD23

B. Dhaliwal, A. Beavil, B. Sutton, 2021, FEBS open bio.

Attenuation of IgE Affinity for FcϵRI Radically Reduces the Allergic Response in Vitro and in Vivo*

S. Fleury, D. Dombrowicz, A. Beavil, 2008, Journal of Biological Chemistry.

Necessity of the stalk region for immunoglobulin E interaction with CD23

Andrew Beavil, Rebecca Beavil, D. Conrad, 2002, Immunology.

Interaction of the Low-Affinity Receptor CD23/FcεRII Lectin Domain with the Fcε3−4 Fragment of Human Immunoglobulin E†

R. Owens, R. Ghirlando, A. Beavil, 1997 .

α-Helical coiled-coil stalks in the low-affinity receptor for lgE(CD23/FcεRll) and related C-type lectins.

A. Beavil, 1992 .

The crystal structure of IgE Fc reveals an asymmetrically bent conformation

R. Owens, A. Beavil, B. Sutton, 2002, Nature Immunology.

Heterogeneous glycosylation of immunoglobulin E constructs characterized by top-down high-resolution 2-D mass spectrometry.

F. McLafferty, A. Beavil, B. Baird, 2000, Biochemistry.

Interaction of the low-affinity receptor CD23/Fc epsilonRII lectin domain with the Fc epsilon3-4 fragment of human immunoglobulin E.

R. Owens, R. Ghirlando, A. Beavil, 1997, Biochemistry.

IgE Trimers Drive SPE-7 Cytokinergic Activity

A. Beavil, B. Sutton, R. Beavil, 2017, Scientific Reports.

Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction*

Susmita Borthakur, A. Beavil, B. Sutton, 2012, The Journal of Biological Chemistry.

Disulfide Linkage Controls the Affinity and Stoichiometry of IgE Fcϵ3–4 Binding to FcϵRI*

James Hunt, A. Beavil, B. Sutton, 2005, Journal of Biological Chemistry.

CHAPTER 8 – Immunoglobulin–Fc Receptor Interactions

A. Beavil, B. Sutton, R. Beavil, 2003 .

Binding IgEDifferentially Affects Human and Murine α RI ε Mutagenesis Within Human

M. Hogarth, A. Beavil, B. Sutton, 2002 .

Handbook of Cell Signalling

A. Beavil, B. Sutton, R. Beavil, 2003 .

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro

M. Gautel, A. Beavil, M. Pfuhl, 2022, bioRxiv.

Time-Resolved Fluorescence Anisotropy and Molecular Dynamics Analysis of a Novel GFP Homo-FRET Dimer

A. Beavil, K. Suhling, C. Molteni, 2020, Biophysical journal.

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

R. Steiner, M. Parsons, A. Beavil, 2017, Proceedings of the National Academy of Sciences.

Antibody conjugates for targeted delivery of Toll-like receptor 9 agonist to the tumor tissue

A. Beavil, J. N. Arnold, S. Diebold, 2023, PloS one.

Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization

T. Ceska, A. Beavil, B. Sutton, 2020, Acta crystallographica. Section F, Structural biology communications.

Immunoglobulin E Receptors

A. Beavil, B. Sutton, H. Gould, 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.

B. Vojnovic, M. Arpin, T. Ng, 2007, Molecular biology of the cell.

Fluorescence Recovery After Photobleaching (FRAP) with simultaneous Fluorescence Lifetime and time-resolved Fluorescence Anisotropy Imaging (FLIM and tr-FAIM)

C. Molteni, Y. Teijeiro-Gonzalez, A. Le Marois, 2019, BiOS.

Functional diversity of FCERI and CD 23

A. Beavil, B. Sutton, R. Beavil, 2005 .

Inhibition of IgE-receptor interactions.

A. Beavil, B. Sutton, R. Beavil, 2000, British medical bulletin.

The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.

D. Cowburn, A. Beavil, B. Sutton, 2001, Nature structural biology.

Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

Kristina M. Ilieva, S. Tsoka, J. Downward, 2023, Nature communications.

Hydrodynamic studies of a complex between the Fc fragment of human IgE and a soluble fragment of the FceRI a chain

A. Beavil, H. Gould, R. Young, 2005 .

Total Synthesis of (.+-.)-Aspercyclide A and Its C19 Methyl Ether.

A. Beavil, B. Sutton, R. Leatherbarrow, 2010 .

IgE and IgE Receptors

A. Beavil, B. Sutton, J. Hunt, 2009 .

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E

A. Beavil, B. Sutton, N. Drinkwater, 2017, Biochimica et Biophysica Acta - Proteins and Proteomics.

Thermal sensitivity and flexibility of the Cϵ3 domains in immunoglobulin E

A. Beavil, B. Sutton, N. Drinkwater, 2017 .

Fluorescence lifetime imaging for viscosity and diffusion measurements

Klaus Suhling, James A. Levitt, Alix Le Marois, 2019, BiOS.

Allergen specificity of IgG(4)-expressing B cells in patients with grass pollen allergy undergoing immunotherapy.

S. Durham, L. James, A. Beavil, 2012, The Journal of allergy and clinical immunology.

Simultaneous Frap, Flim and Faim for Measurements of Protein Mobility and Interaction in Living Cells References and Links a Generalization of Theory for Two- Dimensional Fluorescence Recovery after Photobleaching Applicable to Confocal Laser Scanning Microscopes, " Biophys. Ratiometry and Fluoresce

Tymish Y. Ohulchanskyy, C. Tregidgo, J. Bonifacino, 2022 .

Expanding the Anti-Phl p 7 Antibody Toolkit: An Anti-Idiotype Nanobody Inhibitor

A. Beavil, R. Beavil, A. Davies, 2023, Antibodies.

The crystal structure of rabbit IgG-Fc.

A. Beavil, B. Sutton, A. Davies, 2009, The Biochemical journal.

A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E Fc

S. Ameer-Beg, A. Beavil, B. Sutton, 2012, The Journal of Biological Chemistry.

Homeostasis in Human B Cells Soluble CD23 Controls IgE Synthesis and

A. Beavil, B. Sutton, P. Hobson, 2012 .

Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity

A. Beavil, B. Sutton, R. Beavil, 2023, Molecular immunology.