P. Tawa

发表

Mutational activation of CheA, the protein kinase in the chemotaxis system of Escherichia coli

R. Stewart, P. Tawa, 1994, Journal of bacteriology.

Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.

Sébastien Gagné, Eric Langlois, Jean-François Truchon, 2014, Bioorganic & medicinal chemistry letters.

An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.

J. Falgueyret, S. Venkatraman, M. Percival, 2004, Analytical biochemistry.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

T. Roemer, Xinwei Sher, S. Koseoglu, 2016, Science Translational Medicine.

In Vitro Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor

Jason Burch, Yves Ducharme, Louis-Charles Campeau, 2013, Antimicrobial Agents and Chemotherapy.

Hsp60 accelerates the maturation of pro‐caspase‐3 by upstream activator proteases during apoptosis

P. Tawa, R. Ruel, D. Nicholson, 1999, The EMBO journal.

Examining targeted protein degradation from physiological and analytical perspectives: Enabling translation between cells and subjects.

J. O'neil, P. Tawa, D. McLaren, 2020, ACS chemical biology.

Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities

L. Duong, M. Percival, R. Oballa, 2008, Molecular Pharmacology.

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.

Christopher M. Tan, D. Slipetz, H. Houshyar, 2008, American journal of respiratory cell and molecular biology.

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α

P. Tawa, Rumin Zhang, W. M. Seganish, 2022, The Journal of biological chemistry.

Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors

D. Hazuda, E. Asante-Appiah, Youwei Yan, 2018, The Journal of antimicrobial chemotherapy.

Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: cellular distribution in human leukocyte populations and evidence of diurnal modulation.

J. Falgueyret, M. Percival, J. Gauthier, 2011, Analytical biochemistry.

Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.

J. Falgueyret, R. Oballa, J. Guay, 2011, Bioorganic & medicinal chemistry letters.

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Bioorganic & medicinal chemistry letters.

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2005, Bioorganic & medicinal chemistry letters.

Solid phase synthesis of selective caspase-3 peptide inhibitors.

C. Bayly, R. Zamboni, P. Tawa, 2004, Bioorganic & medicinal chemistry.

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Yongxin Han, R. Zamboni, P. Tawa, 2007, Bioorganic & medicinal chemistry letters.

High-Throughput Scintillation Proximity Assay for Stearoyl-CoA Desaturase-1

J. Falgueyret, P. Tawa, Sébastien Guiral, 2011, Journal of biomolecular screening.

2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.

J. Falgueyret, R. Oballa, P. Tawa, 2010, Bioorganic & medicinal chemistry letters.

Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.

Yongxin Han, P. Tawa, D. Nicholson, 2006, Analytical biochemistry.

Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors

P. Tawa, D. Nicholson, S. Xanthoudakis, 2004, Cell Death and Differentiation.

Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

M. Hayden, S. Hadano, B. Koop, 1998, Cell Death and Differentiation.

Ligand‐induced conformational change in the ferrichrome–iron receptor of Escherichia coli K‐12

J. Turnbull, P. Tawa, J. Coulton, 1996, Molecular microbiology.

Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides

P. Tawa, I. Davies, A. Kerekes, 2021 .

STRUCTURE‐ACTIVITY RELATIONSHIPS OF CLONIDINE‐ AND TOLAZOLINE‐LIKE COMPOUNDS AT HISTAMINE AND α‐ADRENOCEPTOR SITES

P. Tawa, J. Ong, C. Raper, 1980 .

Small molecule photocatalysis enables drug target identification via energy transfer

R. Oslund, C. White, P. Tawa, 2021, bioRxiv.

Kinetics of CheA autophosphorylation and dephosphorylation reactions.

R. Stewart, P. Tawa, 1994, Biochemistry.

pH dependence of CheA autophosphorylation in Escherichia coli

H. Berg, R. Stewart, A. Wolfe, 1994, Journal of bacteriology.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

T. Roemer, S. Koseoglu, P. Tawa, 2017, Journal of medicinal chemistry.

Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α).

Gregory T O'Donnell, Lei Zhang, P. Tawa, 2021, ACS medicinal chemistry letters.

Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis

P. Tawa, D. Nicholson, S. Xanthoudakis, 2001, Cell Death and Differentiation.

Concise syntheses and HCV NS5B polymerase inhibition of (2'R)-3 and (2'S)-2'-ethynyluridine-10 and related nucleosides.

M. Senior, A. Malikzay, P. Tawa, 2017, Bioorganic & Medicinal Chemistry Letters.

Porins of Haemophilus influenzae Type b Mutated in Loop 3 and in Loop 4*

K. Diederichs, P. Tawa, J. Coulton, 1997, The Journal of Biological Chemistry.

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.

R. Oballa, R. Gordon, J. Guay, 2011, Bioorganic & medicinal chemistry letters.