D. Thanos

发表

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

T. Maniatis, D. Thanos, 1995, Cell.

LifeTime and improving European healthcare through cell-based interceptive medicine

Fabian J Theis, S. Linnarsson, I. Amit, 2020, Nature.

Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter.

A. Aggarwal, Leyi Shen, C. Escalante, 2002, Structure.

Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression

D. Thanos, E. Apostolou, 2008, Cell.

Transcription factors mediate long-range enhancer–promoter interactions

Dimitris Thanos, D. J. McKay, Stavros Lomvardas, 2009, Proceedings of the National Academy of Sciences.

Distinct Functional Properties of IkBa and IkBb

M. Merika, D. Thanos, K. Tran, 1997 .

Distinct functional properties of IkappaB alpha and IkappaB beta

M. Merika, D. Thanos, K. Tran, 1997, Molecular and cellular biology.

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

Dimitris Thanos, Tom Maniatis, Stavros Lomvardas, 2000, Cell.

Serum miRNA-based distinct clusters define three groups of breast cancer patients with different clinicopathological and immune characteristics

D. Thanos, N. Arnogiannaki, S. Perez, 2018, Cancer Immunology, Immunotherapy.

Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster

A. Skouroliakou, L. Margaritis, D. Stravopodis, 2017, Fly.

A dimer-specific function of the transcription factor NFATp

J. V. Falvo, T. Maniatis, P. Hwang, 2008, Proceedings of the National Academy of Sciences.

The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia

K. Stamatopoulos, D. Thanos, A. Makris, 2022, Blood advances.

Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression

Santa Jeremy Ono, T. Maniatis, J. Strominger, 1995, The Journal of experimental medicine.

Cloning and functional characterization of mouse IkappaBepsilon.

D. Thanos, G. Chen, S. Liang, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Linking differential chromatin loops to transcriptional decisions.

D. Thanos, E. Apostolou, 2008, Molecular cell.

Multiple regulatory regions on the 5' side of the mouse E alpha gene.

J. Papamatheakis, D. Thanos, G. Mavrothalassitis, 1988, Proceedings of the National Academy of Sciences of the United States of America.

High mobility group I/Y protein functions as a specific cofactor for Oct‐2A: mapping of interaction domains

Santa Jeremy Ono, S. Abdulkadir, V. Casolaro, 1998, Journal of leukocyte biology.

The MHC class II E beta promoter: a complex arrangement of positive and negative elements determines B cell and interferon-gamma (IFN-gamma) regulated expression.

M. Gregoriou, T. Makatounakis, J. Papamatheakis, 1993, Nucleic acids research.

Impaired anti-inflammatory activity of PPARγ in the salivary epithelia of Sjögren's syndrome patients imposed by intrinsic NF-κB activation.

D. Thanos, E. Kapsogeorgou, A. Vakrakou, 2018, Journal of autoimmunity.

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

C. Antoniades, V. Gorgoulis, N. Nagahara, 2022, The Journal of experimental medicine.

Molecular analysis of the mouse class II gene, Eαq

J. Papamatheakis, D. Thanos, G. Mavrothalassitis, 2004, Immunogenetics.

NF-κB: A lesson in family values

T. Maniatis, D. Thanos, 1995, Cell.

Distinct Functional Properties of I k B a and I k B b

M. Merika, D. Thanos, K. Tran, 1997 .

Cloning and functional characterization of mouse IkB«

D. Thanos, S. Simeonidis, S. Liang, 1997 .

Expression, purification, and co‐crystallization of IRF‐I bound to the interferon‐β element PRD I

A. Aggarwal, C. Escalante, D. Thanos, 1997 .

Opening chromatin.

S. Lomvardas, D. Thanos, 2002, Molecular cell.

Overexpression of Proteins HMGA 1 Induces Cell Cycle Deregulation and Apoptosis in Normal Rat Thyroid Cells 1

G. Viglietto, M. Santoro, A. Fusco, 2001 .

Complete nucleotide sequence of the PvuII restriction enzyme gene from Proteus vulgaris.

A. Athanasiadis, M. Kokkinidis, J. Papamatheakis, 1990, Nucleic acids research.

Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation.

J. Papamatheakis, D. Thanos, G. Tsokos, 1992, Journal of immunology.

Interferon‐&lgr; Mediates Non‐redundant Front‐Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

S. Kotenko, D. Thanos, E. Andreakos, 2017, Immunity.

Tracing the First Days of the SARS-CoV-2 Pandemic in Greece and the Role of the First Imported Group of Travelers

K. Zoi, D. Thanos, A. Mentis, 2022, Microbiology spectrum.

Structure of the NF-kappa B transcription factor: a holistic interaction with DNA.

J. Kuriyan, D. Thanos, 1995, Structure.

Deciphering the Transcriptional Histone Acetylation Code for a Human Gene

Dimitris Thanos, Guoying Chen, D. Thanos, 2002, Cell.

Transcriptional regulation of endothelial cell adhesion molecules : NF-icB and cytokine-inducible enhancers

T. Maniatis, T. Collins, D. Thanos, 2004 .

The role of HMG I(Y) in the assembly and function of the IFN‐β enhanceosome

M. Merika, D. Thanos, N. Munshi, 1999, The EMBO journal.

Deep Learning and Association Rule Mining for Predicting Drug Response in Cancer. A Personalised Medicine Approach

Konstantinos Vougas, Vassilis G. Gorgoulis, Jiri Bartek, 2016, bioRxiv.

From Proteomic Mapping to Invasion-Metastasis-Cascade Systemic Biomarkering and Targeted Drugging of Mutant BRAF-Dependent Human Cutaneous Melanomagenesis

Eumorphia G Konstantakou, G. Voutsinas, D. Stravopodis, 2021, Cancers.

Memory and the Regulation of Chromatin Structure

E. Kandel, M. Giustetto, J. H. Schwartz, 2003 .

The transcriptional code of human IFN-beta gene expression.

Dimitris Thanos, D. Thanos, E. Ford, 2010, Biochimica et biophysica acta.

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

Dimitris Thanos, Tom Maniatis, T. Maniatis, 1992, Cell.

The Architectural Transcription Factor High Mobility Group I(Y) Participates in Photoreceptor-Specific Gene Expression

Santa Jeremy Ono, D. Zack, A. Keane-Myers, 2000, The Journal of Neuroscience.

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions

Jeroen A. A. Demmers, D. Thanos, M. Lavigne, 2016, Nucleic acids research.

Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.

G. Viglietto, M. Santoro, A. Fusco, 2018, Cancer research.

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division

S. Gagos, J. Trebicka, D. Stravopodis, 2021, Communications biology.

A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Aristotelis Tsirigos, Hua Zhou, Theodore Sakellaropoulos, 2019, Cell reports.

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

Dimitris Thanos, Tom Maniatis, J. V. Falvo, 1995, Cell.

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

T. Maniatis, D. Thanos, W. Du, 1993, Cell.

Identification of a dynamic gene regulatory network required for pluripotency factor‐induced reprogramming of mouse fibroblasts and hepatocytes

I. Talianidis, D. Thanos, P. Karagianni, 2020, The EMBO journal.

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Fabian J Theis, S. Linnarsson, I. Amit, 2021, Nature.

Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter

J. V. Falvo, T. Maniatis, M. Merika, 2000, Molecular and Cellular Biology.

The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition

D. Thanos, A. Polyzos, Antonis Kokkalis, 2018, Molecular and Cellular Biology.

Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression.

I. Maraziotis, D. Thanos, M. Lavigne, 2015, Cell reports.

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

Aristotelis Tsirigos, Hua Zhou, Konstantinos Vougas, 2019, Pharmacology & therapeutics.

Biochemistry and molecular biology research achievements in Greece

G. Thireos, G. Panayotou, D. Thanos, 2008, IUBMB life.

An HMG-like protein that can switch a transcriptional activator to a repressor

Jun Ma, Dimitris Thanos, Tom Maniatis, 1994, Nature.

Structure of NF-κB p50/p65 Heterodimer Bound to the PRDII DNA Element from the Interferon-β Promoter

A. Aggarwal, Leyi Shen, C. Escalante, 2002 .

Transcriptional Activation by NF-κB Requires Multiple Coactivators

C. Glass, M. Rosenfeld, Z. Haque, 1999, Molecular and Cellular Biology.

Mechanisms by which IkappaB proteins control NF-kappaB activity.

W. Hendrickson, D. Thanos, G. Chen, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1*

C. Glass, M. Rosenfeld, M. Gerritsen, 1998, The Journal of Biological Chemistry.

The Causes and Consequences of Spatial Organization of the Genome in Regulation of Gene Expression

D. Thanos, S. Foutadakis, M. Agelopoulos, 2021, Frontiers in Immunology.

CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation

D. Thanos, E. Kolettas, A. Klinakis, 2019, Life Science Alliance.

The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.

D. Thanos, E. Ford, C. Nikopoulou, 2018, Molecular cell.

Post-induction, Stimulus-specific Regulation of Tumor Necrosis Factor mRNA Expression*

G. Courtois, J. V. Falvo, M. Schmidt-Supprian, 2007, Journal of Biological Chemistry.

Genomic Analysis Reveals a Novel Nuclear Factor-κB (NF-κB)-binding Site in Alu-repetitive Elements*

G. Mosialos, D. Thanos, M. Lavigne, 2011, The Journal of Biological Chemistry.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Dimitris Kletsas, Konstantinos Vougas, Jiri Bartek, 2016, Nature Cell Biology.

Protracted p53-independent stimulation of p21 fuels genomic instability by deregulating the replication licensing machinery

Emanuel, S. Gagos, I. Roninson, 2016 .

Longitudinal ctDNA profiling in precision oncology and immunο-oncology.

D. Thanos, P. Filis, D. Roukos, 2023, Drug discovery today.

Gene regulatory networks modelling using a dynamic evolutionary hybrid

Andrei Dragomir, Ioannis A. Maraziotis, Dimitris Thanos, 2010, BMC Bioinformatics.

A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor

Santa Jeremy Ono, J. Strominger, D. Thanos, 1994, The Journal of experimental medicine.

Exploring and exploiting the systemic effects of deregulated replication licensing.

Vassilios Myrianthopoulos, Emmanuel Mikros, Dimitris Thanos, 2016, Seminars in cancer biology.

Transcription Factor Ets-2 Acts as a Preinduction Repressor of Interleukin-2 (IL-2) Transcription in Naive T Helper Lymphocytes*

D. Thanos, A. Mouzaki, Ioannis Panagoulias, 2016, The Journal of Biological Chemistry.

Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture

S. Lomvardas, D. Thanos, 2002, Cell.

Transcriptomics in tissue glucocorticoid sensitivity

G. Chrousos, D. Thanos, Nicolas C. Nicolaides, 2019, European journal of clinical investigation.

E. Riboli, A. Tjønneland, E. Weiderpass, 2019, Nutrients.

CIITA regulates transcription onset via Ser5‐phosphorylation of RNA Pol II

T. Makatounakis, A. Kretsovali, J. Papamatheakis, 2003, The EMBO journal.

Bypassing the Requirements for Epigenetic Modifications in Gene Transcription by Increasing Enhancer Strength

M. Merika, D. Thanos, George Koutroubas, 2007, Molecular and Cellular Biology.

Epigenetic determination of a cell‐specific gene expression program by ATF‐2 and the histone variant macroH2A

D. Thanos, M. Agelopoulos, 2006, The EMBO journal.

Transcriptional activation by NF-kappaB requires multiple coactivators.

C. Glass, M. Rosenfeld, Z. Haque, 1999, Molecular and cellular biology.

Explorer S-glutathionylation of IRF 3 regulates IRF 3-CBP interaction and activation of the IFN beta pathway

D. Thanos, Eleni Chantzoura, G. Spyrou, 2018 .

S‐glutathionylation of IRF3 regulates IRF3–CBP interaction and activation of the IFNβ pathway

D. Thanos, Eleni Chantzoura, G. Spyrou, 2008, The EMBO journal.

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

Dimitris Thanos, James H. Schwartz, Eric R. Kandel, 2002, Cell.

Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study

Dimitris Thanos, Chryssostomos Chatgilialoglu, Aikaterini Skouroliakou, 2018, Brain and behavior.

Induction of class II major histocompatibility complex antigens in murine placenta by 5‐azacytidine and interferon‐γ involves different cell populations

J. Papamatheakis, D. Thanos, I. Athanassakis-Vassiliadis, 1989, European journal of immunology.

The κB DNA Sequence from the HIV Long Terminal Repeat Functions as an Allosteric Regulator of HIV Transcription*

G. Ghosh, D. Thanos, De-bin Huang, 2002, The Journal of Biological Chemistry.

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

A. Aggarwal, C. Escalante, D. Thanos, 1998, Nature.

Nucleosome Sliding via TBP DNA Binding In Vivo

Dimitris Thanos, Stavros Lomvardas, S. Lomvardas, 2001, Cell.

Triethyllead-induced inhibition of proliferation of normal human lymphocytes through decreased expression of the Tac chain of interleukin 2 receptor.

M. Athanasiou, V. Georgoulias, C. Stournaras, 1990, International journal of immunopharmacology.

Stochastic Responses Are Not Left to Pure “Chance”

D. Thanos, A. Banos, M. Agelopoulos, 2013, Cell.

Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer

K. Zatloukal, D. Thanos, E. Ford, 2018, Hepatology.

Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.

Santa Jeremy Ono, S. Abdulkadir, V. Casolaro, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Structure of the NF-κB transcription factor: a holistic interaction with DNA

J. Kuriyan, D. Thanos, 1995 .

Evaluation of Serum/Urine Genomic and Metabolomic Profiles to Improve the Adherence to Sildenafil Therapy in Patients with Erectile Dysfunction

L. Tenori, D. Thanos, C. Foresta, 2020, Frontiers in Pharmacology.

Radiomics/Radiogenomics in Lung Cancer: Basic Principles and Initial Clinical Results

K. Syrigos, D. Thanos, A. Anagnostopoulos, 2022, Cancers.

LN-10, a brain derived cDNA clone: studies related to CNS development.

J. Papamatheakis, D. Thanos, I. Zarkadis, 1991, Advances in experimental medicine and biology.

Senescent cells in Giant Cell Arteritis have inflammatory phenotype participating in tissue injury via IL-6 dependent pathways

C. Kittas, D. Thanos, C. Salvarani, 2023, bioRxiv.

cDNA cloning of the translocon associated protein beta-subunit in the chick cerebellum.

J. Papamatheakis, D. Thanos, I. Zarkadis, 1997, Gene.

The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.

D. Thanos, E. Ford, C. Nikopoulou, 2019, Molecular cell.

An NF-κB-Like Transcription Factor in Axoplasm is Rapidly Inactivated after Nerve Injury in Aplysia

R. Ambron, D. Thanos, M. Povelones, 1997, The Journal of Neuroscience.

A method for generating highly multiplexed ChIP-seq libraries

D. Thanos, E. Ford, C. Nikopoulou, 2014, BMC Research Notes.

Identifying and profiling structural similarities between Spike of SARS-CoV-2 and other viral or host proteins with Machaon

I. Emiris, G. Blatch, D. Thanos, 2023, Communications biology.

Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity

D. Stravopodis, D. Thanos, E. Ford, 2023, PloS one.

Coordination of a transcriptional switch by HMGI(Y) acetylation.

S. Lomvardas, M. Merika, D. Thanos, 2001, Science.

Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription.

M. Merika, Amyj . Williams, T. Collins, 1998, Molecular cell.

Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1

T. Maniatis, T. Collins, D. Thanos, 1995, Molecular and cellular biology.

Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome.

K. Senger, M. Merika, D. Thanos, 1998, Molecular cell.

Mechanism by which the IFN-beta enhanceosome activates transcription.

K. Senger, D. Thanos, D. Thanos, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

T. Maniatis, T. Collins, D. Thanos, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Microtubule Dynamics Deregulation Induces Apoptosis in Human Urothelial Bladder Cancer Cells via a p53-Independent Pathway

G. Voutsinas, D. Stravopodis, O. Tsitsilonis, 2023, Cancers.

Lessons learned and questions raised during and post-COVID-19 anthropopause period in relation to the environment and climate

C. Zerefos, S. Solomos, J. Kapsomenakis, 2020, Environment, Development and Sustainability.

Gene repression by coactivator repulsion.

K. Senger, M. Merika, A. Aggarwal, 2000, Molecular cell.

Effects of cryopreservation on antiviral responses of primary airway epithelial cells

N. Papadopoulos, D. Thanos, C. Skevaki, 2019, Allergy.

S‐glutathionylation of IRF3 regulates IRF3–CBP interaction and activation of the IFNβ pathway

D. Thanos, Eleni Chantzoura, G. Spyrou, 2008, EMBO Journal.

Time's up: Bursting out of Transcription

Dimitris Thanos, D. Thanos, E. Ford, 2009, Cell.

The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.

D. Thanos, E. Ford, E. Psarra, 2018, Molecular cell.