Yanmin Zhang

发表

Studies on [5,6]-Fused Bicyclic Scaffolds Derivatives as Potent Dual B-RafV600E/KDR Inhibitors Using Docking and 3D-QSAR Approaches

T. Ran, Haichun Liu, San-Zhi Tang, 2015, International journal of molecular sciences.

Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies.

Yanmin Zhang, T. Lu, Yadong Chen, 2021, Journal of medicinal chemistry.

Insight into the key interactions of bromodomain inhibitors based on molecular docking, interaction fingerprinting, molecular dynamics and binding free energy calculation.

T. Ran, Haichun Liu, Shuai Lu, 2015, Molecular bioSystems.

De novo design of N-(pyridin-4-ylmethyl)aniline derivatives as KDR inhibitors: 3D-QSAR, molecular fragment replacement, protein-ligand interaction fingerprint, and ADMET prediction

Haichun Liu, Shuai Lu, Yanmin Zhang, 2012, Molecular Diversity.

3D-QSAR and molecular fragment replacement study on diaminopyrimidine and pyrrolotriazine ALK inhibitors

T. Ran, Haichun Liu, Yanmin Zhang, 2014 .

Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance

Yanmin Zhang, T. Lu, Yadong Chen, 2017, J. Chem. Inf. Model..

Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations

B. Xiang, Haichun Liu, Shuai Lu, 2018, Journal of biomolecular structure & dynamics.

QSAR modeling and in silico design of small-molecule inhibitors targeting the interaction between E3 ligase VHL and HIF-1$$\alpha $$α

T. Ran, Yanmin Zhang, A. Xu, 2017, Molecular Diversity.

Virtual Screening Strategy Combined Bayesian Classification Model, Molecular Docking for Acetyl-CoA Carboxylases Inhibitors.

Haichun Liu, Shuai Lu, Yanmin Zhang, 2019, Current computer-aided drug design.

Identification of Covalent Binding Sites Targeting Cysteines Based on Computational Approaches.

T. Ran, Haichun Liu, Shuai Lu, 2016, Molecular pharmaceutics.

Development of antibacterial compounds that block evolutionary pathways to resistance

E. Shakhnovich, João V. Rodrigues, Yanmin Zhang, 2020, 2011.01098.

Protein flexibility oriented virtual screening strategy for JAK2 inhibitors

T. Ran, Haichun Liu, Shuai Lu, 2015 .

In Silico Design of New B-Raf Kinase Type-II Inhibitors Through Combined Molecular Modeling Studies

Haichun Liu, Shuai Lu, Yanmin Zhang, 2019, Letters in Drug Design & Discovery.

Protein–ligand interaction-guided discovery of novel VEGFR-2 inhibitors

Haichun Liu, Yanmin Zhang, T. Lu, 2020, Journal of biomolecular structure & dynamics.

Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

Haichun Liu, Yanmin Zhang, T. Lu, 2014 .

Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping

Yanmin Zhang, Zhimin Zhang, Wenhai Huang, 2019, Journal of enzyme inhibition and medicinal chemistry.

Fragment virtual screening based on Bayesian categorization for discovering novel VEGFR-2 scaffolds

Shuai Lu, Jing Pan, Yu Jiao, 2015, Molecular Diversity.

Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.

Yanmin Zhang, T. Lu, Weifang Tang, 2017, Organic & biomolecular chemistry.

A combined drug discovery strategy based on machine learning and molecular docking

Shuai Lu, Lu Zhu, Tao Lu, 2019, Chemical biology & drug design.

Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines.

Yanmin Zhang, T. Lu, Yadong Chen, 2018, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase.

Yanmin Zhang, T. Lu, Nianguang Li, 2018, Bioorganic & medicinal chemistry.

An efficient multistep ligand-based virtual screening approach for GPR40 agonists

T. Ran, Haichun Liu, Shuai Lu, 2014, Molecular Diversity.

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis.

Yanmin Zhang, T. Lu, Yadong Chen, 2020, European journal of medicinal chemistry.

Discovery of potent apoptosis signal-regulating kinase 1 inhibitors via integrated computational strategy and biological evaluation

Haichun Liu, Yanmin Zhang, T. Lu, 2020, Journal of biomolecular structure & dynamics.

The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth.

Jianing Song, Yanmin Zhang, T. Lu, 2020, Bioorganic & medicinal chemistry.

A selectivity study of sodium‐dependent glucose cotransporter 2/sodium‐dependent glucose cotransporter 1 inhibitors by molecular modeling

T. Ran, Haichun Liu, Shuai Lu, 2015, Journal of molecular recognition : JMR.

Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.

Yanmin Zhang, T. Lu, Weifang Tang, 2019, European journal of medicinal chemistry.

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency Against Acute Gouty Arthritis.

Yanmin Zhang, T. Lu, Yadong Chen, 2019, Journal of medicinal chemistry.

Identification of N-phenyl-7H-pyrrolo[2,3-d] pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis.

Jianing Song, Haichun Liu, Yanmin Zhang, 2020, Journal of medicinal chemistry.

Novel galactosylated SLN for hepatocyte-selective targeting of floxuridinyl diacetate

Yanmin Zhang, Yongwei Hao, San-qi Zhang, 2008 .

Discovery of 2-Amino-7-sulfonyl-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation.

M. Wang, Yanmin Zhang, Yadong Chen, 2022, Journal of medicinal chemistry.

Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity.

Yanmin Zhang, T. Lu, Yadong Chen, 2020, European journal of medicinal chemistry.

Selective Functionalization of Antimycin A Through an N-Transacylation Reaction.

Yanmin Zhang, S. Hecht, Omar M Khdour, 2016, Organic letters.

Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities.

M. Wang, Haichun Liu, Shuai Lu, 2020, European journal of medicinal chemistry.

Recent advance in the development of novel, selective and potent FGFR inhibitors.

Yanmin Zhang, T. Lu, Nianguang Li, 2019, European journal of medicinal chemistry.

Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents.

Yanmin Zhang, B. Xin, Weifang Tang, 2015, European journal of medicinal chemistry.

Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents.

Yanmin Zhang, Langchong He, Sicen Wang, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Synthesis and cytotoxic evaluation of novel symmetrical taspine derivatives as anticancer agents.

Yanmin Zhang, Langchong He, Sicen Wang, 2011, Medicinal chemistry (Shariqah (United Arab Emirates)).

Drug repositioning: Progress and challenges in drug discovery for various diseases

Haichun Liu, Yanmin Zhang, Yadong Chen, 2022, European Journal of Medicinal Chemistry.

Thermostability Improvement of the d-Allulose 3-Epimerase from Dorea sp. CAG317 by Site-Directed Mutagenesis at the Interface Regions.

W. Mu, Tao Zhang, Yanmin Zhang, 2018, Journal of agricultural and food chemistry.

A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potential

Yakun Wan, Yanmin Zhang, Yadong Chen, 2020, bioRxiv.

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting.

Yanmin Zhang, S. Hecht, Omar M Khdour, 2016, Journal of the American Chemical Society.

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2.

Shuoxing Jiang, Yanmin Zhang, S. Hecht, 2017, Chemical communications.

KID: A Kinase-Focused Interaction Database and Its Application in the Construction of Kinase-Focused Molecule Databases

Haichun Liu, Yanmin Zhang, Yadong Chen, 2022, J. Chem. Inf. Model..

Development of antibacterial compounds that constrain evolutionary pathways to resistance

E. Shakhnovich, João V. Rodrigues, Yanmin Zhang, 2021, eLife.

Recent advances in targeted protein degraders as potential therapeutic agents

Yanmin Zhang, Yadong Chen, Yulei Jiang, 2023, Molecular diversity.

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

T. Ran, Yanmin Zhang, T. Lu, 2016, Bioorganic & medicinal chemistry letters.

Activity Prediction of Small Molecule Inhibitors for Antirheumatoid Arthritis Targets Based on Artificial Intelligence.

Haichun Liu, Yanmin Zhang, T. Lu, 2020, ACS combinatorial science.

Development of evolution drugs - antibacterial compounds that block pathways to resistance

E. Shakhnovich, João V. Rodrigues, Yanmin Zhang, 2020 .

Reducing hERG Toxicity Using hERG Classification Model and Fragment-growing Network

Haichun Liu, Yanmin Zhang, Yadong Chen, 2021 .

In Silico Design and Analysis of a Kinase-Focused Combinatorial Library Considering Diversity and Quality

Li Liang, Yi Hua, Yuchen Wang, 2019, J. Chem. Inf. Model..

Fragment-based strategy for structural optimization in combination with 3D-QSAR

Tao Lu, Shuai Lu, Yanmin Zhang, 2013, Journal of Computer-Aided Molecular Design.

Discovery of Dual FGFR4 and EGFR Inhibitors by Machine Learning and Biological Evaluation

Li Liang, Yi Hua, Yuchen Wang, 2020, J. Chem. Inf. Model..

In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy

Yan Yang, Yuchen Wang, Yadong Chen, 2019, J. Chem. Inf. Model..

Prediction of hERG K+ channel blockage using deep neural networks

Tao Lu, Yadong Chen, Yuchen Wang, 2019, Chemical biology & drug design.

An Integrated Virtual Screening Approach for VEGFR-2 Inhibitors

Tao Lu, Shuai Lu, Yu Jiao, 2013, J. Chem. Inf. Model..

Improving the Catalytic Behavior of DFA I-Forming Inulin Fructotransferase from Streptomyces davawensis with Site-Directed Mutagenesis.

W. Mu, Tao Zhang, B. Jiang, 2017, Journal of agricultural and food chemistry.

Effective Reaction-Based De Novo Strategy for Kinase Targets: A Case Study on MERTK Inhibitors

Haichun Liu, Yanmin Zhang, Yadong Chen, 2022, J. Chem. Inf. Model..

ADME properties evaluation in drug discovery: in silico prediction of blood–brain partitioning

Haichun Liu, Yanmin Zhang, Yadong Chen, 2018, Molecular Diversity.

QSAR modeling and in silico design of small-molecule inhibitors targeting the interaction between E3 ligase VHL and HIF-1$$\alpha $$α

T. Ran, Yanmin Zhang, A. Xu, 2017, Molecular Diversity.

Investigation of Crystal Structures in Structure-Based Virtual Screening for Protein Kinase Inhibitors

Lu Zhu, Yi Hua, Yan Yang, 2019, J. Chem. Inf. Model..

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

Yanmin Zhang, S. Hecht, Omar M Khdour, 2017, Planta Medica.

Production of the endocannabinoids anandamide and 2‐arachidonoylglycerol by endothelial progenitor cells

Yanmin Zhang, J. Rehman, M. Yoder, 2007, FEBS letters.

De novo design of N-(pyridin-4-ylmethyl)aniline derivatives as KDR inhibitors: 3D-QSAR, molecular fragment replacement, protein-ligand interaction fingerprint, and ADMET prediction

Haichun Liu, Shuai Lu, Yanmin Zhang, 2012, Molecular Diversity.

An Interpretable Multitask Framework BiLAT Enables Accurate Prediction of Cyclin-Dependent Protein Kinase Inhibitors

Yingbo Liu, Haichun Liu, Yanmin Zhang, 2023, J. Chem. Inf. Model..

Fragment virtual screening based on Bayesian categorization for discovering novel VEGFR-2 scaffolds

T. Ran, Haichun Liu, Shuai Lu, 2015, Molecular diversity.

Investigation of Machine Intelligence in Compound Cell Activity Classification.

Yi Hua, Yan Yang, Yuchen Wang, 2019, Molecular pharmaceutics.

An efficient multistep ligand-based virtual screening approach for GPR40 agonists

T. Ran, Haichun Liu, Shuai Lu, 2014, Molecular Diversity.

RPBP: Deep Retrosynthesis Reaction Prediction Based on Byproducts

Haichun Liu, Yanmin Zhang, Tao Lu, 2023, J. Chem. Inf. Model..

Activity Prediction of Small Molecule Inhibitors for Antirheumatoid Arthritis Targets Based on Artificial Intelligence.

Haichun Liu, Yanmin Zhang, T. Lu, 2020, ACS combinatorial science.

Multimodal multi-task deep neural network framework for kinase–target prediction

Haichun Liu, Yanmin Zhang, Yadong Chen, 2022, Molecular Diversity.

ADME properties evaluation in drug discovery: in silico prediction of blood–brain partitioning

Yadong Chen, Yuanrong Fan, Yanmin Zhang, 2018, Molecular Diversity.

Molecular modelling on small molecular CDK2 inhibitors: an integrated approach using a combination of molecular docking, 3D-QSAR and pharmacophore modelling

T. Ran, F. Wang, Haichun Liu, 2013, SAR and QSAR in environmental research.