A. Montezano

发表

Vascular biology of ageing—Implications in hypertension

R. Touyz, A. Harvey, A. Montezano, 2015, Journal of Molecular and Cellular Cardiology.

Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies.

R. Touyz, A. Harvey, A. Montezano, 2015, The Canadian journal of cardiology.

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway.

R. Touyz, K. Muir, A. Montezano, 2021, Clinical science.

Magnesium, Vascular Function, and Hypertension

R. Touyz, A. Montezano, T. Antunes, 2016 .

Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain.

R. Touyz, A. Perraud, A. Shrier, 2013, Cellular signalling.

Vascular Nox4: a multifarious NADPH oxidase.

R. Touyz, A. Montezano, 2012, Circulation research.

Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR.

E. Schiffrin, R. Touyz, A. Montezano, 2011, Cardiovascular research.

Biomarkers of Oxidative Stress in Human Hypertension

R. Touyz, A. Montezano, M. Dulak-Lis, 2016 .

Biomarkers Of vascular inflammation and cardiovascular disease

R. Touyz, P. Welsh, A. Harvey, 2015 .

Exercise training protects against atherosclerotic risk factors through vascular NADPH oxidase , ERK 1 / 2 and SAPK / JNK down-regulation in obese rats

R. Touyz, A. Montezano, P. Laurant, 2014 .

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

R. Touyz, S. Ahmed, A. Montezano, 2017, Clinical science.

Microparticles and Exosomes in Cell-Cell Communication

R. Touyz, A. Montezano, D. Burger, 2019, Textbook of Vascular Medicine.

Vascular smooth muscle contraction in hypertension

R. Touyz, A. Montezano, A. Arner, 2018, Cardiovascular research.

Vascular Function in Health and Disease

R. Touyz, A. Montezano, C. Rosendorff, 2014 .

Angiotensin II and the vascular phenotype in hypertension

R. Touyz, A. Montezano, D. Burger, 2011, Expert Reviews in Molecular Medicine.

Redox Stress Defines the Small Artery Vasculopathy of Hypertension: How Do We Bridge the Bench-to-Bedside Gap?

R. Touyz, Mingyu Liang, A. Montezano, 2017, Circulation research.

Reactive Oxygen Species, Vascular Disease, and Hypertension 47

R. Touyz, A. Montezano, 2014 .

Reactive Oxygen Species and the Cardiovascular System

R. Touyz, A. Montezano, 2012 .

Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

R. Touyz, A. Montezano, 2012, Annals of medicine.

Microparticles: biomarkers and beyond.

R. Touyz, C. Thompson, A. Hakim, 2013, Clinical science.

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

K. Andrews, R. Touyz, H. Schmidt, 2013, Circulation.

Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research.

R. Touyz, A. Montezano, 2014, Antioxidants & redox signaling.

Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II–Dependent Chronic Hypertension

R. Touyz, A. Montezano, G. Callera, 2008, Hypertension.

Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence

R. Touyz, C. Thompson, A. Montezano, 2012, Journal of the American Heart Association.

Cell Biology of Vessels

R. Touyz, A. Montezano, Rheure Alves-Lopes, 2019, Textbook of Vascular Medicine.

CVR-2020-0297 High Sodium Intake, Glomerular Hyperfiltration and Protein Catabolism in Patients with Essential Hypertension

R. Touyz, A. Montezano, G. Ceolotto, 2020 .

Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome.

R. Touyz, A. Montezano, F. Rios, 2014, The Canadian journal of cardiology.

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5.

R. Touyz, A. Montezano, D. Burger, 2011, Clinical science.

NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function

R. Touyz, A. Harvey, A. Montezano, 2018, Journal of the American Heart Association.

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis

R. Touyz, A. Harvey, A. Montezano, 2017, Life sciences.

Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3

R. Touyz, A. Montezano, G. Callera, 2016, PloS one.

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

R. Touyz, M. Cooper, A. Montezano, 2013, Clinical science.

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways.

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2015, Clinical science.

Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive and Akt-dependent pathways.

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2018, American journal of physiology. Heart and circulatory physiology.

Redox signaling, Nox5 and vascular remodeling in hypertension

R. Touyz, A. Harvey, A. Montezano, 2015, Current opinion in nephrology and hypertension.

Endothelin, sex and hypertension.

R. Touyz, Z. Fortes, A. Montezano, 2008, Clinical science.

Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats.

E. Schiffrin, R. Touyz, A. Montezano, 2007, Journal of the American Society of Hypertension : JASH.

18 MICROPARTICLES INDUCE ENDOTHELIAL CELL SENESCENCE AND CELL CYCLE ARREST THROUGH REDOX-SENSITIVE PROCESSES: IMPLICATIONS IN VASCULAR AGING

R. Touyz, C. Thompson, A. Montezano, 2012 .

Brown Adipose Tissue Regulates Small Artery Function Through NADPH Oxidase 4–Derived Hydrogen Peroxide and Redox-Sensitive Protein Kinase G-1&agr;

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Ca 2+ dependent-NOX5 exaggerates cardiac hypertrophy through ROS production

R. Touyz, A. Montezano, P. Zhang, 2021 .

Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress

R. Touyz, A. Montezano, G. Callera, 2019, Life sciences.

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase

R. Touyz, F. Jaisser, A. Montezano, 2016, Diabetes.

Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis

Lillia V. Ryazanova, P. Anyfanti, R. Touyz, 2019, Cardiovascular research.

Angiotensin II, NADPH oxidase, and redox signaling in the vasculature.

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2013, Antioxidants & redox signaling.

Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression.

R. Touyz, M. Cooper, A. Montezano, 2014, Journal of the American Society of Nephrology : JASN.

Vascular dysfunction and increased cardiovascular risk in hypospadias

R. Touyz, S. Padmanabhan, L. McCallum, 2022, European heart journal.

Vascular dysfunction and increased cardiovascular risk in hypospadias

R. Touyz, S. Padmanabhan, L. McCallum, 2022, European heart journal.

Reactive oxygen species and endothelial function--role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases.

R. Touyz, A. Montezano, 2012, Basic & clinical pharmacology & toxicology.

Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification.

R. Touyz, A. Montezano, 2008, Cardiovascular research.

ETA Receptor Mediates Altered Leukocyte-Endothelial Cell Interaction and Adhesion Molecules Expression in DOCA–Salt Rats

E. Schiffrin, R. Touyz, Z. Fortes, 2004, Hypertension.

Molecular mechanisms of hypertension--reactive oxygen species and antioxidants: a basic science update for the clinician.

R. Touyz, A. Montezano, 2012, The Canadian journal of cardiology.

Mechanosensitive regulation of cortactin by p47phox: a new paradigm in cytoskeletal remodeling.

R. Touyz, A. Montezano, 2013, Circulation research.

ANTIHYPERTENSIVE TREATMENT Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin) A Potential New Therapy for Hypertension

R. Touyz, E. Sturrock, A. Harvey, 2021 .

Differential renal effects of candesartan at high and ultra-high doses in diabetic mice–potential role of the ACE2/AT2R/Mas axis

R. Touyz, A. Montezano, A. Briones, 2016, Bioscience reports.

Isolation and Differentiation of Murine Macrophages.

R. Touyz, A. Montezano, F. Rios, 2017, Methods in molecular biology.

Renin–angiotensin–aldosterone system: new concepts

R. Touyz, A. Montezano, A. N. D. Cat, 2013 .

TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt

Lillia V. Ryazanova, T. Gudermann, R. Touyz, 2022, Communications Biology.

Running title: Gray et al.; The role of Nox1 in Diabetic Atherosclerosis

K. Andrews, R. Touyz, H. Schmidt, 2013 .

Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis.

R. Touyz, A. Montezano, F. Rios, 2021, Clinical science.

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms.

R. Touyz, A. Montezano, G. Callera, 2006, Clinical science.

Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A

R. Touyz, A. Montezano, M. White, 2012, Therapeutic advances in cardiovascular disease.

Mas Signaling: Resolved and Unresolved Issues

R. Touyz, A. Montezano, A. Nguyen, 2015 .

Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II.

R. Touyz, A. Montezano, T. Paravicini, 2012, Journal of the American Society of Hypertension : JASH.

159 Trpm2 ion channel activation contributes to redox-sensitive vascular dysfunction in hypertension

R. Touyz, A. Montezano, Rheure Alves-Lopes, 2017 .

Vascular Nox compartmentalization, protein hyperoxidation and ER stress response in hypertension

R. Touyz, A. Harvey, A. Montezano, 2018 .

Downregulation of Renal TRPM7 and Increased Inflammation and Fibrosis in Aldosterone-Infused Mice: Effects of Magnesium

R. Touyz, A. Montezano, F. Tabet, 2008, Hypertension.

Nox 1 Plays a Key Role in Diabetes Accelerated Atherosclerosis

K. Andrews, R. Touyz, H. Schmidt, 2013 .

Networking between systemic angiotensin II and cardiac mineralocorticoid receptors.

R. Touyz, A. Montezano, 2008, Hypertension.

Mammalian target of rapamycin: a novel pathway in vascular calcification.

R. Touyz, A. Montezano, 2014, The Canadian journal of cardiology.

TRPM7, Magnesium, and Signaling

R. Touyz, A. Montezano, F. Rios, 2019, International journal of molecular sciences.

Vascular toxicity associated with anti-angiogenic drugs.

R. Touyz, A. Montezano, N. Lang, 2020, Clinical science.

Isolation and Differentiation of Human Macrophages.

R. Touyz, A. Montezano, F. Rios, 2017, Methods in molecular biology.

Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications

R. Touyz, A. Harvey, A. Montezano, 2016, The Canadian journal of cardiology.

Angiotensin II and Vascular Injury

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2014, Current Hypertension Reports.

Cardiovascular and Renal Risk Factors and Complications Associated With COVID-19

R. Touyz, S. Padmanabhan, L. McCallum, 2021, CJC Open.

ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease

R. Touyz, A. Montezano, Jithin Kuriakose, 2021, Clinical science.

Exosomes and the cardiovascular system: role in cardiovascular health and disease

R. Touyz, A. Montezano, F. Rios, 2022, The Journal of physiology.

Role of PARP and TRPM2 in VEGF Inhibitor-Induced Vascular Dysfunction.

R. Touyz, A. Montezano, Rheure Alves-Lopes, 2023, Journal of the American Heart Association.

Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction

R. Touyz, C. Scavone, A. Montezano, 2017, PloS one.

Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice

R. Touyz, A. Montezano, Rheure Alves-Lopes, 2018, International journal of molecular sciences.

Systemic microvascular dysfunction in microvascular and vasospastic angina

C. Berry, R. Touyz, A. Harvey, 2018, European heart journal.

Notch3 signalling and vascular remodelling in pulmonary arterial hypertension

R. Touyz, A. Montezano, K. Neves, 2019, Clinical science.

Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress.

J. Redondo, R. Touyz, M. Bécares, 2021, Cardiovascular research.

Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function

T. Gudermann, R. Touyz, G. Baillie, 2020, Clinical science.

Assessment and pathophysiology of microvascular disease: recent progress and clinical implications

E. Schiffrin, T. Lüscher, R. Touyz, 2020, European heart journal.

Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension

R. Touyz, A. Harvey, A. Montezano, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus.

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2015, Clinical science.

Final Version Differential Regulation of Transient Receptor Potential Melastatin 6 and 7 (TRPM6/7) Cation Channels by Angiotensin II in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats

T. Gudermann, R. Touyz, A. Montezano, 2005 .

Oxidative Stress, Nox Isoforms and Complications of Diabetes—Potential Targets for Novel Therapies

E. Schiffrin, R. Touyz, M. Cooper, 2012, Journal of Cardiovascular Translational Research.

Magnesium and vessels

R. Touyz, A. Montezano, G. Callera, 2013 .

Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy

R. Touyz, N. Jamieson, A. McConnachie, 2023, European heart journal. Cardiovascular pharmacotherapy.

Impact of environmental factors on hypertension and associated cardiovascular disease.

R. Touyz, A. Montezano, F. Rios, 2023, The Canadian journal of cardiology.

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

A. Triantafyllou, P. Anyfanti, G. Grassi, 2023, Journal of hypertension.

Montezano and Touyz Ang II , Aldosterone , and the Heart 1017

R. Touyz, A. Montezano, 2008 .

Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways

R. Touyz, A. Montezano, M. Nilsen, 2023, Hypertension.

Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy.

R. Touyz, A. Montezano, R. Hébert, 2010, American journal of physiology. Renal physiology.

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication

R. Touyz, S. McFarlane, M. Palmarini, 2023, Scientific reports.

LOCAL ENDOTHELIAL DNA REPAIR DEFICIENCY CAUSES AGING-

R. Touyz, M. Ghanbari, J. Essers, 2020 .

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis

R. Touyz, M. Siedlinski, A. Montezano, 2017, British journal of pharmacology.

CADASIL-CAUSING NOTCH3 MUTATION CONTRIBUTES TO THE DEVELOPMENT OF PULMONARY ARTERIAL HYPERTENSION IN MALES

R. Touyz, A. Montezano, A. Joutel, 2021 .

Endothelin-1, but not Ang II, Activates MAP Kinases Through c-Src–Independent Ras-Raf–Dependent Pathways in Vascular Smooth Muscle Cells

E. Schiffrin, R. Touyz, A. Montezano, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Reply to Letter by McIntyre et al.

R. Touyz, A. Montezano, F. Rios, 2014, The Canadian journal of cardiology.

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways.

R. Touyz, A. Montezano, A. Nguyen Dinh Cat, 2015, Clinical science.

Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src–Regulated Redox-Sensitive RhoA Pathways

E. Schiffrin, R. Touyz, A. Montezano, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies.

R. Touyz, A. Harvey, A. Montezano, 2015, The Canadian journal of cardiology.

PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases.

R. Touyz, A. Montezano, Juergen Vormann, 2015, Clinical science.

Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain.

R. Touyz, A. Perraud, A. Shrier, 2013, Cellular signalling.

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

R. Touyz, J. Versmissen, H. Baelde, 2022, Clinical science.

Lysophosphatidylcholine induces oxidative stress in human endothelial 1 cells via NOX 5 activation-implications in atherosclerosis 2 3

R. Touyz, A. Montezano, R. Tostes, 2021 .

Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease

R. Touyz, A. Montezano, Livia L Camargo, 2019, Antioxidants & redox signaling.

An Interaction of Renin-Angiotensin and Kallikrein-Kinin Systems Contributes to Vascular Hypertrophy in Angiotensin II-Induced Hypertension: In Vivo and In Vitro Studies

R. Touyz, D. Fernandes, F. Laurindo, 2014, PloS one.

OXIDATIVE STRESS AND ENDOPLASMIC RETICULAR STRESS INTERPLAY IN THE VASCULOPATHY OF HYPERTENSION.

R. Touyz, A. Montezano, F. Rios, 2023, The Canadian journal of cardiology.

Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells

R. Touyz, A. Harvey, A. Montezano, 2023, Journal of hypertension.

Reactive oxygen species in hypertension.

R. Touyz, A. Montezano, L. Camargo, 2024, Nature Reviews Cardiology.

Recent advances in understanding the mechanistic role of transient receptor potential ion channels in hypertension.

R. Touyz, A. Montezano, F. Rios, 2023, Canadian Journal of Cardiology.

Endothelial Cells: Implications in Vascular Senescence Microparticles Induce Cell Cycle Arrest through Redox-sensitive Processes in Microparticles Induce Cell Cycle Arrest through Redox-sensitive Processes in Endothelial Cells: Implications in Vascular Senescence

R. Touyz, A. Montezano, Dylan G Kwart, 2022 .