Terufumi Takagi

发表

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

Biching Sang, J. Yano, M. Hirose, 2012, Bioorganic & medicinal chemistry.

Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1

H. Sugimoto, Toshimasa Tanaka, Biching Sang, 2019, ChemMedChem.

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.

Toshimasa Tanaka, Biching Sang, T. Kawamoto, 2018, Bioorganic & medicinal chemistry.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2- b ]furan Derivatives as a Novel Class of IKKβ Inhibitors

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.

Terufumi Takagi, H. Oki, Terufumi Takagi, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one.

Terufumi Takagi, Mamoru Tobisu, N. Tada, 2009, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.

Biching Sang, T. Imada, Terufumi Takagi, 2019, Journal of medicinal chemistry.

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.

M. Okaniwa, T. Miyazaki, T. Imada, 2012, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors.

Terufumi Takagi, Naoki Miyamoto, Yuya Oguro, 2012, Bioorganic & medicinal chemistry.

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).

Terufumi Takagi, Terufumi Takagi, Teruki Hamada, 2012, Journal of medicinal chemistry.

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.

H. Oki, Biching Sang, J. Yano, 2012, Journal of medicinal chemistry.

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Terufumi Takagi, T. Imaeda, F. Itoh, 2017, Bioorganic & medicinal chemistry.

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.

Terufumi Takagi, A. Hasuoka, M. Kajino, 2012, Bioorganic & medicinal chemistry.

Detailed comparison between the substrate specificities of two angular dioxygenases, dibenzofuran 4,4a-dioxygenase from Terrabacter sp. and carbazole 1,9a-dioxygenase from Pseudomonas resinovorans

Terufumi Takagi, T. Omori, H. Habe, 2002, Biotechnology Letters.

Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.

Terufumi Takagi, Kotaro Sakamoto, G. Snell, 2017, Bioorganic & medicinal chemistry.

N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.

Terufumi Takagi, K. Okada, Naoki Miyamoto, 2010, Bioorganic & medicinal chemistry.

Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.

Yoshikazu Ohta, Tomoyasu Ishikawa, Terufumi Takagi, 2013, ACS medicinal chemistry letters.

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.

Terufumi Takagi, K. Okada, Naoki Miyamoto, 2010, Bioorganic & medicinal chemistry.

Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.

Tomoyasu Ishikawa, Akito Nakamura, Terufumi Takagi, 2013, Journal of medicinal chemistry.

Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]Pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 2

K. Saikatendu, H. Sugimoto, Toshimasa Tanaka, 2019, ChemMedChem.

Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10

Toshimasa Tanaka, Biching Sang, T. Kawamoto, 2019 .

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.

M. Klein, R. Tjhen, Biching Sang, 2019, ACS medicinal chemistry letters.

Characterization of [3Fe-4S] ferredoxin DbfA3, which functions in the angular dioxygenase system of Terrabacter sp. strain DBF63

Terufumi Takagi, T. Omori, H. Habe, 2005, Applied Microbiology and Biotechnology.

Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs).

Terufumi Takagi, A. Hasuoka, F. Itoh, 2015, Bioorganic & medicinal chemistry letters.

Novel Method for the Evaluation of 3D Conformation Generators

Michiko Amano, Masaki Tomimoto, Terufumi Takagi, 2009, J. Chem. Inf. Model..

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

M. Okaniwa, M. Yabuki, Terufumi Takagi, 2017, PloS one.

A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.

H. Oki, J. Lawson, Terufumi Takagi, 2012, ACS medicinal chemistry letters.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2‐b]furan Derivatives as a Novel Class of IKKβ Inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007, Chemical and pharmaceutical bulletin.

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.

Terufumi Takagi, A. Hasuoka, M. Kajino, 2012, Bioorganic & medicinal chemistry.