T. Ishikawa

发表

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.

Biching Sang, J. Yano, M. Hirose, 2012, Bioorganic & medicinal chemistry.

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Yuta Tanaka, T. Kawamoto, T. Ishikawa, 2013, Journal of medicinal chemistry.

Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.

T. Kojima, M. Yabuki, Sei Yoshida, 2013, Journal of medicinal chemistry.

Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma.

Tomoyasu Ishikawa, Akito Nakamura, Katherine Galvin, 2013, Cancer research.

Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins

M. Yabuki, Sei Yoshida, T. Ishikawa, 2012, Molecular Cancer Therapeutics.

Studies on Anti-MRSA Parenteral Cephalosporins I. Synthesis and Antibacterial Activity of 7β-[2-(5-Amino-l52, 4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3-(substituted imidazo[1, 2-6]-pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds

T. Ishikawa, Y. Iizawa, K. Okonogi, 2000 .

Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.

M. Okaniwa, T. Kawamoto, T. Ishikawa, 2016, Bioorganic & medicinal chemistry letters.

Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model

T. Ishikawa, Y. Ohta, Akiko Nakayama, 2013, Journal of Cancer.

Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.

T. Miyazaki, Sei Yoshida, T. Ishikawa, 2017, Bioorganic & medicinal chemistry.

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.

M. Okaniwa, T. Miyazaki, T. Imada, 2012, Bioorganic & medicinal chemistry.

STRUCTURAL ANALYSIS OF THE MECHANISM OF INHIBITION AND ALLOSTERIC ACTIVATION OF THE KINASE DOMAIN OF HER 2

Toshimasa Tanaka, Biching Sang, J. Yano, 2011 .

TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties.

Y. Ikeda, T. Ishikawa, Y. Tagawa, 2003, Bioorganic & medicinal chemistry.

Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.

T. Taniguchi, Toshimasa Tanaka, J. Yano, 2011, Journal of medicinal chemistry.

Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.

Toshimasa Tanaka, T. Ohashi, T. Ishikawa, 2012, Journal of medicinal chemistry.

(+)-Phorboxazole A synthetic studies. A highly convergent, second generation total synthesis of (+)-phorboxazole A.

Thomas M. Razler, T. Ishikawa, Amos B. Smith, 2005, Organic letters.

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.

H. Oki, Biching Sang, J. Yano, 2012, Journal of medicinal chemistry.

A second-generation total synthesis of (+)-phorboxazole A.

Thomas M. Razler, T. Ishikawa, Amos B. Smith, 2008, The Journal of organic chemistry.

I. Synthesis and Antibacterial Activity of 7j8-[2-(5-Amino-l52,4-thiadiazol-3-yl)-

T. Ishikawa, Yuji, A. Miyake, 2006 .

Porphyrins Coupled with Nucleoside Bases. Synthesis and Characterization of Adenine- and Thymine-Porphyrin Derivatives

T. Ishikawa, K. Yamakawa, M. Hisatome, 1990 .

Studies on Anti-MRSA Parenteral Cephalosporins. III. Synthesis and Antibacterial Activity of 7.BETA.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and Related Compounds.

T. Ishikawa, Y. Iizawa, K. Okonogi, 2000 .

In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599

T. Ishikawa, Y. Iizawa, S. Hashiguchi, 2004, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Synthesis and properties of oligothymidylate containing sulfur-modified thymidine: effect of thiation of pyrimidine ring on the thermostability and conformation of the duplex

T. Ishikawa, K. Fuji, Kiyoshi Tanaka, 1991 .

Studies on anti-MRSA parenteral cephalosporins. I. Synthesis and antibacterial activity of 7beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)- hydroxyiminoacetamido]-3-(substituted imidaz.

T. Ishikawa, Y. Iizawa, K. Okonogi, 2000, The Journal of antibiotics.

HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285

T. Ishikawa, H. Banno, Y. Ohta, 2014, Oncoscience.

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

K. Iwata, M. Okaniwa, T. Kawamoto, 2015, Nature Communications.

Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.

Hiroshi Banno, Tomoyasu Ishikawa, Akihiro Yokota, 2015, Journal of medicinal chemistry.

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

Yoshikazu Ohta, Tomoyasu Ishikawa, Andy Jennings, 2011, The Journal of Biological Chemistry.

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.

M. Yabuki, Sei Yoshida, T. Ishikawa, 2013, Bioorganic & medicinal chemistry.

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.

C. Mol, M. Yabuki, Sei Yoshida, 2013, Bioorganic & medicinal chemistry.

T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production.

M. Yabuki, Sei Yoshida, T. Ishikawa, 2016, Biochemical and biophysical research communications.

Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.

Yoshikazu Ohta, Tomoyasu Ishikawa, Terufumi Takagi, 2013, ACS medicinal chemistry letters.

An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).

Peter G. Smith, M. Yabuki, Sei Yoshida, 2016, Biochemical and biophysical research communications.

Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.

Tomoyasu Ishikawa, Akito Nakamura, Terufumi Takagi, 2013, Journal of medicinal chemistry.

IV. A Novel Water-soluble 7V-Phosphono Type Prodrug for Parenteral Administration

Keiji, Shin-ichi, Kamiyama, 2006 .

Studies on Anti-MRSAParenteral Cephalosporins II . Synthesis and Antibacterial Activity of 7 j 8-[ 2-( 5-Amino-l , 2 , 4-thiadiazol-3-yl )-2 ( Z )-alkoxyiminoacetamido ]-3-( sub stituted imidazo [ l 52-6 ] pyridazinium-l-yl ) methyl-3-cephem-4-carboxylates and Related Compounds

Keiji, Yuji, Hiroyuki, 2006 .

Studies on anti-MRSA parenteral cephalosporins. IV. A novel water-soluble N-phosphono type prodrug for parental administration.

T. Ishikawa, Y. Iizawa, S. Hashiguchi, 2001, The Journal of antibiotics.

Stability and stabilization studies of TAK-599 (Ceftaroline Fosamil), a novel N-phosphono type prodrug of anti-methicillin resistant Staphylococcus aureus cephalosporin T-91825.

Y. Ikeda, T. Ishikawa, S. Hashiguchi, 2008, Chemical & pharmaceutical bulletin.

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Tomohiro Ohashi, Yoshikazu Ohta, Tomoyasu Ishikawa, 2013, Bioorganic & medicinal chemistry.

Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.

Tomoyasu Ishikawa, Akihiro Yokota, Akihiro Ohashi, 2013, Bioorganic & medicinal chemistry.

Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC.

J. Mettetal, P. Vincent, Julie Zhang, 2013 .

Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.

Toshimasa Tanaka, Y. Ikeda, T. Ishikawa, 2012, Bioorganic & medicinal chemistry.