V. Bhat

发表

Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.

Amjad Farooq, Caleb B. McDonald, Jordan E Balke, 2012, Biochemistry.

Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.

Amjad Farooq, Caleb B. McDonald, V. Bhat, 2010, Archives of biochemistry and biophysics.

A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model.

V. Bhat, A. Farooq, Miguel Otero, 2015, Vaccine.

Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase.

M. Sudol, Caleb B. McDonald, V. Bhat, 2014, Biochimie.

pH modulates the binding of early growth response protein 1 transcription factor to DNA

Caleb B. McDonald, V. Bhat, David C. Mikles, 2013, The FEBS journal.

Weighing the DNA content of Adeno-Associated Virus vectors with zeptogram precision using nanomechanical resonators

R. Braatz, S. Manalis, S. Springs, 2021, bioRxiv.

Energetic coupling along an allosteric communication channel drives the binding of Jun‐Fos heterodimeric transcription factor to DNA

Caleb B. McDonald, V. Bhat, David C. Mikles, 2011, The FEBS journal.

Vascular Permeability and Remodelling Coincide with Inflammatory and Reparative Processes after Joint Bleeding in Factor VIII-Deficient Mice

D. Durden, V. Bhat, A. Drygalski, 2018, Thrombosis and Haemostasis.

An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms.

J. Griffin, V. Bhat, D. Elias, 2020, Blood advances.

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant

J. Griffin, V. Bhat, A. Drygalski, 2014, Journal of thrombosis and haemostasis : JTH.

Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa

J. Griffin, V. Bhat, A. Drygalski, 2015, Thrombosis and Haemostasis.

An Engineered Factor Va Prevents Bleeding Induced by Anticoagulant wt Activated Protein C

J. Griffin, V. Bhat, A. Gale, 2014, PloS one.

DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif.

Caleb B. McDonald, V. Bhat, Brian J. Deegan, 2009, Biochemistry.

Vascular remodeling underlies rebleeding in hemophilic arthropathy

J. Luck, T. Hughes, D. Durden, 2015, American journal of hematology.

Vascular Remodeling Underlies Re-Bleeding in Hemophilic Arthropathy

J. Luck, T. Hughes, D. Durden, 2015 .

Synergistic Effect in Bleed Reduction By superfva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

J. Griffin, V. Bhat, A. Drygalski, 2014 .

Safety, Stability and Pharmacokinetic Properties of superFactor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding

J. Griffin, J. Pellequer, V. Bhat, 2016, Pharmaceutical Research.

Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms

Caleb B. McDonald, V. Bhat, Brian J. Deegan, 2011, Journal of molecular recognition : JMR.

Molecular determinants of the binding specificity of BH3 ligands to BclXL apoptotic repressor.

Caleb B. McDonald, V. Bhat, David C. Mikles, 2014, Biopolymers.

Biophysical basis of the promiscuous binding of B‐cell lymphoma protein 2 apoptotic repressor to BH3 ligands

Caleb B. McDonald, V. Bhat, David C. Mikles, 2013, Journal of molecular recognition : JMR.

Heat-induced fibrillation of BclXL apoptotic repressor.

I. Lednev, Caleb B. McDonald, V. Bhat, 2013, Biophysical chemistry.

Biophysical Insights into the Oligomerization of Bclxl Apoptotic Repressor

V. Bhat, 2013 .

Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor.

I. Lednev, Caleb B. McDonald, V. Bhat, 2012, Archives of biochemistry and biophysics.

Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor.

Caleb B. McDonald, V. Bhat, David C. Mikles, 2012, Journal of molecular biology.

Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.

I. Lednev, Caleb B. McDonald, V. Bhat, 2013, Biophysical chemistry.

Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA.

Caleb B. McDonald, V. Bhat, Brian J. Deegan, 2010, Biochemical and biophysical research communications.

Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner

Caleb B. McDonald, V. Bhat, David C. Mikles, 2013, Journal of molecular recognition : JMR.

Bivalent binding drives the formation of the Grb2–Gab1 signaling complex in a noncooperative manner

Caleb B. McDonald, V. Bhat, David C. Mikles, 2012, The FEBS journal.

Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.

R. Aqeilan, Z. Nawaz, M. Sudol, 2012, Journal of molecular biology.

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.

Z. Nawaz, M. Sudol, L. Buffa, 2011, Biochemistry.

Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.

M. Sudol, Caleb B. McDonald, V. Bhat, 2013, Biochemistry.

Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity

M. Sudol, Caleb B. McDonald, V. Bhat, 2014, The FEBS journal.

Effect of osmolytes on the binding of EGR1 transcription factor to DNA

Caleb B. McDonald, V. Bhat, David C. Mikles, 2015, Biopolymers.

Role of promoter DNA sequence variations on the binding of EGR1 transcription factor.

Caleb B. McDonald, V. Bhat, David C. Mikles, 2014, Archives of biochemistry and biophysics.

Enthalpic factors override the polyelectrolyte effect in the binding of EGR1 transcription factor to DNA

Caleb B. McDonald, V. Bhat, David C. Mikles, 2014, Journal of molecular recognition : JMR.

Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch

M. Sudol, Caleb B. McDonald, V. Bhat, 2015, Journal of molecular recognition : JMR.

Weighing the DNA content of Adeno-Associated Virus vectors with zeptogram precision using nanomechanical resonators

R. Braatz, S. Manalis, S. Springs, 2021, bioRxiv.

Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α–DNA interactions

Caleb B. McDonald, V. Bhat, Brian J. Deegan, 2011, Journal of molecular recognition : JMR.

Genetic variations within the ERE motif modulate plasticity and energetics of binding of DNA to the ERα nuclear receptor.

Caleb B. McDonald, V. Bhat, Brian J. Deegan, 2011, Archives of biochemistry and biophysics.

Binding of the ER R Nuclear Receptor to DNA Is Coupled to Proton Uptake †

Caleb B. McDonald, V. Bhat, Brian J. Deegan, 2010 .

Safety, Stability and Pharmacokinetic Properties of superFactor Va, a Novel Engineered Coagulation Factor V for Treatment of Severe Bleeding

J. Griffin, J. Pellequer, V. Bhat, 2016, Pharmaceutical Research.

Helix 8 and the i3 Loop of the Muscarinic M3 Receptor Are Crucial Sites for Its Regulation by the Gβ5-RGS7 Complex

V. Bhat, A. Farooq, C. Volmar, 2014, Biochemistry.

Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells

V. Bhat, S. Bunting, S. Fong, 2022, Molecular therapy : the journal of the American Society of Gene Therapy.