Ying-hua Chen

发表

HIV-1 Glycoprotein 41 Ectodomain Induces Activation of the CD74 Protein-mediated Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway to Enhance Viral Infection*

Lu Lu, Shibo Jiang, C. Zhou, 2011, The Journal of Biological Chemistry.

Possible explanations for the broadly neutralizing activity of HIV-1 gp41 specific monoclonal antibodies by recognition pattern based amino acid sequence analyses.

Ying-hua Chen, Zhifeng Lu, Yue Tan, 2013, Immunology letters.

Epitope-vaccine strategy against HIV-1: today and tomorrow.

Ying-hua Chen, Zuqiang Liu, Yi Xiao, 2003, Immunobiology.

Short communication: HIV type 1 phenotype, tropism, and sequence patterns: association and preference.

Xi Chen, Ying-hua Chen, Xiaonan Dong, 2005, AIDS research and human retroviruses.

Evidence of ATP assay as an appropriate alternative of MTT assay for cytotoxicity of secondary effluents from WWTPs.

Hong-Ying Hu, Yun Lu, Qian-Yuan Wu, 2015, Ecotoxicology and environmental safety.

Profiling the origin, dynamics, and function of traction force in B cell activation

Ying-hua Chen, Yan Shi, Wenjie Zheng, 2018, Science Signaling.

The Membrane-Proximal Region of C–C Chemokine Receptor Type 5 Participates in the Infection of HIV-1

Ying-hua Chen, Yue Tan, Pei Tong, 2017, Front. Immunol..

Predefined GPGRAFY-Epitope-Specific monoclonal antibodies with different activities for recognizing native HIV-1 gp120

Ying-hua Chen, Canhui Lan, H. Tian, 2012 .

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain.

Lu Lu, Shibo Jiang, Ying-hua Chen, 2012, Biochimica et Biophysica Acta.

Deletion of fusion peptide or destabilization of fusion core of HIV gp41 enhances antigenicity and immunogenicity of 4E10 epitope.

X. Chen, Shibo Jiang, Ying-hua Chen, 2008, Biochemical and biophysical research communications.

Marker vaccine strategies and candidate CSFV marker vaccines.

Ying-hua Chen, Xiaonan Dong, 2007, Vaccine.

Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus.

Ying-hua Chen, Xiaonan Dong, 2006, Vaccine.

Candidate multi-peptide-vaccine against classical swine fever virus induced potent immunity with serological marker.

Ying-hua Chen, Xiaonan Dong, Yu Chen, 2005, Vaccine.

Candidate peptide vaccine induced protection against classical swine fever virus.

Ying-hua Chen, Zuqiang Liu, Xiaonan Dong, 2002, Vaccine.

Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure

Q. Wang, Lu Lu, Shibo Jiang, 2013, PloS one.

The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: genetic variability and subtypes.

Ying-hua Chen, Xiaonan Dong, Yi Wu, 2005, Immunology letters.

Design and construction of a recombinant epitope-peptide gene as a universal epitope-vaccine strategy.

Ying-hua Chen, Zuqiang Liu, 2004, Journal of immunological methods.

N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication

Ying-hua Chen, Wanli Liu, Hua Li, 2003, FEMS Immunology and Medical Microbiology.

HIV-1 gp41 Core with Exposed Membrane-Proximal External Region Inducing Broad HIV-1 Neutralizing Antibodies

Lu Lu, Shibo Jiang, Ying-hua Chen, 2011, PloS one.

The interaction between the membrane-proximal external region and the N-trimer region of HIV-1 gp41: Involvement in viral fusion

X. Chen, Lu Lu, Shibo Jiang, 2009 .

Neutralizing epitopes in the membrane-proximal region of HIV-1 gp41: genetic variability and co-variation.

Ying-hua Chen, Xiaonan Dong, 2006, Immunology letters.

Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes.

Ying-hua Chen, Xiaonan Dong, Yi Wu, 2005, Immunology letters.

ELDKWA-epitope-specific monoclonal antibodies inhibit HIV env-mediated syncytium formation.

Ying-hua Chen, Geng Zhang, 2003, Immunobiology.

Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region

Ying-hua Chen, Yun-Yueh Lu, 2003, Chinese science bulletin = Kexue tongbao.

High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins

Ying-hua Chen, Wanli Liu, 2005, European journal of immunology.

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides.

Q. Wang, Lu Lu, Shibo Jiang, 2013, The Journal of antimicrobial chemotherapy.

P20A inhibits HIV-1 fusion through its electrostatic interaction with the distal region of the gp41 fusion core.

Ying-hua Chen, Yue Tan, Pei Tong, 2015, Microbes and infection.

Candidate vaccine focused on a classical Swine Fever virus epitope induced antibodies with neutralizing activity.

Ying-hua Chen, Bing Zhang, Y. Qi, 2009, Viral immunology.

Identification of the HIV‐1 gp41 core‐binding motif – HXXNPF

Shibo Jiang, Ying-hua Chen, Shuwen Liu, 2006, FEBS letters.

Antibodies against human IFN-α and -β recognized the immunosuppressive domain of HIV-1 gp41 and inhibit gp41-binding to the putative cellular receptor protein p45

Ying-hua Chen, M. Dierich, Weicheng Wu, 1999 .

Identiﬁcation of a gp41 Core-Binding Molecule with Homologous Sequence of Human TNNI3K-Like Protein as a Novel Human Immunodeﬁciency Virus Type 1 Entry Inhibitor (cid:1)

Lu Lu, Ying-hua Chen, Liling Xu, 2010 .

Through an ITIM-Independent Mechanism the FcγRIIB Blocks B Cell Activation by Disrupting the Colocalized Microclustering of the B Cell Receptor and CD19

Ying-hua Chen, Liling Xu, Caiyun Yue, 2014, The Journal of Immunology.

Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1

Lu Lu, Shibo Jiang, Ying-hua Chen, 2015, Cellular and Molecular Immunology.

Surface Exposure of the HIV-1 Env Cytoplasmic Tail LLP2 Domain during the Membrane Fusion Process

X. Chen, Lu Lu, Shibo Jiang, 2008, Journal of Biological Chemistry.

Interaction of HIV-1 gp41 Core with NPF Motif in Epsin

Shibo Jiang, Ying-hua Chen, Fan Wu, 2008, Journal of Biological Chemistry.

HIV-1 gp41 by N-Domain Binds the Potential Receptor Protein P45

Ying-hua Chen, M. Dierich, Weicheng Wu, 2000, International Archives of Allergy and Immunology.

A Candidate Vaccine against Influenza Virus Intensively Improved the Immunogenicity of a Neutralizing Epitope

Ying-hua Chen, Wanli Liu, Yun-Yueh Lu, 2002, International Archives of Allergy and Immunology.

Surface simulation synthesis: a new strategy to spy alpha-helix structure.

Ying-hua Chen, Xiaonan Dong, Yu Chen, 2007, Vaccine.

Biological function of HIV-1 transmembrane protein gp41──A study on a putative cellular receptor of gp41

Ying-hua Chen, M. Dierich, 1998 .

A Common Immunological Epitope Existing between HIV-1 gp41 and Human Interferon-α and -β

Ying-hua Chen, M. Dierich, 1998 .

The epitope recognized by a monoclonal antibody in influenza A virus M2 protein is immunogenic and confers immune protection.

Ying-hua Chen, Peng Zou, Wanli Liu, 2005, International immunopharmacology.

High epitope density in a single recombinant protein molecule of the extracellular domain of influenza A virus M2 protein significantly enhances protective immunity.

Ying-hua Chen, Zuqiang Liu, Wanli Liu, 2004, Vaccine.

Human Immunodeficiency Virus Type 1 gp41 Binds to Candida albicans via Complement C3-like Region

Ying-hua Chen, M. Dierich, R. Würzner, 1997 .

Monoclonal antibodies recognizing EVETPIRN epitope of influenza A virus M2 protein could protect mice from lethal influenza A virus challenge.

Ying-hua Chen, Peng Zou, Wanli Liu, 2004, Immunology letters.

Candidate peptide-vaccine induced potent protection against CSFV and identified a principal sequential neutralizing determinant on E2.

X. Chen, Ying-hua Chen, Xiaonan Dong, 2006, Vaccine.

Binding of HIV gp41 with its Receptors Immobilized at Liquid/Solid Interface Studied by Surface Plasmon Resonance

Ying-hua Chen, Weicheng Wu, Sen-fang Sui, 1999 .

V3 CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8+ T cells.

J. Diao, Lu Lu, Ying-hua Chen, 2008, Vaccine.

HIV and Complement

Ying-hua Chen, M. Dierich, H. Stoiber, 1996 .

Characterization of immunity induced by M2e of influenza virus.

Ying-hua Chen, Fan Wu, Xiao-Yi Yuan, 2007, Vaccine.

The cytoplasmic domain of influenza M2 protein interacts with caveolin-1.

Lu Lu, Ying-hua Chen, Fan Wu, 2009, Archives of biochemistry and biophysics.

Important Changes in Biochemical Properties and Function of Mutated LLP12 Domain of HIV‐1 gp41

Lu Lu, Ying-hua Chen, Yun Zhu, 2007, Chemical biology & drug design.

HIV-1 gp41 and type I interferon

Ying-hua Chen, M. Dierich, Yi Xiao, 2000, Immunologic research.

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

Linqi Zhang, Nianshuang Wang, Xi Liu, 2013, Cell Research.

Immunization with high epitope density of M2e derived from 2009 pandemic H1N1 elicits protective immunity in mice.

C. Zhou, Ying-hua Chen, Leilei Zhou, 2012, Vaccine.

Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine.

Ying-hua Chen, Fan Wu, Xiao-Yi Yuan, 2009, Vaccine.

The co-administration of CpG-ODN influenced protective activity of influenza M2e vaccine.

Ying-hua Chen, Fan Wu, Jing Li, 2009, Vaccine.

Substrate stiffness regulates B‐cell activation, proliferation, class switch, and T‐cell‐independent antibody responses in vivo

Ying-hua Chen, Z. Chang, Wenjie Zheng, 2015, European journal of immunology.

HIV‐1 gp41 contains two sites for interaction with several proteins on the helper T‐lymphoid cell line, H9

H. Katinger, T. Schulz, Ying-hua Chen, 1992, AIDS.

Identifying possible sites for antibody neutralization escape: Implications for unique functional properties of the C-terminal tail of Human Immunodeficiency Virus Type 1 gp41.

Ying-hua Chen, Zhifeng Lu, Yue Tan, 2016, Immunology letters.

Neutralizing antibodies

Ying-hua Chen, Yi Xiao, Xiaonan Dong, 2002, Immunologic research.

Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design.

Ying-hua Chen, Peng Zou, Wanli Liu, 2005, Microbes and infection.

Predefined spacers between epitopes on a recombinant epitope-peptide impacted epitope-specific antibody response.

Ying-hua Chen, Zuqiang Liu, Zuguang Wang, 2005, Immunology letters.

Characterization of the antigenicity and immunogenicity of the Escherichia Coli produced RNase domain of the classical swine fever virus glycoprotein E

Ying-hua Chen, Lianchi Liu, Ji Wang, 2009 .

Bioinformatics analysis of SARS-Cov M protein provides information for vaccine development

Ying-hua Chen, Wanli Liu, Yun-Yueh Lu, 2003 .

Identification of the HIV-1 gp41 Core-binding Motif in the Scaffolding Domain of Caveolin-1*

Xi Chen, Lu Lu, Shibo Jiang, 2007, Journal of Biological Chemistry.

Fine-epitope mapping of an antibody that binds the ectodomain of influenza matrix protein 2.

Ying-hua Chen, Fan Wu, Peng Zou, 2008, FEMS immunology and medical microbiology.

The mechanism by which molecules containing the HIV gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium formation.

Shibo Jiang, Ying-hua Chen, Shuwen Liu, 2007, The Biochemical journal.

Recombinant protein comprising multi-neutralizing epitopes induced high titer of antibodies against Influenza A virus

Ying-hua Chen, Hua Li, Jianzu Ding, 2003, Immunobiology.

The neutralizing epitope ELDKWA on HIV-1 gp41: genetic variability and antigenicity.

Ying-hua Chen, Xiaonan Dong, Yi Wu, 2005, Immunology letters.

Enhancement of HIV-1 gp41 binding to raji cells by pwm, lps, interferon-γ and interleukin-6

H. Katinger, Ying-hua Chen, F. Steindl, 1993 .

Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket

Lu Lu, Suiyi Tan, Shibo Jiang, 2011, Journal of Virology.

Peng Targeting the gp 41 Pocket Resistant to Peptide HIV Fusion Inhibitors N-Terminal Heptad Repeat Render Viruses Mutations of Gln 64 in the HIV-1 gp 41

Suiyi Tan, Ying-hua Chen, Pei Tong, 2011 .

Mutations of Gln 64 in the HIV-1 gp 41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp 41 Pocket

Lu Lu, Suiyi Tan, Ying-hua Chen, 2011 .

Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion.

Ying-hua Chen, Yi Xiao, Canhui Lan, 2003, Immunology letters.

Induction of high level of specific antibody response to the neutralizing epitope ELDKWA on HIV-1 gp41 by peptide-vaccine☆

Ying-hua Chen, M. Dierich, Yi Xiao, 2000, Peptides.

The synaptic recruitment of lipid rafts is dependent on CD19‐PI3K module and cytoskeleton remodeling molecules

Ying-hua Chen, Liling Xu, Wenjie Zheng, 2015, Journal of leukocyte biology.

Candidate peptide-vaccines induced immunity against CSFV and identified sequential neutralizing determinants in antigenic domain A of glycoprotein E2.

Ying-hua Chen, Xiaonan Dong, 2006, Vaccine.

10E8-like neutralizing antibodies against HIV-1 induced using a precisely designed conformational peptide as a vaccine prime

Ying-hua Chen, Zhifeng Lu, Pei Tong, 2013, Science China Life Sciences.

Epitope-vaccine induces high levels of ELDKWA-epitope-specific neutralizing antibody

Ying-hua Chen, Yi Xiao, Yun-Yueh Lu, 2000, Immunological investigations.

Mucosal antibodies induced by tandem repeat of 2F5 epitope block transcytosis of HIV-1.

Ying-hua Chen, Liling Xu, Pei Tong, 2011, Vaccine.

Increased levels of antibodies against interferon-α in HIV-1 positive individuals may be explained by a common immunological epitope on the human interferon-α and HIV-1 gp41

Ying-hua Chen, M. Dierich, H. Stoiber, 1997 .

Antibodies to HIV-1 gp41 Recognize Synthetic Peptides of Human IFN-α and IFN-β

Yun Bai, Ying-hua Chen, M. Dierich, 2000, International Archives of Allergy and Immunology.

Sequence variation and consensus sequence of V3 loop on HIV-1 gp120.

Ying-hua Chen, Canhui Lan, H. Tian, 2002, Immunology letters.

Identification of a gp41 Core-Binding Molecule with Homologous Sequence of Human TNNI3K-Like Protein as a Novel Human Immunodeficiency Virus Type 1 Entry Inhibitor

Lu Lu, Shibo Jiang, Ying-hua Chen, 2010, Journal of Virology.

Neutralization of HIV-1 primary isolate by ELDKWA-specific murine monoclonal antibodies.

Hong Lu, Shibo Jiang, Ying-hua Chen, 2005, Immunobiology.

Recombinant multi-epitope vaccine induce predefined epitope-specific antibodies against HIV-1.

Ying-hua Chen, Zuqiang Liu, Hua Li, 2002, Immunology letters.

Strategies for mapping neutralizing epitopes: one way and two sides.

Ying-hua Chen, Xiaonan Dong, 2006, Vaccine.

A predefined epitope-specific monoclonal antibody recognizes ELDEWA-epitope just presenting on gp41 of HIV-1 O clade.

Ying-hua Chen, Zuqiang Liu, Xiaonan Dong, 2002, Immunology letters.

The Recombinant Immunogen with High‐Density Epitopes of ELDKWA and ELDEWA Induced Antibodies Recognizing Both Epitopes on HIV‐1 gp41

Ying-hua Chen, Xiwen Cheng, Zuqiang Liu, 2005, Microbiology and immunology.

IMMUNOGENICITY AND SPECIFICITY OF THE CANDIDATE MULTI-EPITOPE-VACCINES AGAINST HIV-1

Ying-hua Chen, Yun-Yueh Lu, Jianzu Ding, 2001, Immunopharmacology and immunotoxicology.

Induction of High Levels of Antibodies Recognizing the Neutralizing Epitope ELDKWA and the D- or K-Position-Mutated Epitopes by Candidate Epitope Vaccines against HIV-1

Ying-hua Chen, Yi Xiao, Xiaonan Dong, 2000, International Archives of Allergy and Immunology.

Immunogenicity of Neutralizing Epitopes on Multiple–Epitope Vaccines against HIV–1

Ying-hua Chen, M. Dierich, Yi Xiao, 2000, International Archives of Allergy and Immunology.

Preliminary evaluation of a candidate multi-epitope-vaccine against the classical swine fever virus

Ying-hua Chen, Xiaonan Dong, Jian Ying, 2008 .

Identification of critical antibody-binding sites in the HIV-1 gp41 six-helix bundle core as potential targets for HIV-1 fusion inhibitors.

X. Chen, Shibo Jiang, Ying-hua Chen, 2009, Immunobiology.

Biological function of H1V-1 transmembrane protein gp41

Ying-hua Chen, M. Dierich, 1998 .

Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region

Ying-hua Chen, Yun-Yueh Lu, 2003, Chinese science bulletin = Kexue tongbao.

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides.

Lu Lu, Shibo Jiang, Ying-hua Chen, 2013, The Journal of antimicrobial chemotherapy.

A common epitope on gp41, IFN-α and IFN-β induces protective activity

Ying-hua Chen, M. Dierich, 1998 .