D. Del Bufalo

发表

Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations.

R. Foà, S. Chiaretti, G. Zupi, 2009, Neoplasia.

The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells

D. Del Bufalo, L. Conti, C. Matera, 2021, Cells.

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

C. Leonetti, D. Trisciuoglio, A. Mai, 2018, Cell Death & Disease.

Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide.

R. Shoemaker, D. Trisciuoglio, G. Melillo, 2008, Journal of the National Cancer Institute.

Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus.

D. Trisciuoglio, G. Zupi, M. Milella, 2006, Cancer research.

Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90

D. Trisciuoglio, G. Zupi, E. Ziparo, 2010, PloS one.

bcl-2 Induction of Urokinase Plasminogen Activator Receptor Expression in Human Cancer Cells through Sp1 Activation

D. Trisciuoglio, G. Zupi, M. Fanciulli, 2004, Journal of Biological Chemistry.

Bcl‐2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity

C. Leonetti, M. Scarsella, D. Trisciuoglio, 2001, Journal of cellular biochemistry.

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages

V. Farini, A. Sica, E. Gallo, 2020, Journal for ImmunoTherapy of Cancer.

Bcl-2 Overexpression in Human Melanoma Cells Increases Angiogenesis through Vegf Mrna Stabilization and Hif-1-mediated Transcriptional Activity

D. Ribatti, D. Trisciuoglio, G. Zupi, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells.

D. Trisciuoglio, G. Zupi, D. Del Bufalo, 2005, Molecular biology of the cell.

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

D. Del Bufalo, R. Ragno, S. Garzoli, 2020, Cancers.

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells

S. Carradori, D. Trisciuoglio, A. Mai, 2016, Oncotarget.

bcl‐2 inhibits mitochondrial metabolism and lonidamine‐induced apoptosis in adriamycin‐resistant mcf7 cells

G. Zupi, T. Bruno, A. Floridi, 1999, International journal of cancer.

bcl‐2 over‐expression enhances NF‐κB activity and induces mmp‐9 transcription in human MCF7ADR breast‐cancer cells

A. Ricca, A. Santoni, D. Del Bufalo, 2000, International journal of cancer.

Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression.

D. Trisciuoglio, G. Zupi, A. Orlandi, 2009, European journal of cancer.

Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition

S. Shirasawa, M. Milella, L. Ciuffreda, 2022, Frontiers in Oncology.

Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb

D. Trisciuoglio, B. Calabretta, M. Rizzo, 2018, Journal of Experimental & Clinical Cancer Research.

Enhanced antitumour efficacy of gimatecan in combination with Bcl-2 antisense oligonucleotide in human melanoma xenografts.

G. Zupi, F. Zunino, P. Perego, 2005, European journal of cancer.

BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition.

M. Biffoni, D. Trisciuoglio, M. Rizzo, 2013, Carcinogenesis.

Effect of cisplatin and c-myb antisense phosphorothioate oligodeoxynucleotides combination on a human colon carcinoma cell line in vitro and in vivo.

C. Leonetti, I. D'Agnano, T. Geiser, 1996, British Journal of Cancer.

Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.

D. Trisciuoglio, A. Mai, S. Minucci, 2022, European journal of medicinal chemistry.

Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation.

F. Spinella, D. Trisciuoglio, D. Del Bufalo, 2002, Molecular pharmacology.

Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.

D. Trisciuoglio, A. Mai, D. Del Bufalo, 2020, ACS medicinal chemistry letters.

The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells

D. Del Bufalo, A. Tata, M. Fiore, 2020, International journal of molecular sciences.

Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells

D. Trisciuoglio, A. Mai, D. Del Bufalo, 2022, Cancer Gene Therapy.

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

G. Zupi, S. Soddu, A. Sacchi, 1996, The Journal of clinical investigation.

A double point mutation at residues Ile14 and Val15 of Bcl‐2 uncovers a role for the BH4 domain in both protein stability and function

S. Karamanou, J. Parys, H. de Smedt, 2018, The FEBS journal.

Endothelin-1 acts as a survival factor in ovarian carcinoma cells.

F. Spinella, D. Del Bufalo, A. Biroccio, 2002, Clinical science.

New insights into the roles of antiapoptotic members of the Bcl-2 family in melanoma progression and therapy.

D. Trisciuoglio, D. Del Bufalo, 2021, Drug discovery today.

Modulation of bcl-xL in Tumor Cells Regulates Angiogenesis through CXCL8 Expression

D. Trisciuoglio, G. Zupi, U. Zangemeister‐Wittke, 2007, Molecular Cancer Research.

Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells

V. Farini, S. Carradori, D. Trisciuoglio, 2020, Journal of experimental & clinical cancer research : CR.

Interleukin-8 in Colorectal Cancer: A Systematic Review and Meta-Analysis of Its Potential Role as a Prognostic Biomarker

T. Colombo, M. Milella, D. Del Bufalo, 2022, Biomedicines.

N-methylformamide induces changes on adhesive properties and lung-colonizing potential of M14 melanoma cells.

C. Leonetti, G. Zupi, B. Bucci, 1998, British Journal of Cancer.

Involvement of nuclear factor‐kappa B in bcl‐xL‐induced interleukin 8 expression in glioblastoma

D. Trisciuoglio, G. Zupi, M. Kracht, 2008, Journal of neurochemistry.

Targeting the anti-apoptotic Bcl-2 family proteins: machine learning virtual screening and biological evaluation of new small molecules

D. Trisciuoglio, A. Mai, D. Del Bufalo, 2022, Theranostics.

Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy

F. Sacco, F. Furnari, E. Volpe, 2022, Cell Death & Differentiation.

1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

D. Trisciuoglio, L. Altucci, A. Mai, 2014, Journal of medicinal chemistry.

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.

D. Trisciuoglio, L. Altucci, A. Mai, 2016, Journal of medicinal chemistry.

Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity

Satheesh Kumar Palanisamy, D. Trisciuoglio, A. Mai, 2017, Journal of enzyme inhibition and medicinal chemistry.

NAADP-Dependent Ca2+ Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis

A. Filippini, E. Ziparo, F. Padula, 2016, Scientific Reports.

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca2+ signaling

A. Galione, A. Filippini, E. Ziparo, 2014, Proceedings of the National Academy of Sciences.

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

D. Trisciuoglio, D. Del Bufalo, M. R. Ricciardi, 2015, Oncotarget.

Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used.

D. Trisciuoglio, G. Zupi, T. Bruno, 2002, European Journal of Cancer.

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

D. Del Bufalo, R. Ragno, E. Valentini, 2021, Cell death discovery.

Volatile and Non-Volatile Content Determination and Biological Activity Evaluation of Fresh Humulus lupulus L. (cv. Chinook) Leaves and Inflorescences

M. Iriti, D. Del Bufalo, S. Vitalini, 2023, Separations.

Detection of P‐glycoprotein in the Golgi apparatus of drug‐untreated human melanoma cells

A. Stringaro, A. Molinari, A. Calcabrini, 1998, International journal of cancer.

Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells.

G. Zupi, M. D’Incalci, D. Del Bufalo, 2003, Molecular pharmacology.

Phytochemicals as Immunomodulatory Agents in Melanoma

F. Facchiano, A. Stringaro, A. Facchiano, 2023, International journal of molecular sciences.

SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma

G. Ciliberto, P. Visca, G. Bossi, 2021, Journal of experimental & clinical cancer research : CR.

Enhancement of hyperthermic damage on M14 melanoma cells by liposome pretreatment.

G. Zupi, I. Mavelli, A. Calcabrini, 1990, Cancer research.

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

D. Centonze, F. Ferrè, D. Trisciuoglio, 2017, eLife.

Bcl-xL: A Focus on Melanoma Pathobiology

D. Del Bufalo, A. B. Pérez-Oliva, V. Mulero, 2021, International journal of molecular sciences.

Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.

E. Bonmassar, L. Levati, D. Del Bufalo, 2012, Biochemical pharmacology.

HMGA1/E2F1 axis and NFkB pathways regulate LPS progression and trabectedin resistance

D. Trisciuoglio, C. Zoccali, M. D’Incalci, 2018, Oncogene.

Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer

A. Paradiso, P. Chiarappa, A. Azzariti, 2011, British Journal of Cancer.

Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer

D. Del Bufalo, S. D’Aguanno, 2020, Cells.

Bcl‐2 overexpression enhances the metastatic potential of a human breast cancer line

C. Leonetti, G. Zupi, D. Del Bufalo, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

R. Mancini, M. Pisanu, G. Ciliberto, 2017, Oncogene.

Interleukin 8 mediates bcl‐xL‐induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

D. Del Bufalo, A. B. Pérez-Oliva, V. Mulero, 2018, International journal of cancer.

CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells

L. Ricci-Vitiani, S. Carradori, D. Trisciuoglio, 2011, Clinical Cancer Research.

Bcl‐2 overexpression in melanoma cells increases tumor progression‐associated properties and in vivo tumor growth

D. Ribatti, D. Trisciuoglio, G. Zupi, 2005, Journal of cellular physiology.

c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells.

G. Zupi, D. Del Bufalo, B. Benassi, 2001, Molecular pharmacology.

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

D. Trisciuoglio, D. Del Bufalo, M. Di Martile, 2018, Stem cells international.

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

D. Trisciuoglio, D. Del Bufalo, M. Di Martile, 2016, Oncotarget.

microRNA-378a-5p iS a novel positive regulator of melanoma progression

L. Fattore, R. Mancini, G. Ciliberto, 2020, Oncogenesis.

Hypoxia-dependent drivers of melanoma progression

D. Del Bufalo, S. D’Aguanno, M. Marenco, 2021, Journal of Experimental & Clinical Cancer Research.

Bcl‐2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line

G. Zupi, A. Albini, M. Mottolese, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.

M. Sitkovsky, A. Filippini, E. Ziparo, 2010, Neoplasia.

ZD1839 (IRESSA), an EGFR‐selective tyrosine kinase inhibitor, enhances taxane activity in bcl‐2 overexpressing, multidrug‐resistant MCF‐7 ADR human breast cancer cells

G. Zupi, G. Tortora, F. Ciardiello, 2002, International journal of cancer.

Targeting hypoxia in tumor: a new promising therapeutic strategy

G. D’Orazi, D. Del Bufalo, M. Bosco, 2020, Journal of Experimental & Clinical Cancer Research.

Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma.

Justin K. Huang, D. di Bernardo, G. Ciliberto, 2019, Cancer research.

Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.

D. Trisciuoglio, D. Del Bufalo, C. Gabellini, 2017, Carcinogenesis.

BCL-XL overexpression promotes tumor progression-associated properties

D. Trisciuoglio, D. Del Bufalo, M. Desideri, 2017, Cell Death & Disease.

Dual Promoter Usage as Regulatory Mechanism of let-7c Expression in Leukemic and Solid Tumors

H. Stunnenberg, J. Martens, G. Piaggio, 2014, Molecular Cancer Research.

TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo

A. Filippini, E. Ziparo, F. Padula, 2014, Journal of cellular and molecular medicine.

Papillary carcinoma of the thyroid: high expression of COX-2 and low expression of KAI-1/CD82 are associated with increased tumor invasiveness.

D. Del Bufalo, M. Desideri, A. Stoppacciaro, 2013, Thyroid : official journal of the American Thyroid Association.

Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model

S. Carradori, A. Cataldi, D. Del Bufalo, 2022, Molecules.

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

A. Scarpa, V. Corbo, S. Shirasawa, 2018, Journal of experimental & clinical cancer research : CR.

Histone deacetylase inhibitor ITF2357 leads to apoptosis and enhances doxorubicin cytotoxicity in preclinical models of human sarcoma

Nicola Baldini, Michele Milella, D. Trisciuoglio, 2018, Oncogenesis.

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

D. Trisciuoglio, M. Milella, D. Del Bufalo, 2014, Molecular Cancer.

The thiazole derivative CPTH6 impairs autophagy

S. Carradori, D. Trisciuoglio, D. Del Bufalo, 2013, Cell Death and Disease.

Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance

G. Viglietto, L. Fattore, R. Mancini, 2022, Oncogene.

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

C. Leonetti, D. Trisciuoglio, A. Mai, 2018, Cell Death & Disease.

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for “vertical” and “lateral” combination strategies

Stephen L. Abrams, A. Marchetti, R. Foà, 2012, Journal of molecular medicine.

Increase of cisplatin sensitivity by c-myc antisense oligodeoxynucleotides in a human metastatic melanoma inherently resistant to cisplatin.

C. Leonetti, G. Zupi, G. Citro, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia

D. Del Bufalo, E. Valentini, S. D’Aguanno, 2021, Journal of Experimental & Clinical Cancer Research.

miR‐211 and MITF modulation by Bcl‐2 protein in melanoma cells

V. Farini, D. Trisciuoglio, M. Rizzo, 2016, Molecular carcinogenesis.

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

D. Trisciuoglio, L. Altucci, A. Mai, 2020, Cancers.

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

R. Maria, J. McCubrey, G. Blandino, 2012, Journal of Molecular Medicine.

Small molecules targeted to the microtubule–Hec1 interaction inhibit cancer cell growth through microtubule stabilization

D. Trisciuoglio, E. Cundari, A. Brancale, 2017, Oncogene.

Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth.

D. Trisciuoglio, A. Orlandi, D. Del Bufalo, 2013, Neoplasia.

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

M. Todaro, G. Stassi, M. Konopleva, 2017, Scientific Reports.

Trastuzumab Down-Regulates Bcl-2 Expression and Potentiates Apoptosis Induction by Bcl-2/Bcl-XL Bispecific Antisense Oligonucleotides in HER-2Gene–Amplified Breast Cancer Cells

D. Trisciuoglio, G. Zupi, M. Mottolese, 2004, Clinical Cancer Research.

Bcl-2 Overexpression in Human Melanoma Cells Increases Angiogenesis through Vegf Mrna Stabilization and Hif-1-mediated Transcriptional Activity

D. Ribatti, D. Trisciuoglio, G. Zupi, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein

V. Farini, D. Trisciuoglio, A. Urbani, 2016, Cell Death and Disease.

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

D. Trisciuoglio, A. Mai, G. Sbardella, 2023, Journal of medicinal chemistry.

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

D. Trisciuoglio, M. Milella, D. Del Bufalo, 2014, Molecular Cancer.

Lonidamine causes inhibition of angiogenesis-related endothelial cell functions.

C. Leonetti, M. Scarsella, D. Trisciuoglio, 2004, Neoplasia.

Intracellular P‐glycoprotein expression is associated with the intrinsic multidrug resistance phenotype in human colon adenocarcinoma cells

A. Stringaro, E. Monti, A. Calcabrini, 2000, International journal of cancer.

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

E. Salah, D. Trisciuoglio, A. Mai, 2021, Journal of medicinal chemistry.

Adriamycin resistance modulation induced by lonidamine in human breast cancer cells.

P. Matarrese, G. Zupi, A. Molinari, 1995, Anticancer research.

BCL-XL overexpression promotes tumor progression-associated properties

D. Trisciuoglio, D. Del Bufalo, M. Desideri, 2017, Cell Death & Disease.

Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment

D. Del Bufalo, S. Buglioni, A. B. Pérez-Oliva, 2023, Journal of Experimental & Clinical Cancer Research.

CRBP-1 expression in ovarian cancer: a potential therapeutic target.

M. Scioli, A. Orlandi, D. Del Bufalo, 2014, Anticancer research.

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

A. Scarpa, V. Corbo, S. Shirasawa, 2018, Journal of Experimental & Clinical Cancer Research.

Bcl-2 family inhibitors sensitize human cancer models to therapy

G. Damia, I. Manni, M. Chiappa, 2023, Cell death & disease.

Overview of BH3 mimetics in ovarian cancer

G. Damia, D. Del Bufalo, 2024, Cancer Treatment Reviews.

LVI and DI-SPME Combined with GC/MS and GC/MS for Volatile Chemical Profile Investigation and Cytotoxic Power Evaluation of Essential Oil and Hydrolate from Cannabis sativa L. cv. Carmagnola

D. Del Bufalo, Marta Di Martile, Stefania Garzoli, 2024, Molecules.

Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL.

I. Screpanti, M. P. Felli, D. Del Bufalo, 2024, Oncogene.

Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin

L. Fattore, R. Mancini, G. Madonna, 2023, Journal of Experimental & Clinical Cancer Research.