D. Zisterer

发表

Oxidative stress induces apoptosis in C6 glioma cells: Involvement of mitogen-activated protein kinases and nuclear factor kappa B

K. Tipton, M. Marangolo, M. McGee, 2001, Neurotoxicity Research.

Combretastatins: More Than Just Vascular Targeting Agents?

D. Zisterer, L. Greene, M. Meegan, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.

D. Zisterer, M. Meegan, M. Carr, 2019, Bioorganic & medicinal chemistry.

Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor.

G. Campiani, D. Williams, D. Zisterer, 2004, Journal of medicinal chemistry.

Target specific virtual screening: optimization of an estrogen receptor screening platform.

Vladimir Sobolev, Andrew J. S. Knox, Andrew J S Knox, 2007, Journal of medicinal chemistry.

Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects

I. Barrett, D. Zisterer, L. Greene, 2010, Journal of enzyme inhibition and medicinal chemistry.

β-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells

Andrew J. S. Knox, D. Zisterer, M. Meegan, 2008 .

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

Andrew J. S. Knox, Andrew J S Knox, Mary J Meegan, 2008, Bioorganic & medicinal chemistry.

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells

Andrew J. S. Knox, I. Barrett, D. Zisterer, 2007, Journal of enzyme inhibition and medicinal chemistry.

Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors.

M. Brindisi, S. Gemma, G. Campiani, 2019, Drug discovery today.

Guanidinium-based derivatives: searching for new kinase inhibitors.

C. Pérez, D. Zisterer, D. K. Nevin, 2014, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

D. Zisterer, M. Meegan, D. Endringer, 2021, Pharmaceuticals.

Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: absence of correlation with binding to the peripheral-type benzodiazepine binding site.

G. Campiani, D. Williams, D. Zisterer, 1998, Biochemical pharmacology.

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

M. Brindisi, S. Gemma, G. Campiani, 2019, Medicinal research reviews.

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

S. Gemma, G. Campiani, S. Butini, 2016, Cancer biology & therapy.

PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.

S. Gemma, G. Campiani, S. Butini, 2013, European journal of pharmacology.

Telomerase-based cancer therapeutics: a review on their clinical trials.

Simone Brogi, M. Brindisi, S. Gemma, 2020, Current topics in medicinal chemistry.

Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro

D. Williams, D. Zisterer, E. N. Maginn, 2011, Cancer biology & therapy.

The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.

Thomas F. Greene, M. Brindisi, G. Campiani, 2009, Biochemical pharmacology.

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

Andrew J. S. Knox, D. Williams, D. Zisterer, 2011, Bioorganic & medicinal chemistry.

Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells

Andrew J. S. Knox, D. Zisterer, M. Meegan, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.

E. Novellino, G. Greco, G. Campiani, 1996, Journal of medicinal chemistry.

Evaluation of targeting autophagy for the treatment of malignant rhabdoid tumours.

D. Zisterer, S. Magnano, Maureen J O'Sullivan, 2022, Cancer treatment and research communications.

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells

G. Campiani, D. Williams, D. Zisterer, 2010, Cancer Chemotherapy and Pharmacology.

Development of novel cyclic peptides as pro-apoptotic agents.

E. Novellino, P. Campiglia, Simone Brogi, 2016, European journal of medicinal chemistry.

Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.

D. Zisterer, L. Greene, M. Meegan, 2010, Journal of medicinal chemistry.

Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

Andrew J. S. Knox, D. Zisterer, L. Greene, 2010, European journal of medicinal chemistry.

Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines

G. Campiani, D. Williams, D. Zisterer, 2006, Molecular Pharmacology.

Targeting inhibitor of apoptosis proteins (IAPs) with IAP inhibitors sensitises malignant rhabdoid tumour cells to cisplatin.

D. Zisterer, Rachel Coyle, Maureen J O'Sullivan, 2022, Cancer treatment and research communications.

The XIAP inhibitor embelin sensitises malignant rhabdoid tumour cells to TRAIL treatment via enhanced activation of the extrinsic apoptotic pathway.

M. O'sullivan, D. Zisterer, Rachel Coyle, 2019, International journal of oncology.

Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH2-Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-XL

G. Campiani, D. Williams, D. Zisterer, 2004, Journal of Pharmacology and Experimental Therapeutics.

Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine d ] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH 2 -Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl- XL

G. Campiani, D. Williams, D. Zisterer, 2004 .

Selective Induction of Apoptosis by PBOX-6 in Leukemia Cells occurs via the JNK Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-XL

D. Williams, D. Zisterer, L. Greene, 2004 .

STI-571 (Imatinib Mesylate) Enhances the Apoptotic Efficacy of Pyrrolo-1,5-Benzoxazepine-6, a Novel Microtubule-Targeting Agent, in Both STI-571-Sensitive and -Resistant Bcr-Abl-Positive Human Chronic Myeloid Leukemia Cells

G. Campiani, D. Williams, D. Zisterer, 2007, Journal of Pharmacology and Experimental Therapeutics.

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.

L. Altucci, J. O’Sullivan, Simone Brogi, 2020, ACS medicinal chemistry letters.

Activation of the c-Jun N-terminal Kinase (JNK) Signaling Pathway Is Essential during PBOX-6-induced Apoptosis in Chronic Myelogenous Leukemia (CML) Cells*

G. Campiani, D. Zisterer, M. Lawler, 2002, The Journal of Biological Chemistry.

Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents.

D. Zisterer, M. Meegan, N. O’Boyle, 2017, European journal of medicinal chemistry.

Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.

M. Deininger, G. Campiani, D. Williams, 2010, Biochemical pharmacology.

Pyrrolo-1,5-Benzoxazepines Induce Apoptosis in Chronic Myeloid Leukemia (CML) Cells by Bypassing the Apoptotic Suppressor BCR-ABL

G. Campiani, D. Williams, D. Zisterer, 2001, TheScientificWorldJournal.

Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches

D. Zisterer, R. Turkington, J. Blayney, 2022, Cancers.

In vitro cytotoxicity of a composite resin and compomer.

K. Tipton, D. Zisterer, M. O'Sullivan, 2002, International endodontic journal.

Combretazet-3 a novel synthetic cis-stable combretastatin A-4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer.

D. Zisterer, L. Greene, M. Meegan, 2013, Oncology reports.

The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells

G. Campiani, S. Butini, D. Williams, 2016, International journal of oncology.

Caspase‐3 is not essential for DNA fragmentation in MCF‐7 cells during apoptosis induced by the pyrrolo‐1,5‐benzoxazepine, PBOX‐6

G. Campiani, D. Zisterer, Edel M Hyland, 2002, FEBS letters.

Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

D. Zisterer, M. Meegan, N. O’Boyle, 2022, Pharmaceuticals.

Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines.

K. O'Callaghan, J. O’Sullivan, G. Campiani, 2015, Molecular medicine reports.

β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells.

D. Zisterer, L. Greene, M. Meegan, 2017, European journal of medicinal chemistry.

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

E. Novellino, F. Da Settimo, C. La Motta, 2011, Journal of medicinal chemistry.

Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.

E. Novellino, S. Gemma, G. Campiani, 2005, Journal of medicinal chemistry.

Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands1

E. Novellino, G. Greco, G. Campiani, 1996 .

Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).

E. Novellino, G. Campiani, D. Zisterer, 2002, Journal of medicinal chemistry.

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity.

Andrew J. S. Knox, I. Barrett, D. Zisterer, 2017, Journal of medicinal chemistry.

β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells.

Darren Fayne, Fiona O'Connell, Mary J Meegan, 2020, European journal of medicinal chemistry.

Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents.

Thomas F. Greene, D. Zisterer, L. Greene, 2016, Journal of medicinal chemistry.

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Thomas F. Greene, D. Zisterer, M. Meegan, 2021, Pharmaceuticals.

Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents.

E. Crespan, G. Maga, M. Brindisi, 2015, European journal of medicinal chemistry.

Isouronium and N-hydroxyguanidinium derivatives as Cell growth inhibitors: A comparative study.

D. Zisterer, I. Rozas, Seema M. Nathwani, 2016, European journal of medicinal chemistry.

Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting β-lactam combretastatins.

D. Zisterer, L. Greene, M. Meegan, 2013, European journal of medicinal chemistry.

Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones.

D. Zisterer, L. Greene, M. Meegan, 2011, Bioorganic & medicinal chemistry.

β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.

Andrew J. S. Knox, Shu Wang, Andrew J S Knox, 2014, Journal of medicinal chemistry.

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

Andrew J. S. Knox, D. Zisterer, L. Greene, 2011, European journal of medicinal chemistry.

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

E. Novellino, Simone Brogi, M. Brindisi, 2018, Tetrahedron Letters.

Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates.

D. Zisterer, M. Meegan, N. O’Boyle, 2019, Organic & biomolecular chemistry.

3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

Thomas F. Greene, D. Zisterer, M. Meegan, 2019, Pharmaceuticals.

Novel cis-restricted β-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro.

L. Hughes, D. Zisterer, S. Mcdonnell, 2013, Oncology reports.

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.

L. Altucci, D. Lucena‐Agell, J. Díaz, 2022, European journal of medicinal chemistry.

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold

D. Zisterer, M. Meegan, M. Carr, 2016, Biomedicines.

Aromatic bis-N-hydroxyguanidinium derivatives: synthesis, biophysical, and biochemical evaluations.

D. Zisterer, Amila Kahvedžić, I. Rozas, 2013, Journal of medicinal chemistry.

Calmidazolium and other imidazole compounds affect steroidogenesis in Y1 cells: Lack of involvement of the peripheral-type benzodiazepine receptor

D. Williams, D. Zisterer, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.

D. Williams, D. Zisterer, M. Meegan, 2001, Journal of medicinal chemistry.

Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.

D. Nolan, G. Campiani, D. Williams, 2013, International journal of oncology.

The Vascular Targeting Agent Combretastatin-A4 and a Novel cis-Restricted β-Lactam Analogue, CA-432, Induce Apoptosis in Human Chronic Myeloid Leukemia Cells and Ex Vivo Patient Samples Including Those Displaying Multidrug Resistance

D. Zisterer, L. Greene, M. Meegan, 2010, Journal of Pharmacology and Experimental Therapeutics.

BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines

G. Campiani, D. Williams, D. Zisterer, 2008, Molecular Pharmacology.

Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine–induced apoptosis in neuroblastoma cells

G. Campiani, S. Butini, D. Williams, 2016, Investigational New Drugs.

The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.

G. Campiani, S. Butini, D. Williams, 2014, Biochemical Pharmacology.

Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.

G. Campiani, D. Williams, D. Zisterer, 2000, The Journal of pharmacology and experimental therapeutics.

Involvement of NF-κB in mediating the anti-tumour effects of combretastatins in T cells

D. Zisterer, L. Greene, M. Meegan, 2018, Investigational New Drugs.

Effect of isouronium/guanidinium substitution on the efficacy of a series of novel anti-cancer agents.

D. Zisterer, V. Previtali, Cristina Trujillo, 2018, MedChemComm.

Hexachlorocyclohexanes inhibit steroidogenesis in Y1 cells. Absence of correlation with binding to the peripheral-type benzodiazepine binding site.

D. Williams, D. Zisterer, P. Moynagh, 1996, Biochemical pharmacology.

PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent.

D. Williams, D. Zisterer, C. Suñol, 1995, Life sciences.

Peripheral-type benzodiazepine receptors.

D. Williams, D. Zisterer, 1997, General pharmacology.

The effects of the peripheral-type benzodiazepine acceptor ligands, Ro 5-4864 and PK 11195, on mitochondrial respiration.

D. Williams, D. Zisterer, M. Murphy, 1992, Methods and findings in experimental and clinical pharmacology.

Exploring the Anti-Cancer Mechanism of Novel 3,4′-Substituted Diaryl Guanidinium Derivatives

D. Zisterer, V. Previtali, I. Rozas, 2020, Pharmaceuticals.

Treatment of Chronic Myeloid Leukaemia: Current Practice and Future Prospects

D. Zisterer, 2012 .

1 Treatment of Chronic Myeloid Leukaemia : Current Practice and Future Prospects

D. Zisterer, 2012 .

The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.

G. Campiani, D. Williams, D. Zisterer, 2013, International journal of oncology.

Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation

D. Zisterer, M. Meegan, D. Fayne, 2017, Molecules.

A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis.

S. Gemma, G. Campiani, S. Butini, 2021, Pharmacological research.

The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.

G. Campiani, S. Butini, D. Williams, 2009, Cancer research.

Prognostic Subgroups of Chronic Lymphocytic Leukemia Pyrrolo-1 , 5-Benzoxazepine-15 Induces Apoptosis in Poor The Novel Tubulin-Targeting Agent

G. Campiani, S. Butini, D. Williams, 2009 .

BubR 1 is required for the mitotic block induced by combretastatin-A 4 and a novel cis-restricted ß-lactam analogue in human cancer cells

D. Zisterer, L. Greene, M. Meegan, 2022 .

The Microtubule-Targeting Agents, PBOX-6 [Pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and Paclitaxel, Induce Nucleocytoplasmic Redistribution of the Peptidyl-Prolyl Isomerases, Cyclophilin A and Pin1, in Malignant Hematopoietic Cells

S. Pennington, G. Campiani, D. Williams, 2009, Journal of Pharmacology and Experimental Therapeutics.

A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma

D. Zisterer, M. Santos-Martinez, V. Previtali, 2021 .

Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles.

D. Williams, D. Zisterer, M. Meegan, 2016, Bioorganic & medicinal chemistry.

Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species.

J. O’Sullivan, D. Zisterer, S. Magnano, 2021, Toxicology and applied pharmacology.

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.

G. Campiani, D. Williams, D. Zisterer, 2010, Oncology reports.

The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells.

D. Nolan, D. Zisterer, L. Greene, 2012, Biochemical pharmacology.

Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21.

G. Campiani, D. Zisterer, A. Ramunno, 2003, Biochimica et Biophysica Acta.

Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines

G. Campiani, D. Williams, D. Zisterer, 2009, Cancer Chemotherapy and Pharmacology.

A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin

J. Conroy, G. Campiani, S. Butini, 2008, Journal of Molecular Medicine.

Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells.

D. Zisterer, G. Farrar, R. K. Porter, 2017, Oncology letters.

Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver.

D. Williams, D. Zisterer, M. Woods, 1996, Biochemical pharmacology.

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

E. Novellino, M. Steinmetz, L. Altucci, 2019, European journal of medicinal chemistry.

Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

Thomas F. Greene, D. Zisterer, M. Meegan, 2023, Pharmaceuticals.

Inhibition of γ-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5.

D. Zisterer, L. Greene, Seema M. Nathwani, 2016, Oncology letters.

Combretastatin (CA)-4 and its novel analogue CA-432 impair T-cell migration through the Rho/ROCK signalling pathway.

D. Zisterer, M. Meegan, M. Carr, 2014, Biochemical pharmacology.

Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.

G. Campiani, D. Williams, D. Zisterer, 2001, The Journal of pharmacology and experimental therapeutics.

Different Specificities for Taurine Analogues and their Target Sites in Brain

K. Tipton, M. Marangolo, D. Williams, 1997 .

The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours

D. Zisterer, Patricia Hannon Barroeta, Maureen J. O’Sullivan, 2023, Journal of Cancer Research and Clinical Oncology.

The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15

G. Campiani, S. Butini, D. Williams, 2016, Investigational New Drugs.

Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.

G. Campiani, D. Zisterer, L. Greene, 2013, International Journal of Oncology.

Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo

G. Campiani, D. Williams, D. Zisterer, 2010, British Journal of Cancer.

D. Zisterer, M. Santos-Martinez, V. Previtali, 2021, Life sciences.

Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers.

D. Zisterer, M. Meegan, Patricia Hannon Barroeta, 2023, Bioorganic chemistry.

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

S. Gemma, G. Campiani, S. Butini, 2016, Cancer biology & therapy.

The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.

G. Campiani, S. Butini, D. Williams, 2009, Cancer research.

The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.

G. Campiani, D. Williams, D. Zisterer, 2005, Oncology reports.

Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents

G. Campiani, M. McGee, D. Williams, 2001 .

Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin.

D. Zisterer, Patricia Hannon Barroeta, Tianyi Gao, 2024, Experimental cell research.

Probing the metalloproteome: an 8-mercaptoquinoline motif enriches minichromosome maintenance complex components as significant metalloprotein targets in live cells

S. V. van Kasteren, D. Zisterer, Bogdan I. Florea, 2024, RSC chemical biology.

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

Andrew J. S. Knox, D. Zisterer, L. Greene, 2011, European journal of medicinal chemistry.