D. Boyle

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Differential Regulation of Interferon Synoviocyte Innate Immune Responses: I

G. Firestein, S. Sweeney, T. Yoshizawa, 2008 .

Synoviocyte Innate Immune Responses: I. Differential Regulation of Interferon Responses and the JNK Pathway by MAPK Kinases1

G. Firestein, S. Sweeney, T. Yoshizawa, 2008, The Journal of Immunology.

Regulation of c-Jun N-Terminal Kinase by MEKK-2 and Mitogen-Activated Protein Kinase Kinase Kinases in Rheumatoid Arthritis1

Gary S. Firestein, G. Firestein, D. Hammaker, 2004, The Journal of Immunology.

Arthritis Kinase Kinase Kinases in Rheumatoid MEKK-2 and Mitogen-Activated Protein Regulation of c-Jun N-Terminal Kinase by Chabaud

D. Boyle, 2004 .

Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.

G. Firestein, D. Hammaker, D. Boyle, 2003, Arthritis and rheumatism.

Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells.

R. Weinreb, G. Firestein, D. Boyle, 1996, Current eye research.

Notch signaling drives synovial fibroblast identity and arthritis pathology

N. Hacohen, C. Nusbaum, P. Gregersen, 2020, Nature.

Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity

Morgan W. Panitchpakdi, John T. Chang, Austin D. Swafford, 2020, Inflammatory bowel diseases.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

Shuqiang Li, N. Hacohen, C. Nusbaum, 2018, Arthritis Research & Therapy.

Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines1

T. Kipps, S. Kalled, N. Zvaifler, 2005, The Journal of Immunology.

DNA methylome signature in rheumatoid arthritis

Wei Wang, J. Whitaker, G. Firestein, 2012, Annals of the rheumatic diseases.

articlePlatelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes

D. Boyle, M. Corr, S. Rosengren, 2015 .

Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes

D. Boyle, M. Corr, S. Rosengren, 2010, Arthritis research & therapy.

Title Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes

D. Boyle, M. Corr, S. Rosengren, 2010 .

Synovial tissue research: a state-of-the-art review

P. Tak, P. Emery, J. Isaacs, 2017, Nature Reviews Rheumatology.

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

D. Kastner, J. O’Shea, W. Watford, 2009, Immunity.

Regulation and function of apoptosis signal‐regulating kinase 1 in rheumatoid arthritis

I. Mikaelian, G. Firestein, D. Hammaker, 2018, Biochemical pharmacology.

MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice

L. Sorkin, G. Firestein, D. Hammaker, 2009, Neuroscience.

Acquisition, culture, and phenotyping of synovial fibroblasts.

G. Firestein, D. Boyle, S. Rosengren, 2007, Methods in molecular medicine.

AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis.

A. Manning, G. Firestein, D. Boyle, 1998, Autoimmunity.

Novel Phosphoinositide 3-Kinase δ,γ Inhibitor: Potent Anti-Inflammatory Effects and Joint Protection in Models of Rheumatoid Arthritis

G. Firestein, D. Boyle, B. Bartok, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice.

G. Firestein, R. Sah, T. Yoshizawa, 2012, Arthritis and rheumatism.

Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice.

G. Firestein, D. Hammaker, D. Boyle, 2011, Arthritis and rheumatism.

Gadd45β deficiency in rheumatoid arthritis: Enhanced synovitis through JNK signaling: Role of Gadd45β in Rheumatoid Arthritis

C. Svensson, G. Firestein, G. Schett, 2009 .

Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.

C. Svensson, G. Firestein, G. Schett, 2009, Arthritis and rheumatism.

Expression and Regulation of Inducible IκB Kinase (IKK-i) in Human Fibroblast-like Synoviocytes

G. Firestein, F. Mercurio, D. Boyle, 2001 .

Collagen-Induced Arthritis Inhibitor on In Vitro Cytokine Production B κ The Effect of a T Cell-Specific NF -

P. Tak, A. Manning, G. Firestein, 2000 .

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6

G. Firestein, D. Hammaker, D. Boyle, 2014, Journal of Inflammation.

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6.

M. Karin, G. Firestein, D. Hammaker, 2012, Arthritis and rheumatism.

Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression1

R. Flavell, G. Firestein, Roger J. Davis, 2009, The Journal of Immunology.

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.

R. Flavell, G. Firestein, Roger J. Davis, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes

P. Tak, G. Firestein, D. Boyle, 2006, Journal of Pharmacology and Experimental Therapeutics.

Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.

G. Firestein, G. Firestein, N. Zvaifler, 1996, The American journal of pathology.

Dominant-negative p53 mutations in rheumatoid arthritis.

D. Green, G. Firestein, Y. Shi, 1999, Arthritis and rheumatism.

Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis

D. Boyle, A. Kavanaugh, A. Lodi, 2016, RMD Open.

Fcγ receptor type IIIA polymorphisms influence treatment outcomes in patients with inflammatory arthritis treated with tumor necrosis factor α–blocking agents

R. Deutsch, N. Zvaifler, D. Boyle, 2005 .

Fcgamma receptor type IIIA polymorphisms influence treatment outcomes in patients with inflammatory arthritis treated with tumor necrosis factor alpha-blocking agents.

R. Deutsch, N. Zvaifler, D. Boyle, 2005, Arthritis and rheumatism.

References Subscriptions Permissions Email Alerts Expression and Regulation of Aggrecanase in Arthritis: The Role of TGF- β

R. Maki, G. Firestein, D. Boyle, 2013 .

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

R. Maki, G. Firestein, D. Boyle, 2002, Journal of immunology.

Rheumatoid Arthritis Synoviocytes Regulation of DNA Methylation in

G. Firestein, D. Boyle, K. Nakano, 2012 .

Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis.

D. Green, G. Firestein, M. Pinkoski, 2002, The American journal of pathology.

Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment

P. Tak, G. Firestein, D. Boyle, 2006, Annals of the rheumatic diseases.

Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout

Jun Wang, T. Merriman, R. Terkeltaub, 2019, Arthritis & rheumatology.

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19

G. Barsh, M. Peluso, D. Rader, 2021, medRxiv.

cDNA cloning and characterization of A3i, an alternatively spliced rat A3 adenosine receptor variant

G. Firestein, D. Boyle, F. Sajjadi, 1996, FEBS letters.

Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis.

L. Sorkin, G. Firestein, D. Boyle, 2002, Arthritis and rheumatism.

Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis

L. Sorkin, G. Firestein, D. Boyle, 2003, Neuroscience Letters.

Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.

G. Firestein, D. Hammaker, D. Boyle, 2006, Arthritis and rheumatism.

Chapter 34 – Biologic Markers in Clinical Trials and Clinical Care

W. Robinson, D. Boyle, 2017 .

LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis

Wei Wang, J. Whitaker, G. Firestein, 2016, Arthritis & rheumatology.

Cutting Edge: Bim Is Required for Superantigen-Mediated B Cell Death1

D. Boyle, G. Silverman, M. Corr, 2007, The Journal of Immunology.

Microsatallite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis

D. Chang, W. Bugbee, G. Firestein, 2003, The Journal of Immunology.

p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis

D. Green, E. Keystone, G. Firestein, 2004, Arthritis research & therapy.

Quantitative biomarker analysis of synovial gene expression by real-time PCR

W. Bugbee, G. Firestein, D. Boyle, 2003, Arthritis research & therapy.

Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti‐CD20 therapy: the B‐cell roadblock hypothesis

D. Boyle, G. Silverman, David L. Boyle, 2008, Immunological reviews.

Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers

L. Sorkin, G. Firestein, D. Boyle, 2003, Experimental Neurology.

Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro

Christina K. Chan, I. Kang, G. Firestein, 2022, Matrix biology plus.

PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes.

G. Firestein, D. Boyle, H. Cha, 2006, Arthritis and rheumatism.

Modulation of melanocortin signaling ameliorates uremic cachexia.

D. Boyle, W. Cheung, R. Mak, 2008, Kidney international.

Receptor Protein Tyrosine Phosphatase α–Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice

N. Bottini, G. Firestein, J. den Hertog, 2015, Arthritis & rheumatology.

Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis1

S. Thiel, E. Raz, D. Boyle, 2009, The Journal of Immunology.

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

Wei Wang, P. Tak, J. Whitaker, 2015, Arthritis & rheumatology.

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

G. Firestein, D. Boyle, M. Corr, 2011, Annals of the rheumatic diseases.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

N. Bottini, T. Mustelin, G. Firestein, 2014, Annals of the rheumatic diseases.

Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels

D. Boyle, N. Carrier, H. Ménard, 2014, Arthritis Research & Therapy.

PTPome profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role for SHP-2 as a modulator of invasion and survival

N. Bottini, T. Mustelin, G. Firestein, 2013 .

PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.

C. Rommel, W. Bugbee, G. Firestein, 2012, The American journal of pathology.

Response to Proinflammatory Cytokines Cell-Activating Factor of the TNF Family in Mesenchymal Origin Express Functional B Fibroblast-Like Synoviocytes of

T. Kipps, S. Kalled, N. Zvaifler, 2004 .

Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern.

G. Firestein, Yubo Sun, H. Cheung, 2007, The Journal of rheumatology.

p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis.

F. Breedveld, P. Tak, G. Firestein, 1999, Arthritis and rheumatism.

Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene.

E. Seftor, M. Hendrix, E. Seftor, 1998, The American journal of pathology.

Improving Transcriptome Fidelity Following Synovial Tissue Disaggregation

G. Firestein, D. Boyle, J. Hillman, 2022, Frontiers in Medicine.

Measurement of Inflammatory Biomarkers in Synovial Tissue Extracts by Enzyme-Linked Immunosorbent Assay

G. Firestein, D. Boyle, S. Rosengren, 2003, Clinical Diagnostic Laboratory Immunology.

Posttranscriptional regulation of collagenase-1 gene expression in synoviocytes by adenosine receptor stimulation.

G. Firestein, J. Rutter, C. Brinckerhoff, 1997, Arthritis and rheumatism.

Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.

P. Tak, A. Manning, G. Firestein, 2001, Arthritis and rheumatism.

Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis.

G. Firestein, S. Chada, D. Boyle, 1998, The Journal of rheumatology.

Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Iman A. Mohammed, M. Peluso, S. Chanock, 2022, Nature Genetics.

Validation of Gene Expression Biomarker Analysis for Biopsy-based Clinical Trials in Crohn's Disease

John T. Chang, L. Eckmann, G. Firestein, 2015, Inflammatory bowel diseases.

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

G. Firestein, J. Nayar, D. Boyle, 2004, The Lancet.

Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia.

D. Boyle, James L. Mueller, S. Anderson, 2007, The Journal of allergy and clinical immunology.

Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats

S. Kortagere, D. Boyle, C. Mandyam, 2022, Brain sciences.

Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study

A. Radjenovic, P. Emery, G. Firestein, 2008, Annals of the rheumatic diseases.

Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab

K. Kalunian, N. Zvaifler, D. Boyle, 2008, Arthritis research & therapy.

Buch, M. H. et al. (2009) Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging

A. Radjenovic, P. Emery, G. Firestein, 2009 .

IgG Epitopes Processed and Presented by IgG+ B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells

J. Sidney, A. Sette, G. Firestein, 2021, The Journal of Immunology.

DNA mismatch repair enzyme expression in synovial tissue

G. Firestein, D. Boyle, E. Šimelyte, 2004, Annals of the rheumatic diseases.

Influence the Course of Adjuvant Arthritis Immunostimulatory DNA Sequences

E. Raz, S. Albani, B. Prakken, 2001 .

NF-kB Regulation by IkB Kinase in Primary Fibroblast-Like Synoviocytes

P. Tak, A. Manning, G. Firestein, 1999 .

Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation.

G. Firestein, D. Boyle, F. Sajjadi, 1996, Arthritis and rheumatism.

The novel Syk inhibitor R406 blocks JNK-mediated gene expression in synoviocytes 1

P. Tak, G. Firestein, D. Boyle, 2006 .

Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression.

G. Firestein, D. Boyle, M. M. Paine, 1994, Arthritis and rheumatism.

Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme

J. Leighton, D. Boyle, W. Sandborn, 2020, Journal of Crohn's & colitis.

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

G. Firestein, D. Boyle, A. Berdeja, 2012, Arthritis Research & Therapy.

Title Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway Permalink

G. Firestein, D. Boyle, A. Berdeja, 2012 .

Cytokine Expression Mechanism of Action in Inflammation and Role of MAPK Kinase 6 in Arthritis: Distinct

R. Flavell, G. Firestein, G. Schett, 2009 .

Early synovitis--synoviocytes and mononuclear cells.

G. Firestein, N. Zvaifler, D. Boyle, 1994, Seminars in arthritis and rheumatism.

Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

Lina Zheng, G. Firestein, D. Hammaker, 2022, Nature Communications.

PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

G. Firestein, D. Hammaker, D. Boyle, 2006, Arthritis research & therapy.

Pro- and anti-inflammatory functions of the p38 pathway in rheumatoid arthritis: Advantages of targeting upstream kinases MKK3 or MKK6

M. Karin, G. Firestein, D. Hammaker, 2012 .

Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release

G. Firestein, K. Sluka, D. Boyle, 2009, Annals of the rheumatic diseases.

Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.

J. O'Donnell, G. Firestein, K. Sluka, 2013, Arthritis and rheumatism.

Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis.

G. Firestein, D. Hammaker, D. Boyle, 2012, Rheumatology.

SAT0003 ELEVATED BASELINE AND INCREASING AUTOANTIBODY LEVELS ARE ASSOCIATED WITH INCREASED RISK FOR IMMINENT ONSET OF INFLAMMATORY ARTHRITIS IN A PROSPECTIVELY STUDIED ANTI-CITRULLINATED PROTEIN ANTIBODY POSITIVE COHORT: THE TIP-RA COLLECTIVE

W. Robinson, G. Firestein, V. Holers, 2020, Annals of the Rheumatic Diseases.

Synergistic benefit in inflammatory arthritis by targeting IκB kinase ϵ and interferon β

G. Firestein, D. Boyle, M. Corr, 2008, Annals of the rheumatic diseases.

Assessment of rituximab’s immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results

K. Kalunian, G. Firestein, D. Hammaker, 2007, Annals of the rheumatic diseases.

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.

M. Karin, A. Manning, Lufen Chang, 2001, The Journal of clinical investigation.

Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis.

G. Firestein, N. Zvaifler, D. Boyle, 1994, Arthritis and rheumatism.

Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced Th2activity

G. Firestein, Y. Shi, S. Chada, 1999, Gene Therapy.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Nir Hacohen, Kamil Slowikowski, Andrew Filer, 2019, Nature Immunology.

Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis.

G. Firestein, D. Boyle, M. Williams, 2001, The Journal of pharmacology and experimental therapeutics.

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

Tanner Schmidt, W. Giles, G. Firestein, 2017, The Journal of physiology.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

N. Bottini, T. Mustelin, J. Esko, 2015, Science Translational Medicine.

Adenosine kinase inhibitor GP515 improves experimental colitis in mice.

G. Hartmann, H. Lehr, G. Firestein, 2000, The Journal of pharmacology and experimental therapeutics.

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

R. Shoemaker, Wei Wang, J. Whitaker, 2013, Genome Medicine.

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

Joyce B. Kang, P. Gregersen, S. Raychaudhuri, 2022, bioRxiv.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

N. Hacohen, C. Nusbaum, P. Gregersen, 2018, bioRxiv.

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

Shuqiang Li, N. Hacohen, C. Nusbaum, 2018, bioRxiv.

Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium

W. Bugbee, D. Boyle, H. Hoffman, 2004, Annals of the rheumatic diseases.

Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets

Wei Wang, J. Whitaker, G. Firestein, 2015, PloS one.

Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis

P. Tak, G. Firestein, D. Boyle, 2011, Annals of the rheumatic diseases.

Synovial tissue research: a state-of-the-art review

P. Tak, P. Emery, J. Isaacs, 2017, Nature Reviews Rheumatology.

Spinal p38 MAP kinase regulates peripheral cholinergic outflow.

V. Pavlov, K. Tracey, L. Sorkin, 2008, Arthritis and rheumatism.

Inhibitor of nuclear factor κB kinase β is a key regulator of synovial inflammation

P. Tak, A. Manning, G. Firestein, 2001 .

Regulation of CS1 fibronectin expression and function by IL-1 in endothelial cells.

G. Firestein, Y. Shi, D. Boyle, 2000, Cellular immunology.

Microsatellite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis 1

Dong Kyung Chang, William Bugbee, Gary S. Firestein, 2003, The Journal of Immunology.

Rheumatoid Arthritis DNA Repair Enzyme Expression in Microsatellite Instability and Suppressed

Boland, D. Chang, W. Bugbee, 2003 .

Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes

G. Firestein, D. Hammaker, D. Boyle, 2007, Arthritis research & therapy.

Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor.

V. Pavlov, K. Tracey, G. Firestein, 2008, Arthritis and rheumatism.

Regional analysis of p53 mutations in rheumatoid arthritis synovium

D. Green, G. Firestein, N. Zvaifler, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Immunohistochemistry in the era of personalised medicine

M. Salto‐Tellez, D. Boyle, J. James, 2012, Journal of Clinical Pathology.

An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis

R. Pieters, G. Firestein, D. Boyle, 2009, Journal of Pharmacology and Experimental Therapeutics.

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.

Wei Wang, N. Bottini, J. Whitaker, 2016, JCI insight.

Regulation of arthritis by p53: critical role of adaptive immunity.

D. Green, G. Firestein, D. Boyle, 2005, Arthritis and rheumatism.

Jun N-terminal kinase in rheumatoid arthritis.

A. Manning, G. Firestein, D. Boyle, 1999, The Journal of pharmacology and experimental therapeutics.

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

J. David, G. Firestein, M. Zaiss, 2014, PloS one.

Regulation of p38 MAPK by MAPK Kinases 3 and 6 in Fibroblast-Like Synoviocytes1

G. Firestein, D. Hammaker, D. Boyle, 2005, The Journal of Immunology.

3 and 6 in Fibroblast-Like Synoviocytes Regulation of p 38 MAPK by MAPK Kinases

G. Firestein, D. Hammaker, D. Boyle, 2005 .

Structural, expression, and evolutionary analysis of mouse CIAS1.

S. Cannon, D. Boyle, James L. Mueller, 2004, Gene.

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium

G. Firestein, K. Sluka, D. Boyle, 2014, Arthritis Research & Therapy.

NF-κB Regulation by IκB Kinase-2 in Rheumatoid Arthritis Synoviocytes1

A. Manning, G. Firestein, D. Boyle, 2001, The Journal of Immunology.

Protective effect of an adenosine kinase inhibitor in septic shock.

G. Firestein, D. Boyle, K. Mullane, 1994, Journal of immunology.

Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis

S. Rosenthal, D. Boyle, A. Kavanaugh, 2018, Arthritis Research & Therapy.

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

G. Firestein, P. Mease, D. Boyle, 2013, Annals of the rheumatic diseases.

Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior

J. M. Sauder, Wei Wang, Rizi Ai, 2021, ACR open rheumatology.

Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis.

F. Nicoletti, K. Mangano, D. Boyle, 2010, International journal of molecular medicine.

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

G. Firestein, D. Boyle, K. Nakano, 2013, The Journal of Immunology.

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Christopher V. Barback, S. Raychaudhuri, Wei Wang, 2020, Science Advances.

NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes.

A. Manning, G. Firestein, D. Boyle, 2001, Journal of immunology.

PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes

Wei Wang, Y. Khew-Goodall, N. Bottini, 2019, Annals of the rheumatic diseases.

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes

Wei Wang, E. Palescandolo, J. Whitaker, 2018, Nature Communications.

Distinct DNA Methylation Patterns of Rheumatoid Arthritis Peripheral Blood and Synovial Tissue T Cells

Wei Wang, Rizi Ai, G. Firestein, 2021, ACR open rheumatology.

Joint Location–Specific JAK‐STAT Signaling in Rheumatoid Arthritis Fibroblast‐like Synoviocytes

Wei Wang, Rizi Ai, G. Firestein, 2019, ACR open rheumatology.

Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene

Wei Wang, Wei Wang, G. Firestein, 2017, The Journal of Immunology.

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

Wei Wang, Shicai Fan, Rizi Ai, 2016, Nature Communications.

Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.

N. Bottini, T. Mustelin, G. Firestein, 2013, Arthritis and rheumatism.

CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis.

K. Kalunian, D. Boyle, A. Kavanaugh, 2011, Rheumatology.

Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: Potential roles in acute inflammatory pain

Nam-Kyung Yu, B. Kaang, I. Kalcheva, 2014, PAIN®.

Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors.

D. Boyle, W. Buurman, M. Dentener, 1997, Journal of immunology.

Role of Interleukin 17 in Arthritis Chronicity through Survival of Synoviocytes via Regulation of Synoviolin Expression

G. Firestein, D. Boyle, W. B. van den Berg, 2010, PloS one.

Regulation of c-Jun Phosphorylation by the IκB Kinase-ε Complex in Fibroblast-Like Synoviocytes1

G. Firestein, S. Sweeney, D. Hammaker, 2005, The Journal of Immunology.

References Subscriptions Permissions Email Alerts Immunostimulatory DNA Sequences Influence the Course of Adjuvant Arthritis

G. Firestein, E. Raz, S. Albani, 2013 .

SAT0082 ASSOCIATIONS OF BASELINE CLINICAL AND BIOMARKER FACTORS WITH SYMPTOMS AND FUTURE DEVELOPMENT OF CLINICALLY-APPARENT RHEUMATOID ARTHRITIS IN AN ACPA POSITIVE COHORT

W. Robinson, G. Firestein, D. Boyle, 2019, SATURDAY, 15 JUNE 2019.

Identification and validation of an assay predictive of response and prognosis following anthracycline-based chemotherapy for early breast cancer.

F. Couch, M. Salto‐Tellez, T. Davison, 2013 .

University of Birmingham Notch signalling drives synovial fibroblast identity and arthritis pathology

N. Hacohen, C. Nusbaum, P. Gregersen, 2020 .

CXCL 13 : a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis

K. Kalunian, D. Boyle, A. Kavanaugh, 2011 .

Inflammatory Characteristics on Ultrasound Predict Poorer Longterm Response to Intraarticular Corticosteroid Injections in Knee Osteoarthritis

K. Kalunian, T. Hughes, D. Boyle, 2009, The Journal of Rheumatology.

Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats

L. Sorkin, G. Firestein, S. Albani, 2006, PLoS medicine.

Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action.

G. Firestein, D. Boyle, C. Szabó, 1998, The Journal of rheumatology.

Suppression of TNF‐α production in human mononuclear cells by an adenosine kinase inhibitor

G. Hartmann, G. Firestein, D. Boyle, 2000, Journal of Leukocyte Biology.

CXCL13 as a marker for outcome of rheumatoid arthritis: comment on the article by Meeuwisse et al.

K. Kalunian, D. Boyle, Kenneth C Kalunian, 2011, Arthritis and rheumatism.

Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor.

G. Hartmann, G. Firestein, D. Boyle, 2000, Journal of leukocyte biology.

The Effect of a T Cell-Specific NF-κB Inhibitor on In Vitro Cytokine Production and Collagen-Induced Arthritis1

P. Tak, A. Manning, G. Firestein, 2000, The Journal of Immunology.

Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.

B. Bresnihan, C. Wijbrandts, P. Tak, 2007, The Journal of rheumatology.

Kinetic analysis of synovial signalling and gene expression in animal models of arthritis

G. Firestein, D. Boyle, M. Corr, 2009, Annals of the rheumatic diseases.

NF-κB Regulation by IκB Kinase in Primary Fibroblast-Like Synoviocytes

P. Tak, A. Manning, G. Firestein, 1999, The Journal of Immunology.

Correlation of serum protein biomarkers with disease activity in psoriatic arthritis

E. Sasso, D. Boyle, A. Kavanaugh, 2020, Expert review of clinical immunology.

Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis.

G. Firestein, D. Boyle, Hyeonjoo Cheon, 2004, The Journal of rheumatology.

NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.

P. Tak, A. Manning, P. Tak, 1999, Journal of immunology.

Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis.

G. Firestein, D. Boyle, T. Cruz, 2007, The Journal of rheumatology.

The pathobiology of psoriatic synovium

D. Boyle, A. Kavanaugh, 2008, Current opinion in rheumatology.

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

G. Firestein, D. Boyle, M. Corr, 2011, Annals of the rheumatic diseases.

Spinal p38 MAP kinase regulates peripheral cholinergic outflow.

V. Pavlov, K. Tracey, L. Sorkin, 2008, Arthritis and rheumatism.

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

Tanner Schmidt, W. Giles, G. Firestein, 2017, The Journal of physiology.

Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.

G. Firestein, F. Mercurio, D. Boyle, 2001, Cellular immunology.

Kinetic analysis of synovial signalling and gene expression in animal models of arthritis

G. Firestein, D. Boyle, M. Corr, 2009, Annals of the rheumatic diseases.

Response to Intraarticular Corticosteroid Injections in Knee Osteoarthritis Inflammatory Characteristics on Ultrasound Predict Poorer Longterm

K. Kalunian, D. Boyle, A. Quan, 2010 .

Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes.

G. Firestein, S. Sweeney, D. Hammaker, 2005, Journal of immunology.