N. Yao

发表

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.

Shunqi Yan, C. Varaprasad, D. Barawkar, 2006, Bioorganic & medicinal chemistry letters.

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Gary Larson, Shunqi Yan, J. Wu, 2006, Bioorganic & medicinal chemistry letters.

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.

Gary Larson, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Isothiazoles as active-site inhibitors of HCV NS5B polymerase.

Shunqi Yan, J. Wu, R. Hamatake, 2006, Bioorganic & medicinal chemistry letters.

Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase.

M. Allan, Huanming Chen, Weijiang Zhang, 2006, Bioorganic & medicinal chemistry letters.

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase.

P. Weber, N. Yao, P. Reichert, 1999, Structure.

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.

H. Sham, N. Yao, T. Yednock, 2010, Bioorganic & medicinal chemistry letters.

Application of structural biology tools in the study of viral hepatitis and the design of antiviral therapy.

Z. Hong, N. Yao, J. Lau, 2002, Gastroenterology.

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase.

C. Cameron, Z. Hong, W. Zhong, 2001, Virology.

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.

R. Neitz, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Promising candidates for the treatment of chronic hepatitis C

Z. Hong, N. Yao, M. Walker, 2003, Expert opinion on investigational drugs.

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.

G. Tóth, R. Neitz, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.

I. W. Cheney, J. Wu, Z. Hong, 2005, Acta crystallographica. Section D, Biological crystallography.

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

G. Tóth, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Emerging targets in the treatment of hepatitis C virus infection

P. Weber, N. Yao, H. Le, 1998 .

Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

P. Weber, N. Yao, B. Malcolm, 1998, Protein science : a publication of the Protein Society.

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

I. W. Cheney, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.

N. Yao, V. Madison, F. G. Njoroge, 2006, Journal of medicinal chemistry.

Synthesis of Tipranavir Analogues as Non-Peptidic HIV Protease Inhibitors

N. Yao, Yili Ding, Kenneth L. Smith, 2009 .

Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.

J. Wu, N. Yao, G. Larson, 2006, Bioorganic chemistry.

A low energy short hydrogen bond in very high resolution structures of protein receptor-phosphate complexes

F. Quiocho, H. Luecke, N. Yao, 1997, Nature Structural Biology.

Virus-Specific Cofactor Requirement and Chimeric Hepatitis C Virus/GB Virus B Nonstructural Protein 3

S. Lemon, Z. Hong, W. Zhong, 2000, Journal of Virology.

Nucleoside triphosphatase and RNA helicase activities associated with GB virus B nonstructural protein 3.

Z. Hong, W. Zhong, N. Yao, 1999, Virology.

Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus

J. Wu, Z. Hong, W. Zhong, 2005, Antiviral chemistry & chemotherapy.

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.

N. Yao, A. Arasappan, F. G. Njoroge, 2004, Bioorganic & medicinal chemistry letters.

Structure of the hepatitis C virus RNA helicase domain

A. Kwong, P. Weber, Z. Hong, 1997, Nature Structural Biology.

Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors.

Z. Hong, N. Yao, B. Baroudy, 2000, Journal of hepatology.

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Zhuyan Guo, Frank Bennett, Rong-Sheng Yang, 2007, Journal of medicinal chemistry.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Kent Fitzgerald, Paul Beroza, Lee Latimer, 2013, ChemMedChem.

Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super‐families of helicases

G. Waksman, P. Weber, T. Lohman, 1998, Protein science : a publication of the Protein Society.

DEAD and DEAH Domains

P. Weber, N. Yao, 2002 .

helicases ofreveal structural similarities between SF 1 and SF 2 superfamilies Comparisons between the structures of HCV and Rep helicases

G. Waksman, P. Weber, T. Lohman, 1997 .

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.

Paul Beroza, Zhao Ren, Dean R Artis, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C NS3 protease: restoration of NS4A cofactor activity by N-biotinylation of mutated NS4A using synthetic peptides.

Z. Hong, B. Dasmahapatra, N. Yao, 2000, Biochemical and biophysical research communications.

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

John-Michael Sauer, Zhao Ren, Dean R Artis, 2011, Bioorganic & medicinal chemistry letters.

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

T. Shaler, N. Yao, T. Yednock, 2013, Nature Communications.

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.

N. Yao, V. Madison, F. G. Njoroge, 2005, Journal of medicinal chemistry.

Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

I. W. Cheney, J. Wu, Z. Hong, 2005, Journal of Virology.

Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors.

P. Beroza, R. Barbour, N. Yao, 2013, Biochemical and biophysical research communications.

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.

P. Beroza, Jiangli Yan, H. Sham, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.

S. Tamura, N. Yao, B. Malcolm, 2005, Bioorganic & medicinal chemistry letters.

Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex.

A. Kwong, P. Weber, Z. Hong, 1998, Biochemistry.

Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase.

C. Varaprasad, N. Yao, Yili Ding, 2007, Bioorganic & medicinal chemistry letters.

Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein.

P. Weber, N. Yao, H. Le, 1998, Trends in biochemical sciences.

Helicase, a target for novel inhibitors of hepatitis C virus.

P. Weber, N. Yao, 1998, Antiviral therapy.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

G. Tóth, H. Sham, N. Yao, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.

R. Neitz, M. Adler, H. Sham, 2012, Bioorganic & medicinal chemistry letters.

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

I. W. Cheney, Shunqi Yan, R. Hamatake, 2007, Bioorganic & medicinal chemistry letters.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

P. Beroza, R. Motter, R. Neitz, 2013, ChemMedChem.

Discovery of the HCV NS3/4A Protease Inhibitor SCH503034. Key Steps in Structure-Based Optimization

P. Weber, M. Senior, Z. Hong, 2007 .