M. Risbud

发表

Hypoxia Activates MAPK Activity in Rat Nucleus Pulposus Cells: Regulation of Integrin Expression and Cell Survival

T. Albert, I. Shapiro, M. Risbud, 2005, Spine.

Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration.

I. Shapiro, M. Risbud, Elizabeth S. Silagi, 2018, Matrix biology : journal of the International Society for Matrix Biology.

Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.

Zachary R. Schoepflin, I. Shapiro, M. Risbud, 2015, European cells & materials.

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

Zachary R. Schoepflin, R. Kandel, M. Risbud, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Tumor necrosis factor-α- and interleukin-1β-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-κB axis: implications in inflammatory disc disease.

X. Wang, I. Shapiro, M. Risbud, 2014, The American journal of pathology.

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord

Irving M Shapiro, Makarand V Risbud, I. Shapiro, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

Hydrogel-coated textile scaffolds as candidate in liver tissue engineering: II. Evaluation of spheroid formation and viability of hepatocytes

M. Risbud, J. Mayer, E. Karamuk, 2003, Journal of biomaterials science. Polymer edition.

Understanding embryonic development for cell‐based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes

M. Risbud, S. Tessier, 2020, Developmental dynamics : an official publication of the American Association of Anatomists.

New horizons in spine research: Disc biology, tissue engineering, biomechanics, translational, and clinical research

M. Risbud, J. Iatridis, C. Dahia, 2018, JOR spine.

Cell-based therapy for disc repair.

T. Albert, A. Vaccaro, I. Shapiro, 2005, The spine journal : official journal of the North American Spine Society.

Stem cell regeneration of the nucleus pulposus.

T. Albert, A. Vaccaro, I. Shapiro, 2004, The spine journal : official journal of the North American Spine Society.

Tissue engineering: advances in in vitro cartilage generation.

Makarand V Risbud, Michael Sittinger, M. Sittinger, 2002, Trends in biotechnology.

Class I and IIa HDACs Mediate HIF‐1α Stability Through PHD2‐Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF‐1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc

I. Shapiro, M. Risbud, Z. Schoepflin, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells*

Zachary R. Schoepflin, Y. Toyama, I. Shapiro, 2014, The Journal of Biological Chemistry.

Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus*

Shuai Jiang, I. Shapiro, M. Risbud, 2015, The Journal of Biological Chemistry.

Molecular mechanisms of biological aging in intervertebral discs

James D. Kang, D. Kletsas, M. Risbud, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Chitosan-Polyvinyl Pyrrolidone Hydrogel does Not Activate Macrophages: Potentials for Transplantation Applications

M. Risbud, R. Bhonde, M. Bhonde, 2001, Cell transplantation.

Islet immunoisolation: experience with biopolymers

M. Risbud, R. Bhonde, 2001, Journal of biomaterials science. Polymer edition.

Cellular Therapy for Disc Degeneration

T. Albert, A. Vaccaro, I. Shapiro, 2005, Spine.

The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis

P. Ayyaswamy, C. Adams, M. Risbud, 2007, Journal of cellular biochemistry.

Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling.

I. Shapiro, M. Risbud, D. Markova, 2010, Arthritis and rheumatism.

Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc.

T. Albert, I. Shapiro, M. Risbud, 2008, Arthritis and rheumatism.

TonEBP/OREBP Is a Regulator of Nucleus Pulposus Cell Function and Survival in the Intervertebral Disc*

T. Albert, I. Shapiro, M. Risbud, 2006, Journal of Biological Chemistry.

Role of autophagy in intervertebral disc and cartilage function: implications in health and disease.

M. Risbud, Vedavathi Madhu, A. Guntur, 2020, Matrix biology : journal of the International Society for Matrix Biology.

Activation of TonEBP by Calcium Controls β1,3-Glucuronosyltransferase-I Expression, a Key Regulator of Glycosaminoglycan Synthesis in Cells of the Intervertebral Disc*

I. Shapiro, M. Risbud, D. Sakai, 2009, Journal of Biological Chemistry.

Tonicity enhancer binding protein (TonEBP) and hypoxia‐inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: Role of Hsp70 in HIF‐1α degradation

I. Shapiro, M. Risbud, N. Fujita, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

In vivo biocompatibility evaluation of cellulose macrocapsules for islet immunoisolation: Implications of low molecular weight cut-off.

M. Risbud, R. Bhonde, Shobha Y. Bhargava, 2003, Journal of biomedical materials research. Part A.

Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells.

P. Fortina, T. Albert, Yan Zeng, 2010, Tissue engineering. Part A.

Evidence for Skeletal Progenitor Cells in the Degenerate Human Intervertebral Disc

T. Albert, A. Vaccaro, I. Shapiro, 2007, Spine.

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus

I. Shapiro, M. Risbud, Z. Johnson, 2017, Scientific Reports.

Galectin-3 Expression in the Intervertebral Disc: A Useful Marker of the Notochord Phenotype?

T. Albert, I. Shapiro, M. Risbud, 2007, Spine.

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

I. Shapiro, M. Risbud, E. Schipani, 2016, Autophagy.

Notochordal cells in the adult intervertebral disc: new perspective on an old question.

Irving M Shapiro, Makarand V Risbud, I. Shapiro, 2011, Critical reviews in eukaryotic gene expression.

Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death

I. Shapiro, M. Risbud, Elizabeth S. Silagi, 2018, Scientific Reports.

Syndecan-4 in intervertebral disc and cartilage: Saint or synner?

I. Shapiro, M. Risbud, A. Binch, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Selective cytotoxicity of MIA Pa Ca‐2 conditioned medium to acinar cells: a novel approach to reduce acinar cell contaminants in isolated islet preparations from BALB/c mice

M. Risbud, R. Bhonde, S. Kurup, 2001 .

Selective cytotoxicity of MIA Pa Ca-2 conditioned medium to acinar cells: a novel approach to reduce acinar cell contaminants in isolated islet preparations from BALB/c mice

M. Risbud, R. Bhonde, S. Kurup, 2001, Transplant international : official journal of the European Society for Organ Transplantation.

Biocompatible hydrogel supports the growth of respiratory epithelial cells: possibilities in tracheal tissue engineering.

M. Endres, J. Ringe, M. Sittinger, 2001, Journal of biomedical materials research.

Toward an Optimum System for Intervertebral Disc Organ Culture: TGF-β3 Enhances Nucleus Pulposus and Anulus Fibrosus Survival and Function Through Modulation of TGF-β-R Expression and ERK Signaling

V. Denaro, T. Albert, A. Vaccaro, 2006, Spine.

Hydrogel-Coated Textile Scaffolds as Three-Dimensional Growth Support for Human Umbilical Vein Endothelial Cells (HUVECs): Possibilities as Coculture System in Liver Tissue Engineering

M. Risbud, J. Mayer, E. Karamuk, 2002, Cell transplantation.

SMAD3 Functions as a Transcriptional Repressor of Acid‐Sensing Ion Channel 3 (ASIC3) in Nucleus Pulposus Cells of the Intervertebral Disc

I. Shapiro, M. Risbud, Asha Guttapalli, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Polyacrylamide-chitosan hydrogels: in vitro biocompatibility and sustained antibiotic release studies.

M. Risbud, R. Bhonde, Ramesh R. Bhonde, 2000, Drug delivery.

Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk.

T. Albert, I. Shapiro, M. Risbud, 2007, American journal of physiology. Cell physiology.

Microenvironmental Control of Disc Cell Function: Influence of Hypoxia and Osmotic Pressure

I. Shapiro, M. Risbud, 2014 .

HIF‐1α and HIF‐2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

I. Shapiro, M. Risbud, K. Chiba, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Hypoxic regulation of nucleus pulposus cell survival: from niche to notch.

I. Shapiro, M. Risbud, E. Schipani, 2010, The American journal of pathology.

HIF‐1‐PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells

Y. Toyama, I. Shapiro, T. Miyamoto, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Nucleus pulposus cells express HIF‐1α under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment

T. Albert, I. Shapiro, M. Risbud, 2006, Journal of cellular biochemistry.

Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2

P. Ducheyne, E. Vresilovic, I. Shapiro, 2002, Cell and Tissue Research.

Chitosan: a versatile biopolymer for orthopaedic tissue-engineering.

Makarand V Risbud, Michael Sittinger, Alberto Di Martino, 2005, Biomaterials.

Matrix vesicles: Are they anchored exosomes?

W. Landis, I. Shapiro, M. Risbud, 2015, Bone.

Expression of Acid‐Sensing Ion Channel 3 (ASIC3) in Nucleus Pulposus Cells of the Intervertebral Disc Is Regulated by p75NTR and ERK Signaling

T. Albert, I. Shapiro, M. Risbud, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Models of pancreatic regeneration in diabetes.

M. Risbud, R. Bhonde, 2002, Diabetes research and clinical practice.

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

I. Shapiro, M. Risbud, B. Diekman, 2021, Nature Communications.

Model surfaces engineered with nanoscale roughness and RGD tripeptides promote osteoblast activity.

P. Ducheyne, D. Castner, S. Golledge, 2004, Journal of biomedical materials research. Part A.

Osmolarity and Intracellular Calcium Regulate Aquaporin2 Expression Through TonEBP in Nucleus Pulposus Cells of the Intervertebral Disc

I. Shapiro, M. Risbud, D. Sakai, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

MEK/ERK Signaling Controls Osmoregulation of Nucleus Pulposus Cells of the Intervertebral Disc by Transactivation of TonEBP/OREBP

I. Shapiro, M. Risbud, Asha Guttapalli, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Nucleus Pulposus Cells Upregulate PI3K/Akt and MEK/ERK Signaling Pathways Under Hypoxic Conditions and Resist Apoptosis Induced by Serum Withdrawal

T. Albert, E. Vresilovic, I. Shapiro, 2005, Spine.

Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues.

I. Shapiro, M. Risbud, Cassie M Tran, 2013, Matrix biology : journal of the International Society for Matrix Biology.

Hypoxia-inducible Factor (HIF)-1α and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells

K. Lyons, I. Shapiro, M. Risbud, 2013, The Journal of Biological Chemistry.

Hypoxia-inducible Factor ( HIF )-1 and CCN 2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells

K. Lyons, I. Shapiro, M. Risbud, 2013 .

Glycosaminoglycan Synthesis in the Nucleus Pulposus: Dysregulation and the Pathogenesis of Disc Disease

I. Shapiro, M. Risbud, Elizabeth S. Silagi, 2018 .

Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration

M. Risbud, Takashi Ohnishi, Emanuel J. Novais, 2020, Matrix biology plus.

Discovery of the drivers of inflammation induced chronic low back pain: from bacteria to diabetes.

I. Shapiro, M. Risbud, D. Gorth, 2015, Discovery medicine.

Hypoxia and Hypoxia-Inducible Factor-1 a Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion

A. Salgado, I. Shapiro, B. Manadas, 2021 .

Hypoxia and HIF-1α regulate endoplasmic reticulum (ER) stress in nucleus pulposus cells: Implications of ER stress for extracellular matrix secretion.

A. Salgado, I. Shapiro, B. Manadas, 2020, The American journal of pathology.

Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells

A. Salgado, I. Shapiro, B. Manadas, 2022, The American Journal of Pathology.

A simple organ culture system for human fetal skin reveals that there are two phases in the melanocyte maturation in the dermis

M. Risbud, M. Mojamdar, 2001, In Vitro Cellular & Developmental Biology - Animal.

A simple microcapsule generator design for islet encapsulation

A. Hardikar, M. Risbud, R. Bhonde, 1999, Journal of Biosciences.

Effect of chitosan-polyvinyl pyrrolidone hydrogel on proliferation and cytokine expression of endothelial cells: implications in islet immunoisolation.

M. Risbud, R. Bhonde, M. Bhonde, 2001, Journal of biomedical materials research.

PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc

I. Shapiro, M. Risbud, A. Hiyama, 2009, Journal of cellular physiology.

Chitosan–Polyvinyl Pyrrolidone Hydrogels as Candidate for Islet Immunoisolation: In Vitro Biocompatibility Evaluation

A. Hardikar, M. Risbud, R. Bhonde, 2000, Cell transplantation.

p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence.

I. Shapiro, M. Risbud, B. Diekman, 2019, Matrix biology : journal of the International Society for Matrix Biology.

CCN2 Suppresses Catabolic Effects of Interleukin-1β through α5β1 and αVβ3 Integrins in Nucleus Pulposus Cells

Zachary R. Schoepflin, I. Shapiro, M. Risbud, 2014, The Journal of Biological Chemistry.

TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression.

I. Shapiro, M. Risbud, S. Tessier, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Islet Cryopreservation: Improved Recovery following Taurine Pretreatment

B. Reusens, C. Remacle, A. Hardikar, 2001, Cell transplantation.

Nonporous Polyurethane Membranes as Islet Immunoisolation Matrices – Biocompatibility Studies

M. Risbud, P. Nair, R. Bhonde, 2002, Journal of biomaterials applications.

BMP-2 and TGF-β Stimulate Expression of β1,3-Glucuronosyl Transferase 1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP, and Sp1: Role of MAPKs

I. Shapiro, M. Risbud, J. Mochida, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc

I. Shapiro, M. Risbud, Elizabeth S. Silagi, 2022, bioRxiv.

Properties of polyvinyl pyrrolidone/β-chitosan hydrogel membranes and their biocompatibility evaluation by haemorheological method

M. Risbud, S. Bhat, 2001, Journal of materials science. Materials in medicine.

Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems.

Dietmar W Hutmacher, Makarand V Risbud, Michael Sittinger, 2004, Trends in biotechnology.

Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration

I. Shapiro, M. Risbud, D. Gorth, 2018, Cell Death & Disease.

Role of cytokines in intervertebral disc degeneration: pain and disc content

I. Shapiro, M. Risbud, Makarand V. Risbud, 2014, Nature Reviews Rheumatology.

Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment

Samuel K. Cho, James D. Kang, M. Risbud, 2019, JBMR plus.

Substance P Receptor Antagonist Suppresses Inflammatory Cytokine Expression in Human Disc Cells

T. Albert, A. Vaccaro, M. Risbud, 2015, Spine.

Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells

T. Albert, A. Vaccaro, M. Risbud, 2012, Spine.

Preparation, characterization and in vitro biocompatibility evaluation of poly(butylene terephthalate)/wollastonite composites.

J. Jog, M. Risbud, D. Saheb, 2001, Biomaterials.

Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB.

I. Shapiro, M. Risbud, N. Fujita, 2013, The American journal of pathology.

pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery.

A. Hardikar, M. Risbud, R. Bhonde, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Improved post-cryopreservation recovery following encapsulation of islets in chitosan-alginate microcapsules.

A. Hardikar, M. Risbud, R. Bhonde, 2000, Transplantation proceedings.

LIST OF ABBREVIATIONS AF : Annulus Fibrosus ADAMTS : A Disintegrin And Metalloproteinase with Thrombospondin Motifs

D. Kletsas, M. Risbud, J. Hoyland, 2016 .

Designing hydrogel coated textile scaffolds for tissue engineering: Effect of casting conditions and degradation behavior studied at microstructure level

M. Risbud, J. Mayer, E. Karamuk, 2002 .

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

I. Shapiro, M. Risbud, C. L. Le Maitre, 2021, Scientific Reports.

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells

I. Shapiro, M. Risbud, C. L. Le Maitre, 2015, Oncotarget.

Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression.

M. Risbud, D. Sakai, Masahiro Tanaka, 2010, Arthritis and rheumatism.

An organ culture system to model early degenerative changes of the intervertebral disc

T. Albert, A. Vaccaro, I. Shapiro, 2011, Arthritis research & therapy.

Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative

Angela K. Brice, C. Séguin, M. Risbud, 2021, JOR spine.

Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology.

M. Risbud, J. Melrose, S. Tessier, 2021, European cells & materials.

Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.

M. Risbud, Z. Johnson, Hyowon Choi, 2015, Current stem cell research & therapy.

Transcriptional profiling of the nucleus pulposus: say yes to notochord

I. Shapiro, M. Risbud, 2010, Arthritis research & therapy.

Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

I. Shapiro, M. Risbud, Elizabeth S. Silagi, 2016, Oncotarget.

Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease.

T. Albert, I. Shapiro, M. Risbud, 2011, Arthritis and rheumatism.

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

H. Okano, K. Yamamura, M. Risbud, 2012, Nature Communications.

Differentiation of Mesenchymal Stem Cells Towards a Nucleus Pulposus-like Phenotype In Vitro: Implications for Cell-Based Transplantation Therapy

T. Albert, E. Vresilovic, A. Vaccaro, 2004, Spine.

Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging

I. Shapiro, M. Risbud, S. Addya, 2020, Aging cell.

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc*

I. Shapiro, M. Risbud, D. Markova, 2011, The Journal of Biological Chemistry.

Fibroblast Growth Factor-2 Maintains the Differentiation Potential of Nucleus Pulposus Cells In Vitro: Implications for Cell-Based Transplantation Therapy

T. Albert, A. Vaccaro, I. Shapiro, 2007, Spine.

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.

I. Shapiro, M. Risbud, R. Loeser, 2020, JCI insight.

Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation

I. Shapiro, M. Risbud, Vedavathi Madhu, 2019, Scientific Reports.

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

I. Shapiro, M. Risbud, Z. Johnson, 2014, Matrix biology : journal of the International Society for Matrix Biology.

An Organ Culture System for the Study of the Nucleus Pulposus: Description of the System and Evaluation of the Cells

T. Albert, E. Vresilovic, A. Vaccaro, 2003, Spine.

Introduction to the Structure, Function, and Comparative Anatomy of the Vertebrae and the Intervertebral Disc

I. Shapiro, M. Risbud, Makarand V. Risbud, 2014 .

Differential Effect of Long‐Term Systemic Exposure of TNFα on Health of the Annulus Fibrosus and Nucleus Pulposus of the Intervertebral Disc

I. Shapiro, M. Risbud, D. Gorth, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging

R. Tomlinson, I. Shapiro, M. Risbud, 2022, Frontiers in Cell and Developmental Biology.

Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging

R. Tomlinson, I. Shapiro, M. Risbud, 2021, bioRxiv.

Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF‐1α–BNIP3 Axis

I. Shapiro, M. Risbud, I. Kurland, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

E. Petricoin, H. Rui, W. Jiang, 2016, Oncogene.

New horizons in spine research: Intervertebral disc repair and regeneration

R. Kandel, M. Risbud, J. Iatridis, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Growth modulation of fibroblasts by chitosan-polyvinyl pyrrolidone hydrogel: Implications for wound management?

A. Hardikar, M. Risbud, R. Bhonde, 2000, Journal of Biosciences.

Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes.

V. Lefebvre, I. Shapiro, M. Risbud, 2020, Matrix biology : journal of the International Society for Matrix Biology.

HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc.

T. Albert, Yan Zeng, I. Shapiro, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration

M. Risbud, J. Collins, C. Kim, 2022, bioRxiv.

Bicarbonate Recycling by HIF‐1–Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells

Zachary R. Schoepflin, I. Shapiro, M. Risbud, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Is the spinal motion segment a diarthrodial polyaxial joint: what a nice nucleus like you doing in a joint like this?

E. Vresilovic, I. Shapiro, M. Risbud, 2012, Bone.

Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins.

I. Shapiro, M. Risbud, Rena Nasser, 2011, Arthritis and rheumatism.

RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells.

I. Shapiro, M. Risbud, H. Pan, 2019, Matrix biology : journal of the International Society for Matrix Biology.

The role of HIF proteins in maintaining the metabolic health of the intervertebral disc

I. Shapiro, M. Risbud, Elizabeth S. Silagi, 2021, Nature Reviews Rheumatology.

Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health

Aristeidis G. Telonis, I. Shapiro, M. Risbud, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Stem cells in craniofacial and dental tissue engineering.

M. Risbud, I. Shapiro, 2005, Orthodontics & craniofacial research.

Cytomorphology of granular-cell tumor of the bronchus. A case report.

M. Risbud, J. B. Gabriel, L. Thomas, 1984, Acta cytologica.

Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells

I. Shapiro, M. Risbud, C. L. Le Maitre, 2013, The Journal of Biological Chemistry.

Suitability of cellulose molecular dialysis membrane for bioartificial pancreas: in vitro biocompatibility studies.

M. Risbud, R. Bhonde, M V Risbud, 2001, Journal of biomedical materials research.

Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1.

Gail Haddock, Irving M Shapiro, Makarand V Risbud, 2013, Arthritis and rheumatism.

Radio-frequency plasma treatment improves the growth and attachment of endothelial cells on poly(methyl methacrylate) substrates: implications in tissue engineering

M. Risbud, S. Gangal, R. Bhonde, 2002, Journal of biomaterials science. Polymer edition.

HIF‐1α Is a Regulator of Galectin‐3 Expression in the Intervertebral Disc

Yan Zeng, I. Shapiro, M. Risbud, 2007 .

Current strategies for cell delivery in cartilage and bone regeneration.

Dietmar W Hutmacher, Makarand V Risbud, Michael Sittinger, 2004, Current opinion in biotechnology.

PHD3 is a transcriptional coactivator of HIF‐1α in nucleus pulposus cells independent of the PKM2‐JMJD5 axis

Zachary R. Schoepflin, I. Shapiro, M. Risbud, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

Y. Toyama, I. Shapiro, M. Risbud, 2012, The Journal of Biological Chemistry.

Expression and Relationship of Proinflammatory Chemokine RANTES/CCL5 and Cytokine IL-1&bgr; in Painful Human Intervertebral Discs

T. Albert, A. Vaccaro, M. Risbud, 2013, Spine.

The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc

M. Risbud, I. Kurland, Y. Qiu, 2023, Autophagy.

Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc.

I. Shapiro, M. Risbud, D. Markova, 2010, Arthritis and rheumatism.

Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling*

Y. Toyama, I. Shapiro, M. Risbud, 2012, The Journal of Biological Chemistry.

Osteogenic Potential of Adult Human Stem Cells of the Lumbar Vertebral Body and the Iliac Crest

T. Albert, A. Vaccaro, I. Shapiro, 2006, Spine.

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells

Zachary R. Schoepflin, I. Shapiro, M. Risbud, 2018, The Journal of Biological Chemistry.

A New Understanding of the Role of IL‐1 in Age‐Related Intervertebral Disc Degeneration in a Murine Model

I. Shapiro, M. Risbud, D. Gorth, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis.

N. Pleshko, I. Shapiro, M. Risbud, 2018, Matrix biology : journal of the International Society for Matrix Biology.

The Intervertebral Disc

I. Shapiro, M. Risbud, 2014 .

N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions

F. Guilak, L. Setton, C. Gersbach, 2016, Scientific Reports.

1 TNF-α Promotes Nuclear Enrichment of TonEBP / NFAT 5 to Selectively Control Inflammatory but not Osmoregulatory Responses in Nucleus Pulposus Cells

I. Shapiro, M. Risbud, Z. Johnson, 2018 .

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

I. Shapiro, M. Risbud, C. L. Le Maitre, 2017, The Journal of Biological Chemistry.

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells

I. Shapiro, M. Risbud, Z. Johnson, 2016, The Journal of Biological Chemistry.

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

A. Robling, A. Giaccia, I. Shapiro, 2014, PloS one.

Title Exhaustion of nucleus pulposus progenitor cells with ageingand degeneration of the intervertebral disc

H. Okano, K. Yamamura, M. Risbud, 2012 .

NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.

I. Shapiro, M. Risbud, Z. Johnson, 2019, Developmental biology.

Classification and Basic Structure

Society, Sanford, M. Risbud, 2022 .

An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes

T. Albert, A. Vaccaro, I. Shapiro, 2013, Arthritis Research & Therapy.

Tissue engineering: Implications in the treatment of organ and tissue defects

M. Risbud, Makarand Risbud, 2004, Biogerontology.

Conditional Deletion of HIF‐2α in Mouse Nucleus Pulposus Reduces Fibrosis and Provides Mild and Transient Protection From Age‐Dependent Structural Changes in Intervertebral Disc

I. Shapiro, M. Risbud, Vedavathi Madhu, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bone Cell Survival in Microgravity: Evidence that Modeled Microgravity Increases Osteoblast Sensitivity to Apoptogens

P. Ayyaswamy, C. Adams, M. Risbud, 2004, Annals of the New York Academy of Sciences.

Differential Gene Expression in Anterior and Posterior Annulus Fibrosus

T. Albert, A. Vaccaro, M. Risbud, 2014, Spine.

Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.

I. Shapiro, M. Risbud, D. Markova, 2015, The American journal of pathology.

Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc.

I. Shapiro, M. Risbud, B. Perbal, 2011, Arthritis and rheumatism.

In Vitro Expression of Cartilage-Specific Markers by Chondrocytes on a Biocompatible Hydrogel: Implications for Engineering Cartilage Tissue

J. Ringe, M. Sittinger, M. Risbud, 2001, Cell transplantation.

Immunocytochemical localization of growth hormone-releasing hormone-like peptide in the brain of the tiger frog, Rana tigrina.

M. Risbud, Shobha Y. Bhargava, P. Prasad Rao, 2002, General and comparative endocrinology.