M. Maclean

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Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter.

D. Welsh, M. Harnett, M. Maclean, 2004, American journal of respiratory and critical care medicine.

Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries.

D. Welsh, M. Harnett, M. Maclean, 2001, American journal of respiratory and critical care medicine.

Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines.

M. Lean, M. Maclean, A. Crozier, 2000, Journal of agricultural and food chemistry.

Urotensin receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

D. Webb, H. Krum, H. Vaudry, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Cellular and molecular basis of pulmonary arterial hypertension.

N. Weissmann, P. Thistlethwaite, S. Archer, 2009, Journal of the American College of Cardiology.

Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure

J. McMurray, M. Petrie, M. Maclean, 2001 .

Increased expression of the cGMP‐inhibited cAMP‐specific (PDE3) and cGMP binding cGMP‐specific (PDE5) phosphodiesterases in models of pulmonary hypertension

M. Maclean, N. Pyne, F. Murray, 2002, British journal of pharmacology.

Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin‐1 in the control of pulmonary vascular tone

M. Maclean, M. N. Hicks, G. A. Deuchar, 2002, British journal of pharmacology.

5‐hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

M. Maclean, S. Eddahibi, P. Hervé, 2000, British journal of pharmacology.

Contractile responses to human urotensin‐II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat

S. Douglas, M. Maclean, E. Ohlstein, 2000, British journal of pharmacology.

Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats.

M. Maclean, R. Wadsworth, K. Kane, 1996, Respiration physiology.

Endothelin-1 has haemodynamic effects at pathophysiological concentrations in patients with left ventricular dysfunction.

J. Cleland, J. Cleland, M. Maclean, 1998, Cardiovascular research.

EndothelinB receptor‐mediated contraction in human pulmonary resistance arteries

M. Maclean, I. Morecroft, K. M. Mcculloch, 1996, British journal of pharmacology.

Non-steroidal anti-inflammatory drugs and metformin: a cause for

J. McMurray, J. Cleland, M. Maclean, 1998 .

Effects of Pulmonary Hypertension on Vasoconstrictor Responses to Endothelin‐1 and Sarafotoxin S6C and on Inherent Tone in Rat Pulmonary Arteries

M. Maclean, M. Baird, K. McCulloch, 1995, Journal of cardiovascular pharmacology.

Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells.

M. Houslay, M. Maclean, J. Millen, 2006, European journal of cell biology.

Influence of applied tension and nitric oxide on responses to endothelins in rat pulmonary resistance arteries: effect of chronic hypoxia

M. Maclean, K. McCulloch, 1998, British journal of pharmacology.

Interdependent Serotonin Transporter and Receptor Pathways Regulate S100A4/Mts1, a Gene Associated With Pulmonary Vascular Disease

A. Harmar, M. Maclean, A. Schmidt, 2005, Circulation research.

Endothelin-1 and serotonin: mediators of primary and secondary pulmonary hypertension?

M. Maclean, 1999, The Journal of laboratory and clinical medicine.

α1-Adrenergic receptors in the nucleus tractus solitarii region of rats with experimental and genetic hypertension

M. Raizada, M. Maclean, C. Sumners, 1990, Brain Research.

The role of α2‐adrenoceptors in the vasculature of the rat tail

M. Maclean, W. Redfern, J. McGrath, 1995 .

Accumulation of nitrotyrosine correlates with endothelial NO synthase in pulmonary resistance arteries during chronic hypoxia in the rat.

M. Maclean, R. Wadsworth, A. T. Demiryürek, 2000, Pulmonary pharmacology & therapeutics.

Contribution of the 5-HT1B Receptor to Hypoxia-Induced Pulmonary Hypertension: Converging Evidence Using 5-HT1B-Receptor Knockout Mice and the 5-HT1B/1D-Receptor Antagonist GR127935

M. Maclean, I. Morecroft, M. N. Hicks, 2001, Circulation research.

Short-term haemodynamic effects of BQ-123, a selective endothelin ETA-receptor antagonist, in chronic heart failure

J. Cleland, M. Maclean, H. Dargie, 1998, The Lancet.

Role of phosphodiesterases in adult-onset pulmonary arterial hypertension.

P. Insel, M. Maclean, F. Murray, 2011, Handbook of experimental pharmacology.

M. Petrie, M. Maclean, M. Love, 2001, Clinical science.

Urotensin receptor in GtoPdb v.2021.3

D. Webb, H. Krum, H. Vaudry, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: effects of experimental pulmonary hypertension.

M. Maclean, I. Morecroft, M. Nilsen, 2006, European journal of pharmacology.

Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?

M. Maclean, 1999, Trends in pharmacological sciences.

The serotonin hypothesis of pulmonary hypertension revisited.

M. Maclean, Y. Dempsie, 2010, Advances in experimental medicine and biology.

Molecular determinants in pulmonary hypertension: the role of PDE5

M. Maclean, N. Pyne, F. Murray, 2006 .

Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension

M. Maclean, I. Morecroft, A. Gurney, 2009, British journal of pharmacology.

Increased contractile response to 5‐hydroxytryptamine1‐receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy

M. Maclean, I. Morecroft, 2001, British journal of pharmacology.

Pulmonary and systemic responses to exogenous endothelin-1 in patients with left ventricular dysfunction.

J. Cleland, M. Maclean, H. Dargie, 1998, Journal of cardiovascular pharmacology.

Effects of enalapril on changes in cardiac output and organ vascular resistances induced by α1‐ and α2‐adrenoceptor agonists in pithed normotensive rats

M. Maclean, C. Hiley, 1988 .

EndothelinB receptors in rabbit pulmonary resistance arteries: effect of left ventricular dysfunction.

M. Maclean, C. Docherty, 1998, The Journal of pharmacology and experimental therapeutics.

Heterogeneity of endothelin-B receptors in rabbit pulmonary resistance arteries.

M. Maclean, J. F. Mackenzie, C. Docherty, 1998, Journal of cardiovascular pharmacology.

Endothelin ETA- and ETB-Receptor‐Mediated Vasoconstriction in Rat Pulmonary Arteries and Arterioles

M. Maclean, M. Baird, K. McCulloch, 1994, Journal of cardiovascular pharmacology.

Serotonin and pulmonary hypertension--from bench to bedside?

M. Maclean, Y. Dempsie, 2009, Current opinion in pharmacology.

EndothelinB Receptor‐Mediated Contraction of Human and Rat Pulmonary Resistance Arteries and the Effect of Pulmonary Hypertension on Endothelin Responses in the Rat

M. Maclean, K. McCulloch, 1995, Journal of cardiovascular pharmacology.

Developmental changes in endothelium‐dependent vasodilation and the influence of superoxide anions in perinatal rabbit pulmonary arteries

M. Maclean, I. Morecroft, 1998, British journal of pharmacology.

Regional modulation of cyclic nucleotides by endothelin‐1 in rat pulmonary arteries: direct activation of Gi2‐protein in the main pulmonary artery

M. Maclean, I. Mullaney, D. Vaughan, 2000, British journal of pharmacology.

Chronic exposure to hypoxia attenuates contractile responses in rat airways in vitro: a possible role for nitric oxide.

N. Thomson, M. Maclean, J. McGrath, 1999, European journal of pharmacology.

5‐Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats

M. Houslay, M. Maclean, I. Morecroft, 1996, British journal of pharmacology.

Reduction of the serotonin 5-HT1B and 5-HT2A receptor-mediated contraction of human pulmonary artery by the combined 5-HT1B receptor antagonist and serotonin transporter inhibitor LY393558

M. Maclean, B. Malinowska, E. Schlicker, 2020, Pharmacological Reports.

5‐hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5‐HT1B receptor

M. Maclean, I. Morecroft, H. Prentice, 1999, British journal of pharmacology.

5‐HT moduline: an endogenous inhibitor of 5‐HT1B/1D‐mediated contraction in pulmonary arteries

M. Maclean, I. Morecroft, R. Murdoch, 2003, British journal of pharmacology.

Effects of pre‐contraction with endothelin‐1 on α2‐adrenoceptor‐and (endothelium‐dependent) neuropeptide Y‐mediated contractions in the isolated vascular bed of the rat tail

M. Maclean, J. McGrath, Margaret R. MacLean, 1990, British journal of pharmacology.

The role of 5-hydroxytryptamine in the control of pulmonary vascular tone in a rabbit model of pulmonary hypertension secondary to left ventricular dysfunction.

M. Maclean, M. N. Hicks, G. A. Deuchar, 2005, Pulmonary pharmacology & therapeutics.

5‐Hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries

M. Maclean, I. Morecroft, 1998, British journal of pharmacology.

Pulmonary responses to 5-hydroxytryptamine and endothelin-1 in a rabbit model of left ventricular dysfunction.

M. Maclean, S. Cobbe, M. N. Hicks, 1998, Cardiovascular research.

Evidence for 5‐HT1‐like receptor‐mediated vasoconstriction in human pulmonary artery

M. Maclean, I. Morecroft, A. Templeton, 1996, British journal of pharmacology.

Endothelin-1: a mediator of pulmonary hypertension?

M. Maclean, 1998, Pulmonary pharmacology & therapeutics.

The influence of endothelin‐1 on human foeto‐placental blood vessels: a comparison with 5‐hydroxytryptamine

M. Maclean, J. McGrath, A. Templeton, 1992, British journal of pharmacology.

Influences of the endothelium and hypoxia on α1‐ and α2‐adrenoceptor‐mediated responses in the rabbit isolated pulmonary artery

M. Maclean, J. McGrath, K. McCulloch, 1993 .

responsesintherabbit isolated pulmonary artery

M. Maclean, J. McGrath, K. McCulloch, 1993 .

Effects of Hypoxia on Endothelin-1 Release from Human, Sheep and Rabbit Pulmonary Artery Rings

M. Maclean, R. Wadsworth, A. T. Demiryürek, 1994 .

Effects of endothelin-1 on isolated vascular beds from normotensive and spontaneously hypertensive rats.

M. Maclean, J. McGrath, 1990, European journal of pharmacology.

Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin‐1 in the pithed rat

M. Maclean, C. Hiley, M. Randall, 1989, British journal of pharmacology.

Pressor effects of the α2‐adrenoceptor agonist B‐HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine

M. Maclean, C. Hiley, M. Thomson, 1989, British journal of pharmacology.

Influences of the endothelium and hypoxia on neurogenic transmission in the isolated pulmonary artery of the rabbit

M. Maclean, J. McGrath, J. Macmillan, 1993, British journal of pharmacology.

Adverse reactions associated with sumatriptan

M. Maclean, W. Luman, R. S. Gray, 1993, The Lancet.

Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries

M. Maclean, C. Docherty, 1998, British journal of pharmacology.

Influence of chronic hypoxia on the contributions of non‐inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle

M. Maclean, A. Gurney, D. Alexander, 1998, British journal of pharmacology.

Effect of neuropeptide Y on cardiac output, its distribution, regional blood flow and organ vascular resistances in the pithed rat

M. Maclean, C. Hiley, 1990, British journal of pharmacology.

Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties.

Alan Crozier, M. Lean, M. Maclean, 2002, Journal of agricultural and food chemistry.

Cellular and molecular pathobiology of pulmonary arterial hypertension.

M. Humbert, S. Archer, E. K. Weir, 2004, Journal of the American College of Cardiology.

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.

M. Houslay, M. Maclean, K. McCulloch, 1997, The Journal of pharmacology and experimental therapeutics.

Effects of the renin‐angiotensin system on the reflex response of the adrenal medulla to hypotension in the dog.

M. Maclean, A. Ungar, 1986, The Journal of physiology.

Effect of artificial respiratory volume on the cardiovascular responses to an α1‐ and an α2‐adrenoceptor agonist in the air‐ventilated pithed rat

M. Maclean, C. Hiley, 1988 .

Contractile Responses to Sumatriptan in Isolated Bovine Pulmonary Artery Rings: Relationship to Tone and Cyclic Nucleotide Levels

M. Maclean, M. Baird, G. Sweeney, 1995, Journal of cardiovascular pharmacology.

5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone.

M. Maclean, A. Peacock, S. Hillis, 1994, Pulmonary pharmacology.

Pulmonary hypertension: therapeutic targets within the serotonin system

M. Maclean, Y. Dempsie, 2008, British journal of pharmacology.

Functional Interactions between 5-Hydroxytryptamine Receptors and the Serotonin Transporter in Pulmonary Arteries

A. Harmar, M. Maclean, I. Morecroft, 2005, Journal of Pharmacology and Experimental Therapeutics.

Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: effect of chronic hypoxia in the rat

M. Maclean, C. Docherty, K. McCulloch, 1998, British journal of pharmacology.

Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.

M. Maclean, B. Malinowska, H. Kozłowska, 2012, Pharmacological research.

Endothelin B receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction.

J. Cleland, M. Maclean, H. Dargie, 1999, Journal of the American College of Cardiology.

Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries.

S. Douglas, M. Maclean, E. Ohlstein, 2001, American journal of physiology. Heart and circulatory physiology.

Is the Pregnancy Hormone Relaxin Also a Vasodilator Peptide Secreted by the Heart?

J. McMurray, M. Maclean, I. Morecroft, 2002, Circulation.

The role of alpha 2-adrenoceptors in the vasculature of the rat tail.

M. Maclean, W. Redfern, J. McGrath, 1995, British Journal of Pharmacology.

Influences of the endothelium and hypoxia on alpha 1- and alpha 2-adrenoceptor-mediated responses in the rabbit isolated pulmonary artery.

M. Maclean, J. McGrath, K. McCulloch, 1993, British Journal of Pharmacology.

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

I. Clay, J. Westwick, D. Rowlands, 2013, American journal of respiratory and critical care medicine.

EndothelinBreceptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction

J. McMurray, J. Cleland, M. Maclean, 1998 .

Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension

A. Harmar, M. Maclean, S. Shen, 2004, Circulation.

Novel interactions between the 5‐HT transporter, 5‐HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

T. Palmer, M. Maclean, I. Morecroft, 2008, British journal of pharmacology.

Effect of novel mixed ETA/ETB antagonists on responses to ET-1 in human small muscular pulmonary arteries.

M. Maclean, I. Morecroft, C. Docherty, 1998, Pulmonary pharmacology & therapeutics.

An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen‐activated protein kinase pathway in animal and cellular models of pulmonary hypertension

M. Maclean, N. Pyne, F. Murray, 2003, British journal of pharmacology.

The influence of angiotensin II on catecholamine synthesis in neuronal cultures from rat brain.

M. Raizada, M. Maclean, C. Sumners, 1990, Biochemical and biophysical research communications.

Effects of enalapril on changes in cardiac output and organ vascular resistances induced by alpha 1- and alpha 2-adrenoceptor agonists in pithed normotensive rats.

M. Maclean, C. Hiley, 1988, British journal of pharmacology.