M. B. Floyd

发表

Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.

D. Boschelli, D. Berger, M. Dutia, 2003, Bioorganic & medicinal chemistry letters.

4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.

D. Berger, M. Dutia, D. Powell, 2008, Bioorganic & medicinal chemistry.

4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 (CDK4).

R. Nilakantan, M. B. Floyd, S. Rabindran, 2008, Journal of medicinal chemistry.

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

D. Boschelli, R. Nilakantan, D. Berger, 2000, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.

D. Powell, A. Wissner, M. B. Floyd, 2000, Bioorganic & medicinal chemistry letters.

Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

D. Boschelli, F. Moy, D. Berger, 2008, Bioorganic & medicinal chemistry letters.

Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.

A. Wissner, M. B. Floyd, K. Arndt, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of 7-(E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated Heck, Stille, and Suzuki reactions

D. Berger, M. Dutia, M. B. Floyd, 2009 .

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

D. Boschelli, R. Nilakantan, D. Berger, 2000, Journal of medicinal chemistry.

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).

A. Wissner, M. B. Floyd, K. Arndt, 2010, European journal of medicinal chemistry.

Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.

D. Boschelli, D. Berger, M. Dutia, 2003, Bioorganic & medicinal chemistry letters.

Prostaglandins and congeners. 20. Synthesis of prostaglandins via conjugate addition of lithium trans-1-alkenyltrialkylalanate reagents. A novel reagent for conjugate 1,4-additions

M. B. Floyd, M. J. Weiss, K. Bernady, 1979 .

2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2.

R. Nilakantan, F. Loganzo, A. Wissner, 2005, Journal of medicinal chemistry.

The oxidation of acetophenones to arylglyoxals with aqueous hydrobromic acid in dimethyl sulfoxide

M. B. Floyd, P. Fabio, M. Du, 1985 .

Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2.

F. Loganzo, A. Wissner, M. B. Floyd, 2007, Bioorganic & medicinal chemistry.

Efficient synthesis of selected indenones

M. B. Floyd, G. Allen, 1970 .

Cyclobutenes by ring expansion of cyclopropenes

M. B. Floyd, J. J. Langone, W. Gensler, 1971 .

Synthesis of partially-protected d-fructofuranoses and d-fructose-6-phosphates

M. B. Floyd, S. Ayral-Kaloustian, 1991 .

A SYNTHESIS OF 2‐(6′‐CARBOXY‐2′‐CIS‐HEXENYL)‐4‐HYDROXYCYCLOPENT‐2‐EN‐1‐ONE, A PROSTAGLANDIN INTERMEDIATE

M. B. Floyd, 1975 .

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Ramaswamy Nilakantan, Fei Ye, Allan Wissner, 2003 .

Prostaglandins and congeners. 21. Synthesis of some cyclohexyl analogs (11.alpha.-homoprostaglandins)

M. B. Floyd, M. J. Weiss, 1979 .

The reactions of heterocyclic systems with singlet oxygen. Photosensitized oxygenation of imidazoles

M. B. Floyd, H. Wasserman, K. Stiller, 1968 .

The oxidation of heterocyclic systems by moleculr oxygen—IV

M. B. Floyd, H. Wasserman, 1966 .

Syntheses of labelled methyl malvalate

M. B. Floyd, W. Gensler, R. Yanase, 1970 .

15-DEOXY-16-HYDROXYPROSTAGLANDINS SYNTHESIS AND BRONCHODILATOR ACTIVITY

A. Wissner, M. B. Floyd, M. J. Weiss, 1979 .

Synthesis of prostaglandins by alanate additions to cyclopentenones (1).

M. B. Floyd, M. J. Weiss, 1973, Prostaglandins.

Cyclic analog of ethacrynic acid.

M. B. Floyd, G. Allen, 1970, Journal of pharmaceutical sciences.

Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase

Ramaswamy Nilakantan, Allan Wissner, William A. Hallett, 2004, Cancer Research.

Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).

D. Kitchen, Z. Husain, R. Nilakantan, 1999, Biochemical pharmacology.

Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.

Ramaswamy Nilakantan, Allan Wissner, R. Nilakantan, 2005, Journal of medicinal chemistry.

Prostaglandins and congeners, 29. (16RS)-(+/-)-15-Deoxy-16-hydroxy-16-vinyl-prostaglandin E2, an orally and transdermally active hypotensive agent of prolonged duration.

M. B. Floyd, F. Dessy, C. Grudzinskas, 1982, Journal of medicinal chemistry.

PROSTAGLANDINS AND CONGENERS. 22. SYNTHESIS OF 11-SUBSTITUTED DERIVATIVES OF 11-DEOXYPROSTAGLANDINS E1 AND E2. POTENTIAL BRONCHODILATORS

J. Skotnicki, M. B. Floyd, M. J. Weiss, 1981 .

Prostaglandins and congeners. 22. Synthesis of 11-substituted derivatives of 11-deoxyprostaglandins E1 and E2. Potential bronchodilators.

J. Skotnicki, M. B. Floyd, M. J. Weiss, 1980, Journal of medicinal chemistry.

Prostaglandins and congeners. 18. Synthesis of cyclopentenolone precursors to prostaglandins from 2,5-dihydro-2,5-dimethoxyfurans

M. B. Floyd, 1978 .

Kinetics of Autoxidation of Trialkylphosphines

M. B. Floyd, C. E. Boozer, 1963 .

Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines.

D. Boschelli, D. Powell, A. Wissner, 2000, Bioorganic & medicinal chemistry letters.

4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.

D. Berger, M. Dutia, D. Powell, 2008, Bioorganic & medicinal chemistry.