P. Lombroso

发表

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling

Angus C. Nairn, Ping Wang, A. Nairn, 2003, Nature Neuroscience.

Development of the cerebral cortex: IX. Cortical development and experience: I.

S. Hockfield, P. Lombroso, Susan Hockfield, 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

Regulation of NMDA receptor trafficking by amyloid-beta.

P. Greengard, A. Nairn, T. Moran, 2005, Nature neuroscience.

Microinfusion of antineuronal antibodies into rodent striatum: Failure to differentiate between elevated and low titers

J. Mink, J. Leckman, H. Singer, 2005, Journal of Neuroimmunology.

Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway.

J. Sweatt, E. Weeber, P. Lombroso, 2003, Journal of the American Academy of Child and Adolescent Psychiatry.

Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.

Angus C Nairn, Paul Greengard, Denis Hervé, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.

P. Lombroso, J. Kitajewski, T. Karasawa, 2002, The Journal of biological chemistry.

Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

P. Greengard, A. Nairn, K. Seyb, 2014, PLoS biology.

STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice

P. Lombroso, T. Banke, P. Kurup, 2018, Neuropharmacology.

Down‐regulation of BDNF in cell and animal models increases striatal‐enriched protein tyrosine phosphatase 61 (STEP61) levels

A. Nairn, P. Lombroso, Jian Xu, 2016, Journal of neurochemistry.

Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress

J. Leckman, L. Scahill, R. King, 1991, Neurology.

Genetics of childhood disorders: XLVII. Autism, part 6: duplication and inherited susceptibility of chromosome 15q11-q13 genes in autism.

J. Sutcliffe, E. Nurmi, P. Lombroso, 2003, Journal of the American Academy of Child and Adolescent Psychiatry.

Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP

Jiang-Fan Chen, P. Lombroso, P. Popoli, 2014, Neuropsychopharmacology.

STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit

J. Macdonald, P. Lombroso, Jian Xu, 2016, Scientific Reports.

Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway

P. Lombroso, Jian Xu, P. Kurup, 2015, Journal of neurochemistry.

Striatal-Enriched Protein Tyrosine Phosphatase Controls Responses to Aversive Stimuli: Implication for Ethanol Drinking

P. Lombroso, E. Darcq, D. Ron, 2015, PloS one.

Computerizing a department of psychiatry

P. Lombroso, Lenny Eng, 1987, Administration in mental health.

Genetic mechanisms in childhood psychiatric disorders.

J. Leckman, D. Pauls, P. Lombroso, 1994, Journal of the American Academy of Child and Adolescent Psychiatry.

NeuroprotectiveRoleofaBrain-EnrichedTyrosine Phosphatase,STEP,inFocalCerebralIschemia

P. Lombroso, 2013 .

Neuroprotective Role of a Brain-Enriched Tyrosine Phosphatase, STEP, in Focal Cerebral Ischemia

Surojit Paul, P. Lombroso, E. Candelario-Jalil, 2013, The Journal of Neuroscience.

Genetics of childhood disorders: XXI. ADHD, part 5: a behavioral genetic perspective.

P. Lombroso, R. D. Todd, 2000, Journal of the American Academy of Child and Adolescent Psychiatry.

Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases

A. Nairn, P. Lombroso, Jian Xu, 2017, ACS central science.

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome

P. Lombroso, Jian Xu, A. Saavedra, 2016, Molecular Neurobiology.

Reversing the effects of fragile X syndrome.

M. Ogren, P. Lombroso, 2008, Journal of the American Academy of Child and Adolescent Psychiatry.

The Protein Tyrosine Phosphatase STEP Gates Long-term Potentiation and Fear Memory in the Lateral Amygdala

JaneR . Taylor, N. Tronson, P. Olausson, 2008 .

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

J. Bibb, M. Baum, P. Lombroso, 2009, The Journal of Neuroscience.

Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.

A. Nairn, P. Lombroso, J. Ellman, 2015, Bioorganic & medicinal chemistry letters.

Tourette syndrome and obsessive–compulsive disorder

L. Scahill, P. Lombroso, 2008, Brain and Development.

Review article Tourette syndrome and obsessive-compulsive disorder q

L. Scahill, P. Lombroso, 2008 .

The Basal Ganglia and Immune-Based Neuropsychiatric Disorders

P. Lombroso, M. Mercadante, E. Miguel, 2001 .

Epigenetics: behavioral influences on gene function, Part II: Molecular mechanisms.

M. Ogren, P. Lombroso, 2008, Journal of the American Academy of Child and Adolescent Psychiatry.

Fragile X syndrome: keys to the molecular genetics of synaptic plasticity.

M. Ogren, P. Lombroso, 2008, Journal of the American Academy of Child and Adolescent Psychiatry.

STEP61: A Member of a Family of Brain-Enriched PTPs Is Localized to the Endoplasmic Reticulum

J. Naegele, M. Solimena, P. Lombroso, 1996, The Journal of Neuroscience.

Epigenetics: behavioral influences on gene function, part I. Maternal behavior permanently affects adult behavior in offspring.

M. Ogren, P. Lombroso, 2008, Journal of the American Academy of Child and Adolescent Psychiatry.

Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.

P. Lombroso, M. Lerner, G. Murdoch, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Genetics of childhood disorders: XXV. Velocardiofacial syndrome.

P. Lombroso, D. Gothelf, 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia

M. Shamloo, P. Lombroso, Jian Xu, 2008, The European journal of neuroscience.

A Substrate Trapping Mutant Form of the Tyrosine Phosphatase STEP Prevents Amphetamine-induced Stereotypies and Long-term Potentiation in the Striatum

C. Prosperetti, Surojit Paul, P. Lombroso, 2009 .

Therapeutic Implications for Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Neuropsychiatric Disorders

M. Baum, M. Baum, P. Lombroso, 2012, Pharmacological Reviews.

Intra‐prelimbic cortical inhibition of striatal‐enriched tyrosine phosphatase suppresses cocaine seeking in rats

J. McGinty, P. Lombroso, B. Siemsen, 2018, Addiction biology.

Striatal-Enriched Protein Tyrosine Phosphatase—STEPs Toward Understanding Chronic Stress-Induced Activation of Corticotrophin Releasing Factor Neurons in the Rat Bed Nucleus of the Stria Terminalis

D. Rainnie, P. Lombroso, Jian Xu, 2013, Biological Psychiatry.

Striatal-enriched protein tyrosine phosphatase - STEPs toward understanding chronic stress-induced activation of CRF neurons in the rat BNST

D. Rainnie, P. Lombroso, Jian Xu, 2013 .

Striatal‐enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory

M. Picciotto, P. Lombroso, D. Venkitaramani, 2011, The European journal of neuroscience.

Calcium‐Dependent Cleavage of Striatal Enriched Tyrosine Phosphatase (STEP)

T. H. Nguyen, P. Lombroso, J. Gurd, 1999, Journal of neurochemistry.

Hypoxia‐Ischemia in Perinatal Rat Brain Induces the Formation of a Low Molecular Weight Isoform of Striatal Enriched Tyrosine Phosphatase (STEP)

S. Vannucci, T. H. Nguyen, P. Lombroso, 1999, Journal of neurochemistry.

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.

P. Lombroso, Jian Xu, S. Beggs, 2016, Cell reports.

Development of the cerebral cortex: II. Lissencephaly.

O. Reiner, P. Lombroso, 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

Y. de Koninck, P. Lombroso, Jian Xu, 2021, bioRxiv.

Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report.

C. McDougle, B. Peterson, J. Leckman, 1995, Journal of the American Academy of Child and Adolescent Psychiatry.

TICS AND RISPERIDONE

B. Peterson, J. Leckman, L. Scahill, 1996 .

Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome

Bradley S. Peterson, Lawrence Scahill, Haiqun Lin, 2010, European Child & Adolescent Psychiatry.

Potentiation of Synaptic G luN 2 BNMDARCurrents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing Graphical

P. Lombroso, Jian Xu, S. Beggs, 2016 .

Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome

L. Scahill, P. Lombroso, Heidi Grantz, 2014, Child Psychiatry & Human Development.

Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.

L. Raymond, P. Lombroso, Jian Xu, 2012, Human molecular genetics.

Major vault protein is expressed along the nucleus-neurite axis and associates with mRNAs in cortical neurons.

Joanna Mattis, P. Lombroso, C. Paspalas, 2009, Cerebral cortex.

Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.

A. Nairn, P. Lombroso, J. Ellman, 2013, Journal of medicinal chemistry.

Tyrosine Phosphatase STEP Is a Tonic Brake on Induction of Long-Term Potentiation

Rand Askalan, Michael W. Salter, Surojit Paul, 2002, Neuron.

Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice

F. Benfenati, P. Lombroso, M. Milanese, 2018, Molecular Neurobiology.

A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified.

Joann P. Judge, B. Peterson, J. Leckman, 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

Adaptive, emotional, and family functioning of children with obsessive-compulsive disorder and comorbid attention deficit hyperactivity disorder.

B. Peterson, J. Leckman, D. Pauls, 2005, The American journal of psychiatry.

Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)

T. Chung, N. Cosford, A. Bobkov, 2021, International journal of molecular sciences.

Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism

P. Lombroso, Jian Xu, P. Kurup, 2020, Behavioural Brain Research.

Tourette syndrome and tic disorders: a decade of progress.

J. Leckman, L. Scahill, R. King, 2007, Journal of the American Academy of Child and Adolescent Psychiatry.

Striatal-enriched Protein-tyrosine Phosphatase (STEP) Regulates Pyk2 Kinase Activity*

J. Hell, P. Lombroso, Jian Xu, 2012, The Journal of Biological Chemistry.

Synaptic plasticity: one STEP at a time

Angus C. Nairn, A. Nairn, Surojit Paul, 2006, Trends in Neurosciences.

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models

Claudia S. Barros, J. Rapoport, K. Brennand, 2016, Molecular Psychiatry.

The genetics of childhood psychiatric disorders: a decade of progress.

J. Leckman, M. State, D. Pauls, 2000, Journal of the American Academy of Child and Adolescent Psychiatry.

β-Amyloid Modulation of Synaptic Transmission and Plasticity

R. Malinow, W. Netzer, P. Lombroso, 2007, The Journal of Neuroscience.

Involvement of PTPN5, the gene encoding the striatal-enriched protein tyrosine phosphatase, in schizophrenia and cognition

B. Lerer, P. Lombroso, A. Rigbi, 2012, Psychiatric genetics.

Inhibition of striatal‐enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption

P. Lombroso, Jian Xu, Su Wu, 2014, Journal of neurochemistry.

Regulation of NMDA receptor trafficking by amyloid-β

P. Greengard, A. Nairn, T. Moran, 2005, Nature Neuroscience.

The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition

P. Lombroso, Christopher J. Fitzpatrick, Christopher James Fitzpatrick, 2011, Front. Neuroanat..

Development of the cerebral cortex: I. Forming the cortical structure.

P. Rakic, P. Lombroso, P Rakic, 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

Frizzled-9 Is Activated by Wnt-2 and Functions in Wnt/β-Catenin Signaling*

P. Lombroso, J. Kitajewski, T. Karasawa, 2002, The Journal of Biological Chemistry.

Striatal-enriched Protein-tyrosine Phosphatase (STEP)

J. Hell, P. Lombroso, Tommaso Patriarchi, 2012 .

Genetics of childhood disorders: XLVI. Autism, part 5: genetics of autism.

E. Cook, J. Veenstra-VanderWeele, P. Lombroso, 2003, Journal of the American Academy of Child and Adolescent Psychiatry.

Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases.

P. Lombroso, A. Bult, F. Zhao, 1995, Brain research. Molecular brain research.

A Neuronal Protein Tyrosine Phosphatase Induced by Nerve Growth Factor (*)

P. Lombroso, E. Sharma, 1995, The Journal of Biological Chemistry.

Genetics of childhood disorders: XLVIII. Learning and memory, Part 1: Fragile X syndrome update.

P. Lombroso, 2003, Journal of the American Academy of Child and Adolescent Psychiatry.

Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades

A. Sidhu, P. Lombroso, Jun Chen, 2009, The European journal of neuroscience.

An animal model of Tourette's syndrome.

JaneR . Taylor, B. Peterson, J. Leckman, 2002, The American journal of psychiatry.

Chapter 107 – Tourette Syndrome

F. Vaccarino, L. Scahill, M. Bloch, 2015 .

Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder

Dwight R. Johnson, Haiqun Lin, Heping Zhang, 2010, Biological Psychiatry.

Animal Models of Tourette Syndrome

P. Lombroso, K. Burke, 2005 .

Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders

B. Peterson, Heping Zhang, J. Leckman, 2001, Biological Psychiatry.

Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome

Haiqun Lin, Heping Zhang, J. Leckman, 2005, Biological Psychiatry.

Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections.

J. Leckman, R. King, P. Lombroso, 2004, Pediatrics.

STEP inhibition prevents Aβ-mediated damage in dendritic complexity and spine density in Alzheimer’s disease

P. Lombroso, P. Kurup, Manavi Chatterjee, 2020, Experimental Brain Research.

Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit/hyperactivity disorders.

J. Gore, B. Peterson, L. Staib, 2000, Archives of general psychiatry.

Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation

T. Mustelin, T. Chung, Li Yang, 2012, ACS chemical biology.

Molecular basis of genetic neuropsychiatric disorders.

P. Lombroso, D. Venkitaramani, 2007, Child and adolescent psychiatric clinics of North America.

Genetics of childhood disorders: XIV. A gene for Rett syndrome: news flash.

P. Lombroso, 2000, Journal of the American Academy of Child and Adolescent Psychiatry.

Identification of pyruvate kinase as an antigen associated with Tourette syndrome

J. Bibb, J. Leckman, J. Zabriskie, 2006, Journal of Neuroimmunology.

Sydenham's chorea.

P. Lombroso, M. Mercadante, M. J. Marques-Dias, 1997, The Psychiatric clinics of North America.

The psychiatric symptoms of rheumatic fever.

J. Leckman, G. Busatto, P. Lombroso, 2000, The American journal of psychiatry.

Genetics of childhood disorders: XXX. Autoimmune disorders, part 3: myasthenia gravis and Rasmussen's encephalitis.

P. Lombroso, M. Mercadante, Marcos T. Mercadante, 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study.

Dwight R. Johnson, E. Kaplan, Haiqun Lin, 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

Group A streptococcal infections and their potential role in neuropsychiatric disease.

P. Lombroso, D. Bessen, 2001, Advances in neurology.

Newly Acquired Streptococcal Infections Obsessive-Compulsive Disorder: Relationship of Symptom Exacerbations to Prospective Longitudinal Study of Children With Tic Disorders and/or

J. Leckman, R. King, P. Lombroso, 2014 .

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

V. Haroutunian, C. Pittenger, P. Lombroso, 2012, Translational Psychiatry.

The Importance of Genetic Factors in the Etiology of Child Psychiatric Disorders

J. Leckman, D. Pauls, P. Lombroso, 1990 .

Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

A. Nairn, P. Lombroso, Jian Xu, 2015, Cellular and Molecular Life Sciences.

Striatal-enriched protein tyrosine phosphatase in Alzheimer's disease.

A. Nairn, P. Lombroso, Jian Xu, 2012, Advances in pharmacology.

STriatal Enriched Protein Tyrosine Phosphatase mediates Ethanol inhibition of NMDA Receptor Activity

P. Lombroso, M. Browning, R. K. Freund, 2008 .

Striatal Enriched Phosphatase 61 Dephosphorylates Fyn at Phosphotyrosine 420*

P. Lombroso, Paul J Lombroso, Tri-Hung Nguyen, 2002, The Journal of Biological Chemistry.

A Common STEP in the Synaptic Pathology of Diverse Neuropsychiatric Disorders

Micah A. Johnson, P. Lombroso, 2012, The Yale journal of biology and medicine.

Genetics of childhood disorders: XXVIII. Autoimmunity, part I.

P. Lombroso, M. Mercadante, S. Morshed, 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

Molecular mechanisms of developmental disorders

P. Lombroso, M. Brodsky, 1998, Development and Psychopathology.

Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder.

Haiqun Lin, Heping Zhang, J. Leckman, 2007, Journal of child psychology and psychiatry, and allied disciplines.

Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function

A. Nairn, P. Lombroso, J. Benedict, 2016, Neural plasticity.

Protein phosphatases and Alzheimer's disease.

Angus C. Nairn, A. Nairn, J. Stock, 2012, Progress in molecular biology and translational science.

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model

P. Greengard, A. Nairn, C. Pittenger, 2010, Proceedings of the National Academy of Sciences.

Beta-amyloid modulation of synaptic transmission and plasticity.

R. Malinow, W. Netzer, P. Lombroso, 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity

A. Nairn, M. Ogren, P. Lombroso, 2016, F1000Research.

The role of STEP in Alzheimer's disease

P. Lombroso, Jian Xu, P. Kurup, 2010 .

Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

Paul Greengard, Angus C. Nairn, Jian Xu, 2010, The Journal of Neuroscience.

Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment.

M. Riddle, L. Scahill, R. King, 1991, Journal of the American Academy of Child and Adolescent Psychiatry.

FRAGILE X SYNDROME

P. Lombroso, 2000 .

Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing

Y. de Koninck, P. Lombroso, Jian Xu, 2019, Brain : a journal of neurology.

Learning and memory, part II: molecular mechanisms of synaptic plasticity.

M. Ogren, P. Lombroso, 2009, Journal of the American Academy of Child and Adolescent Psychiatry.

Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location.

Nunzio Bottini, Tomas Mustelin, Scott Williams, 2004, The Biochemical journal.

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline

A. Nairn, E. Bézard, B. Bontempi, 2018, Current Biology.

Tourette's syndrome: a multigenerational, neuropsychiatric disorder.

D. Cohen, J. Leckman, L. Scahill, 1995, Advances in neurology.

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition

P. Lombroso, A. Saavedra, J. Alberch, 2016, Pain.

Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks

A. Bordey, P. Lombroso, J. Wen, 2017, Neuroscience Letters.

Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment.

B. Peterson, Heping Zhang, J. Leckman, 2003, Journal of the American Academy of Child and Adolescent Psychiatry.

Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity

H. J. Chung, P. Lombroso, Jian Xu, 2015, Molecular Brain.

Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder

Eli R. Lebowitz, Haiqun Lin, J. Leckman, 2012, European Child & Adolescent Psychiatry.

Reduced levels of the tyrosine phosphatase STEP block beta amyloid‐mediated GluA1/GluA2 receptor internalization

P. Greengard, A. Nairn, P. Lombroso, 2011, Journal of neurochemistry.

A STEP forward in neural function and degeneration

M. Baum, P. Lombroso, Jian Xu, 2010, Communicative & integrative biology.

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

G. Collingridge, E. Molnár, P. Lombroso, 2008, The Journal of Neuroscience.

Status Epilepticus-Induced Somatostatinergic Hilar Interneuron Degeneration Is Regulated by Striatal Enriched Protein Tyrosine Phosphatase

J. Naegele, Boyoung Lee, K. Obrietan, 2007, The Journal of Neuroscience.

Obsessive–compulsive disorder

M. Bloch, P. Lombroso, Bekir B. Artukoğlu, 2020, Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease.

Transport of animals between rooms: A little-noted aspect of laboratory procedure that may interfere with memory

G. Xavier, P. Lombroso, D. Venkitaramani, 2011, Behavioural Processes.

The Dopamine/D1 Receptor Mediates the Phosphorylation and Inactivation of the Protein Tyrosine Phosphatase STEP via a PKA-Dependent Pathway

Angus C. Nairn, Marina R. Picciotto, A. Nairn, 2000, The Journal of Neuroscience.

STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease

A. Nairn, P. Lombroso, Jian Xu, 2015, Proceedings of the National Academy of Sciences.

Pyk 2 signaling STriatal-Enriched Protein Tyrosine Phosphatase ( STEP ) Regulates Pyk 2 Activity *

J. Hell, P. Lombroso, Jian Xu, 2012 .

Assessment of symptom exacerbations in a longitudinal study of children with Tourette's syndrome or obsessive-compulsive disorder.

B. Peterson, Haiqun Lin, J. Leckman, 2002, Journal of the American Academy of Child and Adolescent Psychiatry.

Individualized Assessments in Treatment Research: An Examination of Parent-Nominated Target Problems in the Treatment of Disruptive Behaviors in Youth with Tourette Syndrome

L. Scahill, P. Lombroso, Heidi Grantz, 2014, Child psychiatry and human development.

Development of the Yale Children's Global Stress Index (YCGSI) and its application in children and adolescents ith Tourette's syndrome and obsessive-compulsive disorder.

Haiqun Lin, Heping Zhang, J. Leckman, 2003, Journal of the American Academy of Child and Adolescent Psychiatry.

Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity

J. Lucas, P. Lombroso, Jian Xu, 2011, The Journal of Neuroscience.

The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala

JaneR . Taylor, N. Tronson, P. Olausson, 2007, Biological Psychiatry.

Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation

G. Collingridge, N. Emptage, P. Lombroso, 2014, Molecular Brain.

Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation

M. Picciotto, Surojit Paul, P. Lombroso, 2009, Synapse.

Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61

A. Nairn, P. Lombroso, Jian Xu, 2017, Molecular Neurobiology.

Taking STEPs forward to understand fragile X syndrome.

P. Lombroso, S. Goebel-Goody, 2012, Results and problems in cell differentiation.

Thermal Sensitivity in Tourette Syndrome: Preliminary Report

J. Leckman, L. Scahill, P. Lombroso, 2001, Perceptual and motor skills.

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome

P. Lombroso, Jian Xu, A. Saavedra, 2016, Molecular Neurobiology.

The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity

JaneR . Taylor, P. Olausson, T. Moran, 2012, Neuroscience.

A Substrate Trapping Mutant Form of Striatal-Enriched Protein Tyrosine Phosphatase Prevents Amphetamine-Induced Stereotypies and Long-Term Potentiation in the Striatum

D. Centonze, C. Prosperetti, Surojit Paul, 2009, Biological Psychiatry.

State-of-the-Art-Lectures

L. Rohde, J. Leckman, B. Herpertz-Dahlmann, 2004 .

Atomoxetine and tics in ADHD.

R. King, P. Lombroso, Tih‐Shih W. Lee, 2004, Journal of the American Academy of Child and Adolescent Psychiatry.

Development of the cerebral cortex: III. The reeler mutation.

P. Lombroso, 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

A. Nairn, P. Lombroso, Jian Xu, 2016, Cellular and Molecular Life Sciences.

Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice

F. Benfenati, P. Lombroso, M. Milanese, 2018, Molecular Neurobiology.

STEP regulation of seizure thresholds in the hippocampus

J. Naegele, P. Lombroso, Kemal Asik, 2011, Epilepsia.

STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms.

M. Solimena, P. Lombroso, A. Bult, 1997, European journal of cell biology.

X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

A. Nairn, N. Brandon, S. Geschwindner, 2017, Journal of medicinal chemistry.

Development of the cerebral cortex: XII. Stress and brain development: I.

R. Sapolsky, P. Lombroso, 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

Development of the Cerebral Cortex : XI

R. Sapolsky, P. Lombroso, 2009 .

Stress and Brain Development: I

R. Sapolsky, P. Lombroso, 1998 .

Genetics of Childhood Disorders: XVII. ADHD, Part 1: The Executive Functions and ADHD

R. Barkley, P. Lombroso, R A Barkley, 2000 .

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

R. Radcliffe, P. Lombroso, W. Proctor, 2011, Proceedings of the National Academy of Sciences.

Receptor and nonreceptor protein tyrosine phosphatases in the nervous system

P. Lombroso, S. Paul, P. J. Lombroso, 2003, Cellular and Molecular Life Sciences CMLS.

Genetics of childhood disorders: XXXVII. News flash: a gene for expressive language.

P. Lombroso, 2002, Journal of the American Academy of Child and Adolescent Psychiatry.

Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum.

J. Naegele, P. Lombroso, G. Matthews, 1996, Brain research. Developmental brain research.

Translation of striatal‐enriched protein tyrosine phosphatase (STEP) after β1‐adrenergic receptor stimulation

P. Lombroso, D. Venkitaramani, Yang Zhang, 2007, Journal of neurochemistry.

Genetics of childhood disorders: VII. Cloning genes of interest.

P. Lombroso, J. Gruen, R. Sparks, 1999, Journal of the American Academy of Child and Adolescent Psychiatry.

Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.

U. Francke, P. Lombroso, X. Li, 1995, Genomics.

Schizophrenia in adolescent twins: a case study.

D. Cohen, S. Tyano, P. Lombroso, 2004, Israel journal of psychiatry and related sciences.

Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders

P. Lombroso, T. Karasawa, Paul J. Lombroso, 2014, Neuroscience Research.

[Learning and memory].

P. Lombroso, 2004, Revista Brasileira de Psiquiatria.

Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model

J. Naegele, P. Lombroso, S. Royston, 2012, Genes, brain, and behavior.

The activity of the Striatal‐enriched protein tyrosine phosphatase in neuronal cells is modulated by adenosine A2A receptor

P. Lombroso, P. Popoli, M. Bader, 2020, Journal of neurochemistry.

Protein phosphatases and Alzheimer's disease.

A. Nairn, J. Stock, P. Lombroso, 2012, Progress in molecular biology and translational science.

Genetics of childhood disorders: XXIV. ADHD, part 8: hyperdopaminergic mice as an animal model of ADHD.

R. Gainetdinov, M. Caron, P. Lombroso, 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

Genetics of childhood disorders: XVIII. ADHD, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function.

A. Arnsten, P. Lombroso, A F Arnsten, 2000, Journal of the American Academy of Child and Adolescent Psychiatry.

Genetics of childhood disorders: III. Genetics and intelligence.

R. Plomin, P. Lombroso, 1999, Journal of the American Academy of Child and Adolescent Psychiatry.

Alterations in STriatal‐Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model

L. Raymond, P. Lombroso, Jian Xu, 2014, Journal of neurochemistry.

Genetics of childhood disorders: XXVII. Genes and cognition in Williams syndrome.

P. Lombroso, B. Pober, L. Osborne, 2001, Journal of the American Academy of Child and Adolescent Psychiatry.